Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1

Journal of Biological Chemistry

Volumn 275, Issue 25, 2000, Pages 19000-19008

  Liang, Meina ^a,b   Mallari, Cornell ^b   Rosser, Mary ^b   Ng, Howard P ^a,d   May, Karen ^a   Monahan, Sean ^a,e   Bauman, John G ^a   Islam, Imadul ^a   Ghannam, Ameen ^a   Buckman, Brad ^a   Shaw, Ken ^a   Wei, Guo Ping ^a   Xu, Wei ^a   Zhao, Zuchun ^a   Ho, Elena ^b   Shen, Jun ^b   Oanh, Huynh ^b   Subramanyam, Babu ^b   Vergona, Ron ^b   Taub, Dennis ^c   Dunning, Laura ^a   Harvey, Susan ^b   Snider, R Michael ^a   Hesselgesser, Joseph ^b   Morrissey, Michael M ^a   Perez, H Daniel ^b   Horuk, Richard ^b   more..

^a Discovery Research Group   (United States)

^b BAYER AG   (Germany)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d Coulter Pharmaceutical ^*  (United States)

^e Mirus Bio Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [5 CHLORO 2 [2 [4 (4 FLUOROBENZYL) 2 METHYL 1 PIPERAZINYL] 2 OXOETHOXY]PHENYL]UREA; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR1 ANTAGONIST; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; N [5 CHLORO 2 [2[4[(4 FLUOROPHENYL)METHYL] 2 METHYL 1 PIPERAZINYL] 2 OXOEETHOXY]PHENYL]UREA HYDROCHLORIC ACID; RANTES; UNCLASSIFIED DRUG;

ACIDIFICATION; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; BINDING COMPETITION; CALCIUM MOBILIZATION; CONTROLLED STUDY; DRUG DETERMINATION; DRUG POTENCY; DRUG SELECTIVITY; HUMAN; HUMAN CELL; LEUKOCYTE MIGRATION; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING;

ADMINISTRATION, ORAL; ANIMALS; BINDING, COMPETITIVE; CELL LINE; DNA, COMPLEMENTARY; DOGS; HUMANS; MALE; PHENYLUREA COMPOUNDS; PIPERIDINES; RATS; RATS, INBRED LEW; RECEPTORS, CHEMOKINE;

EID: 0034705618     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M001222200     Document Type: Article

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