Interindividual variability in catalytic activity and immunoreactivity of three major human liver cytochrome P450 isozymes

European Journal of Clinical Pharmacology

Volumn 51, Issue 1, 1996, Pages 79-85

  Transon, C ^a   Lecoeur, S ^b   Leemann, T ^a   Beaune, P ^b   Dayer, P ^a  

^a University Hospital   (Switzerland)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

Catalytic activity; CYP2C9; CYP2D6; CYP3A4; Cytochrome P450; Drug metabolism; Human liver microsomes; Immunoreactivity; Interindividual variability

Indexed keywords

CYTOCHROME P450 ISOENZYME; DEXTROMETHORPHAN; DICLOFENAC; DRUG METABOLIZING ENZYME; LIVER ENZYME; MIDAZOLAM; UNSPECIFIC MONOOXYGENASE;

ARTICLE; CATALYSIS; DEMETHYLATION; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME KINETICS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; LIVER MICROSOME; MALE; PRIORITY JOURNAL;

ADULT; AGE FACTORS; ANESTHETICS, INTRAVENOUS; ANIMALS; ANTITUSSIVE AGENTS; ARYL HYDROCARBON HYDROXYLASES; CYCLOOXYGENASE INHIBITORS; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 ENZYME SYSTEM; DEXTROMETHORPHAN; DICLOFENAC; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; HYDROXYLATION; ISOENZYMES; MALE; METHYLATION; MICE; MICROSOMES, LIVER; MIDAZOLAM; MIXED FUNCTION OXYGENASES; RABBITS; REGRESSION ANALYSIS; SEX FACTORS; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES;

EID: 0029760232     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280050164     Document Type: Article

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