Effect of spermine synthase deficiency on polyamine biosynthesis and content in mice and embryonic fibroblasts, and the sensitivity of fibroblasts to 1,3-bis-(2-chloroethyl)-N-nitrosourea

Biochemical Journal

Volumn 351, Issue 2, 2000, Pages 439-447

  MacKintosh, C A ^a   Pegg, A E ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

1,3 Bis (2 chloroethyl) N nitrosourea (BCNU); Gy; Gyro; Putrescine; Spermidine

Indexed keywords

CARMUSTINE; POLYAMINE; PUTRESCINE; SPERMIDINE; SPERMINE; SPERMINE SYNTHASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BRAIN; CELL GROWTH; CELL KILLING; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; ENZYME ACTIVITY; ENZYME DEFICIENCY; FEMALE; FIBROBLAST CULTURE; HEART; LIVER; MALE; MORTALITY; MOUSE; MOUSE MUTANT; NONHUMAN; POLYAMINE SYNTHESIS; PRIORITY JOURNAL; PROTEIN CONTENT; WEANING;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; BODY WEIGHT; BRAIN; CARMUSTINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MYOCARDIUM; POLYAMINES; SPERMINE; SPERMINE SYNTHASE; TIME FACTORS; TISSUE DISTRIBUTION;

ANIMALIA; EUKARYOTA; GENETTA;

EID: 0034667601     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3510439     Document Type: Article

References (49)

1. Polyamines as targets for therapeutic intervention
2. Use of aminopropyltransferase inhibitors and of non-metabolizable analogues to study polyamine regulation and function
3. Polyamine metabolism and its importance in neoplastic growth and as a target for chemotherapy
4. Polyamine transport in mammalian cells. An update
5. Curative effect of DL-2-difluoromethylornithine on mice bearing mutant L1210 leukemia cells deficient in polyamine uptake
6. Polyamines in microorganisms
7. Analysis of the spermine synthase gene region in Fugu rubripes, Tetraodon fluviatilis, and Danio rerio
8. Spermine is not essential for growth of Saccharomyces cerevisiae: Identification of the SPE4 gene (spermine synthase) and characterization of a spe4 deletion mutant
9. Molecular cloning of a cDNA encoding human spermine synthase
10. Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis in rat tissues
11. Specific depletion of spermidine and spermine in HTC cells treated with inhibitors of aminopropyltransferases
12. Antiproliferative effect of 8spermine depletion by N-cyclohexyl-1,3-diaminopropane in human breast cancer cells
13. Effect of N-(n-butyl)-1,3-diaminopropane on polyamine metabolism, cell growth and sensitivity to chloroethylating agents
14. Inhibition of mammalian spermine synthase by N-alkylated-1,3-diaminopropane derivatives in vitro and in cultured hepatoma cells
15. Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate inhibitor of spermine synthase, on polyamine metabolism in mammalian cells
16. Sequence analysis of 139 kb in Xp22.1 containing spermine synthase and 5' region of Pex
17. Hypophosphatemia: Mouse model for human familial hypophosphatemic (vitamin D-resistant) rickets
18. The Gy mutation: Another cause of X-linked hypophosphatemia in mouse
19. Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia
20. Spermine deficiency in Gy mice caused by deletion of the spermine synthase gene
21. Partial deletion of both the spermine synthase gene and the Pex gene in the X-linked hypophosphatemic, Gyro (Gy) mouse
22. Sterility of Gy males
23. Hearing impairment associated with hypophosphatemia: The Gyro mutant mouse
24. Hearing impairment in two mouse mutants with hypophosphatemia
25. Microdetermination of phosphorus
26. A rapid assay method for spermidine and spermine synthases. Distribution of polyamine synthesizing enzymes and methionine adenosyltransferase in rat tissues
27. A rapid sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
28. 14C] ornithine
29. Assay of mammalian S-adenosylmethionine decarboxylase activity
30. Assay of spermidine and spermine synthases
31. Trans-4-methylcyclohexylamine, a potent new inhibitor of spermidine synthase
32. Specific and potent inhibition of spermidine synthase by the transition-state analog, S-adenosyl-3-thio-1,8-diaminooctane
33. Germ cell development in the XXY mouse: Evidence that X chromosome reactivation is independent of sexual differentiation
34. Association of p53 binding and immortalization of primary C57BL/6 mouse embryo fibroblasts by using sirnian virus T-antigen mutants bearing internal overlapping deletion mutations
35. 6-Benzylguanine and its role in chemotherapy
36. 6-Alkylguanine by alkyltransferases
37. S-adenosylmethionine decarboxylase: Structure, function and regulation by polyamines
38. The upstream open reading frame of the mRNA encoding S-adenosylmethionine decarboxylase is a polyamine-responsive translational control element
39. Interactions of polyamines with ion channels
40. Inward rectifier potassium channels
41. Femoral abnormalities and vitamin D metabolism in X-linked hypophosphatemic (Hyp and Gy) mice
42. Effect of spermine administration on pancreatic maturation in unweaned rats
43. Comparison between the natural postnatal maturation and the spermine-induced maturation of the rat intestine
44. Spermine: An anti-oxidant and anti-inflammatory agent
45. Antioxidant properties of di- and polyamines
46. Protective effect of spermine on DNA exposed to oxidative stress
47. The natural polyamine spermine functions directly as a free radical scavenger
48. Spermine causes caspase activation in leukaemia cells
49. Spermine triggers the activation of caspase-3 in a cell-free model of apoptosis