메뉴 건너뛰기




Volumn 157, Issue 11, 1996, Pages 4781-4789

Activation of STAT4 by IL-12 and IFN-α: Evidence for the Involvement of Ligand-Induced Tyrosine and Serine Phosphorylation

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA BINDING PROTEIN; INTERLEUKIN 12; LIGAND; OLIGODEOXYRIBONUCLEOTIDE; RECOMBINANT INTERFERON; RECOMBINANT PROTEIN; SERINE; STAT4 PROTEIN; STAT4 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TYROSINE;

EID: 0030469719     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (223)

References (61)
  • 1
    • 0028043326 scopus 로고
    • Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
    • Trinchieri, G. 1994. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 84:4008.
    • (1994) Blood , vol.84 , pp. 4008
    • Trinchieri, G.1
  • 2
    • 0028214296 scopus 로고
    • Interleukin-12: A bridge between innate resistance and adaptive immunity with a role in infection and acquired immunodeficiency
    • Chehimi, J., and G. Trinchieri. 1994. Interleukin-12: a bridge between innate resistance and adaptive immunity with a role in infection and acquired immunodeficiency. J. Clin. Immunol 14:149.
    • (1994) J. Clin. Immunol , vol.14 , pp. 149
    • Chehimi, J.1    Trinchieri, G.2
  • 5
    • 0028892869 scopus 로고
    • Cloning and characterization of a mouse IL-12 receptor-beta component
    • Chua, A. O., V. L. Wilkinson, D. H. Presky, and U. Gubler. 1995. Cloning and characterization of a mouse IL-12 receptor-beta component. J. Immunol. 155: 4286.
    • (1995) J. Immunol. , vol.155 , pp. 4286
    • Chua, A.O.1    Wilkinson, V.L.2    Presky, D.H.3    Gubler, U.4
  • 6
    • 0029348007 scopus 로고
    • The Janus protein tyrosine kinases in hematopoietic cytokine signaling
    • Ihle, J. N. 1995. The Janus protein tyrosine kinases in hematopoietic cytokine signaling. Semin. Immunol. 7:247.
    • (1995) Semin. Immunol. , vol.7 , pp. 247
    • Ihle, J.N.1
  • 7
    • 0029858447 scopus 로고    scopus 로고
    • Signaling by IL-2 and related receptors: JAKs, STATs and relationship to immunodeficiency
    • In press
    • Johnston, J. A., C. M. Bacon, M. C. Riedy, and J. J. O'Shea. 1996. Signaling by IL-2 and related receptors: JAKs, STATs and relationship to immunodeficiency. J. Leukocyte Biol. In press.
    • (1996) J. Leukocyte Biol.
    • Johnston, J.A.1    Bacon, C.M.2    Riedy, M.C.3    O'Shea, J.J.4
  • 8
    • 0028910222 scopus 로고
    • Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: Differential use of Janus family tyrosine kinases by IL-2 and IL-12
    • Bacon, C. M., D. W. McVicar, J. R. Ortaldo, R. C. Rees, J. J. O'Shea, and J. A. Johnston. 1995. Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J. Exp. Med. 181:399.
    • (1995) J. Exp. Med. , vol.181 , pp. 399
    • Bacon, C.M.1    McVicar, D.W.2    Ortaldo, J.R.3    Rees, R.C.4    O'Shea, J.J.5    Johnston, J.A.6
  • 9
    • 0029069145 scopus 로고
    • Transcriptional responses to polypeptide ligands: The JAK-STAT pathway
    • Schindler, C., and J. E. Darnell, Jr. 1995. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem. 64:621.
    • (1995) Annu. Rev. Biochem. , vol.64 , pp. 621
    • Schindler, C.1    Darnell Jr., J.E.2
  • 11
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell, J. E., Jr., I. M. Kerr, and G. R. Stark. 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415.
    • (1994) Science , vol.264 , pp. 1415
    • Darnell Jr., J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 13
    • 0028943484 scopus 로고
    • Interleukin-12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4
    • Jacobson, N. G., S. J. Szabo, R. M. Weber-Nordt, Z. Zhong, R. D. Schreiber, J. E. Darnell, Jr., and K. M. Murphy. 1995. Interleukin-12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J. Exp. Med. 181:1755.
    • (1995) J. Exp. Med. , vol.181 , pp. 1755
    • Jacobson, N.G.1    Szabo, S.J.2    Weber-Nordt, R.M.3    Zhong, Z.4    Schreiber, R.D.5    Darnell Jr., J.E.6    Murphy, K.M.7
  • 14
    • 0026520178 scopus 로고
    • Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): Cytolytic activity and proliferation of NK cells are differentially regulated by NKSF
    • Robertson, M. J., R. J. Soiffer, S. F. Wolf, T. J. Manley, C. Donahue, D. Young, S. H. Hermann, and J. Ritz. 1992. Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF. J. Exp. Med. 175:779.
    • (1992) J. Exp. Med. , vol.175 , pp. 779
    • Robertson, M.J.1    Soiffer, R.J.2    Wolf, S.F.3    Manley, T.J.4    Donahue, C.5    Young, D.6    Hermann, S.H.7    Ritz, J.8
  • 15
    • 0027364337 scopus 로고
    • Interferon-a major regulator of natural killer cell-mediated cytotoxicity
    • Reiter, Z. 1993. Interferon-a major regulator of natural killer cell-mediated cytotoxicity. J. Interferon Res. 13:247.
    • (1993) J. Interferon Res. , vol.13 , pp. 247
    • Reiter, Z.1
  • 16
    • 0029671118 scopus 로고    scopus 로고
    • Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development
    • Wenner, C. A., M. L. Guler, S. E. Macatonia, A. O'Garra, and K. M. Murphy. 1996. Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development. J. Immunol. 156:1442.
    • (1996) J. Immunol. , vol.156 , pp. 1442
    • Wenner, C.A.1    Guler, M.L.2    Macatonia, S.E.3    O'Garra, A.4    Murphy, K.M.5
  • 19
    • 0027742729 scopus 로고
    • Interferon-induced nuclear signalling by Jak protein tyrosine kinases
    • Silvennoinen, O., J. N. Ihle, J. Schlessinger, and D. E. Levy. 1993. Interferon-induced nuclear signalling by Jak protein tyrosine kinases. Nature 366:583.
    • (1993) Nature , vol.366 , pp. 583
    • Silvennoinen, O.1    Ihle, J.N.2    Schlessinger, J.3    Levy, D.E.4
  • 20
    • 0026632288 scopus 로고
    • A protein tyrosine kinase in the interferon α/β signaling pathway
    • Velasquez, L., M. Fellows, G. R. Stark, and S. Pellegrini. 1992. A protein tyrosine kinase in the interferon α/β signaling pathway. Cell 70:313.
    • (1992) Cell , vol.70 , pp. 313
    • Velasquez, L.1    Fellows, M.2    Stark, G.R.3    Pellegrini, S.4
  • 22
    • 0028148055 scopus 로고
    • Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors
    • Raz, R., J. E. Durbin, and D. E. Levy. 1994. Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors. J. Biol. Chem. 269:24391.
    • (1994) J. Biol. Chem. , vol.269 , pp. 24391
    • Raz, R.1    Durbin, J.E.2    Levy, D.E.3
  • 23
    • 0030046753 scopus 로고    scopus 로고
    • STATs: Signal transducers and activators of transcription
    • Ihle, J. N. 1996. STATs: signal transducers and activators of transcription. Cell 84:331.
    • (1996) Cell , vol.84 , pp. 331
    • Ihle, J.N.1
  • 24
    • 0028073675 scopus 로고
    • Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor
    • Miura, Y., O. Miura, J. N. Ihle, and N. Aoki. 1994. Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor. J. Biol. Chem. 269:29962.
    • (1994) J. Biol. Chem. , vol.269 , pp. 29962
    • Miura, Y.1    Miura, O.2    Ihle, J.N.3    Aoki, N.4
  • 25
    • 0029133702 scopus 로고
    • Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins
    • David, M., E. Petricoin III, C. Benjamin, R. Pine, M. J. Weber, and A. C. Larner. 1995. Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins. Science 269: 1721.
    • (1995) Science , vol.269 , pp. 1721
    • David, M.1    Petricoin III, E.2    Benjamin, C.3    Pine, R.4    Weber, M.J.5    Larner, A.C.6
  • 26
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen, Z., Z. Zhong, and J. E. Darnell, Jr. 1995. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82:241.
    • (1995) Cell , vol.82 , pp. 241
    • Wen, Z.1    Zhong, Z.2    Darnell Jr., J.E.3
  • 27
    • 0028942656 scopus 로고
    • Requirement of serine phosphorylation for formation of STAT-promoter complexes
    • Zhang, X., J. Blenis, H. C. Li, C. Schindler, and S. Chen-Kiang. 1995. Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science 267:1190.
    • (1995) Science , vol.267 , pp. 1190
    • Zhang, X.1    Blenis, J.2    Li, H.C.3    Schindler, C.4    Chen-Kiang, S.5
  • 28
    • 0029149376 scopus 로고
    • The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors
    • Sakatsume, M., K. Igarashi, K. D. Winestock, G. Garotta, A. C. Larner, and D. S. Finbloom. 1995. The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors. J. Biol. Chem. 270:17528.
    • (1995) J. Biol. Chem. , vol.270 , pp. 17528
    • Sakatsume, M.1    Igarashi, K.2    Winestock, K.D.3    Garotta, G.4    Larner, A.C.5    Finbloom, D.S.6
  • 29
    • 0022501035 scopus 로고
    • Lymphokine activated killer cells: Analysis of progenitors and effectors
    • Ortaldo, J. R., A. Mason, and R. Overton. 1986. Lymphokine activated killer cells: analysis of progenitors and effectors. J. Exp. Med. 164:1193.
    • (1986) J. Exp. Med. , vol.164 , pp. 1193
    • Ortaldo, J.R.1    Mason, A.2    Overton, R.3
  • 32
    • 0020468158 scopus 로고
    • Cell surface phenotype of a cloned line of human natural killer cells
    • Kornbluth, J., N. Flomenberg, and B. Dupont. 1982. Cell surface phenotype of a cloned line of human natural killer cells. J. Immunol. 129:2831.
    • (1982) J. Immunol. , vol.129 , pp. 2831
    • Kornbluth, J.1    Flomenberg, N.2    Dupont, B.3
  • 33
    • 0026347205 scopus 로고
    • Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: Transcriptional induction by gamma-interferon is mediated through common DNA response elements
    • Pearse, R. N., R. Feinman, and J. V. Ravetch. 1991. Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: transcriptional induction by gamma-interferon is mediated through common DNA response elements. Proc. Natl. Acad. Sci. USA 88:11305.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 11305
    • Pearse, R.N.1    Feinman, R.2    Ravetch, J.V.3
  • 34
    • 0029150706 scopus 로고
    • Thrombopoietin (TPO) induces tyrosine phosphorylation and activation of STAT5 and STAT3
    • Bacon, C. M., P. J. Tortolani, A. Shimosaka, R. C. Rees, D. L. Longo, and J. J. O'Shea. 1995. Thrombopoietin (TPO) induces tyrosine phosphorylation and activation of STAT5 and STAT3. FEBS Lett. 370:63.
    • (1995) FEBS Lett. , vol.370 , pp. 63
    • Bacon, C.M.1    Tortolani, P.J.2    Shimosaka, A.3    Rees, R.C.4    Longo, D.L.5    O'Shea, J.J.6
  • 35
    • 0025948991 scopus 로고
    • Determination of phosphoamino acid composition by acid hydrolysis of protein blotted to immobilon
    • Kamps, M. P. 1991. Determination of phosphoamino acid composition by acid hydrolysis of protein blotted to immobilon. Methods Enzymol. 201:21.
    • (1991) Methods Enzymol. , vol.201 , pp. 21
    • Kamps, M.P.1
  • 36
    • 0028097932 scopus 로고
    • Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene
    • Pine, R., A. Canova, and C. Schindler. 1994. Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene. EMBO J. 13:158.
    • (1994) EMBO J. , vol.13 , pp. 158
    • Pine, R.1    Canova, A.2    Schindler, C.3
  • 37
    • 0002756587 scopus 로고
    • Transient expression of proteins using COS cells
    • F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl, eds. John Wiley & Sons, New York
    • Aruffo, A. 1992. Transient expression of proteins using COS cells. In Short Protocols in Molecular Biology. F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl, eds. John Wiley & Sons, New York, pp. 16.53-16.55.
    • (1992) Short Protocols in Molecular Biology , pp. 1653-1655
    • Aruffo, A.1
  • 39
    • 0027090310 scopus 로고
    • Activation of transcription by IFNγ: Tyrosine phosphorylation of a 91-kD DNA binding protein
    • Shuai, K., C. Schindler, V. R. Prezioso, and J. E. Darnell, Jr. 1992. Activation of transcription by IFNγ: tyrosine phosphorylation of a 91-kD DNA binding protein. Science 258:1808.
    • (1992) Science , vol.258 , pp. 1808
    • Shuai, K.1    Schindler, C.2    Prezioso, V.R.3    Darnell Jr., J.E.4
  • 41
    • 0027151991 scopus 로고
    • Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3
    • Pearse, R. N., R. Feinman, K. Shuai, J. E. Darnell, Jr., and J. V. Ravetch. 1993. Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3. Proc. Natl. Acad. Sci. USA 90:4314.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 4314
    • Pearse, R.N.1    Feinman, R.2    Shuai, K.3    Darnell Jr., J.E.4    Ravetch, J.V.5
  • 43
    • 0028284762 scopus 로고
    • Stat3 and Stat4: Members of the family of signal transducers and activators of transcription
    • Zhong, Z., Z. Wen, and J. E. Darnell, Jr. 1994. Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc. Natl. Acad. Sci. USA 91:4806.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 4806
    • Zhong, Z.1    Wen, Z.2    Darnell Jr., J.E.3
  • 46
    • 0029091195 scopus 로고
    • STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase
    • Boulton, T. G., Z. Zhong, Z. Wen, J. E. Darnell, Jr., N. Stahl, and G. D. Yancopoulos. 1995. STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase. Proc. Natl. Acad. Sci. USA 92:6915.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 6915
    • Boulton, T.G.1    Zhong, Z.2    Wen, Z.3    Darnell Jr., J.E.4    Stahl, N.5    Yancopoulos, G.D.6
  • 47
    • 0028938929 scopus 로고
    • Interleukin-6-induced serine phosphorylation of transcription factor APRF: Evidence for a role in interleukin-6 target gene induction
    • Lutticken, C., P. Coffer, J. Yuan, C. Schwartz, E. Caldenhoven, C. Schindler, W. Kruijer, P. C. Heinrich, and F. Horn. 1995. Interleukin-6-induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin-6 target gene induction. FEBS Lett. 360:137.
    • (1995) FEBS Lett. , vol.360 , pp. 137
    • Lutticken, C.1    Coffer, P.2    Yuan, J.3    Schwartz, C.4    Caldenhoven, E.5    Schindler, C.6    Kruijer, W.7    Heinrich, P.C.8    Horn, F.9
  • 48
    • 0024388159 scopus 로고
    • Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways
    • Lew, D. J., T. Decker, and J. E. Darnell, Jr. 1989. Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways. Mol. Cell. Biol. 9:5404.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 5404
    • Lew, D.J.1    Decker, T.2    Darnell Jr., J.E.3
  • 49
    • 0028278181 scopus 로고
    • Signal transduction and gene regulation: The nuclear response to cAMP
    • Lalli, E., and P. Sassone-Corsi. 1994. Signal transduction and gene regulation: the nuclear response to cAMP. J. Biol. Chem. 269:17359.
    • (1994) J. Biol. Chem. , vol.269 , pp. 17359
    • Lalli, E.1    Sassone-Corsi, P.2
  • 50
    • 0028084337 scopus 로고
    • Ternary complex factors: Growth factor regulated transcriptional activations
    • Treisman, R. 1994. Ternary complex factors: growth factor regulated transcriptional activations. Curr. Opin. Genet. Dev. 4:96.
    • (1994) Curr. Opin. Genet. Dev. , vol.4 , pp. 96
    • Treisman, R.1
  • 51
    • 0027385031 scopus 로고
    • A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates ils DNA binding activity
    • Rivera, V. M., C. K. Miranti, R. P. Misra, D. D. Ginty, R. H. Chen, J. Blenis, and M. E. Greenberg. 1993. A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates ils DNA binding activity. Mol. Cell. Biol. 13:6260.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 6260
    • Rivera, V.M.1    Miranti, C.K.2    Misra, R.P.3    Ginty, D.D.4    Chen, R.H.5    Blenis, J.6    Greenberg, M.E.7
  • 52
    • 0028322193 scopus 로고
    • Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors
    • Karin, M. 1994. Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors. Curr. Opin. Cell. Biol. 6:415.
    • (1994) Curr. Opin. Cell. Biol. , vol.6 , pp. 415
    • Karin, M.1
  • 53
    • 0025205256 scopus 로고
    • Evidence for involvement of protein kinase C in the cellular response to interferon alpha
    • Reich, N. C., and L. M. Pfeffer. 1990. Evidence for involvement of protein kinase C in the cellular response to interferon alpha. Prcc. Natl. Acad. Sci. USA 87:8761.
    • (1990) Prcc. Natl. Acad. Sci. USA , vol.87 , pp. 8761
    • Reich, N.C.1    Pfeffer, L.M.2
  • 54
    • 0025888298 scopus 로고
    • Identification of substrate recognition determinant for human ERK1 and ERK2 protein kinases
    • Gonzalez, F. A., D. L. Raden, and R. J. Davis. 1991. Identification of substrate recognition determinant for human ERK1 and ERK2 protein kinases. J. Biol. Chem. 266:22159.
    • (1991) J. Biol. Chem. , vol.266 , pp. 22159
    • Gonzalez, F.A.1    Raden, D.L.2    Davis, R.J.3
  • 55
    • 0028285886 scopus 로고
    • γ-interferon induces rapid and coordinate activation of mitogen-activated protein kinase (extracellular signal-regulated kinase and calcium-independent protein kinase C) in human monocytes
    • Lui, M. K., R. W. Brownsey, and N. E. Reiner. 1994. γ-interferon induces rapid and coordinate activation of mitogen-activated protein kinase (extracellular signal-regulated kinase and calcium-independent protein kinase C) in human monocytes. Infect. Immun. 62:2622.
    • (1994) Infect. Immun. , vol.62 , pp. 2622
    • Lui, M.K.1    Brownsey, R.W.2    Reiner, N.E.3
  • 56
    • 0028014296 scopus 로고
    • Interleukin-12 induces tyrosine phosphorylation and activation of 44-kD mitogen-activated protein kinase in human T cells
    • Pignata, C., J. S. Saghera, L. Cossette, S. L. Pelech, and J. Ritz. 1994. Interleukin-12 induces tyrosine phosphorylation and activation of 44-kD mitogen-activated protein kinase in human T cells. Blood 83:184.
    • (1994) Blood , vol.83 , pp. 184
    • Pignata, C.1    Saghera, J.S.2    Cossette, L.3    Pelech, S.L.4    Ritz, J.5
  • 57
    • 0029061508 scopus 로고
    • Tyrosine-phosphorylated Sta1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3
    • Qureshi, S. A., M. Salditt-Georgieff, and J. E. Darnell, Jr. 1995. Tyrosine-phosphorylated Sta1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3. Proc. Natl. Acad. Sci. USA 92:3829.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3829
    • Qureshi, S.A.1    Salditt-Georgieff, M.2    Darnell Jr., J.E.3
  • 58
    • 0030024563 scopus 로고    scopus 로고
    • Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
    • Durbin, J. E., R. Hackenmiller, M. C. Simon, and D. E. Levy. 1996. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84:443.
    • (1996) Cell , vol.84 , pp. 443
    • Durbin, J.E.1    Hackenmiller, R.2    Simon, M.C.3    Levy, D.E.4
  • 61
    • 0029937270 scopus 로고    scopus 로고
    • Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
    • Kaplan, M. H., Y.-L. Sun, T. Hoey, M. J. Grusby. 1996. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382:174.
    • (1996) Nature , vol.382 , pp. 174
    • Kaplan, M.H.1    Sun, Y.-L.2    Hoey, T.3    Grusby, M.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.