Functional differences between Stat3α and Stat3β

Molecular and Cellular Biology

Volumn 17, Issue 9, 1997, Pages 5307-5316

  Schaefer, Timothy S ^a   Sanders, Laura K ^a   Park, Ohkmae K ^a   Nathans, Daniel ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DNA BINDING PROTEIN; EPIDERMAL GROWTH FACTOR; GROWTH FACTOR; ACUTE PHASE PROTEIN; GROWTH PROMOTOR; STAT3 PROTEIN; TRANSACTIVATOR PROTEIN; TYROSINE;

ANIMAL CELL; ARTICLE; DEPHOSPHORYLATION; DNA BINDING; GENETIC TRANSCRIPTION; NONHUMAN; ONCOGENE C JUN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; PROTEIN STABILITY; TRANSCRIPTION INITIATION; AMINO ACID SEQUENCE; ANIMAL; CELL STRAIN COS1; CHEMISTRY; DNA FOOTPRINTING; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; POLYACRYLAMIDE GEL ELECTROPHORESIS;

ANIMALIA;

ACUTE-PHASE PROTEINS; AMINO ACID SEQUENCE; ANIMALS; COS CELLS; CYTOKINES; DNA FOOTPRINTING; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GROWTH SUBSTANCES; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TYROSINE;

EID: 0030611426     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.17.9.5307     Document Type: Article

References (39)

1. Akira, S., Y. Nishio, M. Inoue, X.-J. Wang, S. Wei, T. Matsuka, K. Yoshida, T. Sudo, M. Naruto, and T. Kishimoto. 1994. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 77:63-71.
2. Andrews, N. C., and D. V. Faller. 1991. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19:2499.
3. Azam, M., H. Erdjument-Bromage, B. L. Kreider, M. Xia, F. Quelle, R. Basu, C. Saris, P. Tempst, J. N. Ihle, and C. Schindler. 1995. Interleukin-3 signals through multiple isoforms of Stat5. EMBO J. 14:1402-1411.
4. Caldenhoven, E., T. B. van Dijk, R. Solari, J. Armstrong, J. A. M. Raaijmakers, J.-W. J. Lammers, L. Koenderman, and R. P. deGroot. 1996. Stat3β, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription. J. Biol. Chem. 271:13221-13227.
5. Chakraborty, A., S. M. White, T. S. Schaefer, E. D. Ball, K. F. Dyer, and D. J. Tweardy. 1996. Granulocyte colony-stimulating factor activation of Stat3α and Stat3β in immature normal and leukemic human myeloid cells. Blood 88:2442-2449.
6. Darnell, J. E., Jr. 1996. Reflections on STAT3, STAT5, and STAT6 as fat STATs. Proc. Natl. Acad. Sci. USA 93:6221-6224.
7. Decker, T., D. J. Lew, J. Mirkovitch, and J. E. Darnell, Jr. 1991. Cytoplasmic activation of GAF, an IFN-γ-regulated DNA-binding factor. EMBO J. 10: 927-932.
8. Downward, J., Y. Yarden, E. Mayes, G. Scrace, N. Totty, P. Stockwell, A. Ullrich, J. Schlessinger, and M. D. Waterfield. 1984. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature 307:521-527.
9. Gamett, D. C., S. E. Tracey, and H. L. Robinson. 1986. Differences in sequences encoding the carboxyl-terminal domain of the epidermal growth factor receptor correlate with differences in the disease potential of viral erbB genes. Proc. Natl. Acad. Sci. USA 83:6053-6057.
10. Gorman, C. M., G. T. Merlino, M. C. Willingham, I. Pastan, and B. H. Howard. 1982. The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection. Proc. Nail. Acad. Sci. USA 79:6777-6781.
11. Gouilleux-Gruart, V., F. Gouilleux, C. Desaint, J.-F. Claisse, J.-C. Capiod, J. Delobel, R. Weber-Nordt, I. Dusanter-Fourt, F. Dreyfus, B. Groner, and L. Prin. 1996. STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. Blood 87:1692-1697.
12. Heim, M. H., I. M. Kerr, G. R. Stark, and J. E. Darnell, Jr. 1995. Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway. Science 267:1347-1349.
13. Hou, J., U. Schindler, W. J. Henzel, T. C. Ho, M. Brasseur, and S. L. McKnight. 1994. An interleukin-4-induced transcription factor: IL-4 Stat. Science 265:1701-1706.
14. Ihle, J. N., and I. Kerr. 1995. Jaks and Stats in signaling by the cytokine receptor superfamily. Trends Genet. 11:69-74.
15. Ivashkiv, L. B. 1995. Cytokines and STATs: how can signals achieve specificity? Immunity 3:1-4.
16. Kunz, D., R. Zimmermann, M. Heisig, and P. Heinrich. 1989. Identification of the promoter sequences involved in the interleukin-6 dependent expression of the rat alpha-2 macroglobulin gene. Nucleic Acids Res. 17:1121-1138.
17. Look, D. C., M. R. Pelletier, R. M. Tidwell, W. T. Roswit, and M. J. Holtzman. 1995. Stall depends on transcriptional synergy with Sp1. J. Biol. Chem. 270:30264-30267.
18. McKendry, R., J. John, D. Flavell, M. Muller, I. M. Kerr, and G. R. Stark. 1991. High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both α and γ interferons. Proc. Natl. Acad. Sci. USA 88:11455-11459.
19. Migone, T.-S., J.-X. Lin, A. Ceresato, J. C. Mulloy, J. J. O'Shea, G. Franchini, and W. J. Leonard. 1995. Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I. Science 269:79-81.
20. Moriggl, R., V. Gouilleux-Gruart, R. Jahne, S. Berchtold, C. Gartmann, X. Liu, L. Hennighausen, A. Sotiropoulos, B. Groner, and F. Gouilleux. 1996. Deletion of the carhoxyl-terminal transactivation domain of MGF-Stat5 results in sustained binding and a dominant negative phenotype. Mol. Cell. Biol. 16:5691-5700.
21. Müller, M., J. Briscoe, C. Laxton, D. Guschin, A. Ziemiecki, O. Silvennoinen, A. G. Harpur, G. Barbieri, B. A. Witthuhn, C. Schindler, S. Pelligrini, A. F. Wilks, J. N. Ihle, G. R. Stark, and I. M. Kerr. 1993. The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Nature 366:129-136.
22. Park, O. K., T. S. Schaefer, and D. Nathans. 1996. In vitro activation of Stat3 by epidermal growth factor kinase. Proc. Natl. Acad. Sci. USA 93:13704-13708.
23. Sadowski, H. B., K. Shuai, J. E. Darnell, Jr., and M. Z. Gilman. 1993. A common nuclear signal transduction pathway activated by growth factor and cytokine receptors. Science 261:1739-1744.
24. Schaefer, T. S., L. K. Sanders, and D. Nathans. 1995. Cooperative transcriptional activity of Jun and Stat3β, a short form of Stat3. Proc. Natl. Acad. Sci. USA 92:9097-9101.
25. Schindler, C., and J. E. Darnell, Jr. 1995. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem. 64:621-651.
26. Shaui, K., G. R. Stark, I. M. Kerr, and J. E. Darnell, Jr. 1993. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-γ. Science 261:1744-1746.
27. Stöcklin, E., M. Wissler, F. Gouilleux, and B. Groner. 1996. Functional interactions between Stat5 and the glucocorticoid receptor. Nature 383:726-728.
28. Stahl, N., T. J. Farruggella, T. G. Boulton, Z. Zhong, and J. E. Yancopoulos. 1995. Choice of STATS and other substrates specified by modular tyrosinebased motifs in cytokine receptors. Science 267:1349-1353.
29. van der Eb, A. J., and F. L. Graham. 1980. Assay of transforming activity of tumor virus DNA. Methods Enzymol. 65:826-839.
30. Velazquez, L., M. Fellows, G. R. Stark, and S. Pellegrini. 1992. A protein tyrosine kinase in the Interferon α/β signalling. Cell 70:313-322.
31. Wagner, B. J., T. E. Hayes, C. J. Hoban, and B. H. Cochran. 1990. The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter. EMBO J. 9:4477-4484.
32. Wakao, H., F. Gouilleux, and B. Groner. 1994. Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J. 13:2182-2191.
33. Wang, D., D. Stravopodis, S. Teglund, J. Kitazawa, and J. N. Ihle. 1996. Naturally occurring dominant negative variants of Stat5. Mol. Cell. Biol. 16:6141-6148.
34. Watling, D., D. Gushin, M. Müller, O. Silvennoinen, B. A. Witthuhn, F. W. Quelle, N. C. Rogers, C. Schindler, G. R. Stark, J. N. Ihle, and I. M. Kerr. 1993. Complementation by the protein tyrosine kinase Jak2 of a mutant cell line defective in the interferon-γ signal transduction pathway. Nature 366: 166-170.
35. Yamamoto, K., F. W. Quelle, W. E. Thierfelder, B. L. Kreider, D. J. Gilbert, N. A. Jenkins, N. G. Copeland, O. Silvennoinen, and J. N. Ihle. 1994. Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation. Mol. Cell. Biol. 14:4342-4349.
36. Van, R., S. Qureshi, Z. Zhong, Z. Wen, and J. E. Darnell, Jr. 1995. The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2. Nucleic Acids Res. 23:459-463.
37. Yu, C.-L., D. J. Moyer, G. S. Campbell, A. C. Larner, C. Carter-Su, J. Schwartz, and R. Jove. 1995. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 269:81-83.
38. Zhong, Z., Z. Wen, and J. E. Darnell, Jr. 1994. Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc. Natl. Acad. Sci. USA 91:4806-4810.
39. Zhong, Z., Z. Wen, and J. E. Darnell, Jr. 1994. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264:95-98.