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Volumn 38, Issue 4, 2003, Pages 978-988

Sex is a major determinant of CYP3A4 expression in human liver

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE; CARBAMAZEPINE; CYTOCHROME P450 3A4; GLYCOPROTEIN P; HYPERICUM PERFORATUM EXTRACT; MESSENGER RNA; OMEPRAZOLE; PANTOPRAZOLE; PREGNANE X RECEPTOR; PROTON PUMP INHIBITOR; VERAPAMIL; XENOBIOTIC AGENT;

EID: 0141532282     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2003.50393     Document Type: Article
Times cited : (448)

References (60)
  • 1
    • 0032924934 scopus 로고    scopus 로고
    • Cytochrome P-450 3A4: Regulation and role in drug metabolism
    • Guengerich FP. Cytochrome P-450 3A4: regulation and role in drug metabolism. Annu Rev Pharmacol Toxicol 1999;39:1-17.
    • (1999) Annu Rev Pharmacol Toxicol , vol.39 , pp. 1-17
    • Guengerich, F.P.1
  • 2
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • Evans WE, Relling MV. Pharmacogenomics: translating functional genomics into rational therapeutics. Science 1999;286:487-491.
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 3
    • 0035071598 scopus 로고    scopus 로고
    • Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
    • Kuehl P, Zhang J, Lin Y, Lamba J, Assem M, Schuerz J, Watkins PB, et al. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat Genet 2001;27:383-391.
    • (2001) Nat Genet , vol.27 , pp. 383-391
    • Kuehl, P.1    Zhang, J.2    Lin, Y.3    Lamba, J.4    Assem, M.5    Schuerz, J.6    Watkins, P.B.7
  • 5
    • 0035038008 scopus 로고    scopus 로고
    • Phenobarbital response elements of cytochrome P450 genes and nuclear receptors
    • , Sueyoshi T, Negishi M. Phenobarbital response elements of cytochrome P450 genes and nuclear receptors. Annu Rev Pharmacol Toxicol 2001;41: 123-143.
    • (2001) Annu Rev Pharmacol Toxicol , vol.41 , pp. 123-143
    • Sueyoshi, T.1    Negishi, M.2
  • 7
    • 0029128720 scopus 로고
    • Gender effects in pharmacokinetics and pharmacodynamics
    • Harris RZ, Benet LZ, Schwartz JB. Gender effects in pharmacokinetics and pharmacodynamics. Drugs 1995;50:222-239.
    • (1995) Drugs , vol.50 , pp. 222-239
    • Harris, R.Z.1    Benet, L.Z.2    Schwartz, J.B.3
  • 8
    • 0036290013 scopus 로고    scopus 로고
    • How important are gender differences in pharmacokinetics?
    • Meibohm B, Beierle I, Derendorf H. How important are gender differences in pharmacokinetics? Clin Pharmacokinet 2002;41:329-342.
    • (2002) Clin Pharmacokinet , vol.41 , pp. 329-342
    • Meibohm, B.1    Beierle, I.2    Derendorf, H.3
  • 9
    • 0036881095 scopus 로고    scopus 로고
    • Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein
    • Cummins CL, Wu CY, Benet LZ. Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein. Clin Pharmacol Ther 2002;72:474-489.
    • (2002) Clin Pharmacol Ther , vol.72 , pp. 474-489
    • Cummins, C.L.1    Wu, C.Y.2    Benet, L.Z.3
  • 11
    • 0024556650 scopus 로고
    • Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients
    • Watkins PB, Murray SA, Winkelman LG, Heuman DM, Wrighton SA, Guzelian PS. Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients. J Clin Invest 1989;83:688-697.
    • (1989) J Clin Invest , vol.83 , pp. 688-697
    • Watkins, P.B.1    Murray, S.A.2    Winkelman, L.G.3    Heuman, D.M.4    Wrighton, S.A.5    Guzelian, P.S.6
  • 12
    • 0018868749 scopus 로고
    • Intersubject and dose-related variability after intravenous administration of erythromycin
    • Austin KL, Mather LE, Philpot CR, McDonald PJ. Intersubject and dose-related variability after intravenous administration of erythromycin. Br J Clin Pharmacol 1980;10:273-279.
    • (1980) Br J Clin Pharmacol , vol.10 , pp. 273-279
    • Austin, K.L.1    Mather, L.E.2    Philpot, C.R.3    McDonald, P.J.4
  • 19
    • 0021222832 scopus 로고
    • Alterations in prednisolone disposition as a result of time of administration, gender and dose
    • Meffin PJ, Brooks PM, Sallustio BC. Alterations in prednisolone disposition as a result of time of administration, gender and dose. Br J Clin Pharmacol 1984;17:395-404.
    • (1984) Br J Clin Pharmacol , vol.17 , pp. 395-404
    • Meffin, P.J.1    Brooks, P.M.2    Sallustio, B.C.3
  • 20
    • 0036890995 scopus 로고    scopus 로고
    • A wide interindividual variability of urinary 6beta-hydroxycortisol to free cortisol in 487 healthy Japanese subjects in near basal condition
    • Inagaki K, Inagaki M, Kataoka T, Sekido I, Gill MA, Nishida M. A wide interindividual variability of urinary 6beta-hydroxycortisol to free cortisol in 487 healthy Japanese subjects in near basal condition. Ther Drug Monit 2002;24:722-727.
    • (2002) Ther Drug Monit , vol.24 , pp. 722-727
    • Inagaki, K.1    Inagaki, M.2    Kataoka, T.3    Sekido, I.4    Gill, M.A.5    Nishida, M.6
  • 21
    • 0026708362 scopus 로고
    • Effect of age and gender on the activity of human hepatic CYP3A
    • Hunt CM, Westerkam WR, Stave GM. Effect of age and gender on the activity of human hepatic CYP3A. Biochem Pharmacol 1992;44:275-283.
    • (1992) Biochem Pharmacol , vol.44 , pp. 275-283
    • Hunt, C.M.1    Westerkam, W.R.2    Stave, G.M.3
  • 23
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 1994;270:414-423.
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 25
    • 0029128788 scopus 로고
    • Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver
    • George J, Byth K, Farrell GC. Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver. Biochem Pharmacol 1995;50:727-730.
    • (1995) Biochem Pharmacol , vol.50 , pp. 727-730
    • George, J.1    Byth, K.2    Farrell, G.C.3
  • 26
    • 0029760232 scopus 로고    scopus 로고
    • Interindividual variability in catalytic activity and immunoreactivity of three major human liver cytochrome P450 isozymes
    • Transon C, Lecoeur S, Leemann T, Beaune P, Dayer P. Interindividual variability in catalytic activity and immunoreactivity of three major human liver cytochrome P450 isozymes. Eur J Clin Pharmacol 1996;51:79-85.
    • (1996) Eur J Clin Pharmacol , vol.51 , pp. 79-85
    • Transon, C.1    Lecoeur, S.2    Leemann, T.3    Beaune, P.4    Dayer, P.5
  • 27
    • 0029028792 scopus 로고
    • Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
    • Wacher VJ, Wu CY, Benet LZ. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol Carcinog 1995;13:129-134.
    • (1995) Mol Carcinog , vol.13 , pp. 129-134
    • Wacher, V.J.1    Wu, C.Y.2    Benet, L.Z.3
  • 30
    • 0029616617 scopus 로고
    • Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms
    • Schuetz EG, Furuya KN, Schuetz JD. Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms. J Pharmacol Exp Ther 1995;275:1011-1018.
    • (1995) J Pharmacol Exp Ther , vol.275 , pp. 1011-1018
    • Schuetz, E.G.1    Furuya, K.N.2    Schuetz, J.D.3
  • 31
    • 0036206856 scopus 로고    scopus 로고
    • Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein
    • Wandel C, Kim R, Wood M, Wood A. Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein. Anesthesiology 2002;96:913-920.
    • (2002) Anesthesiology , vol.96 , pp. 913-920
    • Wandel, C.1    Kim, R.2    Wood, M.3    Wood, A.4
  • 32
    • 0034976635 scopus 로고    scopus 로고
    • Heterotropic cooperativity of cytochrome P450 3A4 and potential drug-drug interactions
    • Tang W, Stearns RA. Heterotropic cooperativity of cytochrome P450 3A4 and potential drug-drug interactions. Curr Drug Metab 2001;2:185-198.
    • (2001) Curr Drug Metab , vol.2 , pp. 185-198
    • Tang, W.1    Stearns, R.A.2
  • 33
    • 0024269576 scopus 로고
    • Positive effectors of the binding of an active site-directed amino steroid to rabbit cytochrome P-450 3c
    • Johnson EF, Schwab GE, Vickery LE. Positive effectors of the binding of an active site-directed amino steroid to rabbit cytochrome P-450 3c. J Biol Chem 1988;263:17672-17677.
    • (1988) J Biol Chem , vol.263 , pp. 17672-17677
    • Johnson, E.F.1    Schwab, G.E.2    Vickery, L.E.3
  • 34
    • 0034948077 scopus 로고    scopus 로고
    • Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver
    • Lang T, Klein K, Fischer J, Nussler AK, Neuhaus P, Hofmann U, Eichelbaum M, et al. Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver. Pharmacogenetics 2001;11:399-415.
    • (2001) Pharmacogenetics , vol.11 , pp. 399-415
    • Lang, T.1    Klein, K.2    Fischer, J.3    Nussler, A.K.4    Neuhaus, P.5    Hofmann, U.6    Eichelbaum, M.7
  • 35
    • 50449100139 scopus 로고
    • The carbon monoxide-binding pigment of liver microsomes
    • Omura T, Sato R. The carbon monoxide-binding pigment of liver microsomes. J Biol Chem 1964;239:2379-2385.
    • (1964) J Biol Chem , vol.239 , pp. 2379-2385
    • Omura, T.1    Sato, R.2
  • 36
    • 0035047478 scopus 로고    scopus 로고
    • A rapid and simple method for sex identification by heteroduplex analysis, using denaturing high-performance liquid chromatography (DHPLC)
    • Shinka T, Naroda T, Tamura T, Sasahara K, Nakahori Y. A rapid and simple method for sex identification by heteroduplex analysis, using denaturing high-performance liquid chromatography (DHPLC). J Hum Genet 2001;46:263-266.
    • (2001) J Hum Genet , vol.46 , pp. 263-266
    • Shinka, T.1    Naroda, T.2    Tamura, T.3    Sasahara, K.4    Nakahori, Y.5
  • 37
    • 0032766430 scopus 로고    scopus 로고
    • Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene
    • Kawamoto T, Sueyoshi T, Zelko I, Moore R, Washburn K, Negishi M. Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol Cell Biol 1999;19:6318-6322.
    • (1999) Mol Cell Biol , vol.19 , pp. 6318-6322
    • Kawamoto, T.1    Sueyoshi, T.2    Zelko, I.3    Moore, R.4    Washburn, K.5    Negishi, M.6
  • 38
    • 0033955502 scopus 로고    scopus 로고
    • Rapid and highly sensitive method for the determination of verapamil, [2H7]verapamil and metabolites in biological fluids by liquid chromatography-mass spectrometry
    • von Richter O, Eichelbaum M, Schonberger F, Hofmann U. Rapid and highly sensitive method for the determination of verapamil, [2H7]verapamil and metabolites in biological fluids by liquid chromatography-mass spectrometry. J Chromatogr B Biomed Sci Appl 2000;738: 137-147.
    • (2000) J Chromatogr B Biomed Sci Appl , vol.738 , pp. 137-147
    • Von Richter, O.1    Eichelbaum, M.2    Schonberger, F.3    Hofmann, U.4
  • 39
    • 0036786382 scopus 로고    scopus 로고
    • Intetindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA
    • Koch I, Weil R, Wolbold R, Brockmoller J, Hustert E, Burk O, Nuessler A, et al. Intetindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA. Drug Metab Dispos 2002;30:1108-1114.
    • (2002) Drug Metab Dispos , vol.30 , pp. 1108-1114
    • Koch, I.1    Weil, R.2    Wolbold, R.3    Brockmoller, J.4    Hustert, E.5    Burk, O.6    Nuessler, A.7
  • 41
    • 0029591169 scopus 로고
    • Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans
    • Busse D, Cosme J, Beaune P, Kroemer HK, Eichelbaum M. Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol 1995;353:116-121.
    • (1995) Naunyn Schmiedebergs Arch Pharmacol , vol.353 , pp. 116-121
    • Busse, D.1    Cosme, J.2    Beaune, P.3    Kroemer, H.K.4    Eichelbaum, M.5
  • 42
    • 0032897280 scopus 로고    scopus 로고
    • Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil
    • Tracy TS, Korzekwa KR, Gonzalez FJ, Wainer IW. Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil. Br J Clin Pharmacol 1999;47:545-552.
    • (1999) Br J Clin Pharmacol , vol.47 , pp. 545-552
    • Tracy, T.S.1    Korzekwa, K.R.2    Gonzalez, F.J.3    Wainer, I.W.4
  • 47
    • 0031960329 scopus 로고    scopus 로고
    • Human cytochrome P450 3A (CYP3A) mediated midazolam metabolism: The effect of assay conditions and regioselective stimulation by alpha-naphthoflavone, terfenadine and testosterone
    • Maenpaa J, Hall SD, Ring BJ, Strom SC, Wrighton SA. Human cytochrome P450 3A (CYP3A) mediated midazolam metabolism: the effect of assay conditions and regioselective stimulation by alpha-naphthoflavone, terfenadine and testosterone. Pharmacogenetics 1998;8:137-155.
    • (1998) Pharmacogenetics , vol.8 , pp. 137-155
    • Maenpaa, J.1    Hall, S.D.2    Ring, B.J.3    Strom, S.C.4    Wrighton, S.A.5
  • 49
    • 0029880041 scopus 로고    scopus 로고
    • The effects of menopause and hormone replacement therapies on prednisolone and erythromycin pharmacokinetics
    • Harris RZ, Tsunoda SM, Mroczkowski P, Wong H, Benet LZ. The effects of menopause and hormone replacement therapies on prednisolone and erythromycin pharmacokinetics. Clin Pharmacol Ther 1996;59:429-435.
    • (1996) Clin Pharmacol Ther , vol.59 , pp. 429-435
    • Harris, R.Z.1    Tsunoda, S.M.2    Mroczkowski, P.3    Wong, H.4    Benet, L.Z.5
  • 50
    • 0031706585 scopus 로고    scopus 로고
    • Quantification of 3-month intraindividual variability and the influence of sex and menstrual cycle phase on CYP3A activity as measured by phenotyping with intravenous midazolam
    • Kashuba AD, Bertino JS Jr, Rocci ML Jr, Kulawy RW, Beck DJ, Nafziger AN. Quantification of 3-month intraindividual variability and the influence of sex and menstrual cycle phase on CYP3A activity as measured by phenotyping with intravenous midazolam. Clin Pharmacol Ther 1998;64:269-277.
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 269-277
    • Kashuba, A.D.1    Bertino J.S., Jr.2    Rocci M.L., Jr.3    Kulawy, R.W.4    Beck, D.J.5    Nafziger, A.N.6
  • 51
    • 0033358528 scopus 로고    scopus 로고
    • STAT5 signaling in sexually dimorphic gene expression and growth patterns
    • Davey HW, Witkins RJ, Waxman DJ. STAT5 signaling in sexually dimorphic gene expression and growth patterns. Am J Hum Genet 1999;65:959-965.
    • (1999) Am J Hum Genet , vol.65 , pp. 959-965
    • Davey, H.W.1    Witkins, R.J.2    Waxman, D.J.3
  • 52
    • 0031948975 scopus 로고    scopus 로고
    • Sex-dependent metabolism of xenobiotics
    • Mugford CA, Kedderis GL. Sex-dependent metabolism of xenobiotics. Drug Metab Rev 1998;30:441-498.
    • (1998) Drug Metab Rev , vol.30 , pp. 441-498
    • Mugford, C.A.1    Kedderis, G.L.2
  • 53
    • 0025341075 scopus 로고
    • Basal plasma growth hormone levels in man: New evidence for rhythmicity of growth hormone secretion
    • Winer LM, Shaw MA, Baumann G. Basal plasma growth hormone levels in man: new evidence for rhythmicity of growth hormone secretion. J Clin Endocrinol Metab 1990;70:1678-1686.
    • (1990) J Clin Endocrinol Metab , vol.70 , pp. 1678-1686
    • Winer, L.M.1    Shaw, M.A.2    Baumann, G.3
  • 55
    • 0037327003 scopus 로고    scopus 로고
    • The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4
    • Tirona RG, Lee W, Leake BF, Lan LB, Cline CB, Lamba V, Parviz F, et al. The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4. Nat Med 2003;9:220-224.
    • (2003) Nat Med , vol.9 , pp. 220-224
    • Tirona, R.G.1    Lee, W.2    Leake, B.F.3    Lan, L.B.4    Cline, C.B.5    Lamba, V.6    Parviz, F.7
  • 56
    • 0034456218 scopus 로고    scopus 로고
    • Involvement of STAT5 (signal transducer and activator of transcription 5) and HNF-4 (hepatocyte nuclear factor 4) in the transcriptional control of the hnf6 gene by growth hormone
    • Lahuna O, Rastegar M, Maiter D, Thissen JP, Lemaigre FP, Rousseau GG. Involvement of STAT5 (signal transducer and activator of transcription 5) and HNF-4 (hepatocyte nuclear factor 4) in the transcriptional control of the hnf6 gene by growth hormone. Mol Endocrinol 2000;14:285-294.
    • (2000) Mol Endocrinol , vol.14 , pp. 285-294
    • Lahuna, O.1    Rastegar, M.2    Maiter, D.3    Thissen, J.P.4    Lemaigre, F.P.5    Rousseau, G.G.6
  • 57
    • 0029815563 scopus 로고    scopus 로고
    • Clinically significant pharmacokinetic drug interactions with carbamazepine. An update
    • Spina E, Pisani F, Perucca E. Clinically significant pharmacokinetic drug interactions with carbamazepine. An update. Clin Pharmacokinet 1996; 31:198-214.
    • (1996) Clin Pharmacokinet , vol.31 , pp. 198-214
    • Spina, E.1    Pisani, F.2    Perucca, E.3
  • 59
    • 0034827301 scopus 로고    scopus 로고
    • Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes
    • Drocourt L, Pascussi JM, Assenat E, Fabre JM, Maurel P, Vilarem MJ. Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes. Drug Metab Dispos 2001;29:1325-1331.
    • (2001) Drug Metab Dispos , vol.29 , pp. 1325-1331
    • Drocourt, L.1    Pascussi, J.M.2    Assenat, E.3    Fabre, J.M.4    Maurel, P.5    Vilarem, M.J.6
  • 60
    • 0027198952 scopus 로고
    • Women in clinical trials of new drugs. A change in Food and Drug Administration policy
    • The Working Group on Women in Clinical Trials
    • Merkatz RB, Temple R, Subel S, Feiden K, Kessler DA. Women in clinical trials of new drugs. A change in Food and Drug Administration policy. The Working Group on Women in Clinical Trials. N Engl J Med 1993;329: 292-296.
    • (1993) N Engl J Med , vol.329 , pp. 292-296
    • Merkatz, R.B.1    Temple, R.2    Subel, S.3    Feiden, K.4    Kessler, D.A.5


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