Differential monocyte chemoattractant protein-1 and chemokine receptor 2 expression by murine lung fibroblasts derived from Th1- and Th2-type pulmonary granuloma models

Journal of Immunology

Volumn 163, Issue 4, 1999, Pages 2193-2201

  Hogaboam, Cory M ^a   Bone Larson, Cynthia L ^a   Lipinski, Scott ^a   Lukacs, Nicholas W ^a   Chensue, Stephen W ^a,b   Strieter, Robert M ^a   Kunkel, Steven L ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; COLLAGEN TYPE 1; COLLAGEN TYPE 3; GAMMA INTERFERON; INTERLEUKIN 4; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROCOLLAGEN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HELPER CELL; LUNG FIBROBLAST; LUNG FIBROSIS; LUNG GRANULOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CHEMOKINE CCL2; DISEASE MODELS, ANIMAL; FEMALE; FIBROBLASTS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GRANULOMA, RESPIRATORY TRACT; INTERFERON TYPE II; INTERLEUKIN-4; LUNG; MICE; MICE, INBRED CBA; PROCOLLAGEN; RECEPTORS, CHEMOKINE; RECEPTORS, CYTOKINE; RNA, MESSENGER; TH1 CELLS; TH2 CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033567017     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Weissler, J. C. 1989. Idiopathic pulmonary fibrosis: cellular and molecular pathogenesis. Am. J. Med. Sci. 297:91.
2. Vath, R. R., C. B. Alexander, and J. D. Fulmer. 1982. The lymphocytic infiltrative lung diseases. Clin. Chest Med. 3:619.
3. Jordana, M. 1993. Mast cells and fibrosis - who's on first? Am. J. Respir. Cell Mol. Biol. 8:7.
4. Zhang, K., M. D. Rekhter, D. Gordon, and S. H. Phan. 1994. Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis: a combined immunohistochemical and in situ hybridization study. Am. J. Pathol. 145:114.
5. Mosmann, T. R., and R. L. Coffman. 1989. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Am. Rev. Immunol. 7:145.
6. Plaut, M., J. H. Pierce, C. J. Watson, J. Hanley-Hyde, R. P. Nordan, and W. E. Paul. 1989. Mast cell lines produce lymphokines in response to crosslinking Fc∈R1 or to calcium ionophores. Nature 339:64.
7. Postlethwaite, A. E., M. A. Holness, H. Katai, and R. Raghow. 1992. Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin-4. J. Clin. Invest. 90:1479.
8. Smith, R. S., T. J. Smith, T. M. Blieden, and R. P. Phipps. 1997. Fibroblasts as sentinel cells: synthesis of chemokines and regulation of inflammation. Am. J. Pathol. 151:317.
9. Antoniades, H. N., J. Neville-Golden, T. Galanopoulos, R. L. Kradin, A. J. Valente, and D. T. Graves. 1992. Expression of monocyte chemoattractant protein-1 mRNA in human idiopathic pulmonary fibrosis. Proc. Natl. Acad. Sci. USA 89:5371.
10. Carr, M. W., S. J. Roth, E. Luther, S. S. Rose, and T. A. Springer. 1994. Monocyte chemoattractant protein-1 acts as a T-lymphocyte chemoattractant. Proc. Natl. Acad. Sci. USA 91:3652.
11. Iyonaga, K., M. Takeya, N. Saita, O. Sakamoto, T. Yoshimura, M. Ando, and K. Takahashi. 1994. Monocyte chemoattractant protein-1 in idiopathic pulmonary fibrosis and other interstitial lung diseases. Hum. Pathol. 25:455.
12. Smith, R. E., R. M. Stricter, S. H. Phan, and S. L. Kunkel. 1996. C-C chemokines: novel mediators of the profibrotic inflammatory response to bleomycin challenge. Am. J. Respir. Cell Mol. Biol. 15:693.
13. Lloyd, C. M., A. W. Minto, M. E. Dorf, A. Proudfoot, T. N. Wells, D. J. Salant, and J. C. Gutierrez-Ramos. 1997. RANTES and monocyte chemoattractant protein-1 (MCP-1) play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescent formation and interstitial fibrosis. J. Exp. Med. 185:1371.
14. Gharaee-Kermani, M., E. M. Denholm, and S. H. Phan. 1996. Costimulation of fibroblast collagen and transforming growth factor betal gene expression by monocyte chemoattractant protein-1 via specific receptors. J. Biol. Chem. 271: 17779.
15. Kunkel, S. L. 1996. Th1- and Th2-type cytokines regulate chemokine expression. Biol. Signals 5:197.
16. Chensue, S. W., K. Warmington, J. Ruth, P. Lincoln, M.-C. Kuo, and S. L. Kunkel. 1994. Cytokine responses during mycobacterial and schistosomal antigen-induced pulmonary granuloma formation: production of Th1 and Th2 cytokines and relative contribution of tumor necrosis factor. Am. J. Pathol. 145: 1105.
17. Chensue, S. W., P. D. Terebuh, K. S. Warmington, S. D. Hershey, H. L. Evanoff, S. L. Kunkel, and G. I. Higashi. 1992. Role of IL-4 and IFN in Schistosoma mansoni egg-induced hypersensitivity granuloma formation: orchestration, relative contribution, and relationship to macrophage function. J. Immunol. 148:900.
18. Chensue, S. W., K. S. Warmington, J. H. Ruth, P. S. Sanghi, P. M. Lincoln, and S. L. Kunkel. 1996. Role of monocyte chemoattractant protein-1 in Th1 (mycobacterial) and Th2 (schistosomal) antigen-induced granuloma formation: relationship to local inflammation, Th cell expression, and IL-12 production. J. Immunol. 157:4602.
19. Boring, L., J. Gosling, S. W. Chensue, S. L. Kunkel, R. V. Farese, H. E. Broxmeyer, and I. F. Charo. 1997. Impaired monocyte migration and reduced type-1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J. Clin. Invest. 100:2552.
20. Boring, L., J. Gosling, F. S. Monteclaro, A. J. Lusis, C.-L. Tsou, and I. F. Charo. 1996. Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein-1) and murine macrophage inflammatory protein-1α receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9. J. Biol. Chem. 271:7551.
21. Lukacs, N. W., S. W. Chensue, R. E. Smith, R. M. Strieter, K. Warmington, C. Wilke, and S. L. Kunkel. 1994. Production of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 by inflammatory granuloma fibroblasts. Am. J. Pathol 144:711.
22. + T cell activation. J. Immunol 160:4606.
23. Grandaliano, G., A. J. Valente, M. M. Rozek, and H. E. Abboud. 1994. γ Interferon stimulates monocyte chemotactic protein (MCP-1) in human mesangial cells. J. Lab. Clin. Med. 123:282.
24. Evanoff, H., M. D. Burdick, S. A. Moore, S. L. Kunkel, and R. M. Strieter. 1992. A sensitive ELISA for the detection of human monocyte chemoattractant protein-1 (MCP-1). Immunol. Invest. 21:39.
25. Lukacs, N. W., C. Addison, J. Gauldie, F. Graham, K. Simpson, R. M. Stricter, K. Warmington, S. W. Chensue, and S. L. Kunkel. 1997. Transgene-induced production of IL-4 alters the development and collagen expression of T helper cell 1-type pulmonary granulomas. J. Immunol. 158:4478.
26. Aragay, A. M., M., Mellado, J. M. Frade, A. M. Martin, M. C. Jimenez-Sainz, A. C. Martinez, and F. Mayor, Jr. 1998. Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2. Proc. Natl. Acad. Sci. USA 95:2985.
27. Lukacs, N. W., S. L. Kunkel, R. M. Strieter, K. Warmington, and S. W. Chensue. 1993. The role of macrophage inflammatory protein 1α in Schistosoma mansoni egg-induced granulomatous inflammation. J. Exp. Med. 177:1551.
28. Cochran, B. H., A. C. Reffel, and C. D. Stiles. 1983. Molecular cloning of gene sequences regulated by platelet-derived growth factor. Cell 33:939.
29. jcoupled receptors. Proc. Natl. Acad. Sci. USA 94:14495.
30. Sempowski, G. D., M. P. Beckmann, S. Derdak, and R. P. Phipps. 1994. Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors: role of IL-4 in enhancing fibroblast proliferation and collagen synthesis. J. Immunol. 152:3606.
31. Standiford, T. J., S. L. Kunkel, S. H. Phan, R. J. Rollins, and R. M. Strieter. 1991. Alveolar macrophage-derived cytokines induce monocyte chemoattractant protein expression from human pulmonary type II-like epithelial cells. J. Biol. Chem. 266:9912.
32. Rollins, B. J., T. Yoshimura, E. J. Leonard, and J. S. Pober. 1990. Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE. Am. J. Pathol. 136:1229.
33. Doucet, C., D. Brouty-Boye, C. Pottin-Clemenceau, G. W. Canonica, C. Jasmin, and B. Azzarone. 1998. Interleukin (IL)-4 and IL-13 act on human lung fibroblasts: implications in asthma. J. Clin. Invest. 101:2129.
34. Rollins, B. J., P. Stier, T. Ernst, and G. G. Wong. 1989. The human homolog of the JE gene encodes a monocyte secretory protein. Mol. Cell Biol. 9:4687.
35. Ozaki, K., S. Hanazawa, A. Takeshita, Y. Chen, A. Watanabe, K. Nishida, V. Miyata, and S. Kitano. 1996. Interleukin-1β and tumor necrosis factor-α stimulate synergistically the expression of monocyte chemoattractant prolein-1 in fibroblastic cells derived from human periodontal ligament. Oral Microbiol. Immunol. 11:109.
36. Stafford, S., H. Li, P. A. Forsythe, M. Ryan, R. Bravo, and R. Alam. 1997. Monocyte chemotactic protein-3 (MCP-3)/fibroblast-induced cytokine (FIC) in eosinophilic inflammation of the airways and the inhibitory effects of an anti-MCP-3/FIC antibody. J. Immunol. 158:4953.
37. Berkhout, T. A., H. M. Sarau, K. Moores, J. R. White, N. Elshourbagy, E. Appelbaum, R. J. Reape, M. Brawner, J. Makwana, J. J. Foley, D. B. Schmidt, C. Imburgia, D. McNulty, J. Matthews, K. O'Donnell, D. O'Shannessy, M. Scott, P. H. E. Groot, and C. Macphee. 1997. Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B. J. Biol. Chem. 272:16404.
38. Sarafi, M. N., E. A. Garcia-Zepeda, J. A. MacLean, I. F. Charo, and A. D. Luster. 1997. Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1. J. Exp. Med. 185:99.
39. Monteclaro, F. S., and I. F. Charo. 1996. The amino-terminal extracellular domain of the MCP-1 receptor, but not the RANTES/MIP-1α receptor, confers chemokine selectivity: evidence for a two-step mechanism for MCP-1 receptor activation. J. Biol. Chem. 271:19084.
40. Monteclaro, F. S., and I. F. Charo. 1997. The amino-terminal domain of CCR2 is both necessary and sufficient for high affinity binding of monocyte chemoattractant protein 1: receptor activation by a pseudo-tethered ligand. J. Biol. Chem. 272:23186.
41. Penton-Rol, G., N. Polentarutti, W. Luini, A. Borsatti, R. Mancinelli, A. Sica, S. Sozzani, and A. Mantovani. 1998. Selective inhibition of expression of the chemokine receptor CCR2 in human monocytes by IFN-γ. J. Immunol. 160:3869.
42. Sica, A., A. Saccani, A. Borsatti, C. A. Power, T. N. Wells, W. Luini, N. Polentarutti, S. Sozzani, and A. Mantovani. 1997. Bacterial lipopolysaccharide rapidly inhibits expression of C-C chemokine receptors in human monocytes. J. Exp. Med. 185:969.
43. Loetscher, P., M. Seitz, M. Baggiolini, and B. Moser. 1996. Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes. J. Exp. Med. 184:569.
44. Kunkel, S. L., N. W. Lukacs, R. M. Strieter, and S. W. Chensue. 1996. Th1 and Th2 responses regulate experimental lung granuloma development. Sarcoidosis Vasc. Diffuse Lung Dis. 13:120.
45. Suganuma, H., A. Sato, R. Tamura, and K. Chida. 1995. Enhanced migration of fibroblasts derived from lungs with fibrotic lesions. Thorax 50:984.
46. Osornio-Vargas, A. R., A. L. Goodell, N. A. Hernandez-Rodriguez, A. R. Brody, P. G. Coin, A. Badgett, and J. C. Bonner. 1995. Platelet-derived growth factor (PDGF)-AA, -AB, and -BB induce differential chemotaxis of early-passage rat lung fibroblasts in vitro. Am. J. Respir. Cell Mol. Biol. 12:33.
47. DiPietro, L. A., P. J. Polverini, S. M. Rahbe, and E. J. Kovacs. 1995. Modulation of JE/MCP-1 expression in dermal wound repair. Am. J. Pathol. 146:868.
48. Derdak, S., D. P. Penney, P. Keng, A. Paxhia, M. E. Felch, D. Brown, and R. P. Phipps. 1989. Collagen production by subpopulations of lung fibroblasts: differential inhibition by γ interferon. Am. Rev. Resp. Dis. 139:A205.
49. Serpier, H., P. Gillery, V. Salmon-Ehr, R. Garnotel, N. Georges, B. Kalis, and F. X. Maquart. 1997. Antagonistic effects of interferon-γ and interleukin-4 on fibroblast cultures. J. Invest. Dermatol. 109:158.
50. + T cells in a pulmonary Cryptococcus neoformans infection. J. Immunol. 155:4790.
51. Car, B. D., F. Meloni, M. Luisetti, G. Semenzato, G. Gialdroni-Grassi, and A. Walz. 1994. Elevated IL-8 and MCP-1 in the bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis. Am. J. Respir. Crit. Care Med. 149:655.
52. Zhang, K., M. Gharaee-Kermani, M. L. Jones, J. S. Warren, and S. H. Phan. 1994. Lung monocyte chemoattractant protein-1 gene expression in bleomycin-induced pulmonary fibrosis. J. Immunol. 153:4733.
53. Brieland, J. K., M. L. Jones, S. J. Clarke, J. B. Baker, J. S. Warren, and J. C. Fantone. 1992. Effect of acute inflammatory lung injury on the expression of monocyte chemoattractant protein-1 (MCP-1) in rat pulmonary alveolar macrophages. Am. J. Respir. Cell Mol. Biol. 7:134.
54. Brieland, J. K., M. L. Jones, C. M. Flory, G. R. Miller, J. S. Warren, S. H. Phan, and J. C. Fantone. 1993. Expression of monocyte chemoattractant protein-1 (MCP-1) by rat alveolar macrophages during chronic lung injury. Am. J. Respir. Cell Mol. Biol. 9:300.
55. Flory, C. M., M. L. Jones, B. F. Miller, and J. S. Warren. 1995. Regulatory roles of tumor necrosis factor-alpha and interleukin-1β in monocyte chemoattractant protein-1-mediated pulmonary granuloma formation in the rat. Am. J. Pathol. 146:450.
56. Tiggelman, A. M., W. Boers, C. Linthorst, M. Sala, and R. A. Chamuleau. 1995. Collagen synthesis by human liver (myo)fibroblasts in culture: evidence for a regulatory role of IL-1β, IL-4, TGF-β and IFN-γ. J. Hepatol. 23:307.
57. Chung, J. H., S. H. Youn, O. S. Kwon, K. H. Cho, J. I. Youn, and H. C. Eun. 1997. Regulations of collagen synthesis by ascorbic acid, transforming growth factor-β and interferon-γ in human dermal fibroblasts cultured in three-dimensional collagen gel are photoaging- and aging-independent. J. Dermatol. Sci. 15:188.
58. Martinet, Y., O. Menard, P. Vaillant, J. M. Vignaud, and N. Martinet. 1996. Cytokines in human lung fibrosis. Arch. Toxicol. Suppl. 18:127.
59. Zhang, K., and S. H. Phan. 1996. Cytokines and pulmonary fibrosis. Biol. Signals 5:232.
60. Standiford, T. J., M. R. Rolfe, S. L. Kunkel, J. P. D. Lynch, F. S. Becker, M. B. Orringer, S. Phan, and R. M. Strieter. 1993. Altered production and regulation of monocyte chemoattractant protein-1 from pulmonary fibroblasts isolated from patients with idiopathic pulmonary fibrosis. Chest 103:121S.
61. Warmington, K. S., L. Boring, J. H. Ruth, C. M. Hogaboam, S. L. Kunkel, I. R. Charo, and S. W. Chensue. 1998. Effect of C-C chemokine receptor 2 (CCR2) knockout on type-2 (schistosomal antigen-elicited) pulmonary granuloma formation: analysis of cellular recruitment and cytokine responses. Am. J. Pathol. 154:1407.