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Current Drug Metabolism

Volumn 2, Issue 2, 2001, Pages 185-198

Heterotropic cooperativity of cytochrome P450 3A4 and potential drug-drug interactions

(2) Tang, Wei a Stearns, Ralph A a

a MERCK RESEARCH LABORATORIES (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFLATOXIN B1; ALPHA NAPHTHOFLAVONE; BENZO[A]PYRENE; CARBAMAZEPINE; CYTOCHROME P450 3A4; DEXTROMETHORPHAN; DIAZEPAM; DICLOFENAC; FLAVONE; ISOPROTEIN; LIGAND; LIVER ENZYME; LOSARTAN; MIDAZOLAM; NEW DRUG; PHENANTHRENE; PROGESTERONE; QUINIDINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; TANGERETIN; WARFARIN; WATER; ZOXAZOLAMINE;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG STRUCTURE; DRUG TRANSFORMATION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME METABOLISM; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; HYDROXYLATION; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; LIGAND BINDING; LIVER CELL; LIVER CLEARANCE; LIVER TOXICITY; MONKEY; NONHUMAN; RAT; RISK ASSESSMENT; TRANSPORT KINETICS;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; HUMANS; LIVER; MIXED FUNCTION OXYGENASES; PHARMACEUTICAL PREPARATIONS;

EID: 0034976635 PISSN: 13892002 EISSN: None Source Type: Journal
DOI: 10.2174/1389200013338658 Document Type: Article

Times cited : (147)

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