Effects of endogenous steroids on CYP3A4-mediated drug metabolism by human liver microsomes

Drug Metabolism and Disposition

Volumn 30, Issue 5, 2002, Pages 534-540

  Nakamura, Hiroyoshi ^a   Nakasa, Hiromitsu ^a   Ishii, Itsuko ^b   Ariyoshi, Noritaka ^a   Igarashi, Takashi ^c   Ohmori, Shigeru ^d   Kitada, Mitsukazu ^a  

^a CHIBA UNIVERSITY HOSPITAL   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c NIPPON BOEHRINGER INGELHEIM CO LTD   (Japan)

^d SHINSHU UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1' HYDROXYTRIAZOLAM; 12 HYDROXYNEVIRAPINE; 17 HYDROXYPREGNENOLONE; 2 HYDROXYNEVIRAPINE; 2 SULFAMOYLACETYLPHENOL; 4 HYDROXYTRIAZOLAM; ALDOSTERONE; ANDROSTENEDIONE; CARBAMAZEPINE; CARBAMAZEPINE 10,11 OXIDE; CYTOCHROME P450 3A4; EPOXIDASE; ERYTHROMYCIN; ESTRONE; HYDROCORTISONE; HYDROXYPROGESTERONE; METHYLTRANSFERASE; NEVIRAPINE; OXIDOREDUCTASE; OXYGENASE; PHENOL DERIVATIVE; PRASTERONE; PRASTERONE SULFATE; PREGNENOLONE; PREGNENOLONE SULFATE; PROGESTERONE; STEROID; TESTOSTERONE; TRIAZOLAM; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ADULT; ARTICLE; CASE REPORT; CONTROLLED STUDY; DEMETHYLATION; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME KINETICS; EPOXIDATION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LIVER MICROSOME; MALE; PRIORITY JOURNAL;

ADULT; CARBAMAZEPINE; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; EPOXY COMPOUNDS; ERYTHROMYCIN; HUMANS; HYDROXYLATION; ISOXAZOLES; KINETICS; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; NEVIRAPINE; PHARMACEUTICAL PREPARATIONS; PHENOLS; STEROIDS; SULFONAMIDES; TRIAZOLAM;

SIGMOIDEA;

EID: 0036239627     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.30.5.534     Document Type: Article

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