Eotaxin and monocyte chemotactic protein-4 mRNA expression in small airways of asthmatic and nonasthmatic individuals

Journal of Allergy and Clinical Immunology

Volumn 103, Issue 3 II, 1999, Pages 476-483

  Taha, Rame A ^a   Minshall, Eleanor M ^a   Miotto, Deborah ^a   Shimbara, Ayako ^a   Luster, Andrew ^b   Hogg, James C ^c   Hamid, Qutayba A ^a  

^a MCGILL UNIVERSITY   (Canada)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Allergic inflammation; Chemokines; Eosinophils; Eotaxin; Monocyte chemotactic protein 4; Peripheral airways

Indexed keywords

CHEMOKINE; EOTAXIN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 4;

ARTICLE; ASTHMA; CHRONIC LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; INFLAMMATORY CELL; INFLAMMATORY DISEASE; MALE; MONOCYTE; PRIORITY JOURNAL;

ASTHMA; BRONCHI; BRONCHIAL NEOPLASMS; CARCINOMA; CELL COUNT; CHEMOKINES, CC; CYTOKINES; EOSINOPHILIA; EOSINOPHILS; HUMANS; IN SITU HYBRIDIZATION; MONOCYTE CHEMOATTRACTANT PROTEINS; RNA, MESSENGER;

EID: 0033051614     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0091-6749(99)70474-4     Document Type: Article

References (31)

1. Azzawi M, Bradley B, Jeffery PK, et al. Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am Rev Respir Dis 1990;142:1407-13.
2. Laitinen LA, Laitinen A, Haahtela T. Airway mucosal inflammation even in patients with newly diagnosed asthma. Am Rev Respir Dis 1993;147:697-704.
3. Robinson DS, Hamid Q, Ying S, et al. Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992;326:298-304.
4. Garcia-Zepeda EA, Combadiere C, Rothenberg ME, et al. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils and basophils induced in allergic and non-allergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. J Immunol 1996;157:5612-26.
5. Ponath PD, Qin SX, Post TW, et al. Molecular cloning and characterisation of a human eotaxin receptor expressed selectively on eosinophils. J Exp Med 1996;183:2437-48.
6. Uguccioni M, Mackay CR, Ochensberger B, et al. High expression of the chemokine receptor CCR3 in human blood basophils. J Clin Invest 1997;100:1137-43.
7. Lamkhioued B, Renzi PM, Abi-Younes S, et al. Increased expression of eotaxin in bronchoalveolar lavage and airways of asthmatics contributes to the chemotaxis of eosinophils to the site of inflammation. J Immunol 1997;159:4593-601.
8. Ying S, Robinson DS, Meng Q, et al. Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells. Eur J Immunol 1997;27:3507-16.
9. Minshall EM, Cameron L, Lavigne F, et al. Eotaxin mRNA and protein expression in chronic sinusitis and allergen-induced nasal responses in seasonal allergic rhinitis. Am J Respir Cell Mol Biol 1997;17:683-90.
10. Wright ED, Frenkiel S, Ghaffar O, Al-Ghamdi K, Miotto D, Hamid Q. Monocyte chemotactic protein expression in allergy and non-allergy-associated chronic sinusitis. J Otolaryngol 1998;27:281-7.
11. Lilly CM, Nakamura H, Kesselman H, et al. Expression of eotaxin by human lung epithelial cells: induction by cytokines and inhibition by glucocorticosteroids. J Clin Invest 1997;99:1767-73.
12. Stellato C, Collins P, Ponath PD, et al. Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines. J Clin Invest 1997;99:926-36.
13. Kawano K, Bosken CH, Pare PD, Bai TR, Wiggs BR, Hogg JC. Small airways dimensions in asthma and in chronic obstructive pulmonary disease. Am Rev Respir Dis 1993;148:1220-5.
14. Wagner EM, Bleecker ER, Permutt S, Liu MC. Direct assessment of small airways reactivity in human subjects. Am J Respir Crit Care Med 1998;157:447-52.
15. Sekizawa K, Sasaki H, Shimizu Y, Takishima T. Dose-response effects of methacholine in normal and in asthmatic subjects. Relationship between the site of airway response and overall airway hyperresponsiveness. Am Rev Respir Dis 1986;133:593-9.
16. Hamid Q, Song YL, Kotsimbos TC, et al. Inflammation of small airways in asthma. J Allergy Clin Immunol 1997;100:44-51.
17. Carroll N, Cooke C, James A. The distribution of eosinophils and lymphocytes in the large and small airways of asthmatics. Eur Respir J 1997;10:292-300.
18. Minshall EM, Hogg JC, Hamid QA. Cytokine mRNA expression in asthma is not restricted to the large airways. J Allergy Clin Immunol 1998;101:386-90.
19. Hamid Q, Azzawi M, Ying S, et al. Expression of mRNA for interleukin-5 in mucosal biopsies from asthma. J Clin Invest 1991;87:1541-6.
20. Ying S, Durham SR, Brakans J, et al. T cells are the principal source of interleukin-5 mRNA in allergen-induced rhinitis. Am J Respir Cell Mol Biol 1993;9:356-60.
21. Frigas E, Motojima S, Gleich GJ. The eosinophilic injury to the mucosa of the airways in the pathogenesis of bronchial asthma. Eur Respir J Suppl 1991;13:123S-35S.
22. Lefort J, Nahori MA, Ruffie C, Vargaftig BB, Pretolani M. In vivo neutralization of eosinophil-derived major basic protein inhibits antigen-induced bronchial hyperreactivity in sensitized guinea pigs. J Clin Invest 1996;97:1117-21.
23. Moqbel R. Synthesis and storage of regulatory cytokines in human eosinophils. Adv Exp Med Biol 1996;409:287-94.
24. Sallusto F, Mackay CR, Lanzavecchia A. Selective expression of the eotaxin receptor CCR3 by human T-helper 2 cells. Science 1997;277:2005-7.
25. Gerber BO, Zanni MP, Uguccioni M, et al. Functional expression of the eotaxin receptor CCR3 in T lymphocytes co-localizing with eosinophils. Curr Biol 1997;7:836-43.
26. Uguccioni M, Loetscher P, Forssmann U, et al. Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin. J Exp Med 1996;183:2379-84.
27. Ponath PD, Qin S, Ringler DJ, et al. Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. J Clin Invest 1996;97:604-12.
28. Berkman N, Krishnan VL, Gilbey T, et al. Expression of RANTES niRNA and protein in airways of patients with mild asthma. Am J Respir Crit Care Med 1996;154:1804-11.
29. Laberge S, Ernst P, Ghaffar O, et al. Increased expression of interleukin-16 in bronchial mucosa of subjects with atopic asthma. Am J Respir Cell Mol Biol 1997;17:193-202.
30. Standiford TJ, Kunkel SL, Basha MA, et al. Interleukin-8 gene expression by a pulmonary epithelial cell line. A model for cytokine networks in the lung. J Clin Invest 1990;86:1945-53.
31. Petering H, Hochstetter R, Kimmig D, Smolarski R, Kapp A, Eisner J. Detection of MCP-4 in dermal fibroblasts and its activation of the respiratory burst in human eosinophils. J Immunol 1998;160:555-8.