Naturally occurring coumarins inhibit human cytochromes P450 and block benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene DNA adduct formation in MCF-7 cells

Chemical Research in Toxicology

Volumn 16, Issue 3, 2003, Pages 415-422

  Kleiner, Heather E ^a   Reed, Melissa J ^a   DiGiovanni, John ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; ALPHA NAPHTHOFLAVONE; BENZO[A]PYRENE; BERGAMOTTIN; CARCINOGEN; COMPLEMENTARY DNA; COUMARIN DERIVATIVE; CYTOCHROME P450; ISOPIMPINELLIN; PENTOSALEN; POLYCYCLIC AROMATIC HYDROCARBON; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CELL STRAIN MCF 7; CHEMICAL CARCINOGENESIS; DNA ADDUCT; DOSE RESPONSE; ENZYME INHIBITION; ENZYME SUBSTRATE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN ANALYSIS; SKIN CARCINOGENESIS; SKIN TUMOR;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANTINEOPLASTIC AGENTS; BENZO(A)PYRENE; BREAST NEOPLASMS; CARCINOGENS; COUMARINS; CYTOCHROME P-450 ENZYME SYSTEM; DNA; DNA ADDUCTS; HUMANS; INHIBITORY CONCENTRATION 50; ISOENZYMES; PSORALENS; TUMOR CELLS, CULTURED;

ANIMALIA; CITRUS; MINK CELL FOCUS-FORMING VIRUS;

EID: 0037350164     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx025636d     Document Type: Article

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