Cutting edge: Differential requirements for Stat4 in expression of glycosyltransferases responsible for selectin ligand formation in Th1 cells

Journal of Immunology

Volumn 167, Issue 2, 2001, Pages 628-631

  White, S J ^a   Underhill, G H ^a   Kaplan, M H ^a   Kansas, G S ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FUCOSYLTRANSFERASE; GLYCOSYLTRANSFERASE; INTERLEUKIN 12; PADGEM PROTEIN; STAT4 PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE ACTIVATION; TH1 CELL; WESTERN BLOTTING;

EID: 0035879351     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.2.628     Document Type: Article

References (17)

1. P- and E-selectin mediate recruitment of T helper 1 but not T helper 2 cells into inflamed tissues
2. IL-12 and IL-4 control T cell adhesion to endothelial selectins through opposite effects on FucT-VII gene expression
3. Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4
4. The α1,3 fucosyltransferase FucT-VII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis
5. Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation
6. Differential requirements for the O-linked branching enzyme core 2 β1-6-N-glucosaminyltransferase (C2GlcNAcT-I) in biosynthesis of ligands for E-selectin and P-selectin
7. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
8. A novel P-selectin glycoprotein ligand-1 (PSGL-1) monoclonal antibody recognizes an epitope within the tyrosine sulfate motif of human PSGL-1 and blocks recognition of both P- and L-selectin
9. A novel transcription factor, T-bet, directs Th1 lineage commitment
10. The fucosyltransferase FucT-VII regulates E-selectin ligand synthesis in human T cells
11. + T lymphocytes on tumor necrosis factor-α activated vascular endothelium under flow
12. Core 2 β-1,6-N-Acetylglucosaminyltransferase enzyme activity is critical for P-selectin glycoprotein ligand-1 binding to P-selectin
13. The p38 mitogen-activated protein kinase is required for IL-12-induced IFN-γ expression
14. Interferon-γ expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway
15. Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity
16. Potent induction of FucT-VII by TGF-β1 through a p38 MAP kinase-dependent pathway
17. Molecular cloning and functional analysis of sialyltransferases