A randomized, placebo-controlled trial of low-dose α- difluoromethylornithine in individuals at risk for colorectal cancer

Cancer Epidemiology Biomarkers and Prevention

Volumn 7, Issue 11, 1998, Pages 989-992

  Love, Richard R ^a,b   Jacoby, Russell ^a   Newton, Michael A ^a   Tutsch, Kendra D ^a   Simon, Kris ^a   Pomplun, Marcia ^a   Verma, Ajit K ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b 7C MSC ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EFLORNITHINE; ORNITHINE DECARBOXYLASE; POLYAMINE; PUTRESCINE; SPERMIDINE;

ADENOMATOUS POLYP; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COLONOSCOPY; COLORECTAL CANCER; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HEARING LOSS; HUMAN; HUMAN TISSUE; MALE; OTOTOXICITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIGMOIDOSCOPY;

ADULT; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; EFLORNITHINE; ENZYME INHIBITORS; FEMALE; HUMANS; INTESTINAL MUCOSA; MALE; MIDDLE AGED; ORNITHINE DECARBOXYLASE; POLYAMINES; SIGMOIDOSCOPY;

EID: 0031733846     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Pegg, A E. Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. Cancer Res., 48: 759-774, 1988
2. Verma, A K. The enzyme-activated irreversible inhibitor of ornithine decarboxylase, DL-α-difluoromethyl omithine a chemopreventive agent Prev Med , 78: 646-652, 1989.
3. Fozard, J. R., and Prakash, N. J. Effects of D,L-α-difluoromethylornithine, an irreversible inhibitor of omithine decarboxylase, on the rat mammary tumor induced by 7,12-dimethylbenz[a]anthracene Arch. Pharmacol., 320: 72-77, 1982.
4. Tutton, P. J. M., and Barkla, D. H. Comparison of the effect of an ornithine decarboxylase inhibitor on the intestinal epithelium and on intestinal tumors. Cancer Res., 46: 6091-6094, 1986.
5. Homma, Y , Kakizoe, T , Samma, S , and Oyasu, R. Inhibition of N-butyl-N-(4-hydroxybutyl)nitrosamine-induced rat urinary bladder carcinogenesis by α-difluoromethylornithine Cancer Res , 47: 6176-6179, 1987.
6. Levin, V. A., Prados, M. D , Yung, W. K. A., Gleason, M. J., Ictech, S., and Malec, M Treatment of recurrent gliomas with eflomithine. J Natl. Cancer Inst., 84. 1432-1437, 1992.
7. Nishioka, K., Melgarejo, A. B , Lyon, R R, and Mitchell, M F. Polyamines as biomarkers of cervical intraepithelial neoplasia. J. Cell Biochem. Suppl., 23: 87-95, 1995.
8. Abeloff, M. D., Slavik, M., Luk, G. D., Greffin, C A, Hermann, J., Blanc, O., Sjoerdsma, A , and Baylin, S B. Phase I trial and pharmacokinetic studies of α-difluoromethylornithine-an inhibitor of polyamine biosynthesis. J Clin. Oncol., 2: 124-130, 1984.
9. Love, R R , Carbone, P P., Verma, A. K., Gilmore, D., Carey, P., Tutsch, K D., Pomplun, M , and Wilding, G. Randomized phase I chemoprevention dose-seeking study of α-difluoromethylornithine. J Natl Cancer Inst., 85: 732-737, 1993.
10. Boyle, J. O., Meyskens, F L., Jr, Garewal, H. S., and Gerner, E. W. Polyamine contents in rectal and buccal mucosae in humans treated with oral difluoromethylornithine. Cancer Epidemiol. Biomark. Prev., 1: 131-136, 1992
11. Kabra, P. M , Lee, H. K., Lubich, W. P., and Marton, L. J Solid-phase extraction and determination of dansyl derivatives of unconjugated and acetylated polyamines by reversed-phase liquid chromatography: improved separation systems for polyamines in cerebral spinal fluid, urine and tissue J. Chromatogr., 380: 19-32, 1986.
12. Higuchi, C. M., and Wang W Comodulation of cellular polyamines and proliferation biomarker application to colorectal mucosa. J Cell. Biochem., 57: 256-261, 1995.
13. Love, R. R., Verma, A. K., Surawicz, T. S , and Morrissey, J. F. Colon ornithine decarboxylase activity following standard endoscopy preparation regimens J. Surg. Oncol., 42: 150-153, 1989
14. Fujimoto, K , Granger, D N , Johnson, L. R , Price, V H , and Tso, P. Diurnal rhythm of L-ornithine decarboxylase activity in small intestine of fasted rat. Gastroenterology, 100 (Suppl.): A523, 1991.
15. Pasic, T R., Heisey, D , and Love, R. R α-Difluoromethylornithine ototoxicity. chemoprevention clinical trial results. Arch Otolaryngol. Head Neck Surg., 123: 1281-1286, 1997.
16. Croghan, M. K , Aickin, M. G., and Meyskens, F. L Dose-related α-difluoromethylornithine ototoxicity. Am J Clin. Oncol., 14: 331-335, 1991.
17. Meyskens, F. L., Jr., Emerson, S. S., Pelot, D , Meshkinpour, H., Shassetz, L. R., Einspahr, J., and Alberts, D. S Dose de-escalation chemoprevention trial of α-difluoromethylornithine in patients with colon polyps J. Natl Cancer Inst , 86: 1122-1130, 1994.