Growth hormone secretion pattern is an independent regulator of growth hormone actions in humans

American Journal of Physiology - Endocrinology and Metabolism

Volumn 283, Issue 5 46-5, 2002, Pages

  Jaffe, Craig A ^a,b   Kim Turgeon, D ^a   Lown, Kenneth ^a,b   Demott Friberg, Roberta ^b   Watkins, Paul B ^c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Bone; Cytochrome P 450; Insulin like growth factor I; Sex characteristics

Indexed keywords

CAFFEINE; DEOXYPYRIDINOLINE; ERYTHROMYCIN; GROWTH HORMONE; OSTEOCALCIN; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 1;

ARTICLE; BLOOD LEVEL; BONE METABOLISM; BREATH ANALYSIS; CLINICAL ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GROWTH HORMONE RELEASE; HORMONAL REGULATION; HORMONE ACTION; HUMAN; MALE; OSSIFICATION; OSTEOLYSIS; PRIORITY JOURNAL; PULSATILE HORMONE RELEASE; SEX DIFFERENCE;

EID: 0036838944     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00513.2001     Document Type: Article

References (51)

1. Achermann JC, Brook CG, Robinson IC, Matthews DR, and Hindmarsh PC. Peak and trough growth hormone (GH) concentrations influence growth and serum insulin like growth factor-1 (IGF-1) concentrations in short children. Clin Endocrinol (Oxf) 50: 301-308, 1999.
2. Beierle I, Meibohm B, and Derendorf H. Gender differences in pharmacokinetics and pharmacodynamics. Int J Clin Pharmacol Ther 37: 529-547, 1999.
3. Biller BM, Sesmilo G, Baum HB, Hayden D, Schoenfeld D, and Klibanski A. Withdrawal of long-term physiological growth hormone (GH) administration: differential effects on bone density and body composition in men with adult-onset GH deficiency. J Clin Endocrinol Metab 85: 970-976, 2000.
4. Carrillo JA and Benitez J. CYP1A2 activity, gender and smoking, as variables influencing the toxicity of caffeine. Br J Clin Pharmacol 41: 605-608, 1996.
5. Cheung NW, Liddle C, Coverdale S, Lou JC, and Boyages SC. Growth hormone treatment increases cytochrome P450-mediated antipyrine clearance in man. J Clin Endocrinol Metab 81: 1999-2001, 1996.
6. Choi HK and Waxman DJ. Growth hormone, but not prolactin, maintains low-level activation of STAT5a and STAT5b in female rat liver. Endocrinology 140: 5126-5135, 1999.
7. Choi HK and Waxman DJ. Pulsatility of growth hormone (GH) signalling in liver cells: Role of the JAK-STAT5b pathway in GH action. Growth Horm IGF Res 10, Suppl B: S1-S8, 2000.
8. Christ ER, Cummings MH, Westwood NB, Sawyer BM, Pearson TC, Sonksen PH, and Russell-Jones DL. The importance of growth hormone in the regulation of erythropoiesis, red cell mass, and plasma volume in adults with growth hormone deficiency. J Clin Endocrinol Metab 82: 2985-2990, 1997.
9. Clark RG and Robinson IC. Growth induced by pulsatile infusion of an amidated fragment of human growth hormone releasing factor in normal and GHRF-deficient rats. Nature 314: 281-283, 1985.
10. Davey HW, Park SH, Grattan DR, McLachlan MJ, and Waxman DJ. STAT5b-deficient mice are growth hormone pulseresistant. Role of STAT5b in sex-specific liver p450 expression. J Biol Chem 274: 35331-35336, 1999.
11. Eden S. Age- and sex-related differences in episodic growth hormone secretion in the rat. Endocrinology 105: 555-560, 1979.
12. Gebert CA, Park SH, and Waxman DJ. Down-regulation of liver JAK2-STAT5b signaling by the female plasma pattern of continuous growth hormone stimulation. Mol Endocrinol 13: 213-227, 1999.
13. Gebert CA, Park SH, and Waxman DJ. Regulation of signal transducer and activator of transcription (STAT) 5b activation by the temporal pattern of growth hormone stimulation. Mol Endocrinol 11: 400-414, 1997.
14. Hindmarsh PC, Dennison E, Pincus SM, Cooper C, Fall CH, Matthews DR, Pringle PJ, and Brook CG. A sexually dimorphic pattern of growth hormone secretion in the elderly. J Clin Endocrinol Metab 84: 2679-2685, 1999.
15. Husman B, Norstedt G, Mode A, and Gustafsson JA. The mode of growth hormone administration is of major importance for the excretion of the major male rat urinary proteins. Mol Cell Endocrinol 40: 205-210, 1985.
16. Isgaard J, Carlsson L, Isaksson OG, and Jansson JO. Pulsatile intravenous growth hormone (GH) infusion to hypophysectomized rats increases insulin-like growth factor I messenger ribonucleic acid in skeletal tissues more effectively than continuous GH infusion. Endocrinology 123: 2605-2610, 1988.
17. Isgaard J, Moller C, Isaksson OG, Nilsson A, Mathews LS, and Norstedt G. Regulation of insulin-like growth factor messenger ribonucleic acid in rat growth plate by growth hormone. Endocrinology 122: 1515-1520, 1988.
18. Jaffe CA, Ocampo-Lim B, Guo W, Krueger K, Sugahara I, DeMott-Friberg R, Bermann M, and Barkan AL. Regulatory mechanisms of growth hormone secretion are sexually dimorphic. J Clin Invest 102: 153-164, 1998.
19. Jaffe CA, Turgeon DK, Friberg RD, Watkins PB, and Barkan AL. Nocturnal augmentation of growth hormone (GH) secretion is preserved during repetitive bolus administration of GH-releasing hormone: Potential involvement of endogenous somatostatin - A clinical research center study. J Clin Endocrinol Metab 80: 3321-3326, 1995.
20. Jansson JO, Ekberg S, Hoath SB, Beamer WG, and Frohman LA. Growth hormone enhances hepatic epidermal growth factor receptor concentration in mice. J Clin Invest 82: 1871-1876, 1988.
21. Jeffery S, Carter ND, Clark RG, and Robinson IC. The episodic secretory pattern of growth hormone regulates liver carbonic anhydrase III. Studies in normal and mutant growthhormone-deficient dwarf rats. Biochem J 266: 69-74, 1990.
22. Johnson D, al-Shawi R, and Bishop JO. Sexual dimorphism and growth hormone induction of murine pheromone-binding proteins. J Mol Endocrinol 14: 21-34, 1995.
23. Jorgensen JO, Blum WF, Moller N, Ranke MB, and Christiansen JS. Short-term changes in serum insulin-like growth factors (IGF) and IGF binding protein 3 after different modes of intravenous growth hormone (GH) exposure in GH-deficient patients. J Clin Endocrinol Metab 72: 582-587, 1991.
24. Jorgensen JO, Moller N, Lauritzen T, and Christiansen JS. Pulsatile versus continuous intravenous administration of growth hormone (GH) in GH-deficient patients: Effects on circulating insulin-like growth factor-I and metabolic indices. J Clin Endocrinol Metab 70: 1616-1623, 1990.
25. Kearns GL, Kemp SF, and Frindik JP. Single and multiple dose pharmacokinetics of methionyl growth hormone in children with idiopathic growth hormone deficiency. J Clin Endocrinol Metab 72: 1148-1156, 1991.
26. Lambert GH, Schoeller DA, Kotake AN, Flores C, and Hay D. The effect of age, gender, and sexual maturation on the caffeine breath test. Dev Pharmacol Ther 9: 375-388, 1986.
27. Lan LB, Dalton JT, and Schuetz EG. Mdr1 limits CYP3A metabolism in vivo. Mol Pharmacol 58: 863-869, 2000.
28. Landi MT, Sinha R, Lang NP, and Kadlubar FF. Human cytochrome P4501A2. IARC Sci Publ (Lyon): 173-195, 1999.
29. Laursen T, Gravholt CH, Heickendorff L, Drustrup J, Kappelgaard AM, Jorgensen JO, and Christiansen JS. Long-term effects of continuous subcutaneous infusion versus daily subcutaneous injections of growth hormone (GH) on the insulin-like growth factor system, insulin sensitivity, body composition, and bone and lipoprotein metabolism in GH-deficient adults. J Clin Endocrinol Metab 86: 1222-1228, 2001.
30. 2 breath test. Dev Pharmacol Ther 12: 90-95, 1989.
31. Liddle C, Goodwin BJ, George J, Tapner M, and Farrell GC. Separate and interactive regulation of cytochrome P450 3A4 by triiodothyronine, dexamethasone, and growth hormone in cultured hepatocytes. J Clin Endocrinol Metab 83: 2411-2416, 1998.
32. Low MJ, Otero-Corchon V, Parlow AF, Ramirez JL, Kumar U, Patel YC, and Rubinstein M. Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth. J Clin Invest 107: 1571-1580, 2001.
33. Mode A, Ahlgren R, Lahuna O, and Gustafsson JA. Gender differences in rat hepatic CYP2C gene expression-regulation by growth hormone. Growth Horm IGF Res 8, Suppl B: 61-67, 1998.
34. Oscarsson J, Carlsson LM, Bick T, Lidell A, Olofsson SO, and Eden S. Evidence for the role of the secretory pattern of growth hormone in the regulation of serum concentrations of cholesterol and apolipoprotein E in rats. J Endocrinol 128: 433-438, 1991.
35. Park SH, Liu X, Hennighausen L, Davey HW, and Waxman DJ. Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption. J Biol Chem 274: 7421-7430, 1999.
36. Relling MV, Lin JS, Ayers GD, and Evans WE. Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2 activities. Clin Pharmacol Ther 52: 643-658, 1992.
37. Reutens AT, Veldhuis JD, Hoffman DM, Leung KC, and Ho KK. A highly sensitive growth hormone (GH) enzyme-linked immunosorbent assay uncovers increased contribution of a tonic mode of GH secretion in adults with organic GH deficiency. J Clin Endocrinol Metab 81: 1591-1597, 1996.
38. Rifkind AB, Saenger P, Levine LS, Pareira J, and New MI. Effects of growth hormone on antipyrine kinetics in children. Clin Pharmacol Ther 30: 127-132, 1981.
39. Rivory LP and Watkins PB. Erythromycin breath test (letter). Clin Pharmacol Ther. 70: 395-399, 2001.
40. Sakuma T, Yokoi T, and Kamataki T. Hormonal regulation of the mRNA level of male-dominant cytochrome P450 (CYP2C27) in hamster livers. Pharmacol Res 31: 371-374, 1995.
41. Sjoberg A, Oscarsson J, Eden S, and Olofsson SO. Continuous but not intermittent administration of growth hormone to hypophysectomized rats increases apolipoprotein-E secretion from cultured hepatocytes. Endocrinology 134: 790-798, 1994.
42. Subramanian A, Wang J, and Gil G. STAT 5 and NF-Y are involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3A10/lithocholic acid 6β-hydroxylase. Nucleic Acids Res 26: 2173-2178, 1998.
43. Udy GB, Towers RP, Snell RG, Wilkins RJ, Park SH, Ram PA, Waxman DJ, and Davey HW. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc Natl Acad Sci USA 94: 7239-7244, 1997.
44. Veldhuis JD. Gender differences in secretory activity of the human somatotropic (growth hormone) axis. Eur J Endocrinol 134: 287-295, 1996.
45. Watkins PB. Breath tests as noninvasive assays of P450s. Methods Enzymol 206: 517-522, 1991.
46. Watkins PB. Noninvasive tests of CYP3A enzymes. Pharmacogenetics 4: 171-184, 1994.
47. Watkins PB, Murray SA, Winkelman LG, Heuman DM, Wrighton SA, and Guzelian PS. Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients. J Clin Invest 83: 688-697, 1989.
48. Watkins PB, Turgeon DK, Jaffe CA, Ho PJ, and Barkan AL. Pulsation frequency of growth hormone may mediate gender differences in CYP3A activity in man (Abstract). Clin Res 41: 132, 1993.
49. Waxman DJ, Pampori NA, Ram PA, Agrawal AK, and Shapiro BH. Interpulse interval in circulating growth hormone patterns regulates sexually dimorphic expression of hepatic cytochrome P450. Proc Natl Acad Sci USA 88: 6868-6872, 1991.
50. Waxman DJ, Ram PA, Pampori NA, and Shapiro BH. Growth hormone regulation of male-specific rat liver P450s 2A2 and 3A2: induction by intermittent growth hormone pulses in male but not female rats rendered growth hormone deficient by neonatal monosodium glutamate. Mol Pharmacol 48: 790-797, 1995.
51. Winer LM, Shaw MA, and Baumann G. Basal plasma growth hormone levels in man: new evidence for rhythmicity of growth hormone secretion. J Clin Endocrinol Metab 70: 1678-1686, 1990.