α-Difluoromethylornithine inhibits N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in zinc-deficient rats: Effects on esophageal cell proliferation and apoptosis

Cancer Research

Volumn 58, Issue 23, 1998, Pages 5380-5388

  Fong, Louise Y Y ^a,c   Pegg, Anthony E ^b   Magee, Peter N ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DIFLUOROMETHYLARGININE; BIS(2 HYDROXYETHYL)NITROSAMINE; ORNITHINE DECARBOXYLASE INHIBITOR; POLYAMINE; PUTRESCINE; SPERMIDINE; ZINC;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL CYCLE S PHASE; CELL PROLIFERATION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; ESOPHAGUS CARCINOMA; EXPERIMENTAL NEOPLASM; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; NEWBORN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; ZINC DEFICIENCY;

ANIMALS; ANTICARCINOGENIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BIOGENIC POLYAMINES; CARCINOGENS; CELL DIVISION; COCARCINOGENESIS; DIET; DIMETHYLNITROSAMINE; EFLORNITHINE; ESOPHAGEAL NEOPLASMS; ESOPHAGUS; MALE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; ZINC;

EID: 0032403096     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (63)

1. Doll, R. Geographical variation in cancer incidence: a clue to causation. World J. Surg., 2: 595-602, 1978.
2. Day, N. E., Munoz, N., and Ghadirian, P. Epidemiology of esophageal cancer: a review. In: P. Correa and W. Haenazel (eds.), Epidemiology of Cancer of the Digestive Tract, pp. 21-57. The Hague, the Netherlands: Martinus Nijhoff, 1982.
3. Joint Iran-International Agency for Research on Cancer Study Group. Esophageal cancer studies in the Caspian littoral of Iran: results of population studies - a prodrome. J. Natl. Cancer Inst., 59: 1127-1138, 1977.
4. Yang, C. S. Research on esophageal cancer in China. Cancer Res., 40: 2633-2644, 1980.
5. van Rensburg, S. J. Epidemiologic and dietary evidence for a specific nutritional predisposition to esophageal cancer. J. Natl. Cancer Inst., 67: 243-251, 1981.
6. Lu, S. H., Montesano, R., Zhang, M. S., Feng, L., Luo, F. J., Chui, S. X., Umbenhauer, D., Saffhill, R., and Rajewsky, M. F. Relevance of N-nitrosamines to esophageal cancer in China. J. Cell. Physiol. (Suppl.), 4: 51-58, 1986.
7. Lu, S. H., Chui, S. X., Yang, W. X., Hu, X. N., Guo, L. P., and Li, F. M. Relevance of N-nitrosamines to esophageal cancer in China. IARC Sci. Publ., 105: 11-7, 1991.
8. Magee, P. N. The experimental basis for the role of nitroso compounds in human cancer. Cancer Surv., 8: 207-239, 1989.
9. Lin, H. J., Chan, W. C., Fong, L. Y. Y., and Newberne, P. M. Zinc levels in serum, hair and tumors from patients with esophageal cancer. Nutr. Report Int., 15: 635-643, 1977.
10. Yang, G., Lipkin, M., Yang, K., Wang, G., Li, J., Yang, C., Winawer, S., Newmark, H., Biot, W. J., and Fraumeni, J. F., Jr. Proliferation of esophageal cells among residents of Linxian, People's Republic of China. J. Natl. Cancer Inst., 79: 1241-1246, 1987.
11. Wang, L. D., Lipkin, M., Qui, S. L., Yang, G. R., Yang, C. S., and Newmark, H. L. Labeling index and labeling distribution of cells in esophageal epithelium of individuals at increased risk for esophageal cancer in Huixian, China. Cancer Res., 50: 2651-2653, 1990.
12. Cohen, S. M., and Ellwein, L. B. Cell proliferation in carcinogenesis. Science (Washington DC), 249: 1007-1011, 1990.
13. Cohen, S. M., and Ellwein, L. B. Genetic errors, cell proliferation and carcinogenesis. Cancer Res., 51: 6493-6505, 1991.
14. Butterworth, B. E., Conolly, R. B., and Morgan, K. T. A strategy for establishing mode of action of chemical carcinogens as a guide for approaches to risk assessments. Cancer Lett., 93: 129-146, 1995.
15. Kelloff, G. J., Boone, C. W., Crowell, J. A., Nayfield, S. G., Hawk, E., Malone, W. F., Steele, V. E., Lubet, R. A., and Sigman, C. C. Risk biomarkers and current strategies for cancer chemoprevention. J. Cell. Biochem., 255: 1-14, 1996.
16. Fong, L. Y. Y., Sivak, A., and Newberne, P. M. Zinc deficiency and methylbenzylnitrosamine induced esophageal cancer in rats. J. Natl. Cancer Inst., 61: 145-150, 1978.
17. van Rensburg, S. J., du Bruyn, D. B., and van Schalkwyk, D. J. Promotion of methylbenzylnitrosamine-induced esophageal cancer in rats by subclinical zinc deficiency. Nutr. Rep. Int., 22: 891-899, 1980.
18. Gabrial G. N., Schrager, T. F., and Newberne, P. M. Zinc deficiency, alcohol, and retinoid: association with esophageal cancer in rats. J. Natl. Cancer Inst., 68: 785-789, 1982.
19. Barch., D. H., Kuemmerle, S., Hollenberg, P., and Iannaccone, P. Esophageal microsomal metabolism of N-nitrosomethylbenzylamine in the zinc-deficient rat. Cancer Res., 44: 5629-5633, 1984.
20. Fong, L. Y. Y., Li, J-X., Farber, J. L., and Magee, P. N. Cell proliferation and esophageal carcinogenesis in the zinc-deficient rat. Carcinogenesis (Lond.), 17: 1841-1848, 1996.
21. Newberne, P. M., Schrager, T. S., and Broitman, S. Esophageal carcinogenesis in the rat: zinc deficiency and alcohol effects on tumor induction. Pathobiology, 65: 39-45, 1997.
22. Stinson, S. P., Squire, R. A., and Sporn, M. B. Pathology of esophageal neoplasms and associated proliferative lesions induced in rats by N-methyl-N-benzylnitrosamine. J. Natl. Inst. Cancer, 61: 1471-1475, 1978.
23. Follis, R. H., Jr. The pathology of zinc deficiency. In: A. S. Prasad (ed.), Zinc Metabolism, pp. 129-141. Springfield, IL: C. Thomas, 1966.
24. Swenerton, H., and Hurley, L. S. Severe zinc deficiency in male and female rats. J. Nutr., 95: 8-18, 1968.
25. Fong, L. Y. Y., Farber, J. L., and Magee, P. N. Zinc replenishment reduces esophageal cell proliferation and N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumor incidence in zinc-deficient rats. Carcinogenesis (Lond.), 19: 1591-1596, 1998.
26. Pegg, A. E., and McCann, P. P. Polyamine metabolism and function. Am. J. Physiol., 243: C212-C221, 1982.
27. Luk, G. D., and Casero, R. A. Polyamines in normal and cancer cells. Adv. Enzyme Regul., 26: 91-105, 1987.
28. Pegg, A. E. Polyamine metabolism and its importance in neoplastic growth and as a target for chemotherapy. Cancer Res., 48: 759-774, 1988.
29. Kelloff, G. J., Crowell, J. A., Boone, C. W., Steele, V. E., Lubet, R. A., Greenwald, P., Alberts, D. S., Covey, J. M., Doody, L. A., Knapp, G. G., Nayfield, S., Parkinson, D. R., Prasad, V. K., Prorok, P. C., Sausville, E. A., and Sigman, C. C. Clinical development plan: 2-difluromethylornithine (DFMO). J. Cell. Biochem., 20: 147-165, 1994.
30. Gerner, E. W., Garewal, H. W., Emerson, S. S., and Sampliner, R. E. Gastrointestinal tissue polyamine contents of patients with Barrett's esophagus treated with α-difluromethylornithine. Cancer Epidemiol. Biomark. Prev., 3: 325-330, 1994.
31. Fong, L. Y. Y., Lau, K. M., Huebner, K., and Magee, P. N. Induction of esophageal tumors in zinc-deficient rats by single low doses of N-nitrosomethylbenzylamine (NMBA): analysis of cell proliferation and mutations in H-ras and p53 genes. Carcinogenesis (Lond.), 18: 1477-1484, 1997.
32. Pegg, A. E., Wechter, R., Poulin, R., Woster, P. M., and Coward, J. K. Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate inhibitor of spermine synthase, on polyamine metabolism in mammalian cells. Biochemistry, 28: 8446-8453, 1989.
33. Seiler, N. Ion-pair partition chromatographic separation of polyamines and their monoacetyl derivatives. Methods Enzymol., 94: 25-29, 1983.
34. Bradford, M. A rapid sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72: 248-254, 1976.
35. Grasl-Krauupp, B., Ruttkay-Nedecky, B., Koudelka, H., Bukowska, K., Bursch, W., and Schulte-Hermann, R. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note. Hepatology, 21: 1465-1468, 1995.
36. Kerr, J. F. R., Winterford, C. M., and Harmon, B. V. Apoptosis, its significance in cancer and cancer therapy. Cancer (Phila.), 73: 2013-2026, 1994.
37. The GLM procedure. SAS/STAT User's Guide, Ed. 4, Vol. 2. Cary, NC: SAS Institute, Inc., 1989.
38. Armitage, P., and Berry, G. Statistical Methods in Medical Research, pp. 125-132. Oxford: Blackwell Scientific Publications, 1987.
39. Thompson, H. J., Herbst, L., Meeker, D., Minocha, R., Ronan, A. M., and Fite, R. Effect of D,L-α-difluoromethylornithine on murine mammary carcinogenesis. Carcinogenesis (Lond.), 12: 1649-1651, 1984.
40. Siglin, J. C., Khare, L., and Stoner, G. D. Evaluation of dose and treatment duration on the esophageal tumorigenicity of N-nitrosomethylbenzylamine in rats. Carcinogenesis (Lond.), 16: 259-265, 1995.
41. Lok, E., Nera, E. A., Iverson, F., Scott, F., So, Y., and Clayson, D. B. Dietary restriction, cell proliferation and carcinogenesis: a preliminary study. Cancer Lett., 38: 249-255, 1988.
42. Lok, E., Scott, F. W., Mongeau, R., Nera, E. A., Malcolm, S., and Clayson, D. B. Calorie restriction and cellular proliferation in various tissues of the female Swiss Webster mouse. Cancer Lett., 51: 67-73, 1990.
43. James, S. J., and Muskhelishvili, L. Rates of apoptosis and proliferation vary with caloric intake and may influence incidence of spontaneous hepatoma in C57BL/6 X C3H F1 mice. Cancer Res., 54: 5508-5510, 1994.
44. Sunderman, F. W. The influence of zinc on apoptosis (review). Ann. Clin. Lab. Sci., 25: 134-142, 1995.
45. Fraker, P. J., and Telford, W. G. A reappraisal of the role of zinc in life and death decisions of cells. Proc. Soc. Exp. Biol. Med., 215: 229-236, 1997.
46. Parchment, R. E. The implications of a unified theory of programmed cell death, polyamines, oxyradicals and histogenesis in the embryo. Int. J. Dev. Biol., 37: 75-83, 1993.
47. Poulin, R., Paterakis, A., Pelletier, G., and Pegg, A. E. Induction of apoptosis by excessive polyamine accumulation in ornithine decarboxylase overproducing L1210 cells under hypoosmotic stress. Biochem. J., 311: 23-27, 1995.
48. Kramer, D. L., Fogel-Petrovic, M., Diegelman, P., Cooley, J. M., Bernacki, R. J., McManis, J. S., Bergeron, R. J., and Porter, C. W. Effects of novel spermine analogues on cell cycle progression and apoptosis in MALME-3M human melanoma cells. Cancer Res., 57: 5521-5527, 1997.
49. Tome, M. E., Fiser, S. M., Payne, C. M., and Gerner, E. W. Excess putrescine accumulation inhibits the formation of modified eukaryotic factor 5A (eIF-5A) and induces apoptosis. Biochem. J., 328: 847-854, 1997.
50. Hu, R-H., and Pegg, A. E. Rapid induction of apoptosis by deregulated uptake of polyamine analogues. Biochem. J., 328: 307-316, 1997.
51. Ha, H. C., Woster, P. M., Yager, J. D., and Casero, R. A., Jr. The role of polyamine catabolism in polyamine analogue-induced programmed cell death. Proc. Natl. Acad. Sci. USA, 94: 11557-11562, 1997.
52. Packham, G., and Cleveland, J. L. Ornithine decarboxylase is a mediator of c-Myc-induced apoptosis. Mol. Cell. Biol., 14: 5741-5747, 1994.
53. Brüne, B., Hartzell, P., Nicotera, P., and Orrenius, S. Spermine prevents endonuclease activation and apoptosis in thymocytes. Exp. Cell Res., 195: 323-329, 1991.
54. Desiderio, M. A., Grassilli, E., Bellesia, E., Salomoni, P., and Franceschi, C. Involvement of ornithine decarboxylase and polyamines in glucocorticoid-induced apoptosis of rat thymocytes. Cell Growth Differ., 6: 505-513, 1995.
55. Harada, J., and Sugimoto, M. Polyamines prevent apoptotic cell death in cultured cerebellar granule neurons. Brain Res., 753: 251-259, 1997.
56. Min, A., Hasuma, T., Yano, Y., Matsui-Yasua, I., and Otani, S. Regulation of apoptosis of interleukin 2-dependent mouse T-cell line by protein tyrosine phosphorylation and polyamines. J. Cell. Physiol., 165: 615-623, 1995.
57. Mori, K., Hibasami, H., Satoh, N., Sonoda, J., Yamasaki, T., Tajima, M., Higuchi, S., Wakabayashi, H., Kaneko, H., Uchida, A., and Nakashima, K. Induction of apoptotic cell death in three human osteosarcoma cell lines by a polyamine synthesis inhibitor, methylglyoxal bis(cyclopentylamidinohydrazone) (MGBCP). Anticancer Res., 17: 2385-2390, 1997.
58. Kaneko, H., Hibasami, H., Mori, K., Kawarada, Y., and Nakashima, K. Apoptosis induction in human breast cancer MRK-nu-1 cells by a polyamine synthesis inhibitor, methylglyoxal bis (cyclopentylamidinohydrazone) (MGBCP). Anticancer Res., 18: 891-896, 1998.
59. Reed, J. C. Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance. Curr. Opin. Oncol., 7: 541-546, 1995.
60. Sarbia, M., Bittinger, F., Porschen, R., Verreet, P., Dutkowski, P., Willers, R., and Gabbert, H. E. bcl-2 expression and prognosis in squamous-cell carcinomas of the esophagus. Int. J. Cancer, 69; 324-328, 1996.
61. Sarbia, M., Bittinger, F., Grabellus, F., Verreet, P., Dutkowski, P., Willers, R., and Gabbert, H. E. Expression of bax, a pro-apoptotic member of the bcl-2 family, in esophageal squamous cell carcinoma. Int. J. Cancer, 73: 508-513, 1997.
62. Wyllie, A. H. Apoptosis and carcinogenesis. Eur. J. Cell Biol., 73: 189-197, 1997.
63. Lyons, S. K., and Clarke, A. R. Apoptosis and carcinogenesis. Br. Med. Bull., 52: 554-569, 1997.