Reproducibility of iodine-123-β-CIT SPECT brain measurement of dopamine transporters

Journal of Nuclear Medicine

Volumn 37, Issue 2, 1996, Pages 222-228

  Seibyl, John P ^a   Laruelle, Marc ^b   Van Dyck, Christopher H ^b   Wallace, Elizabeth ^b   Baldwin, Ronald M ^b   Zoghbi, Sami ^b   Zea Ponce, Yolanda ^b   Neumeyer, John L ^b   Charney, Dennis S ^b   Hoffer, Paul B ^b   Innis, Robert B ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

dopamine transporter; iodine 123 CIT; SPECT

Indexed keywords

3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; CARRIER PROTEIN; DOPAMINE; IODINE 123;

ADULT; AGED; ARTICLE; BOLUS INJECTION; BRAIN SCINTISCANNING; COMPARTMENT MODEL; CORPUS STRIATUM; DRUG UPTAKE; FEMALE; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; REPRODUCIBILITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ADULT; AGED; BRAIN; BRAIN CHEMISTRY; CARRIER PROTEINS; COCAINE; CORPUS STRIATUM; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FEMALE; HUMANS; IODINE RADIOISOTOPES; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; REPRODUCIBILITY OF RESULTS; TIME FACTORS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 9344271127     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Neumeyer JL, Wang S, Milius RA, et al. Iodine-123-2-β-Carbomethoxy-3-β-(4-iodophenyl)-tropane (β-CIT), high affinity SPECT radiotracer of monoamine reuptake sites in brain. J Med Chem 1991;34:3144-3146.
2. Innis R, Seibyl J, Scanley B, et al SPECT imaging demonstrates loss of striatal monoamine transporters in Parkinson's disease. Proc Natl Acad Sci 1993;90:11965-11969.
3. 123I]β-CIT pharmacological characterization of brain uptake in nonhuman primates. Synapse 1993;13:295-309.
4. 123I]β-CIT in healthy human subjects J Nucl Med 1994,35:764-770.
5. 123I]β-CIT binding to dopamine transporters in healthy human subjects. J Cereb Blood Flow Metab 1994,14:982-994.
6. 123I)β-CIT in nonhuman primates pharmacokinetics, biodistribution and SPECT brain imaging coregistered with MRI. Nucl Med Biol 1993;20:597-606
7. Chang LT. A method for attenuation correction in computed tomography. IEEE Trans Nucl Sci 1987;NS-25:638-643.
8. Gandelman MS, Baldwin RM, Zoghbi SS, Zea-Ponce Y, Innis RB Evaluation of ultrafiltration for the free fraction determination of SPECT radiotracers: b-CIT, IBF and iomazenil. J Pharm Sci 1994;83:1014-1019
9. 123I]iomazenil binding to benzodiazepine receptors in nonhuman primates. I Kinetic modeling of single bolus experiments J Cereb Blood Flow Metab 1994;14:439-452.
10. Levenberg K. A method for the solution of certain problems in least squares Quart Appl Math 1944;2:164-168
11. Patlak CS, Balsberg RG, Fenstermacher JD. Graphical evaluation of blond to brain transfer constants from multiple time uptake data. J Cereb Blood Flow Metab 1983;3:1-7.
12. Kirk R. Experimental design: procedures for the behavioral sciences. Pacific Grove, CA: Brooks/Cole Publishing, Co, 1982.
13. Sorensen JA, Phelps ME Physics in Nuclear Medicine. Second Edition, Philadelphia. W.B. Saunders Co , 1987.
14. Neumeyer JL, Wang S, Gao Y, Milius RA, et al N-ω-fluoroalkyl analogs of (1R)-2β-carbomethoxy-3β-(4-iodophenyl)tropane (β-CIT): radiotracers for PET and SPECT imaging of dopamine transporters. J Med Chem 1994;37:1558-1561
15. Zelnik N, Angel I, Paul SM, Kleinman JE Decreased density of human striatal dopamine uptake sites with age Eur J Pharmacol 1986,126:175-176
16. De Keyser J, Ebinger G, Vauquelin G. Age-related changes in the human nigrostriatal dopaminergic system. Ann Neurol 1990;27:157-161
17. 123I]β-CIT SPECT [Abstract]. Soc Neuroici 1994; 20:387.