Chemokines and Asthma

Sarcoidosis Vasculitis and Diffuse Lung Diseases

Volumn 20, Issue 3, 2003, Pages 180-189

  John, Alison E ^a   Lukacs, Nicholas W ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Asthma; Chemokine receptors; Chemokines; Immunopathogenesis

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR; CYTOKINE;

ALLERGIC REACTION; ASTHMA; CHEMOTAXIS; CHILDHOOD DISEASE; CYTOKINE PRODUCTION; ENVIRONMENTAL EXPOSURE; HEREDITY; HUMAN; INFLAMMATION; LEUKOCYTE ACTIVATION; POVERTY; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; REVIEW; URBAN AREA; VIRUS INFECTION;

ASTHMA; CHEMOKINES; HUMANS; HYPERSENSITIVITY; IMMUNOTHERAPY; INFLAMMATION; RECEPTORS, CHEMOKINE; T-LYMPHOCYTES;

EID: 0242268475     PISSN: 11240490     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (129)

1. Hartert TV and Peebles, RS Jr: Epidemiology of asthma: the year in review. Curr Opin Pulm Med 2000. 6: 4-9.
2. Burney P, Epidemiology of asthma. Allergy 1993. 48: 17-21; discussion 22-13.
3. Mitchell EA, International trends in hospital admission rates for asthma. Arch Dis Chim 1985. 60: 376-8.
4. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Lancet 1998. 351: 1225-32.
5. Worldwide variations in the prevalence of asthma symptoms: the International Study of Asthma and Allergies in Childhood (ISAAC). Eur Respir J 1998. 12: 315-35.
6. Shapiro JM: Childhood asthma in the United States: urban issues. Pediatr Pulmonol 2002. 33: 47-55.
7. Rosenstreich DL, Eggleston P, Kattan M, Baker D, Slavin RG, Gergen P, Mitchell H, McNiff-Mortimer K, Lynn H, Ownby D, Malveaux F: The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma. N Engl J Med 1997. 336: 1356-63.
8. Mielck A, Reitmeir P, Wjst M: Severity of childhood asthma by socioeconomic status. Int J Epidemiol 1996. 25: 388-93.
9. Weiss KB, Sullivan SD: The economic costs of asthma: a review and conceptual model. Pharmacoeconomics 1993. 4: 14-30.
10. Weiss KB, Sullivan SD: The health economics of asthma and rhinitis. I. Assessing the economic impact. J Allergy Clin Immunol 2001. 107: 3-8.
11. Busse WW, Banks-Schlegel S, Wenzel SE: Pathophysiology of severe asthma. J Allergy Clin Immunol 2000. 106: 1033-42.
12. Spahn JD, Szefler SJ: Childhood asthma: new insights into management. J Allergy Clin Immunol 2002. 109: 3-13.
13. Dunhill MS, Massarella GR, Anderson JA: A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis and in emphysema. Thorax 1969. 24: 176-9.
14. Dunhill M: The pathology of asthma, with special reference to charges in the bronchial mucosa. J Clin Pathol 1960. 13: 27-33.
15. Busse WW, Lemanske RF Jr: Asthma. N Engl J Med 2001. 344: 350-62.
16. Laitinen LA, Heino M, Laitinen A, Kava T, Haahtela T: Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis 1985. 131: 599-606.
17. Beasley R, Roche WR, Roberts JA, Holgate ST: Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis 1989. 139: 806-17.
18. Roche WR, Beasley R, Williams JH, Holgate ST: Subepithetial fibrosis in the bronchi of asthmatics. Lancet 1989. 1: 520-4.
19. Metcalfe DD, Baram D, Mekori YA: Mast cells. Physiol Rev 1997. 77: 1033-79.
20. Zlotnik A, Yoshie O: Chemokines a new classification system and their role in immunity. Immunity 2000. 12: 121-7.
21. Murphy PM, Baggiolini M, Charo IF, Hebert CA, Horuk R, Matsushima K, Miller LH, Oppenheim JJ, Power CA: International union of pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol Rev 2000. 52: 145-76.
22. Olson TS, Ley K: Chemokines and chemokine receptors in leukocyte trafficking. Am J Physiol Regul Integr Comp Physiol 2002. 283: R7-28.
23. Gerard C, Rollins BJ: Chemokines and disease. Nat Immunol 2001. 2: 108-15.
24. Gonzalo JA, Lloyd CM, Wen D, Albar JP, Wells TN, Proudfoot A, Martinez AC, Dorf M, Bjerke T, Coyle AJ, Gutierrez-Ramos JC: The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness. J Exp Med 1998. 188: 157-67.
25. Lukacs NW, Kunkel SL: Chemokines and their role in disease. Int J Clin Lab Res 1998. 28: 91-5.
26. Lukacs NW: Role of chemokines in the pathogenesis of asthma. Nature Reviews Immunology 2001. 1: 108-16.
27. Alam R, York J, Boyars M, Stafford S, Grant JA, Lee J, Forsythe P, Sim T, Ida N: Increased MCP-1, RANTES, and MIP-1alpha in bronchoalveolar lavage fluid of allergic asthmatic patients. Am J Respir Crit Care Med 1996. 153: 1398-404.
28. Powell N, Humbert M, Durham SR, Assoufi B, Kay AB, Corrigan CJ: Increased expression of mRNA encoding RANTES and MCP-3 in the bronchial mucosa in atopic asthma. Eur Respir J 1996. 9: 2454-60.
29. Wang JH, Devalia JL, Xia C, Sapsford RJ, Davies RJ: Expression of RANTES by human bronchial epithelial cells in vitro and in vivo and the effect of corticosteroids. Am J Respir Cell Mol Biol 1996. 14: 27-35.
30. Berkman N, Krishnan VL, Gilbey T, Newton R, O'Connor B, Barnes PJ, Chung KF: Expression of RANTES mRNA and protein in airways of patients with mild asthma. Am J Respir Crit Care Med 1996. 154: 1804-11.
31. Teran LM, Noso N, Carroll M, Davies DE, Holgate S, Schroder JM: Eosinophil recruitment following allergen challenge is associated with the release of the chemokine RANTES into asthmatic airways. J Immunol 1996. 157: 1806-12.
32. Lukacs NW, Standiford TJ, Chensue SW, Kunkel RG, Strieter RM, Kunkel SL: C-C chemokine-induced eosinophil chemotaxis during allergic airway inflammation. J Leukoc Biol 1996. 60: 573-8.
33. Campbell EM, Kunkel SL, Strieter RM, Lukacs NW: Temporal role of chemokines in a murine model of cockroach allergen-induced airway hyperreactivity and eosinophilia. J Immunol 1998. 161: 7047-53.
34. Mattoli S, Stacey MA, Sun G, Bellini A, Marini M, Eotaxin expression and eosinophilic inflammation in asthma. Biochem Biophys Res Commun 1997. 236: 299-301.
35. Taha RA, Minshall EM, Miotto D, Shimbara A, Luster A, Hogg JC, Hamid QA: Eotaxin and monocyte chemotactic protein-4 mRNA expression in small airways of asthmatic and nonasthmatic individuuls. J Allergy Clin Immunol 1999. 103: 476-483.
36. Jose PJ, Adcock IM, Griffiths-Johnson DA, Berkman N, Wells TN, Williams TJ, Power CA: Eotaxin: cloning of an eosinophil chemoattractant cytokine and increased mRNA expression in allergen-challenged guinea-pig lungs. Biochem Biophys Res Commun 1994. 205: 788-94.
37. Holgate ST, Bodey KS, Janezic A, Frew AJ, Kaplan AP, Teran LM: Release of RANTES, MIP-1 alpha, and MCP-1 into asthmatic airways following endobronchial allergen challenge. Am J Respir Crit Care Med 1997. 156: 1377-83.
38. Stellato C, Collins P, Ponath PD, Soler D, Newman W, La Rosa G, Li H, White J, Schwiebert LM, Bickel C, Liu M, Bochner BS, Williams T, Schleimer RP: Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines. J Clin Invest 1997. 99: 926-36.
39. Lamkhioued B, Garcia-Zepeda EA, Abi-Younes S, Nakamura H, Jedrzkiewicz S, Wagner L, Renzi PM, Allakhverdi Z, Lilly C, Hamid Q, Luster AD: Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines. Am J Respir Crit Care Med 2000. 162: 723-32.
40. Forssmann U, Uguccioni M, Loetscher P, Dahinden CA, Langen H, Thelen M, Baggiolini M: Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes. J Exp Med 1997. 185: 2171-6.
41. Kitaura M, Suzuki N, Imai T, Takagi S, Suzuki R, Nakajima T, Hirai K, Nomiyama H, Yoshic O: Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J Biol Chem 1999. 274: 27975-80.
42. Berkman N, Ohnona S, Chung FK, Breuer R: Eotaxin-3 but not eotaxin gene expression is upregulated in asthmatics 24 hours after allergen challenge. Am J Respir Cell Mol Biol 2001. 24: 682-7.
43. Sekiya T, Yamada H, Yamaguchi M, Yamamoto K, Ishii A, Yoshic O, Sano Y, Morita A, Matsushima K, Hirai K: Increased levels of a TH2-type CC chemokine thymus and activation-regulated chemokine (TARC) in serum and induced sputum of asthmatics. Allergy 2002. 57: 173-7.
44. Hirata H, Arima M, Cheng G, Honda K, Fukushima F, Yoshida N, Eda F, Fukuda T: Production of TARC and MDC by naive T cells in asthmatic patients. J Clin Immunol 2003. 23: 34-45.
45. Wang W, Soto H, Oldham ER, Buchanan M. E, Homey B, Catron D, Jenkins N, Copeland NG, Gilbert DJ, Nguyen N, Abrams J, Kershenovich D, Smith K, McClanahan T, Vicari AP, Zlotnik A. Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). J Biol Chem 2000. 275: 22313-23.
46. Miotto D, Christodoulopoulos P, Olivenstein R, Taha R, Cameron L, Tsicopoulos A, Tonnel AB, Fahy O, Lafitte JJ, Luster AD, Wallaert B, Mapp CE, Hamid Q:Expression of IFN-gamma-inducible protein; monocyte chemotactic proteins 1, 3, and 4; and eotaxin in TH1- and TH2-mediated lung diseases. J Allergy Clin Immunol 2001. 107: 664-70.
47. Rothenberg ME, MacLean JA, Pearlman E, Luster AD, Leder P: Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. J Exp Med 1997. 185: 785-90.
48. Yang Y, Loy J, Ryseck RP, Carrasco D, Bravo R: Antigen-induced eosinophilic lung inflammation develops in mice deficient in chemokine colaxin. Blood 1998. 92: 3912-23.
49. Medoff BD, Sauty A, Tager AM, Maclean JA, Smith RN, Mathew A, Dufour JH, Luster AD: IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma. J Immunol 2002. 168: 5278-86.
50. De Sanctis GT, MacLean JA, Qin S, Wolyniec WW, Grasemann H, Yandava CN, Jiao A, Noonan T, Stein-Streilein J, Green FH, Drazen JM, Interleukin-8 receptor modulates IgE production and B-cell expansion and trafficking in allergen-induced pulmonary inflammation. J Clin Invest 1999. 103: 507-15.
51. MacLean JA, De Sanctis GT, Ackerman KG, Drazen JM, Sauty A, DeHaan E, Green FH, Charo IF, Luster AD: CC chemokine receptor-2 is not essential for the development of antigen-induced pulmonary eosinophilia and airway hyperresponsiveness [In Process Citation]. J Immunol 2000. 165: 6568-75.
52. Ma W, Bryce PJ, Humbles AA, Laouini D, Yalcindag A, Alenius H, Friend DS, Oettgen HC, Gerard C, Geha RS: CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation. J Clin Invest 2002. 109: 621-8.
53. Humbles AA, Lu B, Friend DS, Okinaga S, Lora J, Al-Garawi A, Martin TR, Gerard N, Gerard C: The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness. Proc Natl Acad Sci U S A 2002. 99: 1479-84.
54. Chvatchko Y, Hoogcwerf AJ, Meyer A, Alouani S, Juillard P, Buser R, Conquet F, Proudfoot AE, Wells TN, Power CA: A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock. J Exp Med 2000. 191: 1755-64.
55. Campbell EM, Charo IF, Kunkel SL, Strieter RM, Boring L, Gosling J, Lukacs N. W: Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: the role of mast cells. J Immunol 1999. 163: 2160-7.
56. Chensue SW, Lukacs NW, Yang TY, Shang X, Frait KA, Kunkel SL, Kung T, Wiekowski MT, Hedriek JA, Cook DN, Zingoni A, Narula SK, Zlotnik A, Barrat FJ, O'Garra A, Napolitano M, Lira SA: Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice. J Exp Med 2001. 193: 573-84.
57. Lukacs NW, Prosser DM, Wickowski M, Lira SA, Cook, DN: Requirement for the chemokine receptor CCR6 in allergic pulmonary inflammation. J Exp Med 2001. 194: 551-5.
58. -/- mice during chronic fungal allergic airway disease. J Immunol 2000. 165: 1564-72.
59. Blease K, Mehrad B, Standiford TJ, Lukacs NW, Gosling J, Boring L, Charo IF, Kunkel SL, Hogaboam CM: Enhanced pulmonary allergic responses to Aspergillus in CCR2-/- mice. J Immunol 2000. 165: 2603-11.
60. -/- mice. Faseb J 2002. 16: 1313-5.
61. Schuh JM, Blease K, Hogaboam CM: The role of CC chemokine receptor 5 (CCR5) and RANTES/CCL5 during chronic fungal asthma in mice. Faseb J 2002. 16: 228-30.
62. Sallusto F, Lanzavecchia A, Mackay CR: Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses. Immunol Today 1998. 19: 568-74.
63. Sallusto F, Lenig D, Mackay CR, Lanzavecchia A: Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J Exp Med 1998. 187: 875-83.
64. Bonecchi R, Bianchi G, Bordignon PP, D'Ambrosio D, Lang R, Borsatti A, Sozzani S, Allavena P, Gray PA, Mantovani A, Sinigaglia F: Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med 1998. 187: 129-34.
65. Oyamada H, Kamada Y, Kuwasaki T, Yamada Y, Kobayashi Y, Cui C, Honda K, Kayaba H, Saito N, Chihara J: CCR3 mRNA expression in bronchial epithelial cells and various cells in allergic inflammation. Arch Allergy Immunol 1999. 120 Suppl 1: 45-7.
66. Stellato C, Brummet ME, Plitt JR, Shahabuddin S, Baroody FM, Liu MC, Ponath PD, Beek LA: Expression of the C-C chemokine receptor CCR3 in human airway epithelial cells. J Immunol 2001. 166: 1457-61.
67. Mantovani A, Gray PA, Van Damme J, Sozzani S: Macrophage-derived chemokine (MDC). J Leukoc Biol 2000. 68: 400-4.
68. Matsukawa A, Hogaboam CM, Lukacs NW, Lincoln PM, Evanoff HL, Kunkel SL: Pivotal role of the CC chemokine, macrophage-derived chemokine, in the innate immune response. J Immunol 2000. 164: 5362-8.
69. Kapp A, Zeck-Kapp G, Czech W, Schopf E: The chemokine RANTES is more than a chemoattractant: characterization of its effect on human eosinophil oxidative metabolism and morphology in comparison with IL-5 and GM-CSF. J Invest Dermatol 1994. 102: 906-14.
70. Meurer R, Van Riper G, Feeney W, Cunningham P, Hora D Jr, Springer MS, MacIntyre DE, Rosen H: Formation of eosinophilic and monocytic intradermal inflammatory sites in the dog by injection of human RANTES but not human monocyte chemoattractant protein 1, human macrophage inflammatory protein 1 alpha, or human interleukin 8. J Exp Med 1993. 178: 1913-21.
71. Heath H, Qin S, Rao P, Wu L, La Rosa G, Kassam N, Ponath PD, Mackay CR: Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody. J Clin Invest 1997. 99: 178-84.
72. Gao JL, Sen AI, Kitaura M, Yoshie O, Rothenberg ME, Murphy PM, Luster AD: Identification of a mouse eosinophil receptor for the CC chemokine eotaxin. Biochem Biophys Res Commun 1996. 223: 679-84.
73. Ponath PD, Qin S, Post TW, Wang J, Wu L, Gerard NP, Newman W, Gerard C, Mackay CR: Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. J Exp Med 1996. 183: 2437-48.
74. Combadiere C, Ahuja SK, Murphy PM: Cloning and functional expression of a human eosinophil CC chemokine receptor. J Biol Chem 1996. 271: 11034.
75. Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS: Cloning, expression, and characterization of the human eosinophil eotaxin receptor. J Exp Med 1996. 183: 2349-54.
76. Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA Newman, W, Gutierrez-Ramos JC, Mackay CR: Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. J Clin Invest 1996. 97: 604-12.
77. Lukacs NW, Strieter RM, Warmington K, Lincoln P, Chensue SW, Kunkel SL: Differential recruitment of leukocyte populations and alteration of airway hyperreactivity by C-C family chemokines in allergic airway inflammation. J Immunol 1997. 158: 4398-404.
78. Gonzalo JA, Pan Y, Lloyd CM, Jia GQ, Yu G, Dussault B, Powers CA, Proudfoot AE, Coyle AJ, Gearing D, Gutierrez-Ramos JC: Mouse monocyte-derived chemokine is involved in airway hyperreactivity and lung inflammation. J Immunol 1999. 163: 403-11.
79. Kawasaki S, Takizawa H, Yoneyama H, Nakayama T, Fujisawa R, Izumizaki M, Imai T, Yoshie O, Homma I, Yamamoto K, Matsushima K: Intervention of Thymus and Activation-Regulated Chemokine Attenuates the Development of Allergic Airway Inflammation and Hyperresponsiveness in Mice. J Immunol 2001. 166: 2055-62.
80. Corrigan CJ, Kay AB: T cells and eosinophils in the pathogenesis of asthma. Immunol Today 1992. 13: 501-7.
81. Fujisawa T, Kato Y, Nagase H, Atsuta J, Terada A, Iguchi K, Kamiya H, Morita Y, Kitaura M, Kawasaki H, Yoshie O, Hirai K: Chemokines induce eosinophil degranulation through CCR-3. J Allergy Clin Immunol 2000. 106: 507-13.
82. Sallusto F, Mackay, CR, Lanzavecchia A: Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science 1997. 277: 2005-7.
83. Sallusto F, Kremmer E, Palermo B, Hoy A, Ponath P, Qin S, Forster R, Lipp M, Lanzavecchia A: Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells. Eur J Immunol 1999. 29: 2037-45.
84. D'Ambrosio D, Iellem A, Bonecchi R, Mazzco D, Sozzani S, Mantovani A, Sinigaglia F: Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells. J Immunol 1998. 161: 5111-5.
85. Jagodzinski PP, Trzeciak WH: Differential expression of chemokine receptor CXCR4 in Th1 and Th2 subtypes of CD4+ lymphocytes. Folia Histochem Cytobiol 2000. 38: 21-3.
86. Nanki T, Lipsky PE: Lack of correlation between chemokine receptor and T(h)1/T(h)2 cytokine expression by individual memory T cells. Int Immunol 2000. 12: 1659-67.
87. rd, STCP-1 (MDC) CC chemokine acts specifically on chronically activated Th2 lymphocytes and is produced by monocytes on stimulation with Th2 cytokines IL-4 and IL-13. J Immunol 1998. 161: 5027-38.
88. Mochizuki M, Bartels J, Mallet AI, Christophers E, Schroder JM: IL-4 induces eotaxin: a possible mechanism of selective eosinophil recruitment in helminth infection and atopy. J Immunol 1998. 160: 60-8.
89. Li L, Xia Y, Nguyen A, Feng L, Lo D: Th2-induced eotaxin expression and eosinophilia coexist with Th1 responses at the effector stage of lung inflammation. J Immunol 1998. 161: 3128-35.
90. Zhang S, Lukacs NW, Lawless VA, Kunkel SL, Kaplan MH: Cutting edge: differential expression of chemokines in Th1 and Th2 cells is dependent on stat6 but not stat4. J Immunol 2000. 165: 10-4.
91. Lloyd CM, Delaney T, Nguyen T, Tian J, Martinez AC, Coyle AJ, Gutierrez-Ramos JC: CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo. J Exp Med 2000. 191: 265-74.
92. Panina-Bordignon P, Papi A, Mariani M, Di Lucia P, Casoni G, Bellettato C, Buonsanti C, Miotto D, Mapp C, Villa A, Arrigoni G, Fabbri LM, Sinigaglia F: The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. J Clin Invest 2001. 107: 1357-64.
93. Bernardini G, Hedrick J, Sozzani S, Luini W, Spinetti G, Weiss M, Menon S, Zlotnik A, Mantovani A, Santoni A, Napolitano, M: Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. Eur J Immunol 1998. 28: 582-8.
94. Goya I, Villares R, Zaballos A, Gutierrez J, Kremer L, Gonzalo JA, Varona R, Carramolino L, Serrano A, Pallares P, Criado LM, Kolbeck R, Torres M, Coyle AJ, Gutierrez-Ramos JC, Martinez AC, Marquez G: Absence of CCR8 does not impair the response to ovalbumin-induced allergic airway disease. J Immunol 2003. 170: 2138-46.
95. Chung CD, Kuo F, Kumer J, Motani AS, Lawrence CE, Henderson WR Jr, Venkataraman C: CCR8 is not essential for the development of inflammation in a mouse model of allergie airway disease. J Immunol 2003. 170: 581-7.
96. Holgate ST: Airway inflammation and remodeling in asthma: current concepts. Mol Biotechnol 2002. 22: 179-89.
97. Chiappara G, Gagliardo R, Siena A, Bonsignore MR, Bousquet J, Bonsignore G, Vignola AM: Airway remodelling in the pathogenesis of asthma. Curr Opin Allergy Clin Immunol 2001. 1: 85-93.
98. Saito T, Deskin RW, Casola A, Haeberle, H, Olszewska B, Ernst PB, Alam R, Ogra PL, Garofalo R: Respiratory syncytial virus induces selective production of the chemokine RANTES by upper airway epithelial cells. J Infect Div 1997. 175: 497-504.
99. Li L, Xia Y, Nguyen A, Lai YH, Feng L, Mosmann TR, Lo D: Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithetial cells. Immunol 1999. 162: 2477-87.
100. Chung KF, Patel HJ, Fadlon EJ, Rousel, J, Haddad EB, Jose PJ, Mitchell J, Belvisi M: Induction of eotaxin expression and release from human airway smooth muscle cells by IL-1beta and TNFalpha: effects of IL-10 and corticosteroids. Br J Pharmacol 1999. 127: 1145-50.
101. Ghaffar O, Hamid Q, Renzi PM, Allakhverdi Z, Molet S, Hogg JC, Shore SA, Luster AD, Lamkhioued B: Constitutive and cytokine-stimulated expression of eotaxin by human airway smooth muscle cells. Am J Respir Crit Care Med 1999. 159: 1933-42.
102. Ammit AJ, Hoffman RK, Amrani Y, Lazaar AL, Hay DW, Torphy TJ, Penn RB, Panettieri RA Jr: Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth-muscle cells. Modulation by cyclic adenosine monophosphate. Am J Respir Cell Mol Biol 2000. 23: 794-802.
103. Pype JL, Dupont LJ, Menten P, Van Coillie E, Opdenakker G, Van Damme J, Chung KF, Demedts MG, Verleden GM: Expression of monocyte chemotactic protein (MCP)-1, MCP-2, and MCP-3 by human airway smooth-muscle cells. Modulation by corticosteroids and T-helper 2 cytokines. Am J Respir Cell Mol Biol 1999. 21: 528-36.
104. John M, Hirst SJ, Jose PJ, Robichaud A, Berkman N, Witt C, Twort CH, Barnes PJ, Chung KF: Human airway smooth muscle cells express and release RANTES in response to T helper I cytokines: regulation by T helper 2 cytokines and corticosteroids. J Immunol 1997. 158: 1841-7.
105. Watson ML, Grix SP, Jordan NJ, Place GA, Dodd S, Leithead J, Poll CT, Yoshimura T, Weslwiek J: Interleukin 8 and monocyte chemoattractant protein I production by cultured human airway smooth muscle cells. Cytokine 1998. 10: 346-52.
106. Hayes IM, Jordan NJ, Towers S, Smith G, Paterson JR, Earnshaw JJ, Roach AG, Westwick J, Williams RJ: Human vascular smooth muscle cells express receptors for CC chemokines. Arterioscler Thromb Vasc Biol 1998. 18: 397-403.
107. Schecter AD, Calderon TM, Berman AB, McManus CM, Fallon JT, Rossikhina M Zhao W, Christ G, Berman JW, Taubman MB: Human vascular smooth muscle cells possess functional CCR5. J Biol Chem 2000. 275: 5466-71.
108. Yue TL, Wang X, Sung CP, Olson B, McKenna PJ, Gu JL, Feuerstein GZ: Interleukin-8. A mitogen and chemoattractant for vascular smooth muscle cells. Circ Res 1994. 75: 1-7.
109. Porreca E, Di Febbo C, Reale M, Castellani ML, Baccante G, Barbacane R, Conti P, Cuccurullo F, Poggi A: Monocyte chemotactic protein 1 (MCP-1) is a mitogen for cultured rat vascular smooth muscle cells. J Vasc Res 1997. 34: 58-65.
110. Luo Y, D'Amore P A, Dorf ME: Beta-chemokine TCA3 binds to and activates rat vascular smooth muscle cells. J Immunol 1996. 157: 2143-8.
111. Teran LM, Mochizuki M, Bartels J, Valencia EL, Nakajima T, Hirai K, Schroder JM: Th1- and Th2-type cytokines regulate the expression and production of eotaxin and RANTES by human lung fibroblasts. Am J Respir Cell Mol Biol 1999. 20: 777-86.
112. Hogaboam CM, Bone-Larson CL, Lipinski S, Lukacs NW, Chensuc SW, Stricter RM, Kunkel SL: Differential monocyte chemoattractant protein-1 and chemokine receptor 2 expression by murine lung fibroblasts derived from Th1- and Th2-type pulmonary granuloma models. J Immunol 1999. 163: 2193-201.
113. Simon HU: The neutralization of interleukin-5 as a therapeutic concept in allergic inflammation. Sarcoidosis Vasc Diffuse Lung Dis 2002, 19: 25-8.
114. Agostini C: Cytokine and chemokine blockade as immunointervention strategy for the treatment of diffuse lung diseases. Sarcoidosis Vasc Diffuse Lung Dis 2001. 18: 18-22.
115. Lewis DB: Allergy immunotherapy and inhibition of Th2 immune responses: a sufficient strategy? Curr Opin Immunol 2002. 14: 644-51.
116. Skoner DP: Balancing safety and efficacy in pediatric asthma management. Pediatrics 2002. 109: 381-92.
117. Lloyd C: Chemokines in allergic lung inflammation. Immunology 2002. 105: 144-54.
118. Proudfoot AE: Chemokine receptors: multifaceted therapeutic targets. Nat Rev Immmunol 2002. 2: 106-15.
119. Zimmermann N, Hershey GK, Foster PS, Rothenberg ME: Chemokines in asthma: cooperative interaction between chemokines and IL-13. J Allergy Clin Immunol 2003. 111: 227-42; quiz 243.
120. Proudfoot AE, Power CA, Hoogewerf AJ, Montjovent MO, Borlat F, Offord RE, Wells TN: Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist. J Biol Chem 1996. 271: 2599-603.
121. Elsner J, Petering H, Hochstetter R, Kimmig D, Wells TN, Kapp A, Proudfoot AE: The CC chemokine antagonist Met-RANTES inhibits eosinophil effector functions through the chemokine receptors CCR1 and CCR3. Eur J Immunol 1997. 27: 2892-8.
122. Mack M, Luckow B, Nelson PJ, Cihak J, Simmons G, Clapham PR, Signoret N, Marsh M, Stangassinger M, Borlat F, Wells TN, Schlondorff D, Proudfoot AE: Aminooxypentanc-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity. J Exp Med 1998. 187: 1215-24.
123. Nibbs RJ, Salcedo TW, Campbell JD, Yao XT, Li Y, Nardelli B, Olsen HS, Morris TS, Proudfoot AE, Patel VP, Graham GJ: C-C chemokine receptor 3 antagonism by the beta-chemokine macrophage inflammatory protein 4, a property strongly enhanced by an amino-terminal alanine-methionine swap. J Immunol 2000. 164: 1488-97.
124. Baba M, Nishimura O, Kanzaki N, Okamoto M, Sawada H, Iizawa Y, Shiraishi M, Aramaki Y, Okonogi K, Ogawa Y, Meguro K, Fujino M: A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. Proc Natl Acad Sci U S A 1999. 96: 5698-703.
125. Liang M, Mallari C, Rosser M, Ng HP, May K, Monahan S, Bauman JG, Islam I, Ghannam A, Buckman B, Shaw K, Wei GP, Xu W, Zhao Z, Ho E, Shen J, Oanh H, Subramanyam B, Vergona R, Taub D, Dunning L, Harvey S, Snider RM, Hesselgesser J, Morrissey MM, Perez HD: Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1. J Biol Chem 2000. 275: 19000-8.
126. Anders HJ, Vielhauer V, Frink M, Linde Y, Cohen CD, Blattner SM, Kretzler M, Strutz F, Mack M, Grone HJ, Onuffer J, Horuk R, Nelson PJ, Schlondorff D: A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J Clin Invest 2002. 109: 251-9.
127. Horuk R, Clayberger C, Krensky AM, Wang Z, Grone HJ, Weber C, Weber KS, Nelson PJ, May K, Rosser M, Dunning L, Liang M, Buckman B, Ghannam A, Ng HP, Islam I, Bauman JG, Wei GP, Monahan S, Xu W, Snider RM, Morrissey MM, Hesselgesser J, Perez HD: A non-peptide functional antagonist of the CCR1 chemokine receptor is effective in rat heart transplant rejection. J Biol Chem 2001. 276: 4199-204.
128. Horuk R, Shurey S, Ng HP, May K, Bauman JG, Islam I, Ghannam A, Buckman B, Wei GP, Xu W, Liang M, Rosser M, Dunning L, Hesselgesser J, Snider RM, Morrissey MM, Perez HD, Green C: CCR1-specific non-peptide antagonist: efficacy in a rabbit allograft rejection model. Immunol Lett 2001. 76: 193-201.
129. Sabroe I, Peck MJ, Van Keulen BJ, Jorritsma A, Simmons G, Clapham PR, Williams TJ, Pease JE: A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry. J Biol Chem 2000. 275: 25985-92.