Paracetamol effectively reduces prostaglandin E2 synthesis in brain macrophages by inhibiting enzymatic activity of cyclooxygenase but not phospholipase and prostaglandin E synthase

Journal of Neuroscience Research

Volumn 71, Issue 6, 2003, Pages 844-852

  Greco, Anita ^a   Ajmone Cat, Maria Antonietta ^a   Nicolini, Alessia ^a   Sciulli, Maria Gina ^b   Minghetti, Luisa ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

Author keywords

Acetaminophen; Cyclooxygenase 2; Microglia; Nitric oxide; NSAID; Tumor necrosis factor

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; FLURBIPROFEN; INDOMETACIN; LIPOPOLYSACCHARIDE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PHOSPHOLIPASE; PIROXICAM; PROSTAGLANDIN E SYNTHASE; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN H2; PROSTAGLANDIN SYNTHASE; THROMBOXANE B2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARACHIDONIC ACID METABOLISM; ARTICLE; DEGENERATIVE DISEASE; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; MACROPHAGE; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; RAT;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARACHIDONIC ACID; BLOTTING, WESTERN; CELLS, CULTURED; CEREBRAL CORTEX; DINOPROSTONE; INTRAMOLECULAR OXIDOREDUCTASES; MICROGLIA; NITRIC OXIDE; PHOSPHOLIPASES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037443693     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10543     Document Type: Article

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