Association of apo E polymorphism with plasma lipid levels in a multiethnic elderly population

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 17, Issue 12, 1997, Pages 3534-3541

  Pablos Méndez, Ariel ^a,b   Mayeux, Richard ^b,c   Ngai, Colleen ^d   Shea, Steven ^a,b   Berglund, Lars ^a,b  

^a The New York Presbyterian Hospital   (United States)

^b NONE   (United States)

^c and Epidemiology   (United States)

^d NONE

Author keywords

Apo E; Elderly; Epidemiology; Genetics; Serum lipids

Indexed keywords

APOLIPOPROTEIN E; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

AGED; ALLELE; ARTICLE; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

EID: 0031471572     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.17.12.3534     Document Type: Article

References (21)

1. Newschaffer CJ, Bush TL, Hale WE. Aging and total cholesterol levels: cohort, period, and survivorship effects. Am J Epidemiol. 1992;136:23-34.
2. Wilson PW, Anderson KM, Harris T, Kannel WB, Castelli WP. Determinants of change in total cholesterol and HDL-C with age: the Framingham Study. J Geront. 1994;49:M252-M257.
3. Lamon-Fava S, Jenner JL, Jacques PF, Schaefer EJ. Effects of dietary intakes on plasma lipids, lipoproteins, and apolipoproteins in free-living elderly men and women. Am J Clin Nutr. 1994;59: 32-41.
4. Kronmal RA, Cain KC, Ye Z, Omenn GS. Total serum cholesterol levels and mortality risk as a function of age: a report based on the Framingham data. Arch Intern Med. 1993;153:1065-1073.
5. Manolio TA, Pearson TA, Wenger NK, Barret-Connor E, Payne GH, Harlan WR. Cholesterol and heart disease in older persons and women: review of an NHLBI workshop. Ann Epidemiol. 1992; 2:161-176.
6. Krumholz HM, Seeman TE, Merrill SS, Mendes de Leon CF, Vaccarino V, Silverman DI, Tsukahara R, Ostfeld AM, Berkman LF. Lack of association between cholesterol and coronary heart disease mortality and morbidity and all-cause mortality in persons older than 70 years. JAMA. 1994;272:1335-1340.
7. Benfante R, Reed D, Frank J. Do coronary heart disease risk factors measured in the elderly have the same predictive roles as in the middle aged? Comparisons of relative and attributable risks. Ann Epidemiol. 1992;2:273-282.
8. Hulley SB, Newman TB. Cholesterol in the elderly. Is it important? JAMA. 1994;272:1372-1374.
9. Maria-Chiaa C, Guralnik JM, Salive ME, Harris T, Field TS, Wallace RB, Berkman LF, Seeman TE, Glynn RJ, Hennekens CH, Havilk RJ. HDL cholesterol predicts heart disease mortality in older persons. JAMA. 1995;274:539-544.
10. Weijenberg MP, Feskens EJM, Kromhout D. Total and high density lipoprotein cholesterol as a risk factor for coronary heart disease in elderly men during 5 years of follow-up: the Zutphen Study. Am J Epidemiol. 1996;143:151-158.
11. Mahley RW. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science. 1988;240:662-630.
12. Mahley RW, Innerarity TL, Rail SC Jr, Weisgraber KH, Taylor JM. Apolipoprotein E: genetic variants provide insights into its structure and function. Curr Opin Lipidol. 1990;1:87-95.
13. Davignon J, Gregg RE, Sing CF. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis. 1988;8:1-21.
14. Cumming AM, Robertson FW. Polymorphism at the apolipoprotein-E locus in relation to risk of coronary heart disease. Clin Gen. 1984;25:310-313.
15. Eichner JE, Kuller LH, Orchard TJ, Grandits GA, McCallum LM, Ferrell RE, Neaton JD. Relation of apolipoprotein E phenotype to myocardial infarction and mortality from coronary artery disease. Am J Cardiol. 1993;71:160-165.
16. Wilson PWF, Myers RH, Larson MG, Ordovas JM, Wolf PA, Schaefer EJ. Apolipoprotein E alleles, dyslipidemia and coronary heart disease: the Framingham Offspring Study. JAMA. 1994;272: 1666-1671.
17. Lenzen HJ, Assman G, Buchwaldsky R, Schulte H. Association of apolipoprotein E polymorphism, low-density lipoprotein cholesterol, and coronary artery disease. Clin Chem. 1986;32:778-781.
18. Luc G, Bard JM, Arveiler D, Evans A, Cambou J-P, Bingham A, Amouyel P, Schaffer P, Ruidavets J-B, Cambien F, Fruchart J-C, Ducimetiere P. Impact of apolipoprotein E polymorphism on lipoproteins and risk of myocardial infarction: the ECTIM Study. Arterioscler Thromb. 1994;14:1412-1419.
19. Stengård JH, Zerba KE, Pekkanen J, Ehnholm C, Nissinen A, Sing CF. Apolipoprotein E polymorphism predicts death from coronary artery disease in a longitudinal study of elderly Finnish men. Circulation. 1995;91:265-269.
20. Wilson PWF, Schaefer EJ, Larson MG, Ordovas JM. Apolipoprotein E alleles and risk of coronary heart disease: a meta-analysis. Arterioscler Thromb Vasc Biol. 1996;16:1250-1255.
21. Sing CF, Davignon J. Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. Am J Hum Genet. 1985;37:268-285.