Sunlight and sunburn in human skin cancer: P53, apoptosis, and tumor promotion

Journal of Investigative Dermatology Symposium Proceedings

Volumn 1, Issue 2, 1996, Pages 136-142

  Brash, Douglas E ^a   Ziegler, Annemarie ^a   Jonason, Alan S ^a   Simon, Jeffrey A ^a   Kunala, Subrahmanyam ^a   Leffell, David J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Mutagenesis; Sunburn cells; Ultravioletl actinic keratosis

Indexed keywords

ANIMAL; APOPTOSIS; HUMAN; MOUSE; MUTATION; PHYSIOLOGY; PRECANCER; REVIEW; SKIN TUMOR; SUNBURN; SUNLIGHT; TUMOR SUPPRESSOR GENE; ULTRAVIOLET RADIATION;

ANIMALS; APOPTOSIS; GENES, P53; HUMANS; MICE; MUTATION; PRECANCEROUS CONDITIONS; SKIN NEOPLASMS; SUNBURN; SUNLIGHT; ULTRAVIOLET RAYS;

EID: 0030112303     PISSN: 10870024     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Albino A, Fountain J\V: The molecular genetics of human malignant melanoma. In: Nathamon L (ed.). Current Research anJ Clinical management of Melanoma. Kluwer Academic Press, Nonvcll, MA, 1993, pp 201-255
2. Blum HF: Quantitative aspects of cancer induction by ultraviolet light: including a revised model. In: Urbach F (ed.). The Biologic Effects of Ultraviolet Radiation. Pergamon, Oxford, 1969, pp 543-549
3. Boring CC, Squires TS, Tong T, Montgomery S: Cancer statistics, 1994. CA 44:7-26, 1994
4. Brash DE: UV mutagenîc photoproducts in E. coli and human cells: a molecular genetics perspective on human skin cancer. Photoehem Photobiol 48:59-66, 1988
5. Brash DE, Rudolph JA, Simon JA, Lin A, McKenna GJ. Baden HP, Halperin AJ, Pontén J: A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Katl Acad Sci USA 88:10124-10128, 1991
6. Brash DE, Seetharam S, Kraemer KH, Seidman MM, Bredberg A: Photoproduct frequency is not the major determinant of UV base substitution hot spots or cold spots in human cells. Proc JVarf Acad Sci USA 84:3782-3786, 1987
7. Bums JE, Baird MC, Clark LJ, Burns PA, Edington K, Chapman C, Mitchell R, Robertson G, Soutar D, Parkinson EK: Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines. Br J Cancer 67:1274-1284. 1993
8. Campbell C, Quinn AG, Angus B, Farr PM, Rees JL: Wavelength specific patterns of p53 induction in human skin following exposure to UV radiation. Cancer Res 53:2697-2699, 1993a
9. Campbell C, Quinn AG, Ro Y-S, Angus B, Rees JL: p53 mutations are common and early events that precede tumor invasion in squamous cell neoplasia of the skin. J Invest Dermatol 100:746-748, 1993b
10. Cerutti PA: Prooxidant states and tumor promotion. Science 227:375-381, 1985
11. Cho Y, Gorina S, Jeffrey PD, Pavletich NP: Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science 265: 346-355, 1994
12. Danno K, Horio T: Sunburn cell: factors involved in its formation. Photoehem Photobiol 45:683-690, 1987
13. Dumaz N, Drougard C, Sarasin A, Daya-Grosjean L: Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA repair deficient xeroderma pigmentosum patients. Proc Katl Acad Sci U S A 90:10529-10533, 1993
14. Epstein JH, Epstein WL: Cocarcinogenic effect of ultraviolet light on DMBA tumor initiation in albino mice.J Invest Dcnnatol 39:455-460, 1962
15. Fisher DE: Apoptosis in cancer therapy: crossing the threshold. Cell 78:539-542, 1994
16. Fornace AJ: Mammalian genes induced by radiation: activation of genes associated with growth control. Annu Rev Genet 26:507-526, 1992
17. Frebourg T, Kassel J, Lam KT, Gryka MA, Barbier N, Andersen TI, Borresen A-L, Friend SH: Germ-line mutations of the p53 tumor suppressor gene in patients with lugh risk for cancer inactivate the p53 protein. Proc NatI Acad Sci U S A 89:6413-6417, 1992
18. Gilchrcst BA: Sfeiii and Aging Processes. CRC Press, Boca Raton, FL, 1984
19. Greenblatt MS, Bennett WP, HoIIstein M, Harris CC: Mutations in the pS3 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54:4855-4878, 1994
20. Haake AR, Polakowska RR: Cell death by apoptosis in epidermal biology. J Invest Dermaol 101:107-112, 1993
21. Hall PA, McKee PH, Menage H, Dover R, Lane DP: High levels of p53 protein in UV-irradiated normal human skin. Qncogenc 8:203-207, 1993
22. Herrlich P, Sachsenmaier C, Radler-Pohl A, Gebel S, Blattner C, Rahmsdorf HJ: The mammalian UV response: mechanism of DNA damage induced gene expression. Adv Enzyme Regal 34:381-395, 1994
23. Hinds PW, Finlay CA, Quartin RS, Baker SJ, Fearon ER, Vogelstein B, Levine AJ: Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot": mutant plienotypcs. Cell Growth Di/er 1:571-580, 1990
24. Hutchinson F: Induction of tandem base change mutations. Mutât R 309:11-15, 1994
25. Kanjilal S, Pierceall WE, Cummings KK, Kripke ML, Ananthaswamy HN: High frequency of p53 mutations in ultraviolet radiation-induced murine skin tumors: evidence for strand bias and tumor heterogeneity. Cancer Res 53:2961-2964, 1993
26. Kcmp CJ, Donehower LA, Bradley A, Balmain A: Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell 74:813-822, 1993
27. Kress S, Sutler C, Strickland PT, Mukhtar H, Schweizer J, Schwarz M: Carcinogenspecific mutational pattern in the p53 gene in ultraviolet B radiation-induced squamous cell carcinomas of mouse skin. Cancer Res 52:6400-6403, 1992
28. Kricker A, Armstrong BK, English DR, Heenan PJ: Pigmentary and cutaneous risk factors for non-melanocyric skin cancer-a case-control study. Int J Cancer 48:650-662, 1991
29. Kunala S, Brash DE: Excision repair at individual bases of die Eschcrichia coli lad gene: relation to mutation hotspots and transcription coupling activity. Proc Nail Acad SciUSA 89:11031-11035, 1992
30. Li G, Ho VC, Bercan K, Tron VA: Ultraviolet radiation induction of squamous cell carcinomas in p53 transgenic mice. Cancer Res 55:2070-2074, 1995
31. Maestro R, Boiocchi M: Sunlight and melanoma: an answer from MTS1 (pi 6). Science 267:16, 1995
32. Malkin D, Jolly KW, Barbier N, Look AT, Friend SH, Gebhardt MC, Andersen TI, Borresen A-L, Li FP, Garber J, Strong LC: Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms. N EnglJ Med 326:1309-1315, 1992
33. Malkin D, Li FP, Strong LC, FraumeniJJ, Nelson CE, Kim DH, Kassel J, Gryka MA, BischofT FZ, Tainsky MA, Friend SH: Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Scietice 250:1233-1238,1990
34. Marks R, JoHey D, Lectsas S, Foley P: The role of childhood exposure to sunlight in the development of solar kératoses and non-melanocytic skin cancer. MedJ Anst 152:62-66, 199
35. Miller SJ: Biology of basal cell carcinoma. J Am Acad Dermatol 24:1-13, 161-175, 1991
36. Mitchell DL, Nairn RS: The biology of die (6-4) photoproduct. Photochem Photobiol 49:805-819, 1989
37. Moles J-P, Moyret C, Guillot B, Jeanteur P, Guilhou J-J, Theillet C, Basset-Seguin N: p53 gene mutations in human epithelial skin cancers. Oncogene 8:583-588, 1993
38. Nakazawa H, English D, Randell PL, Nakazawa K, Martel N, Armstrong BK, Yamasaki H: UV and skin cancer: specific p53 gene mutation in normal skin as a biologically relevant exposure measurement. Proc Xaîl Acad Sci USA 91:360-364, 1994
39. Nelson MA, EinspalirJG, Alberts DS, Balfour CA, Wymcr JA, Welch KL, Salasche SJ, Bangert JL, Grogan TM, Bozzo PO: Analysis of the p53 gene in human precancerous actinic keratosis lesions and squamous cell cancers. Cancer Lett 85:23-29, 1994
40. Pierceall WE, Mukhopadhyay T, Goldberg LH, Ananthaswamy HA: Mutations in the p53 tumor suppressor gene in human cutaneous squamous cell carcinoma. Mol Carciiiog 4:445-449, 1991
41. Rady P, Scinicariello F, Wagner RF, Tyring SK: p53 mutations in basal cell carcinomas. Cancer Res 52:3804-3806, 1992
42. Rosario R, Mark GJ, Parrish JA, Mihm MC: Histological changes produced in skin by equally erythemogenic doses of UV-A, UV-B, UV-C and UV-A with psoralens. BrJ Dennatol 101:299-308, 1979
43. Sato M, Nishigori C, Zghal M, Yagi T, Takebe H: Ultraviolet-specific mutations in p53 gene in skin tumors in xeroderma pigmentosum parients. Cancer Res 53:2944-2946, 1993
44. Schwanz RA, Stoll HL: Epithelial precancerous lesions. In: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austen KF (eds.). Dermatology in General Medicine. 4th ed. Vol. I. McGraw-Hill, New York, 1993, pp 804-807
45. Taguchi M, Watanabe S, Yashima K, Murakami Y, Sekiya T, Ikeda S: Aberrations of the tumor suppressor p53 gene and p53 protein in solar keratosis in human skin. J Im-est Dcrmaiol 103:500-503, 1994
46. Toguchida J, Yamaguchi T, Dayton SH, Beauchamp RL, Herrera GE, Isliizaki K, Yamamuro T, Meyers RA, Little JB, Sasaki MS, Weichselbaum RL, Yandell DW: Prevalence and spectrum of germline mutations of the p53 gene among patients with sarcoma. N EnglJ Med 326:1301-1308, 1992
47. Tomei LD, Kanter P, Wenner CE: Inhibition of radiation-induced apoptosis in vitra by tumor promoters. Biochem Bioplifs Res Commun 155:324-331, 1988
48. Tornaletti S, Pfeifer GP: Slow repair of pyrimidine dimers at p53 mutation hotspots in skin cancer. Science 263:1436-1438, 1994
49. Urbach F: Ultraviolet radiation and skin cancer. In: Smith KC (ed.). Topics in Photomedicine. Plenum Press, New York, 1984, pp 67-104
50. Vogelstein B, Kinzler KW: p53 function and dysfunction. Cell 70:523-526, 1992
51. Wei Q, Matanoski GM, Farmer ER, Hedayati MA, Grossman L: DNA repair and aging in basal cell carcinoma: a molecular epiderniological study. Proc Natl Acad Sci U S A 90:1614-1618, 1993
52. Wright SC, Zliong J, Larrick JW: Inhibition of apoptosis as a mechanism of tumor promotion. FASEBJ 8:654-660, 1994
53. Ziegler A, Jonason AS, Leffell DJ, Simon JA, Sharma HW, Kimmelman J, Remington L, Jacks T, Brash DE: Sunburn and p53 in the onset of skin cancer. Nature 372:773-776, 1994
54. Ziegler A, LefFell DJ, Kunala S, Sharma HW, Gailani M, Simon JA, Halperin AJ, Baden HP, Shapiro PE, Bale AE, Brash DE: Mutation hotspots due to sunlight in the p53 gene of non-melanoma skin cancers. Proc Natl Acad Sci U S A 90:4216-4220, 1993