메뉴 건너뛰기




Volumn 102, Issue 9, 1998, Pages 1645-1652

Regulation of an essential innate immune response by the p50 subunit of NF-κB

Author keywords

Lipopolysaccharide; Macrophages; Regulation of transcription; Sepsis; Tumor necrosis factor

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN SUBUNIT; SALMONELLA ENDOTOXIN; TUMOR NECROSIS FACTOR;

EID: 0032211810     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI3877     Document Type: Article
Times cited : (244)

References (32)
  • 2
    • 0027976138 scopus 로고
    • Recognition of endotoxin by cells leading to transmembrane signalling
    • Ulevitch, R.J., and P.S. Tobias. 1994. Recognition of endotoxin by cells leading to transmembrane signalling. Curr. Opin. Immunol. 6:125-130.
    • (1994) Curr. Opin. Immunol. , vol.6 , pp. 125-130
    • Ulevitch, R.J.1    Tobias, P.S.2
  • 3
    • 85025404652 scopus 로고
    • Tolerance to bacterial pyrogen
    • Beeson, P.B. 1947. Tolerance to bacterial pyrogen. J. Exp. Med. 86:29-34.
    • (1947) J. Exp. Med. , vol.86 , pp. 29-34
    • Beeson, P.B.1
  • 4
    • 0024842903 scopus 로고
    • Lipopolysaccharide induces hyporesponsiveness to its own action in RAW 264.7 cells
    • Virca, G.D., S.Y. Kim, K.B. Glaser, and R.J. Ulevitch. 1989. Lipopolysaccharide induces hyporesponsiveness to its own action in RAW 264.7 cells. J. Biol. Chem. 264:21951-21956.
    • (1989) J. Biol. Chem. , vol.264 , pp. 21951-21956
    • Virca, G.D.1    Kim, S.Y.2    Glaser, K.B.3    Ulevitch, R.J.4
  • 5
    • 0025348273 scopus 로고
    • Adaptation to bacterial lipopolysaccharide (LPS) controls LPS-induced tumor necrosis factor production in rabbit macrophages
    • Mathison, J.C., G.D. Virca, N. Wolfson, P.S. Tobias, K. Glaser, and R.J. Ulevitch. 1990. Adaptation to bacterial lipopolysaccharide (LPS) controls LPS-induced tumor necrosis factor production in rabbit macrophages. J. Clin. Invest. 85:1108-1118.
    • (1990) J. Clin. Invest. , vol.85 , pp. 1108-1118
    • Mathison, J.C.1    Virca, G.D.2    Wolfson, N.3    Tobias, P.S.4    Glaser, K.5    Ulevitch, R.J.6
  • 7
    • 0027499515 scopus 로고
    • Lipopolysaccharide-induced selective priming effects on tumor necrosis factor and nitric oxide production in mouse peritoneal macrophages
    • Zhang, X., and D.C. Morrison. 1993. Lipopolysaccharide-induced selective priming effects on tumor necrosis factor and nitric oxide production in mouse peritoneal macrophages. J. Exp. Med. 177:511-516.
    • (1993) J. Exp. Med. , vol.177 , pp. 511-516
    • Zhang, X.1    Morrison, D.C.2
  • 8
    • 0027967441 scopus 로고
    • A labile transcriptional repressor modulates endotoxin tolerance
    • LaRue, K.E.A., and C.E. McCall. 1994. A labile transcriptional repressor modulates endotoxin tolerance. J. Exp. Med. 180:2269-2275.
    • (1994) J. Exp. Med. , vol.180 , pp. 2269-2275
    • LaRue, K.E.A.1    McCall, C.E.2
  • 9
    • 0030227519 scopus 로고    scopus 로고
    • Acquired hyporesponsiveness to bacterial lipopolysaccharide and interferon-gamma in RAW 264.7 macrophages
    • Boyte, W.R., E.A. Meals, and B.K. English. 1996. Acquired hyporesponsiveness to bacterial lipopolysaccharide and interferon-gamma in RAW 264.7 macrophages. Shock. 6:218-222.
    • (1996) Shock , vol.6 , pp. 218-222
    • Boyte, W.R.1    Meals, E.A.2    English, B.K.3
  • 10
    • 0027451272 scopus 로고
    • Lipopolysaccharide structure-function relationship in activation versus reprogramming of mouse peritoneal macrophages
    • Zhang, X., and D.C. Morrison. 1993. Lipopolysaccharide structure-function relationship in activation versus reprogramming of mouse peritoneal macrophages. J. Leukoc. Biol. 54:444-450.
    • (1993) J. Leukoc. Biol. , vol.54 , pp. 444-450
    • Zhang, X.1    Morrison, D.C.2
  • 12
    • 0030101797 scopus 로고    scopus 로고
    • Endotoxin tolerance is induced in Chinese hamster ovary cell lines expressing human CD14
    • Kravchenko, V.V., S. Steinemann, L. Kline, L. Feng, and R.J. Ulevitch. 1996. Endotoxin tolerance is induced in Chinese hamster ovary cell lines expressing human CD14. Shock. 194-201.
    • (1996) Shock , pp. 194-201
    • Kravchenko, V.V.1    Steinemann, S.2    Kline, L.3    Feng, L.4    Ulevitch, R.J.5
  • 13
    • 0028804551 scopus 로고
    • Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
    • Sha, W.C., H.-C. Liou, E.I. Toumanen, and D. Baltimore. 1995. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell. 80:321-330.
    • (1995) Cell , vol.80 , pp. 321-330
    • Sha, W.C.1    Liou, H.-C.2    Toumanen, E.I.3    Baltimore, D.4
  • 14
    • 0029150389 scopus 로고
    • Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
    • Kontgen, F., R.J. Grumont, A. Strasser, D. Metcalf, R. Li, D. Tarlington, and S. Gerondakis. 1995. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 9:1965-1977.
    • (1995) Genes Dev. , vol.9 , pp. 1965-1977
    • Kontgen, F.1    Grumont, R.J.2    Strasser, A.3    Metcalf, D.4    Li, R.5    Tarlington, D.6    Gerondakis, S.7
  • 15
    • 0023884204 scopus 로고
    • Participation of tumor necrosis in the mediation of gram-negative bacterial lipopolysaccharide-induced injury in rabbits
    • Mathison, J.C., E. Wolfson, and R.J. Ulevitch. 1988. Participation of tumor necrosis in the mediation of gram-negative bacterial lipopolysaccharide-induced injury in rabbits. J. Clin. Invest. 81:1925-1937.
    • (1988) J. Clin. Invest. , vol.81 , pp. 1925-1937
    • Mathison, J.C.1    Wolfson, E.2    Ulevitch, R.J.3
  • 16
    • 0025828480 scopus 로고
    • Interactive effects of the tumor necrosis factor promoter and 3′-untranslated regions
    • Han, J., G. Huez, and B. Beutler. 1991. Interactive effects of the tumor necrosis factor promoter and 3′-untranslated regions. J. Immunol. 146:1843-1848.
    • (1991) J. Immunol. , vol.146 , pp. 1843-1848
    • Han, J.1    Huez, G.2    Beutler, B.3
  • 18
    • 0029031505 scopus 로고
    • Platelet-activating factor induces NF-κB activation through a G protein-coupled pathway
    • Kravchenko, V.V., Z. Pan, J. Han, J.-M. Herbert, R.J. Ulevitch, and R.D. Ye. 1995. Platelet-activating factor induces NF-κB activation through a G protein-coupled pathway. J. Biol. Chem. 270:14928-14934.
    • (1995) J. Biol. Chem. , vol.270 , pp. 14928-14934
    • Kravchenko, V.V.1    Pan, Z.2    Han, J.3    Herbert, J.-M.4    Ulevitch, R.J.5    Ye, R.D.6
  • 19
    • 0021100690 scopus 로고
    • Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
    • Dignam, J.D., R.M. Lebovitz, and R.G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-1489.
    • (1983) Nucleic Acids Res. , vol.11 , pp. 1475-1489
    • Dignam, J.D.1    Lebovitz, R.M.2    Roeder, R.G.3
  • 20
    • 0029866670 scopus 로고    scopus 로고
    • Rel deficient T cells exhibit defects in the production of interleukin-3 and granulocyte-macrophage colony stimulating factor
    • Gerondakis, S., A. Strasser, D. Metcalf, G. Grigoriadis, J.-P.Y. Scheerlink, and R.J. Grumont. 1996. Rel deficient T cells exhibit defects in the production of interleukin-3 and granulocyte-macrophage colony stimulating factor. Proc. Natl Acad. Sci. USA. 93:3405-3409.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 3405-3409
    • Gerondakis, S.1    Strasser, A.2    Metcalf, D.3    Grigoriadis, G.4    Scheerlink, J.-P.Y.5    Grumont, R.J.6
  • 21
    • 0030481581 scopus 로고    scopus 로고
    • The Rel subunit of NF-κB-like transcription factors is a positive and negative regulator of macrophage gene expression: Distinct roles for Rel in different macrophage populations
    • Grigoriadis, G., Y. Zhan, R.J. Grumont, D. Metcalf, E. Handman, C. Cheers, and S. Gerondakis. 1996. The Rel subunit of NF-κB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations. EMBO J. 15:7099-7107.
    • (1996) EMBO J. , vol.15 , pp. 7099-7107
    • Grigoriadis, G.1    Zhan, Y.2    Grumont, R.J.3    Metcalf, D.4    Handman, E.5    Cheers, C.6    Gerondakis, S.7
  • 22
    • 0025186678 scopus 로고
    • κB-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor gene in primary macrophages
    • Shakhov, A.N., M.A. Collart, P. Vassalli, S.A. Nedospasov, and C.V. Jongeneel. 1990. κB-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor gene in primary macrophages. J. Exp. Med. 171:35-47.
    • (1990) J. Exp. Med. , vol.171 , pp. 35-47
    • Shakhov, A.N.1    Collart, M.A.2    Vassalli, P.3    Nedospasov, S.A.4    Jongeneel, C.V.5
  • 23
    • 0025260779 scopus 로고
    • Regulation of tumor necrosis factor-transcription in macrophages: Involvement of four κB-like motifs and of constitutive and inducible forms of NF-κB
    • Collart, M.A., P. Baeuerle, and P. Vassalli. 1990. Regulation of tumor necrosis factor-transcription in macrophages: Involvement of four κB-like motifs and of constitutive and inducible forms of NF-κB. Mol. Cell. Biol. 10:1498-1506.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 1498-1506
    • Collart, M.A.1    Baeuerle, P.2    Vassalli, P.3
  • 24
    • 0025789094 scopus 로고
    • Enhancers and transcription factors controlling the inducibility of the tumor necrosis factor-α promoter in primary macrophages
    • Drouet, C., A.N. Shakhov, and C.V. Jongeneel. 1991. Enhancers and transcription factors controlling the inducibility of the tumor necrosis factor-α promoter in primary macrophages. J. Immunol. 147:1694-1700.
    • (1991) J. Immunol. , vol.147 , pp. 1694-1700
    • Drouet, C.1    Shakhov, A.N.2    Jongeneel, C.V.3
  • 25
    • 0025943986 scopus 로고
    • The p65 subunit is responsible for the strong transcription activating potential of NF-κB
    • Lienhard Schmitz, M., and P.A. Baeuerle. 1991. The p65 subunit is responsible for the strong transcription activating potential of NF-κB. EMBO J. 10:3805-3817.
    • (1991) EMBO J. , vol.10 , pp. 3805-3817
    • Lienhard Schmitz, M.1    Baeuerle, P.A.2
  • 26
    • 0026758170 scopus 로고
    • The candidate oncoprotein Bcl-3 is an antagonist of p50/ NF-κB-mediated inhibition
    • Franzoso, G., V. Bours, S. Park, M. Tomita-Yamaguchi, K. Kelly, and U. Siebenlist. 1992. The candidate oncoprotein Bcl-3 is an antagonist of p50/ NF-κB-mediated inhibition. Nature. 359:339-342.
    • (1992) Nature , vol.359 , pp. 339-342
    • Franzoso, G.1    Bours, V.2    Park, S.3    Tomita-Yamaguchi, M.4    Kelly, K.5    Siebenlist, U.6
  • 27
    • 0025782658 scopus 로고
    • NF-κB contacts DNA by a heterodimer of the p50 and p65 subunit
    • Urban, M.B., R. Schreck, and P.A. Baeuerle. 1991. NF-κB contacts DNA by a heterodimer of the p50 and p65 subunit. EMBO J. 10:1817-1825.
    • (1991) EMBO J. , vol.10 , pp. 1817-1825
    • Urban, M.B.1    Schreck, R.2    Baeuerle, P.A.3
  • 28
    • 0026774239 scopus 로고
    • Selection of optimal κB/Rel DNA-binding motifs: Interaction of both subunits of NF-κB with DNA is required for transcriptional activation
    • Kunsch, C., S.M. Ruben, and C.A. Rosen. 1992. Selection of optimal κB/Rel DNA-binding motifs: interaction of both subunits of NF-κB with DNA is required for transcriptional activation. Mol. Cell. Biol. 12:4412-4421.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 4412-4421
    • Kunsch, C.1    Ruben, S.M.2    Rosen, C.A.3
  • 29
    • 0028123062 scopus 로고
    • A set of inducible genes expressed by activated human monocytic and endothelial cells contain κB-like sites that specifically bind c-Rel-p65 heterodimers
    • Parry, G.C.N., and N. Mackman. 1994. A set of inducible genes expressed by activated human monocytic and endothelial cells contain κB-like sites that specifically bind c-Rel-p65 heterodimers. J. Biol. Chem. 269:20823-20825.
    • (1994) J. Biol. Chem. , vol.269 , pp. 20823-20825
    • Parry, G.C.N.1    Mackman, N.2
  • 30
    • 0025200592 scopus 로고
    • The 65-kD subunit of NF-κB is a receptor for IκB and a modulator of DNA-binding specifity
    • Urban, M.B., and P.A. Baeuerle. 1990. The 65-kD subunit of NF-κB is a receptor for IκB and a modulator of DNA-binding specifity. Genes Dev. 4: 1975-1984.
    • (1990) Genes Dev. , vol.4 , pp. 1975-1984
    • Urban, M.B.1    Baeuerle, P.A.2
  • 31
    • 0031435750 scopus 로고    scopus 로고
    • LPS tolerance in monocytes/macrophages: Three 3′ cytosins are required in the DNA binding motif for detection of upregulated NF-κB p50 homodimers
    • Loms-Ziegler-Heitbrock, H.W., and M. Frankenberger. 1998. LPS tolerance in monocytes/macrophages: three 3′ cytosins are required in the DNA binding motif for detection of upregulated NF-κB p50 homodimers. Immunobiologv. 198:81-90.
    • (1998) Immunobiologv. , vol.198 , pp. 81-90
    • Loms-Ziegler-Heitbrock, H.W.1    Frankenberger, M.2
  • 32
    • 0027212534 scopus 로고
    • Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-κB proteins in human monocytic THP-1 cells
    • Cordle, S.R., R. Donald, M.A. Read, and J. Hawiger. 1993. Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-κB proteins in human monocytic THP-1 cells. J. Biol. Chem. 268:11803-11810.
    • (1993) J. Biol. Chem. , vol.268 , pp. 11803-11810
    • Cordle, S.R.1    Donald, R.2    Read, M.A.3    Hawiger, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.