Genetics of human prefrontal function

Brain Research Reviews

Volumn 43, Issue 1, 2003, Pages 134-163

  Winterer, Georg ^a,b   Goldman, David ^b  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

COMT; Endophenotype; Genetics; Intelligence; Prefrontal function

Indexed keywords

CATECHOL METHYLTRANSFERASE;

BRAIN FUNCTION; COGNITION; CULTURAL ANTHROPOLOGY; ELECTROPHYSIOLOGY; EVENT RELATED POTENTIAL; FRONTAL LOBE; GENETIC REGULATION; HERITABILITY; HUMAN; IMAGING; INTELLIGENCE; MOLECULAR EVOLUTION; NERVE CELL DIFFERENTIATION; NERVE DEGENERATION; NEUROANATOMY; NEUROPSYCHOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRECURSOR; PREFRONTAL CORTEX; PRIORITY JOURNAL; REVIEW; VELOCITY; X CHROMOSOME;

EID: 0141741739     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0173(03)00205-4     Document Type: Review

References (374)

1. Abitbol M., Menini C., Delezoide A.L., Rhyner T., Vekemans M., Mallet J. Nucleus basalis magnocellularis and hippocampus are the major sites of FMR1 expression in the human fetal brain. Nat. Genet. 4:1993;147-153.
2. Abrams M.T., Reiss A.L., Freund L.S., Baumgardner T.L., Chase G.A., Denckla M.B. Molecular-neurobehavioral associations in females with the fragile X full mutation. Am. J. Med. Genet. 51:1994;317-327.
3. Akbarian S., Kim J.J., Potkin S.G., Hagman J.O., Tafazzoli A., Bunney W.E. Jr., Jones E.G. Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics. Arch. Gen. Psychiatry. 52:1995;258-266.
4. Almasy L., Porjesz B., Blangero J., Chorlian D.B., O'Connor S.J., Kuperman S., Rohrbaugh J., Bauer L.O., Reich T., Polich J., Begleiter H. Heritability of event-related brain potentials in families with a history of alcoholism. Am. J. Med. Genet. 88:1999;383-390.
5. Almasy L., Porjesz B., Blangero J., Goate A., Edenberg H., Chorlian D., Kuperman S., O'Connor S., Rohrbaugh J., Bauer L., Foroud T., Rice J., Reich T., Begleiter H. Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism. Am. J. Hum. Genet. 68:2001;128-135.
6. Amar K., Macgowan S., Wilcock G., Lewis T., Scott M. Are genetic factors important in the aetiology of leukoariosis? Results from a memory clinic population. Int J. Geriatr. Psychiatry. 13:1998;585-590.
7. Diagnostic and Statistical Manual of Mental Disorders. 1995;American Psychiatric Association, Washington, DC.
8. Amouyel P., Richard F., Cotel D., Amant C., Codron V., Helbecque N. The deletion of the angiotensin I converting enzyme gene as a genetic susceptibility factor for cognitive impairment. Neurosci. Lett. 217:1996;203-205.
9. Anderson B., Harvey T. Alterations of cortical thickness and neuronal density in the frontal cortex of Albert Einstein. Neurosci. Lett. 210:1996;161-164.
10. Ando J., Ono Y., Wright M.J. Genetic structure of spatial and verbal working memory. Behav. Genet. 31:2001;615-624.
11. Andreasen N.C., Flaum M., Swaze V., O'Leary D.S., Alliger R., Cohen G., Ehrhardt J., Yuh W.T. Intelligence and brain structure in normal individuals. Am. J. Psychiatry. 150:1993;130-134.
12. Aylward E.H., Li Q., Honneycutt N.A., Warren A.C., Pulsifer M.B., Barta P.E., Chan M.D., Smith P.D., Jerram M., Pearlson G.D. MRI volumes of the hippocampus and amygdala in adults with Down's syndrome with and without dementia. Am. J. Psychiatry. 156:1999;564-568.
13. Baaré W.F.C., Hulshoff Pol H.E., Boomsma D.I., Posthuma D., de Geus E.J.C., Schnack H.G., van Haren N.E.M., van Oel C.J., Kahn R.S. Quantitative genetic modeling of variation in human brain morphology. Cereb. Cortex. 11:2001;816-824.
14. Baddeley A.D. Working Memory. 1986;Oxford University Press, Oxford.
15. Baker L.A., Vernon P.A., Ho H. The genetic correlation between intelligence and speed of information processing. Behav. Genet. 21:1991;351-367.
16. Bandettini P.A., Wong E.C. Magnetic resonance imaging of human brain function. Neurosurg. Clin. North Am. 8:1997;345-371.
17. Barrett P.T., Eysenck H.J. Brain evoked potentials and intelligence: the Hendrickson paradigm. Intelligence. 16:1992;360-381.
18. Barrett P.T., Eysenck H.J. The relationship between evoked potential component amplitude, latency, contour length, variability, zero-crossings, and psychometric intelligence. Person. Individ. Diff. 16:1994;3-32.
19. Bartfai A., Pedersen N.L., Asarnow R.F., Schalling D. Genetic factors for the span of apprehension test: a study of normal twins. Psychiatry Res. 38:1991;115-124.
20. Bartley A.J., Jones D.W., Weinberger D.R. Genetic variability of human brain size and cortical gyral patterns. Brain. 120:1997;257-269.
21. Bartrés-Faz D., Junqué C., Clemente I.C., López-Alomar A., Valveny N., López-Guillén A., López T., Cubells M.J., Moral P. Angiotensin I converting enzyme polymorphism in humans with age-associated memory impairment: relationship with cognitive performance. Neurosci. Lett. 290:2000;117-180.
22. Begleiter H., Porjesz B., Reich T., Edenberg H.J., Goate A., Blangero J., Almasy L., Foroud T., van Eerdewegh P., Polich J., Rohrbaugh J., Kuperman S., Bauer L.O., O'Connor S.J., Chorlian D.B., Li T.K., Conneally P.M., Hesselbrock V., Rice J.P., Schuckit M.A., Cloninger R., Nuernberger J., Crowe R., Bloom F.E. Quantitative trait loci analysis of human event-related brain potentials: P3 voltage. Electroencephalogr. Clin. Neurophysiol. 108:1998;244-250.
23. Benson D.F., Kuhl D.E., Phelps M.E., Cummings J.L., Tsai S.Y. Positron emission tomography in the diagnosis of dementia. Trans. Am. Neurol. Assoc. 106:1981;68-71.
24. Berman K.F., Torrey E.F., Daniel D.G., Weinberger D.R. Regional cerebral blood flow in monozygotic twins discordant and concordant for schizophrenia. Arch. Gen. Psychiatry. 49:1992;927-934.
25. Blinkhorn S.F., Hendrickson D.E. Averaged evoked responses and psychometric intelligence. Nature. 295:1982;596-597.
26. Block N. How heritability misleads about race. Cognition. 56:1995;99-128.
27. Boccardi M., Laasko M.P., Bresciani L., Galluzzi S., Geroldi C., Beltramello A., Soininen H., Frisoni G.B. The MRI pattern of frontal and temporal brain atrophy in fronto-temporal dementia. Neurobiol. Aging. 24:2003;95-103.
28. Bonan I., Argenti A.M., Duyme M., Hasboum D., Dorion A., Marsault C., Zouaoui A. Magnetic resonance imaging of cerebral central sulci: a study of monozygotic twins. Acta Genet. Med. Gemellol. 47:1998;89-100.
29. Bondi M.W., Salmon D.P., Monsch A.U., Galasko D., Butters N., Klauber M.R., Thal L.J., Saitoh T. Episodic memory changes are associated with the APOε4 allele in nondemented older adults. Neurology. 45:1995;2203-2206.
30. Borrell J., Vela J.M., Arevalo-Martin A., Molina-Holgado E., Guaza C. Prenatal immune challenge disrupts sensorimotor gating in adult rats. Implications for the etiopathogenesis of schizophrenia. Neuropsychopharmacology. 26:2002;204-215.
31. Botstein D., Risch N. Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. Nat. Genet. 33:(Suppl.):2003;228-237.
32. Bouchard T.J., Lykken D.T., McGue M., Degal N.L., Tellegen A. Sources of human psychological differences: the Minnesota study of twins reared apart. Science. 250:1990;223-228.
33. Boutros N., Torello M.W., Burns E.M., Wu S.-S., Nasrallah H.A. Evoked potentials in subjects at risk for Alzheimer's disease. Psychiatry Res. 57:1995;57-63.
34. Bozzali M., Franceschi M., Falini A., Pontesilli S., Cercignani M., Magnani G., Scotti G., Comi G., Filippi M. Quantification of tissue damage in AD using diffusion tensor and magnetization transfer MRI. Neurology. 57:2001;1135-1137.
35. Braun K., Segal M. FMRP involvement in formation of synapses among cultured hippocampal neurons. Cereb. Cortex. 10:2000;1045-1052.
36. Brockwell R., Turner G. High resolution banding and the locus of the Xq fragile site. Hum. Genet. 61:1983;77.
37. Brown W.S., Marsh J.T., LaRue A. Event-related potentials in psychiatry: differentiating depression and dementia in the elderly. Bull. Los Angeles Neurol. Soc. 47:1983;91-107.
38. Buchsbaum M.S., Mirsky A.F., DeLisi L.E., Morihisa J., Karson C.N., Mendelson W.B., King A.C., Johnson J., Kessler R. The Genain quadruplets: electrophysiological, positron emission, and X-ray tomographic studies. Psychiatry Res. 13:1984;95-108.
39. Burggren A.C., Small G.W., Sabb F.W., Bookheimer S.Y. Specificity of brain activation patterns in people at genetic risk for Alzheimer disease. Am. J. Geriatr. Psychiatry. 10:2002;44-51.
40. Burns N.R., Nettelbeck T., Cooper C.J. The string measure of the event-related potential IQ and inspection time. Person. Individ. Diff. 21:1996;563-572.
41. Burt C. The genetic determination of differences in intelligence: a study of monozygotic twins reared together and apart. Br. J. Psychol. 57:1966;137-153.
42. Campi N., Todeshini G.P., Scarzella L. Selegiline versus L-acetylcarnitine in the treatment of Alzheimer-type dementia. Clin. Ther. 12:1990;306-314.
43. Cardon L.R., Fulker D.W., DeFries J.C., Plomin R. Multivariate genetic analysis of specific cognitive abilities in the Colorado Adoption Project at age 7. Intelligence. 16:1992;383-400.
44. Carpenter P.A., Just M., Shell P. What one intelligence test measures: a theoretical account of processing in the Raven's Progressive Matrices Test. Psychol. Rev. 97:1990;404-431.
45. Caryl P.G., Harper A. Event-related potentials (ERPs) in elementary cognitive tasks reflect task difficulty and task threshold. Intelligence. 22:1996;1-22.
46. Casas C., Martinez S., Pritchard M.A., Fuentes J.J., Nadal M., Guimera J., Arbones M., Florez J., Soriano E., Estivill X., Alcantara S. DSCR1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis. Mech. Dev. 101:2001;289-292.
47. Caskey C.T., Pizzuti A., Fu Y.H., Fenwick R.G., Nelson D.L. Triplet repeat mutations in human disease. Science. 256:1992;784-789.
48. Castro Costa M.R., Edelstein S.B., Castiglione C.M., Chao H., Breakefield X.O. Properties of monoamine oxidase in control and Lesh-Nyhan fibroblasts. Biochem. Genet. 18:1980;577-590.
49. Chapman C.R., Chen C.A.N., Colpitts Y.M., Martin R.W. Sensory decision theory describes evoked potentials in pain discrimination. Psychophysiology. 18:1981;114-120.
50. Chiurazzi P., Pomponi M.G., Willemsen R., Oostra B.A., Neri G. In vitro reactivation of the FMR1 gene involved in fragile X syndrome. Hum. Mol. Genet. 7:1998;109-113.
51. Chiurazzi P., Hamel B.C., Neri G. XLMR genes: update 2000. Eur. J. Hum. Genet. 9:2001;71-81.
52. Clark C.M., Klonoff H., Tyhurst J.S., Ruth T., Adam M., Rogers J., Harrop R., Martin W., Pate B. Regional cerebral glucose metabolism in identical twins. Neuropsychologia. 26:1988;615-621.
53. Colet A.V., Piera P.J.F., Pueyo A.A. Initial stages of information processing and inspection time: electrophysiological correlates. Person. Individ. Diff. 14:1993;733-738.
54. Comery T.A., Haris J.B., Willems P.J., Oostra B.A., Irwin S.A., Weiler I.J., Greenough W.T. Abnormal dendritic spines in fragile X knock-out mice: maturation and pruning deficits. Proc. Natl. Acad. Sci. USA. 94:1997;5401-5404.
55. Contreras D., Steriade M. Cellular basis of EEG slow rhythms: a study of dynamic corticothalamic relationships. J. Neurosci. 15:1995;604-622.
56. Corder E.H., Saunders A.M., Strittmatter W.J., Schmechel D.E., Gaskell P.C., Small G.W., Roses A.D., Haines J.L., Pericak-Vance M.A. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 261:1993;921-923.
57. Creutzfeldt O.T., Watanabe S., Lux H.D. Relations between E.E.G. phenomena and potentials of single cortical cells. II. Spontaneous and convulsoid activity. Electroencephalogr. Clin. Neurophysiol. 20:1966;19-37.
58. Creutzfeldt O.T., Rosina A., Ito M., Probst W. Visual evoked response of single cells and of the EEG in primary visual area of the cat. J. Neurophysiol. 32:1969;127-139.
59. Crowe S.F., Hay A. Neuropsychological dimensions of the fragile X syndrome: support for a non-dominant hemisphere dysfunction hypothesis. Neuropsychologia. 28:1990;9-16.
60. Cudmore L.J., Segalowitz S.J. Signal-to-noise ratio sensitivity in ERPs to stimulus and task complexity: different effects for early and late components. Brain Cogn. 43:2000;130-134.
61. Dailey M.E., Smith S.J. The dynamics of dendritic structure in developing hippocampal slices. J. Neurosci. 16:1996;2983-2994.
62. Das H.K., McPherson J., Bruns G.A.P., Karathanasis S.K., Breslow J.L. Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene. J. Biol. Chem. 260:1985;6240-6247.
63. De Santi S., de Leon M.J., Rusinek H., Convit A., Tarshish C.Y., Roche A., Tsu W.H., Kandil E., Boppana M., Daisley K., Wang G.J., Schlyer D., Fowler J. Hippocampal formation glucose metabolism and volume loss in MCI and AD. Neurobiol. Aging. 22:2001;529-539.
64. Deary I.J., Stough C. Intelligence and inspection time: achievements, prospects and problems. Am. Psychol. 51:1996;599-608.
65. Deary I.J., Caryl P.G. Neuroscience and human intelligence differences. Trends Neurosci. 20:1997;365-371.
66. Deary I.J. Human intelligence differences: a recent history. Trends Cogn. Sci. 5:2001;127-130.
67. Deary I.J. Human intelligence differences: towards a combined experimental-differential approach. Trends Cogn. Sci. 5:2001b;164-170.
68. DeMille M.M.C., Kidd J.R., Ruggeri V., Palmatier M.A., Goldman D., Odunsi A., Okonofua F., Grigorenko E., Schulz L.O., Bonne-Tamir B., Lu R.-B., Paranas J., Pakstis A.J., Kidd K.K. Population variation in linkage disequilibrium across the COMT gene considering promoter region and coding region variation. Hum. Genet. 111:2002;521-537.
69. Devys D., Lutz Y., Rouyer N., Bellocq J.P., Mandel J.L. The FMR-1 protein is most abundant in neurons and appears normal in carriers of a fragile X syndrome. Nat. Genet. 4:1993;335-340.
70. Diehl J., Kurz A. Frontotemporal dementia: patient characteristics, cognition and behaviour. Int. J. Geriatr. Psychiatry. 17:2002;914-918.
71. Dierks T., Persic I., Frölich L., Ihl R., Maurer K. Topography of the quantitative electroencephalogram in dementia of the Alzheimer type: relation to severity of dementia. Psychiatry Res. 40:1991;181-194.
72. Duffy F.H., Albert M.S., McAnulty G. Brain electrical activity in patients with presenile and senile dementia of the Alzheimer type. Ann. Neurol. 16:1984;439-448.
73. Duffy F.H., McAnulfy G.B., Jones K., Als H., Albert M. Brain electrical correlates of psychological measures: strategies and problems. Brain Topogr. 5:1993;399-412.
74. Duncan J., Seitz R.J., Kolodny J., Bor D., Herzog H., Ahmed A., Newell F.N., Emslie H. A neural basis for general intelligence. Science. 289:2000;457-460.
75. Durstewitz D., Kelc M., Güntürkün O. A neurocomputational theory of the dopaminergic modulation of working memory functions. J. Neurosci. 19:2000;2807-2822.
76. Eberhart D.E., Malter H.E., Feng Y., Warren S.T. The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals. Hum. Mol. Genet. 5:1996;1083-1091.
77. Egan M.F., Goldberg T.E., Gscheidle T., Weirich M., Bigelow L.B., Weinberger D.R. Relative risk of attention deficits in siblings of patients with schizophrenia. Am. J. Psychiatry. 157:2000;1309-1316.
78. Egan M.F., Goldberg T.E., Kolachana B.S., Callicott J.H., Mazzanti C.M., Straub R.E., Goldman D., Weinberger D.R. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc. Natl. Acad. Sci. USA. 98:2001;6917-6922.
79. Egan V.G., Chiswick A., Brettle R.P., Goodwin R.M. The Edinburgh cohort of HIV-positive drug users: the relationship between auditory P3 latency, cognitive function and self-rated mood. Psychol. Med. 23:1992;613-622.
80. Eischen S., Polich J. P300 from families. Electroencephalogr. Clin. Neurophysiol. 92:1994;369-372.
81. Eliez S., Blasey C.M., Freund L.S., Hastie T., Reiss A.L. Brain anatomy, gender and IQ in children and adolescents with fragile X syndrome. Brain. 124:2001;1610-1618.
82. Elsworth J.D., Leahy D.J., Roth R.H., Redmond D.E. Homovanillic acid concentrations in brain CSF and plasma as indicators of central dopamine function in primates. J. Neural Transm. 68:1987;51-62.
83. Engle R.W., Tuholski S.W., Laughlin J.E., Conway A.R.A. Working memory, short-term memory, and general fluid intelligence: a latent-variable approach. J. Exp. Psychol. Gen. 128:1999;309-331.
84. Epstein C.J., Korenberg J.R., Anneren G., Antonarakis S.E., Ayme S., Courchesne E., Epstein L.B., Fowler A., Groner Y., Huret J.L., Kemper T., Lotti I., Lubin B., Magenis E., Opitz J., Patterson D., Priest J., Pueschel S., Rapoport S., Sinet P.-M., Tanzi R., de la Cruz F. Protocols to establish genotype-phenotype correlations in Down syndrome. Am. J. Hum. Genet. 49:1991;207-235.
85. Ermak G., Morgan T.E., Davies K.J. Chronic overexpression of the calcineurin inhibitory gene DSCR1 (ADAPT78) is associated with Alzheimer's disease. J. Biol. Chem. 276:2001;38787-38794.
86. Evin G., Smith M.J., Tziotis A., McLean C., Canterford L., Sharples R.A., Cappai R., Weidemann A., Beyreuther K., Cotton R.G., Masters C.L., Culvenor J.G. Alternative transcripts of presenilin-1 associated with frontotemporal dementia. Neuroreport. 13:2002;917-921.
87. Fallgatter A.J., Jatzke S., Bartsch A.J., Hamelbeck B., Lesch K.P. Serotonin transporter promoter polymorphism influences topography of inhibitory motor control. Int. J. Neuropsychopharmacol. 2:1999;115-120.
88. Fan J., Wu Y., Fossella J.A., Posner M.I. Assessing the heritability of attentional networks. BMC Neurosci. 2:2001;14.
89. Farrer L.A., Cupples L.A., Haines J.L., Hyman B., Kukull W.A., Mayeux R., Myers R.H., Pericak-Vance M.A., Risch N., van Duijn C.M. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: a meta-analysis. J. Am. Med. Assoc. 278:1997;1349-1356.
90. Feng Y., Absher D., Eberhart D.E., Brown V., Malter H.E., Warren S.T. FMRP associates with polyribosomes as an mRNP and the 1304N mutations of severe fragile X syndrome abolishes this association. Mol. Cell. 1:1997;109-118.
91. Feng Y., Gutekunst C.A., Eberhart D.E., Yi H., Warren S.T., Hersch S.M. Fragile X mental retardation protein: nucleocytoplasmatic shuttling and association with somatodendritic ribosomes. J. Neurosci. 17:1997;1539-1547.
92. Ferri R., Muscumeci S.A., Elia M., Del Gracco S., Scuderi C., Bergonzi P. BIT-mapped somatosensory evoked potentials in the fragile X syndrome. Neurophysiol. Clin. 24:1994;413-426.
93. Fiala J.C., Feinberg M., Popov V., Harris K.M. Synaptogenesis via dendritic filopodia in developing hippocampal area CA1. J. Neurosci. 18:1998;8900-8911.
94. Finkel D., McGue M. The origins of individual differences in memory among the elderly: a behavior genetic analysis. Psychol. Aging. 8:1993;527-537.
95. Finkel D., McGue M. Age differences in the nature and origin of individual differences in memory: a behavior genetic analysis. Int. J. Aging Hum. Dev. 47:1998;217-239.
96. Finkel D., Pedersen N.L., McGue M., McClearn G.E. Heritability of cognitive abilities in adult twins: comparison of Minnesota and Swedish data. Behav. Genet. 25:1995;421-431.
97. Finkel D., Petersen N., McGue M. Genetic influences on memory performance in adulthood: comparison of Minnesota and Swedish twin data. Psychol. Aging. 10:1995;437-446.
98. S.E. Fisher, C.S. Lai, A.P. Monaco, Deciphering the genetic basis of speech and language disorders, Annu. Rev. Neurosci., epublished ahead of print.
99. Fox S.S., Brien J.H. Duplication of evoked potential waveform by curve of probability of firing of a single cell. Science. 147:1965;888-890.
100. Freund L., Reiss A.L. Cognitive profiles associated with the fragile X syndrome in males and females. Am. J. Med. Genet. 38:1991;542-547.
101. Fuentes J.J., Pritchard M.A., Planas A.M., Bosch A., Ferrer I., Estivill X. A new human gene from Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart. Am. J. Mol. Genet. 4:1995;1935-1944.
102. Fuentes J.J., Pritchard M.A., Estivill X. Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene. Genomics. 44:1997;358-361.
103. Fuster J.M. The Prefrontal Cortex. 1997;Lippincott-Raven, Philadelphia, PA.
104. Gabriel S.B., Schaffner S.F., Nguyen H., Moore J.M., Roy J., Blumenstiel B., Higgins J., DeFelice M., Lochner A., Faggart M., Liu-Cordero S.N., Rotimi C., Adeyemo A., Cooper R., Ward R., Lander E.S., Daly M.J., Altshuler D. The structure of haplotype blocks in the human genome. Science. 296:2002;2225-2229.
105. Gallinat J., Mulert C., Bajbouj M., Rentzsch J., Senkowski D., Schunter J., Muchtieva R., Kronfeldt D., Nisslé S., Herrmann W.M., Winterer G. Frontal and temporal dysfunction of auditory stimulus processing in schizophrenia. Neuroimage. 17:2002;110-127.
106. Gallinat J., Senkowski D., Wernicke C., Juckel G., Becker I., Sander T., Smolka M., Hegerl U., Rommelspacher H.-P., Winterer G., Herrmann W.M. Allelic variants of the functional promoter polymorphism of the human serotonin transporter gene is associated with auditory cortical stimulus processing. Neuropsychopharmacology. 28:2002;530-532.
107. 108/15Met) gene polymorphism with prefrontal P300 during information processing, Biol. Psychiatry, in press.
108. Galton F. Hereditary Genius: An Inquiry Into Its Laws and Consequences. 1869/1962;Macmillan/Fontana, London.
109. Gardner H. Intelligence Reframed: Multiple Intelligence for the 21th Century. 2000;Basic Books, New York.
110. Geffen G.M., Wright M.J., Green H.J., Gillespie N.A., Smyth D.C., Evans D.M., Geffen L.B. Effects of memory load and distraction on performance and event-related slow potentials in a visuospatial working memory task. J. Cogn. Neurosci. 9:1997;743-757.
111. Gelowitz D.L., Richardson J.S., Wishart T.B., Yu P.H., Lai C.T. Chronic L-deprenyl or L-amphetamine: equal cognitive enhancement, unequal MAO inhibition. Pharmacol. Biochem. Behav. 47:1994;41-45.
112. Gerdes L.U., Klausen I.C., Sihm I., Faergeman O. Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world. Genet. Epidemiol. 9:1992;155-167.
113. Geschwind D.H., Robidoux J., Alarcon M., Miller B.L., Wilhelmsen K.O., Cummings J.L., Nasreddine Z.S. Dementia and neurodevelopmental predisposition: cognitive dysfunction in presymptomatic subjects precedes dementia by decades in frontotemporal dementia. Ann. Neurol. 50:2001;741-746.
114. Geschwind D.H., Miller B.L., DeCarli C., Carmelli D. Heritability of lobar brain volumes in twins supports genetic models of cerebral laterality and handedness. PNAS. 99:2002;3176-3181.
115. Gevins A., Smith M.E. Neurophysiological measures of working memory and individual differences in cognitive ability and cognitive style. Cereb. Cortex. 10:2000;829-839.
116. Giannakopoulos P., Kovari E., Savioz A., de Bilbao F., Dubois-Dauphin M., Hof P.R., Bouras C. Differential distribution of presenillin-1, Bax, and Bcl-(X) in Alzheimer's disease and frontotemporaldementia. Acta Neuropathol. (Berl.). 98:1999;141-149.
117. Gilbert D.G., Johnson S., Gilbert B., McColloch M.A. Event-related potential correlates of IQ. Person. Individ. Diff. 12:1991;1183-1184.
118. Giros B., Jaber M., Jones S.R., Wightman R.M., Caron M.G. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature. 379:1996;606-612.
119. Gogos J.A., Morgan M., Luine V., Santha M., Ogawa S., Pfaff D. Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc. Natl. Acad. Sci. USA. 95:1998;9991-9996.
120. Gorbachevskaia N.L., Denisova L.V. Brain bioelectrical activity in patients with the fragile X-chromosome syndrome and their mothers. Zh. Nevrol. Psihkiatr. Im S. S. Korsakova. 97:1997;33-37.
121. Gould S.J. The Mismeasure of Man. 1996;Norton, New York.
122. Grady C.L., Haxby J.V., Horwitz B., Sundaram M., Berg G., Schapiro M., Friedland R.P., Rapoport S.I. Longitudinal study of the early neuropsychological and cerebral metabolic changes in dementia of the Alzheimer type. J. Clin. Exp. Neuropsychol. 10:1988;576-596.
123. Grady C.L., Maisog J.M., Horwitz B., Ungerleider L.G., mentis M.J., Salerno J.A., Pietrini P., Wagner E., Haxby J.V. Age-related changes in cortical blood flow activation during visual processing of faces and location. J. Neurosci. 14:1994;1450-1462.
124. Green J., Levey A.I. Event-related potential changes in groups at increased risk for Alzheimer disease. Arch. Neurol. 56:1999;1398-1403.
125. Gregory C.A., Serra-Mestres J., Hodges J.R. Early diagnosis of the frontal variant of frontotemporal dementia: how sensitive are standard neuroimaging and neuropsychological tests. Neuropsychiatry Neuropsychol. Behav. Neurol. 12:1999;128-135.
126. Grimsby J., Lan N.C., Neve R., Chen K., Shih J.C. Tissue distribution of human monoamine oxidase A and B mRNA. J. Neurochem. 55:1990;1166-1169.
127. Grossman M. Frontotemporal dementia: a review. J. Int. Neuropsychol. Soc. 8:2002;566-583.
128. Grundman M., Sencakova D., Jack C.R., Petersen R.C., Kim H.T., Schultz A., Weiner M.F., DeCarli C., DeKosky S.T., van Dyck C., Thomas R.G., Thai L.J. Brain MRI hippocampal volume and prediction of clinical status in mild cognitive impairment. J. Mol. Neurosci. 19:2002;23-27.
129. Guerreiro M.M., Camargo E.E., Kato M., Marques-de-Faria A.P., Ciasca S.M., Guerreiro C.A., Netto J.R., Moura-Ribeiro M.V. Fragile X syndrome: clinical, electroencephalographic and neuroimaging characteristics. Arq. Neuropsiquiatr. 56:1998;18-23.
130. Hagerman R.J., Kemper M., Hudson M. Learning disabilities and attentional problems in boys with the fragile X syndrome. Am. J. Dis. Child. 139:1985;674-678.
131. Hagerman R.J., Chronister A. Fragile X Syndrome Diagnosis, Treatment, and Research. 1996;John-Hopkins University Press, Baltimore, MD.
132. Haier R.J., Robinson D.L., Braden W., Williams D. Electrical potentials of the cerebral cortex and psychometric intelligence. Person. Individ. Diff. 5:1983;591-599.
133. Halgren E., Baudena P., Clarke J.M., Heit G., Liegeois C., Chauvel P., Musolino A. Intracerebral potentials to rare target and distractor auditory and visual stimuli. I. Superior temporal plane and parietal lobe. Electroencephalogr. Clin. Neurophysiol. 94:1995;191-220.
134. Hänninen T., Hallikainen M., Koivisto K., Helkala E.L., Reinikainen K.J., Soininen H., Mykkanen L., Laakso M., Pyorala K., Riekkinen P.J. A follow-up study of age-associated memory impairment: neuropsychological predictors of dementia. J. Am. Geriatr. Soc. 43:1995;1007-1015.
135. Hansell N.K., Wright M.J., Geffen G.M., Geffen L.B., Smith G.A., Martin N.G. Genetic influence on ERP slow wave measures of working memory. Behav. Genet. 31:2001;603-614.
136. Hariri A.R., Mattay V.S., Tessitore A., Kolachana B., Fera F., Goldman D., Egan M.F., Weinberger D.R. Serotonin transporter genetic variation and the response of the human amygdala. Science. 297:2002;400-403.
137. Harlow H.F., Uehling H., Maslow A.H. Comparative behavior of primates: I. Delayed reaction tests on primates from the lemur to the orangutan. J. Comp. Psychol. 13:1932;313-343.
138. Harwood D.G., Barker W.W., Ownby R.L., Mullan M., Duara R. Apolipoprotein E polymorphism and cognitive impairment in a bi-ethnic community-dwelling elderly sample. Alzheimer Dis. Assoc. Disord. 16:2002;8-14.
139. Helkala E.-L., Lakka T., Vanhanen M., Tuomainen T.-P., Ehnholm C., Kaplan G.A., Salonen J.T. Associations between apolipoprotein E phenotype, glucose metabolism and cognitive function in men. Diabetes. 18:2001;991-997.
140. Hendrickson D.E., Hendrickson A.E. The biological basis of individual differences in intelligence. Person. Individ. Diff. 1:1980;3-33.
141. Hendrickson D.E., Hendrickson A.E. The biological basis of intelligence. Eysenck H.J. A Model For Intelligence. 1982;Springer, New York.
142. Herholz K., Schopphoff H., Schmidt M., Mielke R., Eschner W., Scheidhauer K., Schicha H., Heiss W.D., Ebmeier K. Direct comparison of spatially normalized PET and SPECT scans in Alzheimer's disease. J. Nucl. Med. 43:2002;21-26.
143. Herrnstein R.J., Murray C. The Bell Curve. 1994;Free Press, New York.
144. Higuchi M., Arai H., Nakagawa T., Higuchi S., Muramatsu T., Matsushita S., Kosaka Y., Itoh M., Sasaki H. Regional cerebral glucose utilization is modulated by the dosage of apolipoprotein E type 4 allele and alpha1-antichymotrypsin type A allele in Alzheimer's disease. Neuroreport. 8:1997;2639-2643.
145. Hinton V.J., Brown W.T., Wisniewski K., Rudelli R.D. Analysis of neocortex in three males with the fragile X syndrome. Am. J. Med. Genet. 41:1991;289-294.
146. Hjalgrim H., Jacobsen T.B., Nogaard K., Lou H.C., Brondum-Nielsen K., Jonassen O. Frontal-subcortical hypofunction in the fragile X syndrome. Am. J. Med. Genet. 83:1999;140-141.
147. Ho H., Baker L.A., Decker S.N. Covariation between intelligence and speed of cognitive processing: genetic and environmental influences. Behav. Genet. 18:1988;247-261.
148. Hoddap R.M., Leckman J.F., Dykens E.M., Sparrow S., Zelinsky D., Ort S.I. K-ABC profiles with children with fragile X syndrome, Down's syndrome and non-specific mental retardation. Am. J. Mental Retard. 97:1992;39-46.
149. Holschneider D.P., Chen K., Seif I., Shih J.C. Biochemical, behavioral, physiologic, and neurodevelopmental changes in mice deficient in monoamine oxidase A or B. Brain Res. Bull. 56:2001;453-462.
150. Hornstra I.K., Nelson D.L., Warren S.T., Yang T.P. High resolution methylation analysis of the FMR1 gene trinucleotide repeat region in fragile X syndrome. Hum. Mol. Genet. 2:1993;1659-1665.
151. Hotamisligil G.S., Breakefield X.O. Human monoamine oxidase A gene determines levels of enzyme activity. Am. J. Hum. Genet. 49:1991;383-392.
152. Howard L., Polich J. P300 latency and memory span development. Dev. Psychol. 21:1985;283-289.
153. Huang C., Wahlund L., Dierks T., Julin P., Winblad B., Jelic V. Discrimination of Alzheimer's disease and mild cognitive impairment by equivalent EEG sources: a cross-sectional and longitudinal study. Clin. Neurophysiol. 111:2000;1961-1967.
154. Irwin S.A., Idupulapi M., Mehta A.B., Crisostomo R.A., Rogers E.J., et al. Abnormal dendritic and dendritic spine characteristics in fragile-X patients and the mouse model of fragile-X syndrome. Soc. Neurosci. Abstr. 25:1999;2548.
155. Irwin S.A., Patel B., Idupulapati M., Harris J.B., Crisotomo R.A., Larsen B.P., Kooy F., Willems P.J., Cras P., Kozlowski P.B., Swain R.A., Weiler I.J., Greenough W.T. Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile X syndrome. Am. J. Med. Genet. 98:2001;161-167.
156. Iznak A.F., Gorbachevskaia N.L., Zhigul'skaia S.E., Grigor'eva N.V., Grachev V.V., Vasil'eva A.G., Chaianov N.V., Gavrilova S.I., Roshchina I.F., Kolykhalov I.V., Bashina V.M., Simashkova N.V. Quantitative EEG correlates of the human frontal lobe dysfunction. Vestn. Ross. Akad. Med. Nauk. 7:2001;48-53.
157. Jack C.R., Petersen R.C., O'Brien P.C., Tangalos E.G. MR-based hippocampal volumetry in the diagnosis of Alzheimer's disease. Neurology. 42:1992;183-188.
158. Jackson D.N. Multidimensional Aptitude Battery II - Manual. 1998;Sigma Assessment Systems, Port Huron.
159. Jakala P., Hanninen T., Ryynaum M., Laakso M., Partanen K., Mannermaa A., Soinem H. Fragile X: neuropsychological test performance, CGG triplet repeat lengths, and hippocampal volumes. J. Clin. Invest. 100:1997;331-338.
160. Jarrold C., Baddeley A.D. Short-term memory in Down's syndrome: applying the working memory model. Downs Syndr. Res. Pract. 7:2001;17-23.
161. Jensen A.R. The nature of the black-white difference on various psychometric tests: Spearman's hypothesis. Behav. Brain Sci. 8:1985;193-219.
162. Jensen A.R. Why is reaction time correlated with psychometric g. Dir. Psychol. Sci. 2:1993;53-56.
163. Jensen A.R. Galton's legacy to research on intelligence. J. Biosoc. Sci. 34:2002;145-172.
164. Jiang S., Xin R., Lin S., Qian Y., Tang G., Wang D., Wu X. Linkage studies between attention-deficit hyperactivity disorder and the monoamine oxidase genes. Am. J. Med. Genet. 105:2001;783-788.
165. Jin P., Warren S.T. Understanding the molecular basis of fragile X syndrome. Hum. Mol. Genet. 9:2000;901-908.
166. Jobst K.A., Smith A.D., Szatamari M., Molyneux A., Esiri M.E., King E., Smith A., Jaskowski A., McDonald B., Wald N. Detection in life of confirmed Alzheimer's disease using a single measurement of medial temporal lobe atrophy by computed tomography. Lancet. 340:1992;1179-1183.
167. Johnston M.V., Jeon O.-H., Pevsner J., Blue M.E., Naidu S. Neurobiology of Rett syndrome: a genetic disorder of synapse development. Brain Dev. 23:2001;S206-S213.
168. Joober R., Gauthier J., Lal S., Bloom D., Lalonde P., Rouleau G., Benkelfat C., Labelle A. Catechol-O-methyltransferase Val 108/158-Met gene variants associated with performance on the Wisconsin Card Sorting Test. Arch. Gen. Psychiatry. 59:2002;662-663.
169. Kamin L.J. The Science and Politics of IQ. 1974;Wiley, New York.
170. Kamino K., Orr H.T., Payami H., Wijsman E.M., Alonso M.E., Pulst S.M., Anderson L., O'dahl S., Nemens E., White J.A. Linkage and mutation analysis of familial Alzheimer disease kindreds for the ATP gene region. Am. J. Hum. Genet. 51:1992;998-1014.
171. Kandel E.R., Schwartz J.H., Jessell T.M. Principles of Neuroscience. 2000;McGraw-Hill, New York.
172. Karlinsky H., Vaula G., Haines J.L., Ridgley J., Bergeron C., Mortilla M., Tupler R.G., Percy M.E., Robitaille Y., Noldy N.E., et al. Molecular and prospective phenotypic characterization of a pedigree with familial Alzheimer's disease and a missense mutation in codon 717 of the beta-amyloid precursor protein gene. Neurology. 42:1992;1445-1453.
173. Karoum F., Chrapusta S.J., Egan M.F. 3-Methoxytyramine is the major metabolite of released dopamine in the rat frontal cortex: reassessment of the effects of antipsychotics on the dynamics of dopamine release and metabolism in the frontal cortex, nucleus accumbens, and striatum by a simple two pool model. J. Neurochem. 63:1994;972-979.
174. Karrer R., Wojtascek Z., Davis M.G. Event-related potentials and information processing in infants with and without Down syndrome. Am. J. Ment. Retard. 100:1995;146-159.
175. Katsanis J., Iacono W.G., McGue M.K., Carlson S.R. P300 event-related potential heritability in monozygotic twins. Psychophysiology. 34:1997;47-58.
176. Kaufman W.E., Moser H.W. Dendritic anomalies in disorders associated with mental retardation. Cereb. Cortex. 10:2000;981-991.
177. Kegeles L.S., Zea-Ponce Y., Abi-Dargham A., Rodenhiser J., Wang T., Weiss R., Van Heertum R.L., Mann J.J., Laruelle M. Stability of [123I]IBZM SPECT measurement of amphetamine-induced striatal dopamine release in humans. Synapse. 31:1999;302-308.
178. Killiany R.J., Hyman B.T., Gomez-Isla T., Moss M.B., Kikinis R., Jolesz F., Tanzi R., Jones K., Albert M.S. MRI measures of entorhinal cortex vs. hippocampus in preclinical AD. Neurology. 58:2002;1188-1196.
179. Kimura Y., Hsu H., Toyama H., Senda M., Alpert N.M. Improved signal-to-noise ratio in parametric images by cluster analysis. Neuroimage. 9:1999;554-561.
180. Klee M.R., Offenloch K., Tigges J. Cross-correlation analysis of electroencephalographic potentials and slow membrane transients. Science. 147:1965;519-521.
181. Kola I., Herzog P.J. Down syndrome and mouse models. Curr. Opin. Genet. Dev. 8:1998;316-321.
182. Korenberg J.R., Kawashima H., Pulst S.M., Ikeuchi T., Ogazawara N., Yamamoto K., Schonberg S.A., West R., Allen L., Magenis E., Ikawa K., Taniguchi N., Epstein C.J. Molecular definition of a region of chromosome 21 that causes features of the Down syndrome phenotype. Am. J. Hum. Genet. 17:1990;236-246.
183. Krawczun M.S., Jenkins E.C., Brown W.T. Analysis of the fragile X chromosome: localization and detection of the fragile site in high resolution preparation. Hum. Genet. 69:1985;209-211.
184. Kwon H., Menon V., Eliez S., Warsofky I.S., White C.D., Dyer-Friedman J., Taylor A.K., Glover G.H., Reiss A.L. Functional neuroanatomy of visuospatial working memory in fragile X syndrome: relation to behavioral and molecular measures. Am. J. Psychiatry. 158:2001;1040-1051.
185. Kylonen P.C., Christal R.E. Reasoning ability is (little more than) working memory capacity?! Intelligence. 14:1990;389-433.
186. Lachman H.M., Papolos D.F., Saito T., Yu Y.M., Szumlanski C.L., Weinshilboum R.M. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics. 6:1996;243-250.
187. Laggerbauer B., Ostareck D., Keidel E.M., Ostareck-Lederer A., Fischer U. Evidence that fragile X mental retardation protein is a negative regulator of translation. Hum. Mol. Genet. 10:2001;329-338.
188. Lahn B.T., Page D.C. Four evolutionary strata on the human X chromosome. Science. 286:1999;964-967.
189. Lehtovirta M., Soininen H., Laakso M.P., Partanen K., Helisalmi S., Mannermaa A., Ryynanen M., Kuikka J., Hartikainen P., Riekkinen P.J. SPECT and M.R.I. analysis in Alzheimer's disease: relation to apolipoprotein E epsilon 4 allele. J. Neurol. Neurosurg. Psychiatry. 60:1996;644-649.
190. Lewis E.G., Dustman R.E., Beck E.C. Evoked response similarity in monozygotic, dizygotic and unrelated individuals: a comparative study. Electroencephalogr. Clin. Neurophysiol. 23:1971;309-316.
191. Lewis D.A., Melchitzky D.S., Sesack S.R., Whitehead R.E., Auh S., Sampson A. Dopamine transporter immunoreactivity in monkey cerebral cortex: regional, laminar, and ultrastructural localization. J. Comp. Neurol. 432:2001;119-136.
192. Lewontin R.C. Population genetics. Annu. Rev. Genet. 19:1985;81-102.
193. Li Z., Zhang Y., Ku L., Wilkinson K.D., Warren S.T., Feng Y. The fragile X mental retardation protein inhibits translation via interacting with mRNA. Nucleic Acids Res. 29:2001;2276-2283.
194. Liljequist R., Haapalinna A., Ahlander M., Li Y.H., Mannisto P.T. Catechol O-methyltransferase inhibitor tolcapone has minor influence on performance in experimental memory models in rats. Behav. Brain Res. 82:1997;195-202.
195. Lindau M., Jelic V., Johasson S.E., Andersen C., Wahlund L.O., Almkvist O. Quantitative EEG abnormalities and cognitive dysfunctions in frontotemporal dementia and Alzheimer's disease. Dement. Geriatr. Cogn. Disord. 15:2003;106-114.
196. Loeh J.P., Synhorst D.P., Wolfe R.R., Hagerman R.J. Aortic root dilation and mitral valve prolapse in the fragile X syndrome. Am. J. Med. Genet. 23:1986;189-194.
197. Lohmann G., van Cramon Y., Steinmetz H. Sulcal variability of twins. Cereb. Cortex. 9:1999;754-763.
198. Lotta T., Vidgren J., Tilgmann C., Ulmanen I., Melen K., Julkunen I. Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry. 34:1995;4202-4210.
199. Luciano M., Wright M., Smith G.A., Geffen G.M., Geffen L.B., Martin N.G. Genetic covariance among measures of information processing speed, working memory, and IQ. Behav. Genet. 31:2001;581-592.
200. S.J. Luck, M. Girelli, Electrophysiological approaches to the study of selective attention, in: R. Parasuraman (Ed.), The Attentive Brain, MIT Press, Cambridge, MA, 1998.
201. Luo D., Petrill S.A., Thompson L.A. An exploration of genetic g: hierarchical factor analysis of cognitive data from the Western Reserve Twin project. Intelligence. 18:1994;335-347.
202. Mahon S., Deniau J.-M., Charpier S. Relationship between EEG potentials and intracellular activity of striatal and cortico-striatal neurons: an in vivo study under different anesthetics. Cereb. Cortex. 11:2001;360-373.
203. Malhotra A.K., Kestler L.J., Mazzanti C., Bates J.A., Goldberg T., Goldman D. A functional polymorphism in the COMT gene and performance on a test of prefrontal function. Am. J. Psychiatry. 159:2002;652-654.
204. Malter H.E., Iber J.C., Willemsen R., de Graaf E., Tarleton J.C., Leisti J., Warren S.T., Oostra B.A. Characterization of the full fragile X syndrome mutation in fetal gamets. Nat. Genet. 15:1997;165-169.
205. Manoach D.S., Halpern E.F., Kramer T.S., Chang Y., Goff D.C., Rauch S.L., Kennedy D.N., Gollub R.L. Test-retest reliability of a functional MRI working memory paradigm in normal and schizophrenic subjects. Am. J. Psychiatry. 158:2001;955-958.
206. Martinez D., Broft A., Laruelle M. Imaging neurochemical endophenotypes: promises and pitfalls. Pharmacogenomics. 2:2001;223-237.
207. Masterton B., Skeen L.C. Origins of anthropoid intelligence: prefrontal system and delayed alternation in hedgehog, tree shrew, and bush baby. J. Comp. Physiol. Psychol. 81:1972;423-433.
208. Mazurek M.E., Shadlen M.N. Limits to the temporal fidelity of cortical spike rate signals. Nat. Neurosci. 5:2002;463-471.
209. Mazziotta J.C., Frackowiak R.S., Phelps M.E. The use of positron-emission tomography in the clinical assessment of dementia. Semin. Nucl. Med. 22:1992;233-246.
210. Mazziotta J., Toga A., Evans A., Fox P., Lancaster J., Zilles K., Woods R., Paus T., Simpson G., Pike B., Holmes C., Collins L., Thompson P., MacDonald D., Iacoboni M., Schormann T., Amunts K., Palomero-Gallagher N., Geyer S., Parsons L., Narr K., Kabani N., Le Goualher G., Boomsma D., Cannon T., Kawashima R., Mazoyer B. A probabilistic atlas and reference system for the human brain: International Consortium for Brain Mapping (ICBM). Philos. Trans. R. Soc. Lond. B Biol. Sci. 356:2001;1293-1322.
211. McClearn G.E., Johansson B., Berg S., Pedersen N.L., Ahern F., Petrill S.A., Plomin R. Substantial genetic influence on cognitive abilities in twins 80 or more years old. Science. 276:1997;1560-1563.
212. McCormick M.K., Schinzel A.I., Petersen M.B. Molecular genetic approach to the characterization of the 'Down syndrome region' of chromosome 21. Genomics. 5:1989;325-331.
213. McGarry-Roberts P.A., Stelmack R.M., Campbell K.B. Intelligence, reaction time, and event-related potentials. Intelligence. 16:1992;289-313.
214. McGeer E.G., Norman M., Boyes B., O'Kusky J., Suzuki J., McGeer P.L. Acetylcholine and aromatic amine systems in postmortem brain of an infant with Down's syndrome. Exp. Neurol. 87:1985;557-570.
215. McGue M., Bouchard T.J. Genetic and environmental determinants of informational processing and special mental abilities. Sternberg R.J. Advances in the Psychology of Human Intelligence. vol. 5:1989;Erlbaum, Hillsdale.
216. McMillan P.J., Leverenz J.B., Dorsa D.M. Specific downregulation of presenilin 2 gene expression is prominent during early stages of sporadic late-onset Alzheimer's disease. Brain Res. Mol. Brain Res. 78:2000;138-145.
217. Merenstein S.A., Sobesky W.E., Taylor A.K., Riddle J.E., Tran H.X., Hagerman R.J. Molecular-clinical correlations in males with an expanded FMR1 mutation. Am. J. Med. Genet. 64:1996;388-394.
218. Mielke R., Zerres K., Uhlhaas S., Kessler J., Heiss W.D. Apolipoprotein E polymorphism influences the cerebral metabolic pattern in Alzheimer's disease. Neurosci. Lett. 254:1998;49-52.
219. Miyazaki T., Kanou Y., Murata Y., Ohmori S., Niwa T., Maeda K., Yamamura H., Seo H. Molecular cloning of a novel thyroid hormone-responsive gene, ZAKI-4, in human skin fibroblasts. J. Biol. Chem. 271:1996;14567-14571.
220. Morley K.I., Montgomery G.W. The genetics of cognitive processes: candidate genes in humans and animals. Behav. Genet. 31:2002;511-531.
221. Moron J.A., Brockington A., Wise R.A., Rocha B.A., Hope B.T. Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. J. Neurosci. 22:2002;389-395.
222. Morris G.L., Alcorn M.B. Raven's progressive matrices and inspection time: P200 slope correlates. Person. Individ. Diff. 18:1995;81-87.
223. Mulert C., Gallinat J., Schlattmann P., Dorn H., Pascual-Marqui R., Mientus S., Herrmann W.M., Winterer G. Reduced event-related current density in the anterior cingulate cortex in schizophrenia. Neuroimage. 13:2001;589-600.
224. Munir F., Cornish K.M., Wilding J. Nature of the working memory deficit in Fragile-X syndrome. Brain Cogn. 44:2000;387-401.
225. Murata T., Koshino Y., Omori M., Murata I., Nishio M., Horie T., Isaki K. Quantitative EEG study on premature aging in adult Down's syndrome. Biol. Psychiatry. 35:1994;422-425.
226. Murphy D.L., Wright C., Buchsbaum M., Nichols A., Costa J.L., Wyatt R.J. Platelet and plasma amine oxidase activity in 680 normals: sex and age differences and stability over time. Biochem. Med. 16:1976;254-265.
227. Myles-Worsley M., Coon H. Genetic and developmental factors in spontaneous selective attention: a study of normal twins. Psychiatry Res. 71:1997;163-174.
228. Neisser U., Boodoo G., Bouchard J.R., Boykin A.W., Brody N., Ceci S.J., Halpern D.F., Loehlin J.C., Perloff R., Sternberg R.J., Urbina S. Intelligence: knowns and unknowns. Am. Psychol. 51:1996;77-101.
229. Neubauer A.C., Spinath F.M., Riemann R., Borkenau P., Angleitner A. Genetic and environmental influences on two measures of speed of information processing and their relation to psychometric intelligence: evidence from the German Observational Study of Adult Twins. Intelligence. 28:2000;267-289.
230. Nielsen J.B., Friberg L., Lou H., Lassen N.A., Sam I.L. Immature pattern of brain activity in Rett syndrome. Arch. Neurol. 47:1990;982-986.
231. Nimchinsky E.A., Oberlander A.M., Svoboda K. Abnormal development of dendritic spines in FMR1 knock-out mice. J. Neurosci. 21:2001;5139-5146.
232. Nittono H., Nageishi Y., Nakajiama Y., Ullsberger P. Event-related potential correlates of individual differences in working memory capacity. Psychophysiology. 36:1999;745-754.
233. Numminen H., Lehto J.E., Ruoppila I. Tower of Hanoi and working memory in adult persons with intellectual disability. Res. Dev. Disabil. 22:2001;373-387.
234. O'Connor S., Morzorati S.J.C., Li T. Heritable features of the auditory oddball event-related potential: peaks, latencies, morphology and topography. Electroencephalogr. Clin. Neurophysiol. 92:1994;115-125.
235. O'Donnell B.F., Friedman S., Swearer J.M., Drachman D.A. Active and passive P3 latency and psychometric performance: influence of age and individual differences. Int. J. Psychophysiol. 12:1992;187-195.
236. O'Donnell W.T., Warren S.T. A decade of molecular studies of fragile X syndrome. Annu. Rev. Neurosci. 25:2002;315-338.
237. Ohira M., Seki N., Nagase T., Suzuki E., Nomura N., Ohara O., Hattori M., Sakaki Y., Eki T., Murakami Y., Saito T., Ichikawa H., Ohki M. Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21. Genome Res. 7:1997;47-58.
238. Ohm T.G., Kirca M., Bohl J., Scharnagl H., Gross W., Marz W. Apolipoprotein E polymorphism influences not only cerebral senile plaque load but also Alzheimer-type neurofibrillatory tangle formation. Neuroscience. 66:1995;583-587.
239. Ojemann J.G., Buckner R.L., Akbudak E., Snyder A.Z., Ollinger J.M., McKinstry R.C., Rosen B.R., Petersen S.E., Raichle M.E., Conturo T.E. Functional M.R.I. studies of word-stem completion: reliability across laboratories and comparison to blood flow imaging with PET. Hum. Brain Mapp. 6:1998;203-215.
240. Opitz J.M., Sutherland G.R. Conference report: International Workshop on the fragile X and X-linked mental retardation. Am. J. Med. Genet. 17:1984;5-94.
241. Opitz J.M. Editorial comment: on the gates of hell and a most unusual gene. Am. J. Med. Genet. 23:1986;1-10.
242. Osaka R., Umemoto A. Shintei Kyodai NX 15 Dai Nihan (Kyoto University New NX15 Intelligence Test). 1973;Taisei Shuppan, Tokyo.
243. Ott H., McDonald R.J., Fichte K., Herrmann W.M. Interpretation of correlations between EEG-power-spectra and psychological performance variables within the concepts of subvigilance, attention and psychometric impulsion. Herrmann W.M. Electroencephalography in Drug Research. 1982;Fischer, Stuttgart.
244. Pablos-Mendez A., Mayeux R., Ngai C., Shea S., Berglund L. Association of apo E polymorphism with plasma lipid levels in a multiethnic elderly population. Arterioscler. Thromb. Vasc. Biol. 17:1997;3534-3541.
245. Palmatier M.A., Kang A.M., Kidd K.K. Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles. Biol. Psychiatry. 46:1999;557-567.
246. Panegyres P.K., Zafiris-Toufexis K., Kakulas B.A. Amyloid precursor protein gene isoforms in Alzheimer's disease and other neurodegenerative disorders. J. Neurol. Sci. 173:2000;81-92.
247. Paya-Cano J.L., Galsworthy M., Stephenson J., Plomin R. Developing a mouse model for the functional investigation of cognitive abilities and disabilities. Am. J. Med. Genet. 96:2000;560.
248. Pedersen N.L., Plomin R., Nesselroade J.R., McClearn G.E. A quantitative genetic analysis of cognitive abilities during the second half of the life span. Psychol. Sci. 3:1992;346-353.
249. Pedersen N.L., Oreland L., Reynolds C., McClearn G.E. Importance of genetic effects for monoamine oxidase activity in thrombocytes in twins reared apart and twins reared together. Psychiatry Res. 46:1993;239-251.
250. Pelosi L., Holly M., Slade T., Hayward M., Barrett G., Blumhardt L.D. Event-related potential (ERP) correlates of performance of intelligence tests. Electroencephalogr. Clin. Neurophysiol. 84:1992;515-520.
251. Pennington B.F., Filipek P.A., Lefly D., Chhabildas N., Kennedy D.N., Simon J.H., Filley C.M., Galaburda A., DeFries J.C. A twin MRI study of size variations in human brain. J. Cogn. Neurosci. 12:2000;223-232.
252. Petrill S.A., Ball D.M., Eley T.C., Hill L., Plomin R. Failure to replicate a QTL association between a DNA marker identified by EST00083 and IQ. Intelligence. 25:1998;179-184.
253. Piedrahita J.A., Zhang S.H., Hagaman J.R., Oliver P.M., Maeda N. Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc. Natl. Acad. Sci. USA. 89:1992;4471-4475.
254. Pieretti M., Zhang F.P., Fu Y.H., Warren S.T., Oostra B.A., Caskey C.T., Nelson D.L. Absence of expression of the FMR-1 gene in the fragile X syndrome. Cell. 66:1991;817-822.
255. Pinter J.D., Eliez S., Schmitt G.T., Capone G.T., Reiss A.L. Neuroanatomy of Down's syndrome: a high-resolution MRI study. Am. J. Psychiatry. 158:2001;1659-1665.
256. Plomin R., McClearn G.E., Smith D.L., Skuder P., Vignetti S., Chorney M.J., Chorney K., Kasarda S., Thompson L.A., Detterman D.K., Petrill S.A., Daniels J., Owen M.J., McGuffin P. Allelic associations between 100 DNA markers and high versus low IQ. Intelligence. 21:1995;31-48.
257. Plomin R., Craig I. Genetics, environment and cognitive abilities: review and work in progress towards a genome scan for quantitative trait associations using DNA pooling. Br. J. Psychiatry. 178:(Suppl. 40):2001;41-48.
258. Plomin R., Hill L., Craig I.W., McGuffin P., Purcell S., Sham P., Lubinski D., Thompson L.A., Fisher P.J., Turic D., Owen M.J. A genome-wide scan of 1842 DNA markers for allelic associations with general cognitive ability: a five-stage design using DNA pooling and extreme selected groups. Behav. Genet. 31:2001;497-509.
259. Plomin R., Spinath F.M. Genetics and general cognitive ability (g). Trends Cogn. Sci. 6:2002;169-176.
260. Polich J., Burns T. P300 from identical twins. Neuropsychologia. 25:1987;299-304.
261. Polich J., Ladish C., Burns T. Normal variation of P300 in children: age, memory span, and head size. Int. J. Psychophysiol. 9:1990;237-248.
262. Polich J., Martin S. P300, cognitive capability, and personality: a correlational study of university undergraduates. Person. Indiv. Differ. 13:1992;533-543.
263. Ponomareva N.V., Fokin V.F., Selesna N.D., Voskresenskaia N.I. Possible neurophysiological markers of genetic predisposition to Alzheimer's disease. Dement. Geriatr. Cogn. Disord. 9:1998;267-273.
264. Porter C.M., Havens M.A., Clipstone N.A. Identification of amino acid residues and protein kinases involved in the regulation of NFATc subcellular localization. J. Biol. Chem. 275:2000;3543-3551.
265. Porjesz B., Almasy L., Edenberg H.J., Wang K., Chorlian D.B., Foroud T., Goate A., Rice J.P., O'Connor S.J., Rohrbaugh J., Kuperman S., Bauer L.O., Crowe R.R., Schuckit M.A., Hesselbrock V., Conneally P.M., Tischfield J.A., Li T.K., Reich T., Begleiter H. Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus. Proc. Natl. Acad. Sci. USA. 99:2002;3729-3733.
266. Posner M.I., Petersen S.E., Fox P.T., Raichle M.E. Localization of cognitive operations in the human brain. Science. 24:1988;1627-1631.
267. Posthuma D., de geus E.J.C., Baaré W.F.C., Hulshoff Pol H.E., Kahn R.S., Boomsma D.I. The association between brain volume and intelligence is of genetic origin. Nat. Neurosci. 5:2002;83-84.
268. Price D.L. Aging of the brain and dementia of the Alzheimer type. Kandel E.R., Schwartz J.H., Jessell T.M. Principles of Neural Science. 2000;1149-1159 McGraw-Hill, New York.
269. Puglielli L., Tanzi R.E., Kovacs D.M. Alzheimer's disease: the cholesterol connection. Nat. Neurosci. 6:2003;345-351.
270. Purpura D.P. Dendritic spine 'dysgenesis' and mental retardation. Science. 186:1974;1126-1128.
271. Raber J., Sorg O., Horn T.F., Yu N., Koob G.F., Campbell I.L., Bloom F.E. Inflammatory cytokines: putative regulators of neuronal and neuroendocrine function. Brain Res. Brain Res. Rev. 26:1998;320-326.
272. Rascovsky K., Salmon D.P., Ho G.J., Galasko D., Peavy G.M., Hansen L., Thal L.J. Cognitive profiles differ in autopsy-confirmed frontotemporal dementia and AD. Neurology. 58:2002;1801-1808.
273. Raux G., Gantier R., Thomas-Anterion C., Boulliat J., Verpillat P., Hannequin D., Brice A., Frebourg T., Campoin D. Dementia with prominent frontotemporal features associated with L113P presenilin 1 mutation. Neurology. 55:2000;1577-1578.
274. Reed T., Carmelli D., Swan G.E., Breitner J.C.S., Welsh K.A., Jarvik G.P., Deeb S., Auwerx J. Lower cognitive performance in normal older adult male twins carrying the apolipoprotein Eε4 allele. Arch. Neurol. 51:1994;1189-1192.
275. Reeves R.H., Irving N.G., Moran T.H., Wohn A., Kitt C., Sisodia S.S., Schmidt C., Bronson R.T., Davisson M.T. A mouse model for Down syndrome exhibits leaning and behaviour deficits. Nat. Genet. 11:1995;177-183.
276. Reiss A.L., Faruque F., Naidu S., Abrams M., Beaty T., Bryan N., Moser H. Neuroanatomy of Rett syndrome: a volumetric imaging study. Ann. Neurol. 34:1993;227-234.
277. Reiss A.L., Abrams M.T., Singer H.S., Ross J.L., Denckla M.B. Brain development, gender and IQ in children. A volumetric imaging study. Brain. 119:1996;1763-1774.
278. Rijsdijk F.V., Vernon P.A., Boomsma D.I. The genetic basis of the relation between speed-of-information processing and IQ. Behav. Brain Res. 95:1998;77-84.
279. Rijsdijk F.V., Vernon P.A., Boomsma D.I. Application of hierarchical genetic models to Raven and WAIS subtests: a Dutch twin study. Behav. Genet. 32:2002;199-210.
280. Rincon-Limas D.E., Geske R.S., Xue J.J., Hsu C.Y., Overbeek P.A., Patel P.I. 5′-flanking sequences of the human HPRT gene direct neuronal expression in the brain of transgenic mice. J. Neurosci. Res. 38:1994;259-267.
281. Risch N., Merikangas K.R. The future of genetic studies of complex human diseases. Science. 273:1996;1516-1517.
282. Rivera-Calimlim L., Reilly D.K. Differences in erythrocyte catechol-O-methyltransferase activity between Orientals and Caucasians: difference in levodopa tolerance. Clin. Pharmacol. Ther. 35:1984;804-809.
283. Rivera S.M., Menon V., White C.D., Glaser B., Reiss A.L. Functional brain activation during arithmetic processing in females with fragile X syndrome is related to FMR1 protein expression. Hum. Brain Mapp. 16:2002;206-218.
284. Robinson D.L. The EEG and intelligence: an appraisal of methods and theories. Person. Individ. Diff. 15:1993;695-716.
285. Rogers T.D., Deary J. The P300 component of the auditory event-related potential in monozygotic and dizygotic twins. Acta Psychiatr. Scand. 83:1991;412-416.
286. Rosenberg N.A., Pritchard J.K., Weber J.L., Cann H.M., Kidd K.K., Zhivotovsky L.A., Feldman M.W. Genetic structure of human populations. Science. 298:2002;2381-2385.
287. Ruchkin D.S., Canoune H.L., Johnson R., Ritter W. Working memory and preparation elicit different patterns of slow wave event-related brain potentials. Psychophysiology. 32:1995;399-410.
288. Rudelli R.D., Brown W.T., Wisniewsky K., Jenkins E.C., Laure-Kaminowska M. Adult fragile X syndrome: clinico-neuropathologic findings. Acta Neuropathol. 67:1985;289-295.
289. Rutten G.J.M., Ramsey N.F., van Rijen P.C., van Veelen C.W.M. Reproducibility of fMRI-determined language lateralization in individual subjects. Brain Lang. 80:2002;421-437.
290. Ryan J.J., Morris J., Yaffa S., Peterson L. Test-retest reliability of the Wechsler memory scale, form I. J. Clin. Psychol. 37:1981;847-848.
291. Sabaratnam M., Vroegop P.G., Gangadharan S.K. Epilepsy and EEG findings in 18 males with fragile X syndrome. Seizure. 10:2001;60-63.
292. Sandman C.A., Barron J.L. Parameters of the event-related potential are related to functioning in the mentally retarded. Int. J. Neurosci. 29:1986;37-44.
293. Sawaguchi T., Matsumura M., Kubota K. Dopamine enhances the neuronal activity of spatial short-term memory task in the primate prefrontal cortex. Neurosci. Res. 5:1988;465-473.
294. Sawaguchi T., Goldmanrakic P.S. The Role of D1-dopamine receptor in working-memory - local injections of dopamine antagonists into the prefrontal cortex of Rhesus-monkeys performing an oculomotor delayed-response task. J. Neurophysiol. 71:1994;515-528.
295. Schaefer S.M., Abercrombie H.C., Lindgren K.A., Larson C.L., Ward R.T., Oakes T.R., Holden J.E., Perlman S.B., Turski P.A., Davidson R.J. Six-month test-retest reliability of MRI-defined PET measures of regional cerebral glucose metabolic rate in selected subcortical structures. Hum. Brain Mapp. 10:2000;1-9.
296. Scheltens P., Leys D., Barkhof F., Huglo D., Weinstein H.C., Vermesch P., Kuiper M., Steinling M., Wolters E.C., Valk J. Atrophy of medial temporal lobes on MRI in 'probable' Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates. J. Neurol. Neurosurg. Psychiatry. 55:1992;967-972.
297. Schmid R.G., Tirsch W.S., Rappelsberger P., Weinmann H.M., Poppl S.J. Comparative coherence studies in healthy volunteers and Down's syndrome patients from childhood to adult age. Electroencephalogr. Clin. Neurophysiol. 83:1992;112-123.
298. Schoenemann P.T., Budinger T.F., Sarich V.M., Wang W.S. Brain size does not predict general cognitive ability within families. PNAS. 97:2000;4932-4937.
299. Seibyl J.P., Laruelle M., van Dyck C.H., Wallace E., Baldwin R.M., Zoghbi S., Zea-Ponce Y., Neumeyer J.L., Charney D.S., Hoffer P.B., Innis R.B. Reproducibility of iodine-123-beta-CIT SPECT brain measurement of dopamine transporters. J. Nucl. Med. 37:1996;222-228.
300. Selkoe D.J. Amyloid β protein and the genetics of Alzheimer disease. J. Biol. Chem. 271:1996;18295-18298.
301. Sendera T.J., Ma S.Y., Jaffar S., Kozlowski P.B., Kordower J.H., Mawal Y., Saragovi H.U., Mufson E.J. Reduction of TrkA-immunoreactive neurons is not associated with an overexpression of galaninergic fibers within the nucleus basalis in Down's syndrome. J. Neurochem. 74:2000;1185-1196.
302. Sesack S.R., Hawrylak V.A., Matus C., Guido M.A., Levey A.I. Dopamine axon varicosities in the prelimbic division of the rat prefrontal cortex exhibit sparse immunoreactivity for the dopamine transporter. J. Neurosci. 18:1998;2697-2708.
303. Shadlen M.N., Newsome W.T. Noise, neural codes and cortical organization. Curr. Opin. Neurobiol. 4:1994;569-579.
304. Shah P., Miyake A. The separability of working memory resources for spatial thinking and language processing: an individual differences approach. J. Exp. Psychol. Gen. 125:1996;4-27.
305. Shagass C., Roemer R.A., Straumanis J.J., Josiassen R.C. Intelligence as a factor in evoked potential studies of psychopathology. I. Comparison of low and high IQ subjects. Biol. Psychiatry. 16:1981;1007-1030.
306. Shallice T. From Neuropsychology To Mental Structure. 1982;Cambridge University Press, Cambridge.
307. Shapiro M.B., Murphy D.G., Hagerman R.J., Azari N.P., Alexander G.E., Miezejeski C.M., Hinton V.J., Horwitz B., Haxby J.V., Kumar A. Adult fragile X syndrome: neuropsychology, brain anatomy, and metabolism. Am. J. Med. Genet. 60:1995;480-493.
308. Sherman S.L., Morton N.E., Jacobs P.A., Turner G. The marker (X) syndrome: a cytogenetic and genetic analysis. Ann Hum. Genet. 48:1984;21-37.
309. Sherman S.L., Jacobs P.A., Morton N.E., Froster-Iskenius U., Howard-Peebles P.N., Nielsen K.B., Partington M.W., Sutherland G.R., Turner G., Watson M. Further segregation analysis of the fragile X syndrome with special reference to transmitting males. Hum. Genet. 69:1985;289-299.
310. Shi J.C., Thompson R.F. Monoamine oxidase in neuropsychiatry and behavior. Am. J. Hum. Genet. 65:1999;593-598.
311. Silverstein A.B. Two- and four-subtest short forms of the WAIS-R: a closer look at validity and reliability. J. Clin. Psychol. 41:1985;95-97.
312. Small G.W., Leuchter A.F., Mandelkern M.A., La Rue A., Okonek A., Lufkin R.B., Jarvik L.F., Matsuyama S.S., Bondareff W. Clinical, neuroimaging, and environmental risk differences in monozygotic female twins appearing discordant for dementia of the Alzheimer type. Arch. Neurol. 50:1993;209-219.
313. Small G.W., Mazziotta J.C., Collins M.T., Baxter L.R., Phelps M.E., Mandelkern M.A., Kaplan A., La Rue A., Adamson C.F., Chang L., et al. Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease. J. Am. Med. Assoc. 273:1995;942-947.
314. Small G.W., Ercoli L.M., Silverman D.H., Huang S.C., Komo S., Bookheimer S.Y., Lavresky H., Miller K., Siddarth P., Rasgon N.L., Mazziotta J.C., Saxena S., Wu H.M., Mega M.S., Cummings J.L., Saunders A.M., Pericak-Vance M.A., Roses A.D., Barrio J.R., Phelps M.E. Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 97:2000;6037-6042.
315. Smith D.J., Stevens M.E., Suclanagunta S.P., Bronson R.T., Makhinson M., Watabe A.M., O'Dell T.J., Fung J., Weier H.U., Cheng J.F., Rubin E.M. Functional screening of 2MB of human chromosome 21q22.2 in transgenic mice implicates minibrain in leaning defects associated with Down's syndrome. Nat. Genet. 16:1997;28-36.
316. Spearman C.E. General 'intelligence', objectively determined and measured. Am. J. Psychol. 15:1904;201-293.
317. Srinivasan S.R., Ehnholm C., Wattigney W., Berenson G.S. Apolipoprotein E polymorphism with serum lipoprotein concentrations in black versus white children: the Bogalusa Heart Study. Metabolism. 42:1993;381-386.
318. St. George-Hyslop P., Tanzi R.E., Polinsky R.J., Haines J.L., Nee L., Watkins P.C., Myers R.H., Feldman R.G., Pollen D., Drachman D. The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science. 235:1987;885.
319. Stassen H.H., Coppola R., Gottesman I.I., Torrey E.F., Kuny S., Rickler K.C., Hell D. EEG differences in monozygotic twins discordant and concordant for schizophrenia. Psychgophysiology. 36:1999;109-117.
320. Steriade M. Synchronized activities of coupled oscillators in the cerebral cortex and thalamus at different levels of vigilance. Cereb. Cortex. 7:1997;583-604.
321. Stough C.K.K., Nettelbeck T., Cooper C.J. Evoked brain potentials, string length, and intelligence. Person. Individ. Diff. 11:1990;401-406.
322. Surwillo W.W. Cortical evoked potentials in monozygotic twins and unrelated subjects: comparison of exogenous and endogenous components. Behav. Genet. 10:1980;201-209.
323. Sutcliffe J.S., Nelson D.L., Zhang F., Pieretti M., Caskey C.T., Sare D., Warren S.T. DNA methylation represses FMR-1 transcription in fragile X syndrome. Hum. Mol. Genet. 1:1992;397-400.
324. Swan G.E., Carmelli D. Evidence for genetic mediation of executive control: a study of aging male twins. J. Gerontol. B Psychol. Sci. Soc. Sci. 57:2002;133-143.
325. Syndulko K., Hansch E.C., Cohen S.N., Pearce J.W., Goldberg Z., Montan B., Tourtelotte W.W., Potvin A.R. Long-latency event-related potentials in normal aging and dementia. Adv. Neurol. 32:1982;279-285.
326. Tanzi R.E., Vaula G., Romano D.M., Mortilla M., Huang T.L., Tupler R.G., Wasco W., Hyman B.T., Haines J.L., Jenkins B.J. Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases. Am. J. Hum. Genet. 51:1992;273-282.
327. Tarantino L.M., Buæan M. Dissection of behavior and psychiatric disorders using the mouse as a model. Hum. Mol. Genet. 9:2000;953-965.
328. Thompson P.M., Cannon T.D., Narr K.L., van Erp T., Poutanen V.P., Huttunen M., Lonnqvist J., Standertskjold-Nordenstam C.G., Kaprio J., Khaledy M., Dail R., Zoumalan C.I., Toga A.W. Genetic influences on brain structure. Nat. Neurosci. 4:2001;1253-1258.
329. Todd R.D., Health A.C., Raichle M.E., Botteron K.N. Heritability of human brain morphometry. Mol. Psychiatry. 4:1999;527-528.
330. Tramo N.J., Loftus W.C., Thomas C.E., Green R.L., Mott L.A., Gazzaniga M.S. Surface area of human cerebral cortex and its gross morphological subdivisions: in vivo measurements in monozygotic twins suggest differential hemisphere effects of genetic factors. J. Cogn. Neurosci. 7:1995;292-301.
331. Trubnikov V., Uvarova L., Alfimova M., Orlova V., Ozerova N. Neurophysiological and psychological predictors of genetic risk for schizophrenia. Behav. Genet. 23:1993;455-460.
332. Turner G., Opitz J.M., Brown W.T., Davies K.E., Jacobs P.A., Jenkins E.C., Mikkelsen M., Partington M.W., Sutherland G.R. Conference report: Second International Workshop on the Fragile X and on X-linked Mental Retardation. Am. J. Med. Genet. 23:1986;11-67.
333. Van Baal G.C.M., de Geus E.J.C., Boomsma D.I. Genetic influences on EEG coherence in 5-year-old twins. Behav. Genet. 28:1998;9-19.
334. Van Baal G.C.M., Boomsma D.I., de Geus E.J.C. Longitudinal genetic analysis of EEG coherence in young twins. Behav. Genet. 31:2001;637-651.
335. Van Bejsterveldt C.E.M., Boomsma D.I. Genetics of the human electroencephalogram (EEG) and event-related brain potentials (ERPs): a review. Hum. Genet. 94:1994;313-330.
336. Van Beijsterveldt C.E.M., Molenaar P.C.M., de Geus E.J.C., Boomsma D.I. Heritability of human brain functioning as assessed by electroencephalography. Am. J. Hum. Genet. 58:1996;562-573.
337. Van Beijsterveldt C.E.M., Molenaar P.C.M., de Geus E.J.C., Boomsma D.I. Individual differences in P300 amplitude: a genetic study in adolescent twins. Biol. Psychol. 47:1998;97-120.
338. Van Beijsterveldt C.E.M., Molenaar P.C.M., de Geus E.J.C., Boomsma D.I. Genetic and environmental influences on EEG coherence. Behav. Genet. 28:1998b;443-453.
339. Van Beijsterveldt C.E.M., van Baal G.C.M., Molenaar P.C.M., Boomsma D.I., de Geus E.J.C. Stability of genetic and environmental influences on P300 amplitude: a longitudinal study in adolescent twins. Behav. Genet. 31:2001;533-543.
340. Varma A.R., Adams W., Lloyd J.J., Carson K.J., Snowdon J.S., Testa H.J., Jackson A., Neary D. Diagnostic patterns of regional atrophy on M.R.I. and regional cerebral blood flow change on SPECT in young onset patients with Alzheimer's disease, frontotemporal dementia and vascular dementia. Acta Neurol. Scand. 105:2002;261-269.
341. Venter J.C., et al. The sequence of the human genome. Science. 291:2001;1304-1351.
342. Vernon P.A. The heritability of measures of speed of information processing. Person. Individ. Diff. 10:1989;576-579.
343. Vernon P.A., Mori M. The heritability of measures of speed of information processing. Person. Individ. Differ. 10:1989;573-576.
344. Vieregge P., Verleger R., Schulze-Rava H., Kompf D. Late cognitive event-related potentials in adult Down's syndrome. Biol. Psychiatry. 32:1992;118-1134.
345. Visser J.E., Bar P.R., Jinnah H.A. Lesh-Nyhan disease and the basal ganglia. Brain Res. Brain Res. Rev. 32:2000;449-475.
346. Vogel F., Kruger J., Schalt E., Schnobel R., Hassling L. No consistent relationship between oscillations and latencies of visually and auditory evoked EEG potentials and measures of mental performance. Hum. Neurobiol. 6:1987;173-182.
347. Vogel F. Genetics and the Electroencephalogram. 2000;Springer, Berlin.
348. Wahlström J. Gene map of mental retardation. J. Mental Def. Res. 34:1990;11-27.
349. Wayment H.K., Schenk J.O., Sorg B.A. Characterization of extracellular dopamine clearance in the medial prefrontal cortex: role of monoamine uptake and monoamine oxidase inhibition. J. Neurosci. 21:2001;35-44.
350. Weis S., Weber G., Neuhold A., Rett A. Down syndrome: MR quantification of brain structures and comparison with normal control subjects AJNR, AM. J. Neuroradiol. 12:1991;1207-1211.
351. White D.R., Houston A.S., Sampson W.F., Wilkins G.P. Intra- and interoperator variations in region-of-interest drawing and their effect on the measurement of glomerular filtration rates. Clin. Nucl. Med. 24:1999;117-181.
352. White T., O'Leary D., Magnotta V., Arndt S., Flaum M., Andreasen N.C. Anatomic and functional variability: the effects of filter size in group fMRI data analysis. Neuroimage. 13:2001;577-588.
353. White T., Andreasen N.C., Nopoulos P. Brain volumes and surface morphology in monozygotic twins. Cereb. Cortex. 12:2002;486-493.
354. Wisniewski K.E., Segan S.M., Miezejeski C.M., Sersen E.A., Rudelli R.D. The Fra(X) syndrome: neurological, electrophysiological, and neuropathological abnormalities. Am. J. Med. Genet. 38:1991;476-480.
355. Widaman K.F., Carlson J.S., Saetermoe C.L., Galbraith G.C. The relationship of auditory-evoked potentials to fluid and crystallized intelligence. Person. Individ. Diff. 15:1991;205-217.
356. Williams G.V., Goldman-Rakic P.S. Modulation of memory fields by dopamine D1 receptors in prefrontal cortex. Nature. 376:1995;572-575.
357. Winterer G., Ziller M., Dorn H., Frick K., Mulert C., Dahhan N., Herrmann W.M., Coppola R. Cortical activation, signal-to-noise ratio and stochastic resonance during information processing in man. Clin. Neurophysiol. 110:1999;1193-1203.
358. Winterer G., Smolka M., Samochowiec J., Mulert C., Ziller M., Mahlberg R., Wuebben Y., Gallinat J., Rommelspacher H., Herrmann W.M., Sander T. Association analysis of GABA-A beta2 and gamma2 gene polymorphisms with event-related prefrontal activity in man. Hum. Genet. 107:2000;513-518.
359. Winterer G., Ziller M., Dorn H., Frick K., Mulert C., Wuebben Y., Herrmann W.M., Coppola R. Schizophrenia: reduced signal-to-noise ratio and impaired phase-locking during information processing. Clin. Neurophysiol. 111:2000;837-849.
360. Winterer G., Ziller M., Dorn H., Frick K., Mulert C., Wuebben Y., Herrmann W.M. Frontal dysfunction in schizophrenia - a new electrophysiological classifier for research and clinical applications. Eur. Arch. Psychiatry Clin. Neurosci. 250:2000c;207-214.
361. G. Winterer, Basic and clinical aspects of the electrophysiology of the prefrontal network. Postdoctoral Thesis, Free University, Berlin, 2001.
362. Winterer G., Adams C.M., Jones D.W., Knutson B. Volition to action? An event-related fMRI-study. Neuroimage. 17:2002;851-857.
363. G. Winterer, M.F. Egan, T. Raedler, C. Sanchez, D.W. Jones, R. Coppola, D.R. Weinberger, P300 and genetic risk for schizophrenia, Arch. Gen. Psychiatry, in press.
364. G. Winterer, R. Coppola, T. Goldberg, M.F. Egan, D.W. Jones, C. Sanchez, D.R. Weinberger, Prefrontal broadband noise, working memory and genetic risk for schizophrenia, Am. J. Psychiatry (in press).
365. 108/158Met) COMT polymorphism in schizophrenia, Neuropsychopharmacology, submitted for publication.
366. Wright I.C., Sham P., Murray R.M., Weinberger D.R., Bullmore E.T. Genetic contributions to regional variability in human brain structure: methods and preliminary results. Neuroimage. 17:2002;256-271.
367. Wright J.J., Robinson P.A., Rennie C.J., Gordon E., Bourke P.D., Chapman C.L., Hawthorn N., Lees G.J., Alexander D. Toward an integrated continuum model of cerebral dynamics: the cerebral rhythms, synchronous oscillation and cortical stability. Biosystems. 63:2001;71-88.
368. Wright M.J., Boomsma D.I., de Geus E.J.C., Posthuma D., van Baal G.C.M., Luciano M., Hansell N.K., Ando J., Hasegawa T., Hiraishi K., Ono Y., Miyake A., Smith G.A., Geffen G.A., Geffen L.B., Martin N.G. Genetics of cognition: outline of collaborative twin study. Twin Res. 4:2001;48-56.
369. Yaffe K., Gauley J., Sands L., Browner W. Apolipoprotein E phenotype and cognitive decline in a prospective study of elderly community women. Arch. Neurol. 54:1997;1110-1114.
370. Yasuno F., Hasnine A.H., Suhara T., Ichimiya T., Sudo Y., Inoue M., Takano A., Ou T., Ando T., Toyama H. Template-based method for multiple volumes of interest of human brain PET images. Neuroimage. 16:2002;577-586.
371. Yurgelun-Todd D.A., Killgore W.D., Young A.D. Sex differences in cerebral tissue volume and cognitive performance during adolescence. Psychol. Rep. 91:2002;743-757.
372. Zechner U., Wilda M., Kehrer-Sawatzki H., Vogel W., Fundele R., Hameister H. A high density of X-linked genes for general cognitive ability: a run-away process shaping human evolution? Trends Genet. 17:2001;697-701.
373. Zhang S.H., Reddick R.L., Piedrahita J.A., Maeda N. Spontaneous hypercholesterolemia in mice lacking apolipoprotein E. Science. 258:1992;468-471.
374. Zhang Y., Caryl P.G., Deary I.J. Evoked potentials, inspection time and intelligence. Person. Individ. Diff. 10:1989;1079-1094.