IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells

Journal of Immunology

Volumn 162, Issue 12, 1999, Pages 7256-7262

  Galon, Jérôme ^a   Sudarshan, Chitra ^a   Ito, Satochi ^b   Finbloom, David ^b   O'Shea, John J ^a  

^a NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 12; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; STAT4 PROTEIN;

ARTICLE; CELL DIFFERENTIATION; CELLULAR IMMUNITY; CONTROLLED STUDY; GENE EXPRESSION; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOREGULATION; NATURAL KILLER CELL; PRIORITY JOURNAL; T LYMPHOCYTE; TRANSACTIVATION;

3T3 CELLS; ANIMALS; CELL LINE; CELLS, CULTURED; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; INTERFERON REGULATORY FACTOR-1; INTERFERON-ALPHA; INTERFERONS; INTERLEUKIN-12; KILLER CELLS, NATURAL; MICE; PHOSPHOPROTEINS; SIGNAL TRANSDUCTION; STAT4 TRANSCRIPTION FACTOR; T-LYMPHOCYTES; TRANS-ACTIVATORS; UP-REGULATION;

EID: 0033564574     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Trinchieri, G. 1995. Inlerleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251.
2. Magram, J., S. E. Connaughton, R. R. Warrier, D. M. Carvajal, C. Y. Wu, J. Ferrante, C. Stewart, U. Sarmiento, D. A. Faherty, and M. K. Gately. 1996. IL-12-deficient mice are defective in IFN-γ production and type 1 cytokine responses. Immunity 4:471.
3. Bacon, C. M., D. W. McVicar, J. R. Ortaldo, R. C. Rees, J. J. O'Shea, and J. A. Johnston. 1995. Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J. Exp. Med. 181:399.
4. Gollob, J. A., E. A. Murphy, S. Mahajan, C. P. Schnipper, J. Ritz, and D. A. Frank. 1998. Altered interleukin-12 responsiveness in Th1 and Th2 cells is associated with the differential activation of STAT5 and STAT1. Blood 91:1341.
5. Bacon, C. M., E. F. R. Petricoin, J. R. Ortaldo, R. C. Rees, A. C. Larner, J. A. Johnston, and J. J. O'Shea. 1995. Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc. Natl. Acad. Sci. USA 92:7307.
6. Jacobson, N. G., S. J. Szabo, R. M. Weber-Nordt, Z. Zhong, R. D. Schreiber, J. E. J. Darnell, and K. M. Murphy. 1995. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat) 3 and Stat4, J. Exp. Med. 181:1755.
7. Darnell, J. E. J. 1997. STATs and gene regulation. Science 277:1630.
8. Schindler, C., and J. E. J. Darnell. 1995. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem. 64:621.
9. Boehm, U., T. Klamp, M. Groot, and J. C. Howard. 1997. Cellular responses to interferon-γ. Annu. Rev. Immunol. 15:749.
10. Cho, S. S., C. M. Bacon, C. Sudarshan, R. C. Rees, D. Finbloom, R. Pine, and J. J. O'Shea. 1996. Activation of STAT4 by IL-12 and IFN-α: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation. J. Immunol. 157:4781.
11. Leonard, W. J., and J. J. O'Shea. 1998. Jaks and STATs: biological implications. Annu. Rev. Immunol. 16:293.
12. Miyamoto, M., T. Fujita, Y. Kimura, M. Maruyama, H. Harada, Y. Sudo, T. Miyata, and T. Taniguchi. 1988. Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements. Cell 54:903.
13. Tanaka, N., M. Ishihara, M. Kitagawa, H. Harada, T. Kimura, T. Matsuyama, M. S. Lamphier, S. Aizawa, T. W. Mak, and T. Taniguchi. 1994. Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. Cell 77:829.
14. Tamura, T., M. Ishihara, M. S. Lamphier, N. Tanaka, I. Oishi, S. Aizawa, T. Matsuyama, T. W. Mak, S. Taki, and T. Taniguchi. 1995. An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature 376:596.
15. Kamijo, R., H. Harada, T. Matsuyama, M. Bosland, J. Gerecitano, D. Shapiro, J. Le, S. I. Koh, T. Kimura, S. J. Green, et al. 1994. Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science 263:1612.
16. Ogasawara, K., S. Hida, N. Azimi, Y. Tagaya, T. Sato, T. Yokochi-Fukuda, T. A. Waldmann, T. Taniguchi, and S. Taki. 1998. Requirement for IRF-1 in the microenvironment supporting development of natural killer cells. Nature 391:700.
17. + thymocytes, Immunity 7:243.
18. Taki, S., T. Sato, K. Ogasawara, T. Fukuda, M. Sato, S. Hida, G. Suzuki, M. Mitsuyama, E. H. Shin, S. Kojima, et al. 1997. Multistage regulation of Th1-type immune responses by the transcription factor IRF-1. Immunity 6:673.
19. Lohoff, M., D. Ferrick, H. W. Mittrucker, G. S. Duncan, S. Bischof, M. Rollinghoff, and T. W. Mak. 1997. Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo. Immunity 6:681.
20. Ma, X., J. M. Chow, G. Gri, G. Carra, F. Gerosa, S. F. Wolf, R. Dzialo, and G. Trinchieri. 1996. The interleukin 12 p40 gene promoter is primed by interferon γ in monocytic cells. J. Exp. Med. 183:147.
21. Bach, E. A., M. Aguet, and R. D. Schreiber. 1997. The IFN-γ receptor: a paradigm for cytokine receptor signaling. Annu. Rev. Immunol. 15:563.
22. Pine, R., A. Canova, and C. Schindler. 1994. Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN-α and IFN-γ, and is likely to autoregulate the p91 gene. EMBO J. 13:158.
23. Chen, M., A. Cheng, Y.-Q. Chen, A. Hymel, E. P. Hanson, L. Kimmel, Y. Minami, T. Taniguchi, P. S. Changelian, and J. J. O'Shea. 1997. The amino terminus of JAK3 is necessary and sufficient for binding to the common γ chain and confers the ability to transmit interleukin 2-mediated signals. Proc. Natl. Acad. Sci. USA 94:6910.
24. Ohmori, Y., and T. A. Hamilton. 1997. IL-4-induced STAT6 suppresses IFN-γ-stimulated STAT1-dependent transcription in mouse macrophages. J. Immunol. 159:5474.
25. Zhou, Y. J., E. P. Hanson, Y. Q. Chen, K. Magnuson, M. Chen, P. G. Swann, R. L. Wange, P. S. Changelian, and J. J. O'Shea. 1997. Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity. Proc. Natl. Acad. Sci. USA 94:13850.
26. Bug, G., M. J. Aman, T. Tretter, C. Huber, and C. Peschel. 1998. Induction of macrophage-inflammatory protein 1α (MIP-1α) by interferon-α. Exp. Hematol. 26:117.
27. Huang, Y., L. M. Blatt, and M. W. Taylor. 1995. Type 1 interferon as an anti-inflammatory agent: inhibition of lipopolysaccharide-induced interleukin-1 β and induction of interleukin-1 receptor antagonist. J. Interferon Cytokine Res. 15:317.
28. Veals, S. A., D. S. Kessler, S. Josiah, D. G. Leonard, and D. E. Levy. 1991. Signal transduction pathway activating interferon-α-stimulated gene expression. Br. J. Haematol. 79(Suppl. 1):9.
29. Salcedo, T. W., L. Azzoni, S. F. Wolf, and B. Perussia. 1993. Modulation of perform and granzyme messenger RNA expression in human natural killer cells. J. Immunol. 151:2511.
30. Thierfelder, W. E., J. M. van Deursen, K. Yamamoto, R. A. Tripp, S. R. Sarawar, R. T. Carson, M. Y. Sangster, D. A. Vignali, P. C. Doherty, G. C. Grosveld, and J. N. Ihle. 1996. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382:171.
31. Kaplan, M. H., Y. L. Sun, T. Hoey, and M. J. Grusby. 1996. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382:174.
32. + T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA 90:10188.
33. + T cells. J. Exp. Med. 178:1655.
34. Rogge, L., L. Barberis-Maino, M. Biffi, N. Passini, D. H. Presky, U. Gubler, and F. Sinigaglia. 1997. Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J. Exp. Med. 185:825.
35. Schrum, S., P. Probst, B. Fleischer, and P. F. Zipfel. 1996. Synthesis of the CC-chemokines MIP-1α, MIP-1β, and RANTES is associated with a type 1 immune response. J. Immunol. 157:3598.
36. Aman, M. J., U. Keller, G. Derigs, M. Mohamadzadeh, C. Huber, and C. Peschel. 1994. Regulation of cytokine expression by interferon-α in human bone marrow stromal cells: inhibition of hematopoietic growth factors and induction of interleukin-1 receptor antagonist. Blood 84:4142.
37. Siveke, J. T., and A. Hamann. 1998. T helper 1 and T helper 2 cells respond differentially to chemokines. J. Immunol. 160:550.
38. Yamamoto, K., F. W. Quelle, W. E. Thierfelder, B. L. Kreider, D. J. Gilbert, N. A. Jenkins, N. G. Copeland, O. Silvennoinen, and J. N. Ihle. 1994. Stat4, a novel γ interferon activation site-binding protein expressed in early myeloid differentiation. Mol. Cell. Biol. 14:4342.
39. Nelson, N., Y. Kanno, C. Hong, C. Contursi, T. Fujita, B. J. Fowlkes, E. O'Connell, J. Hu-Li, W. E. Paul, D. Jankovic, A. F. Sher, J. E. Coligan, A. Thornton, E. Appella, Y. Yang, and K. Ozato. 1996. Expression of IFN regulatory factor family proteins in lymphocytes: induction of STAT-1 and IFN consensus sequence binding protein expression by T cell activation. J. Immunol. 156:3711.