Absence of detectable IL-1β production in murine prion disease: A model of chronic neurodegeneration

Journal of Neuropathology and Experimental Neurology

Volumn 60, Issue 2, 2001, Pages 173-182

  Walsh, Desmond T ^a,b   Betmouni, Samar ^a,c   Perry, V Hugh ^a,d  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^c FRENCHAY HOSPITAL   (United Kingdom)

^d UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Brain; Cytokines; Inflammation; Monocyte Microglia; Neurodegeneration; Prion disease

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CHRONIC DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEGENERATIVE DISEASE; DELAYED HYPERSENSITIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MICROGLIA; MONOCYTE; MOUSE; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE ACTIVATION;

EID: 0035111243     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/60.2.173     Document Type: Article

References (62)

1. Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease
2. Interleukin-6 and alpha-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices
3. Characterization of the microglial response in murine scrapie
4. Inflammatory mechanisms in neurodegeneration and Alzheimer's Disease: The role of the complement system
5. Evidence for an early inflammatory response in the central nervous system of mice with scrapie
6. Presence of T-cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer's disease brain tissue
7. Demonstration of microglial cells in and around senile (neuritic) plaque; in the Alzheimer brain - An immunohistochemical study using a novel monoclonal-antibody
8. Brain interleukin 1 and S-100 immunoreactivity are elevated in Down's syndrome and Alzheimer disease
9. Brain interleukin-1-beta in Alzheimers disease and vascular dementia
10. Cytokine indexes in Alzheimer's temporal cortex - No changes in mature IL-1-beta or IL-1ra but increases in the associated acute-phase proteins IL-6, alpha-2-macroglobulin and C-reactive protein
11. Longitudinal study of inflammatory factors in serum, cerebrospinal fluid and brain tissue in Alzheimer's Disease: Interleukin-1 beta, interleukin-6, interleukin-1 receptor antagonist, tumour necrosis factor-alpha, the soluble tumour necrosis factor receptors I and II, and alpha 1-antichymotrypsin
12. The molecular pathology of Alzheimer's disease
13. Alzheimer's disease and Creutzfeldt-Jakob disease: Overlap of pathogenic mechanisms
14. Novel proteinaceous infectious particles cause scrapie
15. Molecular biology of prion diseases
16. Neurotoxicity of a prion protein fragment
17. Activation of cerebral cytokine gene expression and its correlation with onset of reactive astrocyte and acute phase response gene expression in scrapie
18. Heightened expression of tumor-necrosis-factor-alpha, interleukin-1-alpha, and glial fibrillary acidic protein in experimental Creutzfeldt-Jakob-disease in mice
19. Cytokines, prostaglandins and lipocortin-1 are present in the brains of scrapie infected mice
20. Immunocytochemical appearance of cytokines, prostaglandin E-2 and lipocortin-1 in the CNS during the incubation period of murine scrapie correlates with progressive PrP accumulations
21. The acute inflammatory response in CNS following injection of prion brain homogenate or normal brain homogenate
22. Behavioural consequences of prion disease targeted to the hippocampus in mice
23. Cerebral amyloidosis in scrapie in the mouse: Effect of agent strain and mouse genotype
24. Effect of route of infection on the frequency and distribution of cerebral amyloid plaques in scrapie in mice
25. Electrophysiological properties of dorsal lateral geniculate neurons in brain slices from ME7 scrapie-infected mice
26. Synapse loss associated with abnormal PrP precedes neuronal degeneration in the scrapie-infected murine hippocampus
27. The acute inflammatory response to lipopolysaccharide in CNS parenchyma differs from that in other body tissues
28. Delayed-type hypersensitivity lesions in the central nervous system are prevented by inhibitors of matrix metalloproteinases
29. Neutralization of interleukin-1 beta activity in vivo with a monoclonal antibody alleviates collagen-induced arthritis in DBA/1 mice and prevents the associated acute-phase response
30. Macrosialin, a macrophage-restricted membrane sialoprotein differentially glycosylated in response to inflammatory stimuli
31. Prion protein immunocytochemistry-UK five centre consensus report
32. Constructing polycompetitor cDNAs for quantitative PCR
33. Quantitation of matrix metalloproteinases in cultured rat astrocytes using the polymerase chain reaction with a multicompetitor cDNA standard
34. Differential expression of inflammatory cytokines parallels progression of central nervous pathology in two clinically distinct models of multiple sclerosis
35. Monocyte recruitment into scrapie-affected brain
36. Neuronal apoptosis in Creutzfeldt-Jakob disease
37. Encephalopathy in mice produced by inoculation with scrapie brain material
38. Changes in drinking and feeding habits of mice with experimental scrapie
39. Tumor necrosis factor alpha-deficient, but not interleukin-6-deficient, mice resist peripheral infection with scrapie
40. Interleukin 1 of the central nervous system is produced by amoeboid microglia
41. Production of tumour necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus
42. Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta
43. Modulation of microglia phenotype
44. Inflammation in the nervous system
45. Effect of scrapie infection on the activity of neuronal nitric oxide synthase in brain and neuroblastoma cells
46. Kinetics of virus spread and changes in levels of several cytokine mRNAs in the brain after intranasal infection of rats with Borna disease virus
47. Characterization of the cellular and cytokine response in the central nervous system following Semliki Forest virus infection
48. Expression pattern and cellular origin of cytokines in the normal and Toxoplasma gondii-infected murine brain
49. Scrapie in immunologically deficient mice
50. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy
51. Regulation of brain-derived T cells during acute central nervous system inflammation
52. Interleukin-1 expression in different plaque types in Alzheimer's disease - Significance in plaque evolution
53. Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain
54. Microglial activation varies in different models of Creutzfeldt-Jakob disease
55. Role of microglia - Extracellular matrix interactions in acute and chronic neurodegeneration
56. Amyloidogenic role of cytokine TGF-β1 in transgenic mice and in Alzheimer's Disease
57. Protective effect of transforming growth factor beta 1 on experimental autoimmune diseases in mice
58. Inhibition of microglial cell RANTES production by IL-10 and TGF-beta
59. Cyclooxygenase-2 is highly expressed in microglial-like cells in a murine model of prion disease
60. Increased brain synthesis of prostaglandin E2 and F2-isoprostane in human and experimental transmissible spongiform brain encephalopathies
61. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGFβ, PGE2 and PAF
62. Neuronal cell death in scrapie-infected mice is due to apoptosis