Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence

Journal of Immunology

Volumn 163, Issue 10, 1999, Pages 5374-5382

  Holz, Andreas ^a   Adrian, Bot ^b   Coon, Bryan ^a   Wolfe, Tom ^a   Grusby, Michael J ^c,d   Von Herrath, Matthias G ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Alliance Pharmaceutical Corporation   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GLYCOPROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; NUCLEOPROTEIN; STAT4 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; AUTOIMMUNE DISEASE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXIC LYMPHOCYTE; HELPER CELL; IMMUNOCOMPETENCE; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY; NONHUMAN; PANCREAS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SERUM; SIGNAL TRANSDUCTION; SPLEEN; TRANSGENIC MOUSE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYTOTOXICITY, IMMUNOLOGIC; DIABETES MELLITUS, TYPE 1; DNA-BINDING PROTEINS; INSULIN; INTERFERON TYPE II; ISLETS OF LANGERHANS; LYMPHOCYTE COUNT; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; LYMPHOPENIA; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NUCLEOPROTEINS; PROMOTER REGIONS (GENETICS); RATS; SEQUENCE DELETION; SIGNAL TRANSDUCTION; STAT4 TRANSCRIPTION FACTOR; STEM CELLS; T-LYMPHOCYTES, CYTOTOXIC; TH1 CELLS; TH2 CELLS; TRANS-ACTIVATORS;

EID: 0345422708     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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