Radioprotection of DNA by spermine: A molecular modelling approach

International Journal of Radiation Biology

Volumn 75, Issue 8, 1999, Pages 953-961

  Sy, D ^a,b   Hugot, S ^a,b   Savoye, C ^a   Ruiz, S ^a   Charlier, M ^a   Spotheim Maurizot, M ^a  

^a CENTRE DE BIOPHYSIQUE MOLÉCULAIRE   (France)

^b UNIVERSITÉ D'ORLÉANS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; SPERMINE;

ARTICLE; COMPLEX FORMATION; DNA BINDING; DNA STRAND BREAKAGE; MOLECULAR MODEL; PRIORITY JOURNAL; RADIATION PROTECTION; RADIOSENSITIVITY;

BASE SEQUENCE; COMPUTER SIMULATION; DNA; DNA ADDUCTS; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROSTATICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; RADIATION TOLERANCE; RADIATION-PROTECTIVE AGENTS; SPERMINE;

EID: 0032815259     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530099139719     Document Type: Article

References (45)

1. 13C-NMR chemical shift assignments of spermine and homologs. Biophysical Chemistry, 17, 67-74.
2. BALASUBRAMANIAN, B., POGOZELSKI, W. K. and TULLIUS, T. D., 1998, DNA strand breaking by hydroxyl radical is governed by the accessible surface areas of the hydrogen atoms of the DNA backbone. Proceedings of the National Academy of Sciences, USA, 95, 9738-9743.
3. BLOOMFIELD, V., 1997, DNA condensation by multivalent cations. Biopolymers, 44, 269-282.
4. BROWN, P. E., 1969, Some effects of binding agents on the X-irradiation of DNA. Radiation Research, 34, 24-35.
5. BRAUNLIN, W. H., STRICK, T. J. and RECORD, M. T., 1982, Equilibrium dialysis studies of polyamine binding to DNA. Biopolymers, 21, 1310-1314.
6. CHIU, S. and OLEINICK, N. L., 1997, radioprotection against the formation of DNA double-strand breaks in cellular DNA but not native cellular chromatin by polyamine spermine. Radiation Research, 148, 188-192.
7. CHIU, S. and OLEINICK, N. L., 1998, Radioprotection of cellular chromatin by the polyamine spermine and putrescine: preferential action against formation of DNA protein crosslinks. Radiation Research, 149, 543-549.
8. FEUERSTEIN, B. G., PATTABIRAMAN, N. and MARTON, L. J., 1986, Spermine DNA interactions: a theoretical study. Proceedings of the National Academy of Sciences, USA, 83, 5948-5952.
9. FEUERSTEIN, B. G., WILLIAMS, L. D., BASU, H. S. and MARTON, L. J., 1991, Implications and concepts of polyamine nucleic acid interactions. Journal of Cellular Biochemistry, 46, 37-47.
10. FRANCHET-BEUZIT, J., SPOTHEIM-MAURIZOT, M., SABATTIER, R., BLAZY-BAUDRAS, B. and CHARLIER, M., 1993, Radiolytic footprinting. Beta rays, gamma photons and fast neutrons probe DNA protein interactions. Biochemistry, 32, 2104-2110.
11. HAWORTH, I. S., RODGER, A. and RICHARDS, W. G., 1991, A molecular study of spermine complexation to DNA: a new model for spermine-poly (dG-dC) binding. Proceedings of the Royal Society of London Series B: Biological Sciences, 244, 107-116.
12. HELD, K. D. and AWAD, S., 1991, Effects of polyamines and thiols on the radiation sensitivity of bacterial transforming DNA. International Journal of Radiation Biology, 59, 699-710.
13. HONIG, B. and NICHOLLS, A., 1995, Classical electrostatics in biology and chemistry. Science, 268, 1144-1149.
14. ISABELLE, V., FRANCHET-BEUZIT, J., SABATTIER, R., LAINE, B., SPOTHEIM-MAURIZOT, M. and CHARLIER, M., 1993, Radioprotection of DNA by a DNA-binding protein: MCI chromosomal protein from the archœbacterium Methanosarcina sp. CHTI55. International Journal of Radiation Biology, 63, 749-758.
15. LIQUORI, A. M., CONSTANTINO, L., CRESCENZI, V., ELIA, V., GIGLIO, E., PULITI, R., DE SANTIS SAVINO, M. and VITAGLIANO, V., 1967, Complexes between DNA and polyamine: a molecular model. Journal of Molecular Biology, 24, 113-122.
16. MANNING, G., 1978, The molecular theory of polyelectrolyte solutions with application to the electrostatic properties of polynucleotides. Quarterly Review of Biophysics, II, 179-246.
17. MANNING, G., 1989, Self-attraction and natural curvature in null DNA. Journal of Biomolecular Structure and Dynamics, 7, 41-61.
18. MANNING, G. and RAY, J., 1998, Counterion condensation revisited. Journal of Biomolecular Structure and Dynamics, 16, 461-476.
19. MARQUET, R., WYART, A. and HOUSSIER, C., 1987, Influence of DNA length on spermine-induced condensation. Importance of the bending and stiffening of DNA. Biochemical and Biophysical Acta, 25, 165-172.
20. NEIDLE, S., 1992, Minor-groove width and accessibility in B-DNA drug and protein complexes. FEBS Letters, 298, 97-99.
21. NEWTON G. L., AGUILERA, J. A., WARD, J. F. and FAHEY, R. C., 1996, Polyamine-induced compaction and aggregation of DNA a major factor in radioprotection of chromatin under physiological conditions. Radiation Research, 145, 776-780.
22. NEWTON G. L., AGUILERA, J. A., WARD, J. F. and FAHEY, R. C., 1997, Effect of polyamine-induced compaction and aggregation of DNA on the formation of radiation-induced strand breaks: quantitative models for cellular radiation damage. Radiation Research, 148, 272-284.
23. PORSCHKE, D., 1986, Structure and dynamics of double helices in solution: modes of DNA bending. Journal of Biomolecular Structure and Dynamics, 4, 373-389.
24. POWELL, M. D., 1977, Restart procedures for the conjugate gradient method. Mathematical Programming, 12, 241-254.
25. RAU, D. C. and PARSEGIAN, V. A., 1992, Direct measurement of the intermolecular forces between counterion-condenscd DNA double helices, evidence for long range attractive hydration forces. Biophysical Journal, 61, 246-259.
26. RAY, J. and MANNING, G. S., 1994, An attractive force between two rodlike polyions mediated by the sharing of condensed counterions. Langmuir, 10, 2450-2461.
27. ROBINSON, H. and WANG, A. H., 1996, Neomycin, spermine and hexaamminecobalt(III) share common structural motifs in converting B-to A-DNA. Nucleic Acids Research, 24, 676-682.
28. RODGER, A., TAYLOR, S., ADLAM, G., BLAGBROUGH, I. S. and HAWORTH, I. S., 1995, Multiple DNA binding modes of anthracene-9-carbonyl-N1-spermine. Bioorganic and Medicinal Chemistry, 3, 861-872.
29. ROUZINA, I. and BLOOMFIELD, V., 1998, DNA bending by small, mobile multivalent cations. Biophysical Journal, 74, 3152-3164.
30. SANGHANI, R., ZAKRZEWSKA, K. and LAVERY, R., 1996, Modeling DNA bending induced by phosphate neutralisation. In R. H. Sarma and M. H. Sarma (eds), Biological Structure and Dynamics (New York: Adenine), pp. 267-278.
31. SAVOYE, C., SWENBERG, C., HUGOT, S., SY, D., SABATTIER, CHARLIER, M. and SPOTHEIM-MAURIZOT, M., 1997, Thiol WR-1065 and disulphide WR-33278, two metabolites of the drug Ethyol (WR-2721) protect DNA against fast neutron-induced strand breakage. International Journal of Radiation Biology, 71, 193-202.
32. SCHELLMAN, J. A. and PARTHASARATHY, N., 1904, X-ray diffraction studies on cation collapsed DNA. Journal of Molecular Biology, 175, 313-329.
33. SCHMID, N. and BEHR, J. P., 1991, Location of spermine and other polyamines on DNA as revealed by photoaffinity cleavage with polyaminobenzenediazonium salts. Biochemistry, 30, 4357-3461.
34. SNYDER, R. D. and SCHROEDER, K. K., 1994, Radiosensitivity of polyamine-depleted HeLa cells and modulation by the aminothiol WR-1065. Radiation Research, 137, 67-75.
35. SPOTHEIM-MAURIZOT, M., RUIZ, S., SABATTIER, R. and CHARLIER, M., 1995, Radioprotection of DNA by polyamines. International Journal of Radiation Biology, 68, 571-577.
36. STRAUSS, J. K. and MAHER III, L. J., 1994, DNA bending by asymmetric phosphate neutralisation. Science, 266, 1829-1834.
37. SY, D., DURAND, C., HUGOT, S., SAVOYE, C., SWENBERG, C., CHARLIER, M. and SPOTHEIM-MAURIZOT, M., 1999, Sequence dependence of DNA radioprotection by the thiols WR-1065 and WR-151326. Theoretical Chemistry Accounts, 101, 114-120.
38. SY, D., SAVOYE, C., BEGUSOVA, M., MICHALIK, V., CHARLIER, M. and SPOTHEIM-MAURIZOT, M., 1997, Sequence-dependent variations of DNA structure modulate radiation-induced strand breakage. International Journal of Radiation Biology, 72, 147-155.
39. n insert. Journal of Biological Chemistry, 266, 6137-6141.
40. TULLIUS, T. D., 1996, Chemical mapping of nucleic acid conformation. In S. M. Hecht (ed.), Bioorganic Chemistry: Nucleic Acids (New York: Oxford University Press), pp. 144-162.
41. WARTERS, R. L., NEWTON, G. L., OLIVE, P. L. and FAHEY, R. C., 1999, Radioprotection of human cell nuclear DNA by polyamines: radiosensitivity of chromatin is influenced by tightly bound spermine. Radiation Research, 151, 354-362.
42. WEINER, S. J., KOLLMAN, P. A., CASE, D. A., SINGH, U. C., GHIO, C., ALAGONA, G., PROFETA, S. Jr and WEINER, P., 1984, A new force field for molecular mechanical simulation of nucleic acids and proteins. Journal of American Chemical Society, 106, 765-784.
43. YOUNG, M. A., JAYARAM, B. and BEVERIDGE, D. L., 1997, Intrusion of counterions into the spine of hydration in the minor groove of B-DNA: fractional occupancy of electronegative pockets. Journal of American Chemical Society, 119, 59-69.
44. YUKI, M., GRUKHIN, V., LEE, C. S. and HAWORTH, I. S., 1996, Spermine binding to GC-rich DNA: experimental and theoretical studies. Archives of Biochemistry and Biophysics, 325, 39-46.
45. ZAKRZEWSKA, K. and PULLMAN, B., 1986, Spermine-nucleic acid interactions: a theoretical study. Biopolymers, 25, 375-392.