A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition

American Journal of Psychiatry

Volumn 159, Issue 4, 2002, Pages 652-654

  Malhotra, Anil K ^a   Kestler, Lisa J ^a   Mazzanti, Chiara ^a   Bates, John A ^a   Goldberg, Terry ^a   Goldman, David ^a  

^a ZUCKER HILLSIDE HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE; DOPAMINE; NEUROTRANSMITTER;

ADULT; ALLELE; ARTICLE; COGNITION; CONTROLLED STUDY; DNA POLYMORPHISM; DOPAMINE METABOLISM; ENZYME ACTIVITY; FEMALE; GENOTYPE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PERFORMANCE; PREFRONTAL CORTEX; PRIORITY JOURNAL; TASK PERFORMANCE;

ADULT; ALLELES; CODON; COGNITION; FEMALE; GENOTYPE; HUMANS; MALE; METHIONINE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; POLYMORPHISM, GENETIC; PREFRONTAL CORTEX; REFERENCE VALUES; VALINE;

EID: 0036214991     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.159.4.652     Document Type: Article

References (12)

1. Cognition and control in schizophrenia: A computational model of dopamine and prefrontal function
2. Subchronic phencyclidine administration reduces mesoprefrontal dopamine utilization and impairs prefrontal cortical-dependent cognition in the rat
3. Cognitive improvement during tolcapone treatment in Parkinson's disease
4. 3-Methoxytyramine is the major metabolite of released dopamine in the rat frontal cortex: Reassessment of the effects of antipsychotics on the dynamics of dopamine release and metabolism in the frontal cortex, nucleus accumbens, and striatum by a simple two pool model
5. Human catechol-O-methyltransferase pharmacogenetics: Description of a functional polymorphism and its potential application to neuropsychiatric disorders
6. 108/158 Met genotype on frontal lobe function and risk for schizophrenia
7. On the comparison of several mean values: An alternative approach
8. Interaction of COMT gene deletion and environment on cognition
9. Transmission-disequilibrium tests for quantitative traits
10. Use of unlinked genetic markers to detect population stratification in association studies
11. Family-based linkage disequilibrium mapping using SNP marker haplotypes: Application to a potential locus for schizophrenia at chromosome 22q11