Chronopharmacology of intravenous and oral modified release verapamil

British Journal of Clinical Pharmacology

Volumn 47, Issue 4, 1999, Pages 413-419

  Dilger, Karin ^a   Eckhardt, Klaus ^a   Hofmann, Ute ^a   Kucher, Klaus ^b   Mikus, Gerd ^a   Eichelbaum, Michel ^a  

^a Dr Margarete F B I fur K P   (Germany)

^b Knoll AG   (Germany)

Author keywords

Chronopharmacology; Presystemic metabolism; Stable isotope technique; Verapamil

Indexed keywords

VERAPAMIL;

ADULT; AREA UNDER THE CURVE; ARTICLE; CHRONOPHARMACOLOGY; CIRCADIAN RHYTHM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG FORMULATION; ENANTIOMER; FEMALE; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; MALE; MASS SPECTROMETRY; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PHARMACODYNAMICS; PR INTERVAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0032907609     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1999.00910.x     Document Type: Article

References (23)

1. 1 Lemmer B, Bruguerolle B. Chronopharmacokenetics. Arc they clinically relevant? Clin Pharmacokinet 1994; 26: 419-427.
2. 2 Belanger PM. Chronopharmacology in drug research and therapy. Adv Drug Res 1993; 24: 1-80.
3. 3 Goo RH, Moore JG, Greenberg E, Alazraki NP. Circadian variation in gastric emptying of meals in humans. Gastroenterology 1987; 93: 515-518.
4. 4 Lemmer B, Nold G. Circadian changes in estimated hepatic blood flow in healthy subjects. Br J Clin Pharmacol 1991; 32: 627-629.
5. 5 Lemmer B, Nold G, Behne S, Kaiser R. Chronopharmacokinetics and cardiovascular effects of nifedipine. Chronobiol Int 1991; 8: 485-494.
6. 6 Krishna DR, Klotz U. Extrahepathic melabolism of drugs in humans. Clin Pharmacokinet 1994; 26: 144-160.
7. 7 Jespersen CM, Frederiksen M, Hansen JF, Klitgaard NA, Sorum C. Circadian variation in the pharmacokinetics of verapamil. Eur J Clin Pharmacol 1989; 37: 613-615.
8. 8 Eichelbaum M, Somogyi A, von Unruh GE, Dengler HJ. Simultaneous determination of the intravenous and oral pharmacokinetic parameters of D,L verapamil using stable isotope-labelled verapamil. Eur J Clin Pharmacol 1981; 19: 133-137.
9. 9 Back DJ, Orme MLE. Pharmacokinetic drug interactions with oral contraceptives. Clin Pharmacokenet 1990; 18: 472-484.
10. 10 Mikus G, Eichelbaum M, Fischer C, Gumulka S, Klotz U, Kroemer HK. Interaction of verapamil and cimetidine: stereochemical aspects of drug metabolism, drug disposition and drug action. J Pharmacol Exp Ther 1990; 253: 1042-1048.
11. 11 Fischer C, Schönberger F, Mück W, Heuck K, Eichelbaum M. Simultaneous assessment of the intravenous and oral disposition of the enantiomers of racemic nimodipine by chiral stationary-phase high-performance liquid chromatography and gas chromatography/mass spectroscopy combined with a stable isotope technique. J Pharm Sci 1993; 82: 244-250.
12. 12 Somogyi A, Eichelbaum M, Gugler R. Prediction of bioavailability for drugs with a high first pass effect using oral clearance data. Eur J Clin Pharmacol 1982; 22: 85-90.
13. 13 Wynne HA, Cope LH, Mutch E, Rawlins MD, Woodhouse KW, James OFW. The effect of age upon liver volume and apparent liver blood flow in healthy men. Hepatology 1989; 9: 297-301.
14. 14 Echizen H, Brecht T, Niedergesäss S, Vogelgesang B, Eichelbaum M. The effect of dextro-, levo-, and racemic verapamil on atrioventricular conduction in humans. Am Heart J 1985; 109: 210-217.
15. 15 Ohdo S, Nakano S, Ogawa N. Circadian changes of valproate kinetics depending on meal condition in humans. J Clin Pharmacol 1992; 32: 822-826.
16. 16 Henry JA, Hla KK, Volans G, Latham AN, Bhamra R. Influence of time of dosing on the pharmacokenetics and pharmacodynamics of sustained release verapamil. Br J Clin Pharmacol 1988; 25: 97P-98P.
17. 17 Hla KK, Litham AN, Henry JA. Influence of time of administration on verapamil pharmacokenetics. Clin Pharmacol Ther 1992; 51: 366-370.
18. 18 Eldon MA, Battle MM, Voigtman RE, Colburn WA. Differences in oral verapamil absorption as a function of time of day. J Clin Pharmacol 1989; 29: 989-993.
19. 19 Gupta SK, Yih BM, Atkinson L, Longstreth J. The effect of food, time of dosing, and body position on the pharmacokenetics and pharmacodynamics of verapamil and norverapamil. J Clin Pharmacol 1995; 35: 1083-1093.
20. 20 Schmucker DL, Vesell ES. Underrepresentation of women in clinical drug trials. Clin Pharmacol Ther 1993; 54: 11-15.
21. 21 Sasaki M, Tateishi T, Ebihara A. The effects of age and gender on the stereoselective pharmacokinetics of verapamil. Clin Pharmacol Ther 1993; 54: 278-285.
22. 22 Gupta SK, Atkinson L, Tu T, Longstreth JA. Age and gender related changes in stereoselective pharmacokenetics and pharmacodynamics of verapamil and norverapamil. Br J Clin Pharmacol 1995; 40: 325-331.
23. 23 Schwartz JB, Capili H, Wainer IW. Verapamil stereoisomers during racemic verapamil administration: Effects of aging and comparisons to administration of individual stereoisomers. Clin Pharmacol Ther 1994; 56: 368-376.