Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis

Mechanisms of Development

Volumn 101, Issue 1-2, 2001, Pages 289-292

  Casas, C ^a   Martinez S ^b   Pritchard, M A ^a   Fuentes, J J ^a   Nadal, M ^a   Guimera J ^a   Arbones M ^a   Florez J ^c   Soriano, E ^d   Estivill, X ^a   Alcantara S ^d  

^a HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^b UNIVERSITY OF MURCIA   (Spain)

^c UNIVERSITY OF CANTABRIA   (Spain)

^d UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Calcineurin; Chromosome 21; Down syndrome; Dscr1; Heart; Nervous system; Nuclear factor of activated T cells; Rhombomere; Ts65Dn mouse

Indexed keywords

CALCINEURIN;

ANIMAL TISSUE; ARTICLE; BRAIN; DOWN SYNDROME; EMBRYO; EMBRYO DEVELOPMENT; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; HEART VENTRICLE; MOLECULAR CLONING; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEUROMERE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRISOMY;

ANIMALS; BLOTTING, NORTHERN; BRAIN; CALCINEURIN; CENTRAL NERVOUS SYSTEM; CLONING, MOLECULAR; DNA, COMPLEMENTARY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE LIBRARY; HEART; HUMANS; IN SITU HYBRIDIZATION; IN SITU HYBRIDIZATION, FLUORESCENCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MUSCLE PROTEINS; NEURONS; SIGNAL TRANSDUCTION; TIME FACTORS; TISSUE DISTRIBUTION; TRISOMY;

EID: 0035111345     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(00)00583-9     Document Type: Article

References (12)

1. Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse
2. Segmental trisomy as a mouse model for Down syndrome
3. Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum
4. A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart
5. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways
6. Expression of a Delta homologue in prospective neurons in the chick
7. Distinct cellular expression of calcineurin A alpha and A beta in rat brain
8. YAC and cosmid FISH mapping of an unbalanced chromosomal translocation causing partial trisomy 21 and Down syndrome
9. The transcription factor NF-ATc is essential for cardiac valve formation
10. A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling
11. Comparative study of the distribution of calmodulin kinase II and calcineurin in the mouse brain
12. Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription