Differential distribution of presenilin-1, Bax, and Bcl-X(L) in Alzheimer's disease and frontotemporal dementia

Acta Neuropathologica

Volumn 98, Issue 2, 1999, Pages 141-149

  Giannakopoulos, Panteleimon ^a,c   Kövari, Enikò ^a   Savioz, Armand ^a   De Bilbao, Fabienne ^a   Dubois Dauphin, Michel ^a   Hof, Patrick R ^b   Bouras, Constantin ^a,b,d  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c Clinic of Geriatric Psychiatry   (Switzerland)

^d Division of Neuropsychiatry   (Switzerland)

Author keywords

Apoptosis; Dementia; Neurofibrillary tangles; Neuroprotection; Presenilin

Indexed keywords

PRESENILIN 1; PROTEIN BAX; PROTEIN BCL X;

AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN CORTEX; CELL DENSITY; CELL LOSS; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FRONTOTEMPORAL DEMENTIA; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MALE; NERVE CELL; NEUROPROTECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; DEMENTIA; FEMALE; FRONTAL LOBE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE PROTEINS; PRESENILIN-1; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; REFERENCE VALUES; TEMPORAL LOBE; TISSUE DISTRIBUTION;

EID: 0344326254     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010051062     Document Type: Article

References (53)

1. Boise LH, Gonzàlez-Garcìa M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nùnez G, Thompson CB (1993) bcl-x, a bcl-2 related gene that functions as a dominant regulator of apoptotic cell death. Cell 74:597-608
2. Brun A, Passant U (1996) Frontal lobe degeneration of non-Alzheimer type. Structural characteristics, diagnostic criteria and relation to other frontotemporal dementia. Acta Neurol Scand Suppl 168:28-30
3. Busciglio J, Hartmann H, Lorenzo A, Wong C, Baumann K, Sommer B, Staufenbiel M, Yankner BA (1997) Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease. J Neurosci 17:5101-5107
4. Chui DH, Shirotani K, Tanahashi H, Akiyama H, Ozawa K, Kunishita T, Takahashi K, Makifuchi T, Tabira T (1998) Both N-terminal and C-terminal fragments of presenilin 1 colocalize with neurofibrillary tangles in neurons and dystrophic neurites of senile plaques in Alzheimer's disease. J Neurosci Res 53: 99-106
5. Cook DG, Sung JC, Golde TE, Felsenstein KM, Wojczyk BS, Tanzi RE, Trojanowski JQ, Lee VM-Y, Doms RW (1996) Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites. Proc Natl Acad Sci USA 93:9223-9228
6. Cotman CW (1998) Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease. Neurobiol Aging 19: S29-32
7. Cotman CW, Anderson AJ (1995) A potential role for apoptosis in neurodegeneration and Alzheimer's disease. Mol Neurobiol 10:19-45
8. Dessi F, Charriaut-Marlangue C, Khrestchatisky M, Ben-Ari Y (1993) Glutamate-induced neuronal death is not a programmed cell death in cerebellar culture. J Neurochem 60: 1953-1955
9. Drache B, Diehl GE, Beyreuther K, Perlmutter LS, König G (1998) Bcl-xl-specific antibody labels acted microglia associated with Alzheimer's disease and other pathological states. J Neurosci Res 47:98-108
10. Duff K, Eckman C, Zehr C, Yu X, Prada C-M, Pérez-Tur C, Hutton M, Buée L, Harigaya Y, Yager D, Morgan D, Gordon MN, Holcomb L, Refolo L, Zenk B, Hardy J, Younkin S (1996) Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature 383:710-713
11. Folstein MF, Folstein SE, McHugh PR (1975) Mini-Mental State: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189-198
12. Forloni G, Chiesa R, Smiroldo S, Verga L, Salmona M, Tagliavini F, Angeretti N (1993) Apoptosis mediated neurotoxicity induced by chronic application of β-amyloid fragment 25-35. NeuroReport 4:532-536
13. Garcia I, Martinou I, Tsujimoto Y, Martinou J-C (1992) Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene. Science 258:302-304
14. Giannakopoulos P, Hof PR, Bouras C (1995) Dementia lacking distinctive histology: clinicopathological evaluation of 32 cases. Acta Neuropathol 89:346-355
15. Giannakopoulos P, Bouras C, Kövari E, Shioi J, Tezapsidis N, Hof PR, Robakis NK (1997) Presenilin-1-immunoreactive neurons are preserved in late-onset Alzheimer disease. Am J Pathol 150:429-436
16. Gonzàlez-Garcìa M, Garcìa I, Ding L, O'shea S, Boise LH, Thompson CB, Nùnez G (1995) Bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death. Proc Natl Acad Sci USA 92:4304-4308
17. Grunberg J, Walter J, Loetscher H, Deuschle U, Jacobsen H, Haass C (1998) Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family. Biochemistry 37:2263-2270
18. Gschwind M, Huber G (1995) Apoptotic cell death induced by β-amyloid (1-42) peptide is cell type dependent. J Neurochem 65:292-300
19. Guo Q, Sopher BL, Furukawa K, Pham DG, Robinson N, Martin GM, Mattson MP (1997) Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals. J Neurosci 17:4212-4222
20. Harrigan MR, Kunkel DD, Nguyen LB, Malouf AT (1995) Beta amyloid is neurotoxic in hippocampal slice cultures. Neurobiol Aging 16:779-789
21. Hendricks L, De Jonghe C, Lubke U, Woodrow S, Vanderhoeven I, Boons J, Cras P, Martin JJ, Van Broeckhoven C (1998) Immunoreactivity of presenilin-1 and tau in Alzheimer's disease brain. Exp Neurol 149:341-348
22. Heyman A, Wilkinson WE, Hurwitz BL, Helms MJ, Haynes CS, Utley CM, Gwyther LP (1987) Early-onset Alzheimer's disease: clinical predictors of institutionalization and death. Neurology 37:980-984
23. Huynh DP, Vinters HV, Ho DH, Ho VV, Pulst SM (1997) Neuronal expression and intracellular localization of presenilins in normal and Alzheimer disease brains. J Neuropathol Exp Neurol 56: 1009-1017
24. Kane DJ, Sarafian TA, Anton R, Hahn H, Gralla EB, Valentine JS, Ord T, Bredesen DE (1993) Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 262: 1274-1277
25. Keller JN, Guo Q, Holtsberg FW, Bruce-Keller AJ, Mattson MP (1998) Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production. J Neurosci 18:4439-4450
26. Kim TW, Pettingell WH, Jung YK, Kovacs DM, Tanzi RE (1997) Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science 277:373-376
27. Kitamura Y, Shimohama S, Kamoshima W, Ota T, Matsuoka Y, Nomura Y, Smith MA, Perry G, Whitehouse PJ, Taniguchi T (1998) Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32 in Alzheimer's disease. Brain Res 780:260-269
28. Korsmeyer SJ, Shutter JR, Veis DJ, Merry DE, Oltvai ZN (1993) Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death. Semin Cancer Biol 4:327-332
29. MacGibbon GA, Lawlor PA, Sirimanne ES, Walton MR, Connor B, Young D, Williams C, Gluckman P, Faull RL, Hughes P, Dragunow M (1997) Bax expression in mammalian neurons undergoing apoptosis, and in Alzheimer's disease hippocampus. Brain Res 750:223-234
30. Martinou JC, Dubois-Dauphin M, Staple JK, Rodriguez I, Frankowski H, Missotten M, Albertini P, Talabot D, Catsicas S, Pietra C, Huarte J (1994) Overexpression of BCL-2 in transgenic mice protects neurons from naturally occuring cell death and experimental ischemia. Neuron 13:1017-1030
31. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, Belle G van, Berg L (1991) The Consortium to Establish a Registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer disease. Neurology 41:479-486
32. Moussaoui S, Czech C, Pradier L, Blanchard V, Bonici B, Gohin M, Imperato A, Revah F (1996) Immunohistochemical analysis of presenilin-1 expression in the mouse brain. FEBS Lett 383:219-222
33. Nagy ZS, Esiri MM (1997) Apoptosis-related protein expression in the hippocampus in Alzheimer's disease. Neurobiol Aging 18:565-571
34. O'Barr S, Schultz J, Rogers J (1996) Expression of the protooncogene bcl-2 in Alzheimer's disease brain. Neurobiol Aging 17:131-136
35. Oltvai ZN, Milliman CL, Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619
36. Paradis E, Douillard H, Koutroumanis M, Goodyer C, LeBlanc A (1996) Amyloid beta peptide of Alzheimer's disease down-regulates Bcl-2 and upregulates bax expression in human neurons. J Neurosci 16:7533-7539
37. Robakis NK (1994) β-amyloid and amyloid precursor protein: chemistry, molecular biology, and neuropathology. In: Terry RD, Katzman R, Bick KL (eds) Alzheimer's disease. Raven Press, New York, pp 317-326
38. Roperch JP, Alvaro V, Prieur S, Tuynder M, Nemani M, Lethrosne F, Piouffre L, Gendron MC, Israeli D, Dausset J, Oren M, Amson R, Telerman A (1998) Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression. Nat Med 4:835-838
39. Satou T, Cummings CW, Cotman CW (1995) Immunoreactivity for Bcl-2 protein within neurons in the Alzheimer's disease brain increases with disease severity. Brain Res 697:35-43
40. Schnell SA, Wessendorf MW (1998) Reduction of lipofuscin autofluorescence in monkey tissue sections. Soc Neurosci Abstr 24:1062
41. Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S (1997) Skeletal and CNS defects in presenilin-1 deficient mice. Cell 89:629-639
42. Smale G, Nichols NR, Brady DR, Finch CE, Horton WE Jr (1995) Evidence for apoptotic cell death in Alzheimer's disease. Exp Neurol 133:225-230
43. Stadelmann C, Bruck W, Bancher C, Jellinger K, Lassmann H (1998) Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis. J Neuropathol Exp Neurol 57:456-464
44. Sterio DC (1984) The unbiased estimation of number and sizes of arbitrary particles using the disector. J Microsc 134:127-136
45. Su JH, Anderson AJ, Cummings BJ, Cotman CW (1994) Immunohistochemical evidence for apoptosis in Alzheimer's disease. NeuroReport 5:2529-2533
46. Su JH, Satou T, Anderson AJ, Cotman CW (1996) Upregulation of Bcl-2 is associated with neuronal DNA damage in Alzheimer's disease. NeuroReport 7:437-440
47. Su JH, Deng G, Cotman CW (1997) Bax protein expression is increased in Alzheimer's brain: correlations with DNA damage, Bcl-2 expression, and brain pathology. J Neuropathol Exp Neurol 56:86-93
48. Tanimukai H, Imaizumi K, Kudo T, Katayama T, Tsuda M, Takagi T, Tohyama M, Takeda M (1998) Alzheimer-associated presenilin-1 gene is induced in gerbil hippocampus after transient ischemia. Mol Brain Res 54:212-218
49. Tortosa A, Lòpez E, Ferrer I (1998) Bcl-2 and Bax protein expression in Alzheimer's disease. Acta Neuropathol 95:407-412
50. Uchihara T, El Hachimi HK, Duyckaerts C, Foncin JF, Fraser PE, Levesque L, St George-Hyslop PH, Hauw JJ (1996) Widespread immunoreactivity of presenilin in neurons of normal and Alzheimer's disease brains: double labeling immunohistochemical study. Acta Neuropathol 92:325-330
51. Vallet PG, Guntern R, Hof PR, Golaz J, Delacourte A, Robakis NK, Bouras C (1992) A comparative study of histological and immunohistochemical methods for neurofibrillary tangles and senile plaques in Alzheimer's disease. Acta Neuropathol 83: 170-178
52. Yin XM, Oltvai ZN, Korsmeyer SJ (1994) BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 369:321-323
53. Zhong LT, Sarafian T, Kane DJ, Charles AC, Man SP, Edwards RH, Bredesen DE (1993) bcl-2 inhibits death of central neural cells induced by multiple agents. Proc Natl Acad Sci USA 90:4533-4537