Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase

Bioorganic and Medicinal Chemistry

Volumn 4, Issue 6, 1996, Pages 825-836

  Wu, Ronghui ^a   Saab, Nada H ^a   Huang, Huatao ^a   Wiest, Laurie ^b   Pegg, Anthony E ^b   Casero Jr , Robert A ^c   Woster, Patrick M ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; N CYCLOHEPTYLMETHYL N' ETHYL 4,8 DIAZAUNDECANE; N CYCLOPROPYLMETHYL N' ETHYL 4,8 DIAZAUNDECANE; N1,N11 DIETHYLNORSPERMINE; PHOSPHINIC ACID DERIVATIVE; PHOSPHONAMIDIC ACID DERIVATIVE; POLYAMINE DERIVATIVE; SPERMIDINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL METABOLISM; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; POLYAMINE SYNTHESIS;

ACETYLTRANSFERASES; CARCINOMA, NON-SMALL-CELL LUNG; ENZYME INHIBITORS; HUMANS; LUNG NEOPLASMS; MAGNETIC RESONANCE SPECTROSCOPY; POLYAMINES; RECOMBINANT PROTEINS; SPECTROPHOTOMETRY, INFRARED; SPERMINE; TUMOR CELLS, CULTURED;

EID: 0029929834     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/0968-0896(96)00072-7     Document Type: Article

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