Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man

Carcinogenesis

Volumn 22, Issue 9, 2001, Pages 1413-1420

  Murray, Stephen ^a   Lake, Brian G ^b   Gray, Stuart ^a   Edwards, Anne J ^b   Springall, Christine ^b   Bowey, Elizabeth A ^b   Williamson, Gary ^c   Boobis, Alan R ^a   Gooderham, Nigel J ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b TNOBIBRA International   (United Kingdom)

^c INSTITUTE OF FOOD RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; 2 AMINO 3,8 DIMETHYLIMIDAZO[4,5 F]QUINOXALINE; AROMATIC AMINE; BIOLOGICAL MARKER; CAFFEINE; CARCINOGEN; CYTOCHROME P450 1A2; DNA; HETEROCYCLIC COMPOUND;

ADULT; ARTICLE; BROCCOLI; BRUSSEL; CANCER PREVENTION; CANCER SUSCEPTIBILITY; CAUCASIAN; COLON CANCER; CONTROLLED STUDY; COOKING; CRUCIFERA; DIET; ENZYME ACTIVITY; EVIDENCE BASED MEDICINE; HUMAN; HUMAN EXPERIMENT; KINETICS; LIVER MICROSOME; LYMPHOCYTE; MALE; MEAT; METABOLIC ACTIVATION; METABOLISM; MUTAGENICITY; OXIDATION; PRIORITY JOURNAL; SMOKING; URINALYSIS; URINARY EXCRETION; VEGETABLE;

EID: 0034806866     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/22.9.1413     Document Type: Article

References (43)

1. The lessons of life
2. Meat, cooking methods and colorectal cancer. A case referent study in Stockholm
3. Identification of the mutagens in cooked beef
4. Heterocyclic-amine mutagens/carcinogens in foods
5. Carcinogenicity in mice of a mutagenic compound, 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline (MeIQx) from cooked foods
6. Carcinogenicity in rats of a mutagenic compound, 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
7. Induction of lymphoma in CDF1 mice by the food mutagen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
8. Induction of intestinal adenocarcinomas by 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine in Nagase analbuminemic rats
9. A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP)
10. Intra- and interindividual variability in systemic exposure in humans to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline and 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, carcinogens present in cooked beef
11. N-Hydroxy-MeIQx is the major microsomal oxidation product of the dietary carcinogen MeIQx with human liver
12. Metabolism of the food derived mutagen and carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) by human liver microsomes
13. CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans
14. Effect of cooking temperature on the formation of heterocyclic amines in fried meat products and pan residues
15. Carcinogenic heterocyclic amines in model systems and cooked foods: A review on formation, occurrence and intake
16. A review of mechanisms underlying anticarcinogenicity by brassica vegetables
17. Stimulatory effect of brussels sprouts and cabbage on human drug metabolism
18. Effect of brussels sprouts and cabbage on drug conjugation
19. Consumption of brussels sprouts results in elevated α-class glutathione S-transferase levels in human blood plasma
20. Evaluation of caffeine as a test drug for CYP1A2, NAT2 and CYP2E1 phenotyping in man by in vivo versus in vitro correlations
21. 2-(2′-deoxyguanosin-8-yl)-PhIP
22. Identification of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo-(4,5-b)pyridine as the major adduct formed by the food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, with DNA
23. 32P-postlabelling analysis of IQ, MeIQx and PhIP adducts formed in vitro in DNA and polynucleotides and found in vivo in hepatic DNA from IQ-, MeIQx- and PhIP-treated monkeys
24. 2-(2′-deoxyguanosin-8-yl)PhIP adducts in DNA
25. Measurement of MeIQx and DiMeIQx in fried beef by capillary column gas chromatography electron capture negative ion chemical ionisation mass spectrometry
26. Quantification of the carcinogens 2-amino-3,8-dimethyl- and 2-amino-3,4,8-trimethylimidazo(4,5-f)quinoxaline and 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine in food using a combined mass spectrometry
27. Selective increase of the anticarcinogenic 4-methylsulphinylbutyl glucosinolate in broccoli
28. Simplified colorimetric determination of thiocyanate in biological fluids, and its application to the investigation of the toxic amblyopias
29. Revised method for the Salmonella mutagenicity test
30. Heterocyclic aromatic amines in human urine following a fried meat meal
31. Chemical and biological properties of indole glucosinolates (glucobrassicins): A review
32. Effects of consumption of Brussels sprouts on intestinal and lymphocytic glutathione S-transferases in humans
33. Effects of dietary broccoli on human in vivo drug metabolizing enzymes: Evaluation of caffeine, oestrone and chlorzoxazone metabolism
34. Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine
35. Brassica vegetables increase and apiaceous decrease cytochrome P4501A2 activity in humans: Changes in caffeine metabolite ratios in response to controlled vegetable diets
36. Glucosinolates in Brassica: Occurrence and significance as cancer-modulating agents
37. A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure
38. Metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine by human cytochrome P4501A1, P4501A2 and P4501B1
39. 14C)2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine metabolites in humans
40. Metabolism of the food-borne mutagen 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline in humans
41. Formation of a glutathione conjugate and a semistable transportable glucuronide conjugate of N2-oxidised species of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) in rat liver
42. DNA and protein adduct formation in the colon and blood of humans after exposure to a dietary-relevent dose of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine