Quantification of 3-month intraindividual variability and the influence of sex and menstrual cycle phase on CYP3A activity as measured by phenotyping with intravenous midazolam

Clinical Pharmacology and Therapeutics

Volumn 64, Issue 3, 1998, Pages 269-277

  Kashuba, Angela D M ^b   Bertino Jr , Joseph S ^b   Rocci Jr , Mario L ^b   Kulawy, Robert W ^b   Beck, Debra J ^b   Nafziger, Anne N ^a  

^a BASSETT RESEARCH INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; MIDAZOLAM;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; ENZYME ACTIVITY; FEMALE; FOLLICULAR PHASE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LUTEAL PHASE; MALE; MENSTRUAL CYCLE; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; SEX DIFFERENCE; STATISTICAL ANALYSIS;

ADULT; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; FOLLICULAR PHASE; HUMANS; HYDROXYLATION; HYPNOTICS AND SEDATIVES; INFUSIONS, INTRAVENOUS; LUTEAL PHASE; MALE; MENSTRUAL CYCLE; MIDAZOLAM; MIDDLE AGED; OXIDOREDUCTASES, N-DEMETHYLATING; PHENOTYPE; REFERENCE VALUES; SEX CHARACTERISTICS; TIME FACTORS;

EID: 0031706585     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-9236(98)90175-8     Document Type: Article

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