Development of a multi-organ rat model for evaluating chemopreventive agents: Efficacy of indole-3-carbinol

Carcinogenesis

Volumn 23, Issue 2, 2002, Pages 265-272

  Stoner, Gary ^a   Casto, Bruce ^a   Ralston, Sherry ^a   Roebuck, Bill ^b   Pereira, Clifford ^c   Bailey, George ^c  

^a OHIO STATE UNIVERSITY   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c OREGON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 INDOLEMETHANOL; 7,12 DIMETHYLBENZ[A]ANTHRACENE; AFLATOXIN B1; ANTIESTROGEN; AZOXYMETHANE; GLUTATHIONE TRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOASSAY; BREAST CANCER; CANCER INCIDENCE; CANCER INHIBITION; CANCER PREVENTION; CANCER SURVIVAL; CARCINOGENESIS; CATERING SERVICE; CHEMOPROPHYLAXIS; CLINICAL PROTOCOL; COLON CANCER; CONTROLLED STUDY; DIETARY INTAKE; DISEASE MODEL; DRUG ACTIVITY; DRUG EFFICACY; DRUG MARKETING; EXPERIMENTAL MODEL; FEMALE; FISH; INTESTINE CRYPT; LATENT PERIOD; LIVER CANCER; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; RODENT; TUMOR PROMOTION;

EID: 0036119630     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/23.2.265     Document Type: Article

References (47)

1. Inhibition of polycyclic aromatic hydrocarbon induced neoplasia by naturally occurring indoles
2. Comparative cytotoxicities of selected minor dietary non-nutrients with chemopreventive properties
3. Effects of micronutrients, antioxidants and related compounds on the mutagenicity of 3,2′-dimethyl-4-aminobiphenyl, a colon and breast carcinogen
4. Toxicology of glucosinolates, related compounds (nitriles, R-goitrin, isothiocyanates) and vitamin U found in Cruciferae
5. Intrinsic acute toxicity and hepatic enzyme inducing properties of the chemoprotectants, indole-3-carbinol and 5,10-dihydroindeno[1,2-b]indole in mice
6. Promotion of aflatoxin B1 carcinogenesis by the natural tumor modulator indole-3-carbinol: Influence of dose, duration and intermittent exposure on indole-3-carbinol promotional potency
7. Effects of indole-3-carbinol on lung tumorigenesis and DNA methylation induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and on the metabolism and disposition of NNK in A/J mice
8. Inhibition and promotion of 7,12-dimethylbenz[a]anthracene (DMBA) carcinogenesis in rainbow trout by indole-3-carbinol (13C)
9. Inhibition of aflatoxin B1 carcinogenesis in rainbow trout by flavone and indole compounds
10. Inhibitory effects of the natural products indole-3-carbinol and sinigrin during initiation and promotion phases of 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis
11. Estrogen metabolism and human papilloma virus-induced tumors of the larynx: Chemo-prophylaxis with indole-3-carbinol
12. Chemoprevention of spontaneous endometrial cancer in female Donryu rats by dietary indole-3-carbinol
13. Induction of estradiol metabolism by dietary indole-3-carbinol in humans
14. Altered estrogen metabolism in humans following consumption of indole-3-carbinol
15. The stability of the nitrosated products of indole, indole-3-acetonitrile, indole-3-carbinol and 4-chloroindole
16. Mutagen formation on nitrite treatment of indole compounds derived from indole-glucosinolate
17. Anti-mutagenesis and anti-promotion by apigenin, robinetin and indole-3-carbinol
18. Antitumor promoting activity of indole-3-carbinol in mouse skin carcinogenesis
19. Multiple dietary factors in the enhancement of dimethylhydrazine carcinogenesis: Main effect of indole-3-carbinol
20. Protection by green tea, black tea and indole-3-carbinol against 2-amino-3-methylimidazo[4,5-f]quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat
21. Protection by chlorophyllin and indole-3-carbinol against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced DNA adducts and colonic aberrant crypts in the F344 rat
22. Modifying responses of allyl sulfide, indole-3-carbinol and germanium in a rat multi-organ carcinogenesis model
23. Enhancement by indole-3-carbinol of liver and thyroid gland neoplastic development in a rat medium-term multiorgan carcinogenesis model
24. AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc Writing Committee on the reformulation of the AIN-76A rodent diet
25. Potent inhibition of aflatoxin-induced hepatic tumorigenesis by the monofunctional enzyme inducer 1,2-dithiole-3-thione
26. Reliable stereological method for estimating the number of microscopic hepatocellular foci from their transections
27. Morphogenesis of chemically induced neoplasms of the colon and small intestine in rats
28. Dose response and proliferative characteristics of aberrant crypt foci: Putative preneoplastic lesions in rat colon
29. Effects of dietary perilla oil, soybean oil and safflower oil on 7,12-dimethylbenz [a]athracene (DMBA) and 1,2-dimethylhydrazine (DMH)-induced mammary gland and colon carcinogenesis in female SD rats
30. Biphasic modifying effect of indole-3-carbinol on diethylnitrosamine-induced preneoplastic glutathione S-transferase placental form-positive liver cell foci in Sprague-Dawley rats
31. Organ-selective induction of cytochrome P-450-dependent activities by indole-3-carbinol-derived products: Influence on covalent binding of benzo[a]pyrene to hepatic and pulmonary DNA in the rat
32. Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice
33. Chemoprotective and hepatic enzyme induction properties of indole and indenoindole antioxidants in rats
34. Experimental down-regulation of intermediate biomarkers of carcinogenesis in mouse mammary epithelial cells
35. Selective responsiveness of human breast cancer cells to indole-3-carbinol, a chemopreventive agent
36. Indole-3-carbinol. A novel approach to breast cancer prevention
37. Mechanism of action of dietary chemoprotective agents in rat liver: Induction of phase I and II drug metabolizing enzymes and aflatoxin B1 metabolism
38. Regulation of rat glutathione S-transferase A5 by cancer chemopreventive agents: Mechanisms of inducible resistance to aflatoxin B1
39. Indole-3-carbinol protects against covalent binding of benzo[a]pyrene and N-nitrosodimethylamine metabolites to mouse liver molecules
40. Modulation of mycotoxin and nitrosamine carcinogenesis by indole-3-carbinol: Quantitative analysis of inhibition versus promotion
41. Chemopreventive properties of indole-3-carbinol (I3C): Inhibition of DNA adduct formation of the dietary carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in female F344 rats
42. Indole-3-carbinol as a scavanger of free radicals
43. Potency of dietary indole-3-carbinol as a promoter of aflatoxin B1-initiated hepatocarcinogenesis: Results from a 9000 animal tumor study
44. Effects of dietary anticarcinogens on rat gastrointestinal glutathione S-transferase theta 1-1 levels
45. Induction of cytochrome P4501A1 in rat colon and liver by indole-3-carbinol and 5,6-benzoflavone
46. β-catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol
47. Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl-imidazo[4,5-f]quinoline