메뉴 건너뛰기




Volumn 1, Issue 4, 2003, Pages 187-206

Surgical sepsis: Dysregulation of immune function and therapeutic implications

Author keywords

Cytokines; Dendritic cells; MODS; Quorum sensing molecules; Sepsis; SIRS; Treatment

Indexed keywords

ACTIVATED PROTEIN C; ADRENALIN; ANTIBIOTIC AGENT; ANTICOAGULANT AGENT; ANTITHROMBIN III; ANTITHROMBIN III CONCENTRATE; CATECHOLAMINE DERIVATIVE; CORTICOSTEROID; CYTOKINE; DOBUTAMINE; DROTRECOGIN; ENDOTOXIN; HYDROCORTISONE; INOTROPIC AGENT; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; MONOCLONAL ANTIBODY; NORADRENALIN; STEROID; TISSUE FACTOR PATHWAY INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; TUMOR NECROSIS FACTOR RECEPTOR; UNINDEXED DRUG; VASOCONSTRICTOR AGENT;

EID: 0042195844     PISSN: 1479666X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1479-666X(03)80018-5     Document Type: Review
Times cited : (26)

References (142)
  • 3
    • 0034924156 scopus 로고    scopus 로고
    • Epidemiology of sepsis. an update
    • Angus DC, Wax RS: Epidemiology of sepsis. an update. Crit Care Med 2001, 29: S109-16.
    • (2001) Crit. Care Med. , vol.29
    • Angus, D.C.1    Wax, R.S.2
  • 4
    • 0034456047 scopus 로고    scopus 로고
    • Nosocomial bloodstream infections. organisms, risk factors, and implications
    • Karchmer AW: Nosocomial bloodstream infections. organisms, risk factors, and implications. Clin Infect Dis 2000, 31: S139-43.
    • (2000) Clin. Infect. Dis. , vol.31
    • Karchmer, A.W.1
  • 7
    • 0028893025 scopus 로고
    • The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study
    • Rangel-Frausto MS, Pittet D, Costigan M, Hwang T, Davis CS, Wenzel RP. The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. Jama 1995, 273: 117-23.
    • (1995) Jama , vol.273 , pp. 117-123
    • Rangel-Frausto, M.S.1    Pittet, D.2    Costigan, M.3    Hwang, T.4    Davis, C.S.5    Wenzel, R.P.6
  • 8
    • 0026710191 scopus 로고
    • Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
    • The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine
    • Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992, 101: 1644-55.
    • (1992) Chest , vol.101 , pp. 1644-1655
    • Bone, R.C.1    Balk, R.A.2    Cerra, F.B.3    Dellinger, R.P.4    Fein, A.M.5    Knaus, W.A.6
  • 9
    • 0034085626 scopus 로고    scopus 로고
    • Sepsis and the systemic inflammatory response syndrome
    • Paterson RL, Webster NR. Sepsis and the systemic inflammatory response syndrome. J R Coll Surg Edinb 2000, 45:178-82.
    • (2000) J. R. Coll. Surg. Edinb. , vol.45 , pp. 178-182
    • Paterson, R.L.1    Webster, N.R.2
  • 10
    • 0036568730 scopus 로고    scopus 로고
    • Bacterial avoidance of phagocytosis
    • Celli J, Finlay BB. Bacterial avoidance of phagocytosis. Trends Microbiol 2002, 10: 232-37.
    • (2002) Trends Microbiol. , vol.10 , pp. 232-237
    • Celli, J.1    Finlay, B.B.2
  • 11
    • 0036216769 scopus 로고    scopus 로고
    • Phagocytosis of microbes: Complexity in action
    • Underhill DM, Ozinsky A. Phagocytosis of microbes: complexity in action. Annu Rev Immunol 2002, 20: 825-52.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 825-852
    • Underhill, D.M.1    Ozinsky, A.2
  • 12
    • 0033046220 scopus 로고    scopus 로고
    • Mechanisms of phagocytosis in macrophages
    • Aderem A, Underhill DM. Mechanisms of phagocytosis in macrophages. Annu Rev Immunol 1999, 17: 593-623.
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 593-623
    • Aderem, A.1    Underhill, D.M.2
  • 13
  • 15
    • 0031975707 scopus 로고    scopus 로고
    • The role of the complement cascade in sepsis
    • Haeney MR. The role of the complement cascade in sepsis. J Antimicrob Chemother 1998, 41: 41-46.
    • (1998) J. Antimicrob. Chemother. , vol.41 , pp. 41-46
    • Haeney, M.R.1
  • 16
    • 0033965810 scopus 로고    scopus 로고
    • Antigen receptors and dendritic cells
    • Lebecque S. Antigen receptors and dendritic cells. Vaccine 2000, 18:1603-1605.
    • (2000) Vaccine , vol.18 , pp. 1603-1605
    • Lebecque, S.1
  • 17
    • 0033966411 scopus 로고    scopus 로고
    • Toll signaling pathways in the innate immune response
    • Anderson KV. Toll signaling pathways in the innate immune response. Curr Opin Immunol 2000, 12: 13-19.
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 13-19
    • Anderson, K.V.1
  • 19
    • 0027537675 scopus 로고
    • Lipid modification of the 17-kilodalton membrane immunogen of Treponema pallidum determines macrophage activation as well as amphiphilicity
    • Akins DR, Purcell BK, Mitra MM, Norgard MV, Radolf JD. Lipid modification of the 17-kilodalton membrane immunogen of Treponema pallidum determines macrophage activation as well as amphiphilicity. Infect Immun 1993, 61: 1202-10.
    • (1993) Infect. Immun. , vol.61 , pp. 1202-1210
    • Akins, D.R.1    Purcell, B.K.2    Mitra, M.M.3    Norgard, M.V.4    Radolf, J.D.5
  • 20
    • 0035142623 scopus 로고    scopus 로고
    • The role of Toll-like receptors in host defense against microbial infection
    • Krutzik SR, Sieling PA, Modlin RL. The role of Toll-like receptors in host defense against microbial infection. Curr Opin Immunol 2001, 13: 104-08.
    • (2001) Curr. Opin. Immunol. , vol.13 , pp. 104-108
    • Krutzik, S.R.1    Sieling, P.A.2    Modlin, R.L.3
  • 22
    • 0034123135 scopus 로고    scopus 로고
    • Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: Selective expression of TLR3 in dendritic cells
    • Muzio M, Bosisio D, Polentarutti N, D'Amico G, Stoppacciaro A, Mancinelli R et al. Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J Immunol 2000, 164: 5998-6004.
    • (2000) J. Immunol. , vol.164 , pp. 5998-6004
    • Muzio, M.1    Bosisio, D.2    Polentarutti, N.3    D'Amico, G.4    Stoppacciaro, A.5    Mancinelli, R.6
  • 24
    • 0035150620 scopus 로고    scopus 로고
    • The Toll receptor family
    • Muzio M, Mantovani A. The Toll receptor family. Allergy 2001, 56: 103-08.
    • (2001) Allergy , vol.56 , pp. 103-108
    • Muzio, M.1    Mantovani, A.2
  • 25
    • 0033580949 scopus 로고    scopus 로고
    • Peptidoglycan- And lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2
    • Schwandner R, Dziarski R, Wesche H, Rothe M, Kirschning CJ. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem 1999, 274: 17406-09.
    • (1999) J. Biol. Chem. , vol.274 , pp. 17406-17409
    • Schwandner, R.1    Dziarski, R.2    Wesche, H.3    Rothe, M.4    Kirschning, C.J.5
  • 27
    • 0035854686 scopus 로고    scopus 로고
    • The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS). Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2
    • Michelsen KS, Aicher A, Mohaupt M, Hartung T, Dimmeler S, Kirschning CJ et al. The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS). Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2. J Biol Chem 2001, 276: 25680-86.
    • (2001) J. Biol. Chem. , vol.276 , pp. 25680-25686
    • Michelsen, K.S.1    Aicher, A.2    Mohaupt, M.3    Hartung, T.4    Dimmeler, S.5    Kirschning, C.J.6
  • 32
    • 0034927975 scopus 로고    scopus 로고
    • Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice
    • Kaisho T, Akira S. Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice. Trends Immunol 2001, 22: 78-83.
    • (2001) Trends. Immunol. , vol.22 , pp. 78-83
    • Kaisho, T.1    Akira, S.2
  • 33
    • 0035339861 scopus 로고    scopus 로고
    • Endotoxin-induced maturation of MyD88-deficient dendritic cells
    • Kaisho T, Takeuchi O, Kawai T, Hoshino K, Akira S. Endotoxin-induced maturation of MyD88-deficient dendritic cells. J Immunol 2001, 166: 5688-94.
    • (2001) J. Immunol. , vol.166 , pp. 5688-5694
    • Kaisho, T.1    Takeuchi, O.2    Kawai, T.3    Hoshino, K.4    Akira, S.5
  • 34
    • 0033966740 scopus 로고    scopus 로고
    • The control of T cell responses by dendritic cell subsets
    • Reid SD, Penna G, Adorini L. The control of T cell responses by dendritic cell subsets. Curr Opin Immunol 2000, 12: 114-21.
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 114-121
    • Reid, S.D.1    Penna, G.2    Adorini, L.3
  • 35
    • 0034880197 scopus 로고    scopus 로고
    • Dendritic cell subsets and the regulation of Th1/Th2 responses
    • Maldonado-Lopez R, Moser M. Dendritic cell subsets and the regulation of Th1/Th2 responses. Semin Immunol 2001, 13: 275-82.
    • (2001) Semin. Immunol. , vol.13 , pp. 275-282
    • Maldonado-Lopez, R.1    Moser, M.2
  • 36
    • 0034995061 scopus 로고    scopus 로고
    • Dendritic cells as sensors of infection
    • Reis e Sousa C. Dendritic cells as sensors of infection. Immunity 2001, 14:495-98.
    • (2001) Immunity , vol.14 , pp. 495-498
    • Reis e Sousa, C.1
  • 38
    • 0031814098 scopus 로고    scopus 로고
    • Th1 cells induce and Th2 inhibit antigen-dependent IL-12 secretion by dendritic cells
    • Ria F, Penna G, Adorini L. Th1 cells induce and Th2 inhibit antigen-dependent IL-12 secretion by dendritic cells. Eur J Immunol 1998, 28: 2003-16.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 2003-2016
    • Ria, F.1    Penna, G.2    Adorini, L.3
  • 39
    • 0033178828 scopus 로고    scopus 로고
    • The role of dendritic cells in the induction and regulation of immunity to microbial infection
    • Reis e Sousa C, Sher A, Kaye P. The role of dendritic cells in the induction and regulation of immunity to microbial infection. Curr Opin Immunol 1999, 11: 392-99.
    • (1999) Curr. Opin. Immunol. , vol.11 , pp. 392-399
    • Reis e Sousa, C.1    Sher, A.2    Kaye, P.3
  • 40
    • 0035469894 scopus 로고    scopus 로고
    • Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation
    • Morelli AE, Zahorchak AF, Larregina AT, Colvin BL, Logar AJ, Takayama T et al. Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation. Blood 2001, 98: 1512-23.
    • (2001) Blood , vol.98 , pp. 1512-1523
    • Morelli, A.E.1    Zahorchak, A.F.2    Larregina, A.T.3    Colvin, B.L.4    Logar, A.J.5    Takayama, T.6
  • 42
    • 0036039739 scopus 로고    scopus 로고
    • Essential Roles for Dendritic Cells in the Pathogenesis and Potential Treatment of HIV Disease
    • Piguet V, Blauvelt A. Essential Roles for Dendritic Cells in the Pathogenesis and Potential Treatment of HIV Disease. J Invest Dermatol 2002, 119: 365-69.
    • (2002) J. Invest. Dermatol. , vol.119 , pp. 365-369
    • Piguet, V.1    Blauvelt, A.2
  • 43
    • 0036668250 scopus 로고    scopus 로고
    • The role of dendritic cells during Salmonella infection
    • Wick MJ. The role of dendritic cells during Salmonella infection. Curr Opin Immunol 2002, 14: 437-43.
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 437-443
    • Wick, M.J.1
  • 45
    • 0037198015 scopus 로고    scopus 로고
    • The frail elderly: Role of dendritic cells in the susceptibility of infection
    • Uyemura K, Castle SC, Makinodan T. The frail elderly: role of dendritic cells in the susceptibility of infection. Mech Ageing Dev 2002, 123: 955-62.
    • (2002) Mech. Ageing Dev. , vol.123 , pp. 955-962
    • Uyemura, K.1    Castle, S.C.2    Makinodan, T.3
  • 46
    • 0035885243 scopus 로고    scopus 로고
    • Inhibition of inflammatory cytokine production and lymphocyte proliferation by structurally different sesquiterpene lactones correlates with their effect on activation of NF-kappaB
    • Koch E, Klaas CA, Rungeler P, Castro V, Mora G, Vichnewski W, Merfort I. Inhibition of inflammatory cytokine production and lymphocyte proliferation by structurally different sesquiterpene lactones correlates with their effect on activation of NF-kappaB. Biochem Pharmacol 2001, 62: 795-801.
    • (2001) Biochem. Pharmacol. , vol.62 , pp. 795-801
    • Koch, E.1    Klaas, C.A.2    Rungeler, P.3    Castro, V.4    Mora, G.5    Vichnewski, W.6    Merfort, I.7
  • 48
    • 0034064042 scopus 로고    scopus 로고
    • The inflammatory balance in human sepsis
    • Adrie C, Pinsky MR. The inflammatory balance in human sepsis. Intensive Care Med 2000, 26: 364-75.
    • (2000) Intensive Care Med. , vol.26 , pp. 364-375
    • Adrie, C.1    Pinsky, M.R.2
  • 49
    • 0028244816 scopus 로고
    • Tumor necrosis factor: A pleiotropic cytokine and therapeutic target
    • Tracey KJ, Cerami A. Tumor necrosis factor: a pleiotropic cytokine and therapeutic target. Annu Rev Med 1994, 45: 491-503.
    • (1994) Annu. Rev. Med. , vol.45 , pp. 491-503
    • Tracey, K.J.1    Cerami, A.2
  • 50
    • 0031985386 scopus 로고    scopus 로고
    • The systemic inflammatory response syndrome: Definitions and aetiology
    • Nystrom PO. The systemic inflammatory response syndrome: definitions and aetiology. J Antimicrob Chemother 1998, 41: 1-7.
    • (1998) J. Antimicrob. Chemother. , vol.41 , pp. 1-7
    • Nystrom, P.O.1
  • 53
    • 0022411888 scopus 로고
    • Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin
    • Beutler B, Milsark IW, Cerami AC. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science 1985, 229: 869-71.
    • (1985) Science , vol.229 , pp. 869-871
    • Beutler, B.1    Milsark, I.W.2    Cerami, A.C.3
  • 54
    • 0023491364 scopus 로고
    • Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
    • Tracey KJ, Fong Y, Hesse DG, Manogue KR, Lee AT, Kuo GC et al. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature 1987, 330: 662-64.
    • (1987) Nature , vol.330 , pp. 662-664
    • Tracey, K.J.1    Fong, Y.2    Hesse, D.G.3    Manogue, K.R.4    Lee, A.T.5    Kuo, G.C.6
  • 55
    • 0023884204 scopus 로고
    • Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits
    • Mathison JC, Wolfson E, Ulevitch RJ. Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits. J Clin Invest 1988, 81: 1925-37.
    • (1988) J. Clin. Invest. , vol.81 , pp. 1925-1937
    • Mathison, J.C.1    Wolfson, E.2    Ulevitch, R.J.3
  • 56
    • 0027496501 scopus 로고
    • Tumor necrosis factor in the pathogenesis of infectious diseases
    • Beutler B, Grau GE. Tumor necrosis factor in the pathogenesis of infectious diseases. Crit Care Med 1993, 21: S423-35.
    • (1993) Crit. Care Med. , vol.21
    • Beutler, B.1    Grau, G.E.2
  • 57
    • 0033969341 scopus 로고    scopus 로고
    • Pro-versus anti-inflammatory cytokine profile in patients with severe sepsis: A marker for prognosis and future therapeutic options
    • Gogos CA, Drosou E, Bassaris HP, Skoutelis A. Pro-versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options. J Infect Dis 2000, 181: 176-80.
    • (2000) J. Infect. Dis. , vol.181 , pp. 176-180
    • Gogos, C.A.1    Drosou, E.2    Bassaris, H.P.3    Skoutelis, A.4
  • 60
    • 0031452476 scopus 로고    scopus 로고
    • Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock
    • Dinarello CA. Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock. Chest 1997, 112: 321S-29S.
    • (1997) Chest , vol.112
    • Dinarello, C.A.1
  • 61
    • 0027731546 scopus 로고
    • Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome
    • Casey LC, Balk RA, Bone RC. Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Ann Intern Med 1993, 119: 771-78.
    • (1993) Ann. Intern. Med. , vol.119 , pp. 771-778
    • Casey, L.C.1    Balk, R.A.2    Bone, R.C.3
  • 62
    • 0028450108 scopus 로고
    • Interleukin-6: A cytokine with potential diagnostic and therapeutic roles
    • Borden EC, Chin P. Interleukin-6: a cytokine with potential diagnostic and therapeutic roles. J Lab Clin Med 1994, 123: 824-29.
    • (1994) J. Lab. Clin. Med. , vol.123 , pp. 824-829
    • Borden, E.C.1    Chin, P.2
  • 63
    • 0034573399 scopus 로고    scopus 로고
    • Relationship between interleukin-6 plasma concentration in patients with sepsis, monocyte phenotype, monocyte phagocytic properties, and cytokine production
    • Spittler A, Razenberger M, Kupper H, Kaul M, Hackl W, Boltz-Nitulescu G et al. Relationship between interleukin-6 plasma concentration in patients with sepsis, monocyte phenotype, monocyte phagocytic properties, and cytokine production. Clin Infect Dis 2000, 31: 1338-42.
    • (2000) Clin. Infect. Dis. , vol.31 , pp. 1338-1342
    • Spittler, A.1    Razenberger, M.2    Kupper, H.3    Kaul, M.4    Hackl, W.5    Boltz-Nitulescu, G.6
  • 64
    • 9344246862 scopus 로고    scopus 로고
    • Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: A multicenter, randomized, placebo-controlled, dose-ranging study
    • Reinhart K, Wiegand-Lohnert C, Grimminger F, Kaul M, Withington S, Treacher D et al. Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: a multicenter, randomized, placebo-controlled, dose-ranging study. Crit Care Med 1996, 24: 733-42.
    • (1996) Crit. Care Med. , vol.24 , pp. 733-742
    • Reinhart, K.1    Wiegand-Lohnert, C.2    Grimminger, F.3    Kaul, M.4    Withington, S.5    Treacher, D.6
  • 65
    • 0027432393 scopus 로고
    • High levels of interleukin-8 in the blood and alveolar spaces of patients with pneumonia and adult respiratory distress syndrome
    • Chollet-Martin S, Montravers P, Gibert C, Elbim C, Desmonts JM, Fagon JY et al. High levels of interleukin-8 in the blood and alveolar spaces of patients with pneumonia and adult respiratory distress syndrome. Infect Immun 1993, 61: 4553-59.
    • (1993) Infect. Immun. , vol.61 , pp. 4553-4559
    • Chollet-Martin, S.1    Montravers, P.2    Gibert, C.3    Elbim, C.4    Desmonts, J.M.5    Fagon, J.Y.6
  • 68
    • 0026094306 scopus 로고
    • Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
    • de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991, 174: 1209-20.
    • (1991) J. Exp. Med. , vol.174 , pp. 1209-1220
    • de Waal Malefyt, R.1    Abrams, J.2    Bennett, B.3    Figdor, C.G.4    de Vries, J.E.5
  • 69
    • 0027478367 scopus 로고
    • Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia
    • Gerard C, Bruyns C, Marchant A, Abramowicz D, Vandenabeele P, Delvaux A et al. Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J Exp Med 1993, 177: 547-50.
    • (1993) J. Exp. Med. , vol.177 , pp. 547-550
    • Gerard, C.1    Bruyns, C.2    Marchant, A.3    Abramowicz, D.4    Vandenabeele, P.5    Delvaux, A.6
  • 71
    • 0028826247 scopus 로고
    • Clinical and biological significance of interleukin-10 plasma levels in patients with septic shock
    • Marchant A, Alegre ML, Hakim A, Pierard G, Marecaux G, Friedman G et al. Clinical and biological significance of interleukin-10 plasma levels in patients with septic shock. J Clin Immunol 1995, 15: 266-73.
    • (1995) J. Clin. Immunol. , vol.15 , pp. 266-273
    • Marchant, A.1    Alegre, M.L.2    Hakim, A.3    Pierard, G.4    Marecaux, G.5    Friedman, G.6
  • 72
    • 16944363557 scopus 로고    scopus 로고
    • Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: Sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13
    • van der Poll T, de Waal Malefyt R, Coyle SM, Lowry SF. Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. J Infect Dis 1997, 175: 118-22.
    • (1997) J. Infect. Dis. , vol.175 , pp. 118-122
    • van der Poll, T.1    de Waal Malefyt, R.2    Coyle, S.M.3    Lowry, S.F.4
  • 74
    • 0028819936 scopus 로고
    • Release of anti-inflammatory mediators after mechanical trauma correlates with severity of injury and clinical outcome
    • discussion 885-877
    • Ertel W, Keel M, Bonaccio M, Steckholzer U, Gallati H, Kenney JS et al. Release of anti-inflammatory mediators after mechanical trauma correlates with severity of injury and clinical outcome. J Trauma 1995, 39: 879-85; discussion 885-77.
    • (1995) J. Trauma , vol.39 , pp. 879-885
    • Ertel, W.1    Keel, M.2    Bonaccio, M.3    Steckholzer, U.4    Gallati, H.5    Kenney, J.S.6
  • 75
    • 0033373858 scopus 로고    scopus 로고
    • Release of anti-inflammatory mediators after major torso trauma correlates with the development of postinjury multiple organ failure
    • Partrick DA, Moore EE, Moore FA, Biffl WL, Barnett CC, Jr. Release of anti-inflammatory mediators after major torso trauma correlates with the development of postinjury multiple organ failure. Am J Surg 1999, 178: 564-69.
    • (1999) Am. J. Surg. , vol.178 , pp. 564-569
    • Partrick, D.A.1    Moore, E.E.2    Moore, F.A.3    Biffl, W.L.4    Barnett C.C., Jr.5
  • 76
    • 0031831906 scopus 로고    scopus 로고
    • Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist
    • Dinarello CA. Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist. Int Rev Immunol 1998, 16: 457-99.
    • (1998) Int. Rev. Immunol. , vol.16 , pp. 457-499
    • Dinarello, C.A.1
  • 77
    • 0027489870 scopus 로고
    • Hematologic and immunomodulatory effects of an interleukin-1 receptor antagonist coinfusion during low-dose endotoxemia in healthy humans
    • Granowitz EV, Porat R, Mier JW, Orencole SF, Callahan MV, Cannon JG et al. Hematologic and immunomodulatory effects of an interleukin-1 receptor antagonist coinfusion during low-dose endotoxemia in healthy humans. Blood 1993, 82: 2985-90.
    • (1993) Blood , vol.82 , pp. 2985-2990
    • Granowitz, E.V.1    Porat, R.2    Mier, J.W.3    Orencole, S.F.4    Callahan, M.V.5    Cannon, J.G.6
  • 78
    • 0030843156 scopus 로고    scopus 로고
    • Sepsis: A new hypothesis for pathogenesis of the disease process
    • Bone RC, Grodzin CJ, Balk RA. Sepsis: a new hypothesis for pathogenesis of the disease process. Chest 1997, 112: 235-43.
    • (1997) Chest , vol.112 , pp. 235-243
    • Bone, R.C.1    Grodzin, C.J.2    Balk, R.A.3
  • 79
    • 0028873282 scopus 로고
    • The acute respiratory distress syndrome
    • Kollef MH, Schuster DP. The acute respiratory distress syndrome. N Engl J Med 1995, 332: 27-37.
    • (1995) N. Engl. J. Med. , vol.332 , pp. 27-37
    • Kollef, M.H.1    Schuster, D.P.2
  • 80
    • 0031801139 scopus 로고    scopus 로고
    • Pathophysiology of cardiovascular dysfunction in septic shock
    • Parker MM. Pathophysiology of cardiovascular dysfunction in septic shock. New Horiz 1998, 6: 130-38.
    • (1998) New Horiz , vol.6 , pp. 130-138
    • Parker, M.M.1
  • 81
    • 0032199199 scopus 로고    scopus 로고
    • Myocardial dysfunction in the septic rat heart: Role of nitric oxide
    • McDonough KH, Smith T, Patel K, Quinn M. Myocardial dysfunction in the septic rat heart: role of nitric oxide. Shock 1998, 10: 371-76.
    • (1998) Shock , vol.10 , pp. 371-376
    • McDonough, K.H.1    Smith, T.2    Patel, K.3    Quinn, M.4
  • 82
    • 0028790087 scopus 로고
    • Role of nitric oxide in the vascular dysfunction of septic shock
    • Rees DD. Role of nitric oxide in the vascular dysfunction of septic shock. Biochem Soc Trans 1995, 23: 1025-29.
    • (1995) Biochem. Soc. Trans. , vol.23 , pp. 1025-1029
    • Rees, D.D.1
  • 83
    • 0031945838 scopus 로고    scopus 로고
    • Cardiac dysfunction in sepsis: New theories and clinical implications
    • Grocott-Mason RM, Shah AM. Cardiac dysfunction in sepsis: new theories and clinical implications. Intensive Care Med 1998, 24: 286-95.
    • (1998) Intensive Care Med. , vol.24 , pp. 286-295
    • Grocott-Mason, R.M.1    Shah, A.M.2
  • 84
    • 0032569446 scopus 로고    scopus 로고
    • Myocardial dysfunction in sepsis: Clinical and experimental investigations
    • Suffredini AF. Myocardial dysfunction in sepsis: clinical and experimental investigations. Schweiz Med Wochenschr 1998, 128: 1444-52.
    • (1998) Schweiz. Med. Wochenschr. , vol.128 , pp. 1444-1452
    • Suffredini, A.F.1
  • 85
    • 0031921380 scopus 로고    scopus 로고
    • Pathogenesis of renal failure in sepsis
    • Thijs A, Thijs LG. Pathogenesis of renal failure in sepsis. Kidney Int Suppl 1998, 66: S34-37.
    • (1998) Kidney Int. Suppl. , vol.66
    • Thijs, A.1    Thijs, L.G.2
  • 86
    • 0028124593 scopus 로고
    • Pathogenesis of acute renal failure during sepsis
    • Groeneveld AB. Pathogenesis of acute renal failure during sepsis. Nephrol Dial Transplant 1994, 9: 47-51.
    • (1994) Nephrol. Dial. Transplant. , vol.9 , pp. 47-51
    • Groeneveld, A.B.1
  • 87
    • 7144251856 scopus 로고    scopus 로고
    • Antithrombin III (ATIII) replacement therapy in patients with sepsis and/or postsurgical complications: A controlled double-blind, randomized, multicenter study
    • Baudo F, Caimi TM, de Cataldo F, Ravizza A, Arlati S, Casella G et al. Antithrombin III (ATIII) replacement therapy in patients with sepsis and/or postsurgical complications: a controlled double-blind, randomized, multicenter study. Intensive Care Med 1998, 24: 336-42.
    • (1998) Intensive Care Med. , vol.24 , pp. 336-342
    • Baudo, F.1    Caimi, T.M.2    de Cataldo, F.3    Ravizza, A.4    Arlati, S.5    Casella, G.6
  • 88
  • 89
    • 0034927828 scopus 로고    scopus 로고
    • Hepatic response to sepsis: Interaction between coagulation and inflammatory processes
    • Dhainaut JF, Marin N, Mignon A, Vinsonneau C. Hepatic response to sepsis: interaction between coagulation and inflammatory processes. Crit Care Med 2001, 29: S42-47.
    • (2001) Crit. Care Med. , vol.29
    • Dhainaut, J.F.1    Marin, N.2    Mignon, A.3    Vinsonneau, C.4
  • 90
    • 0033636643 scopus 로고    scopus 로고
    • The hepatic microvascular responses to sepsis
    • Ring A, Stremmel W. The hepatic microvascular responses to sepsis. Semin Thromb Hemost 2000, 26: 589-94.
    • (2000) Semin. Thromb. Hemost. , vol.26 , pp. 589-594
    • Ring, A.1    Stremmel, W.2
  • 92
    • 0033029748 scopus 로고    scopus 로고
    • Characterization of the Kupffer cell response to exogenous endotoxin in a rodent model of obstructive jaundice
    • Kennedy JA, Clements WD, Kirk SJ, McCaigue MD, Campbell GR, Erwin PJ et al. Characterization of the Kupffer cell response to exogenous endotoxin in a rodent model of obstructive jaundice. Br J Surg 1999, 86: 628-33.
    • (1999) Br. J. Surg. , vol.86 , pp. 628-633
    • Kennedy, J.A.1    Clements, W.D.2    Kirk, S.J.3    McCaigue, M.D.4    Campbell, G.R.5    Erwin, P.J.6
  • 94
    • 0031799302 scopus 로고    scopus 로고
    • Neurological complications in critically ill patients; septic encephalopathy, critical illness polyneuropathy
    • Nauwynck M, Huyghens L. Neurological complications in critically ill patients; septic encephalopathy, critical illness polyneuropathy. Acta Clin Belg 1998, 53: 92-97.
    • (1998) Acta Clin. Belg. , vol.53 , pp. 92-97
    • Nauwynck, M.1    Huyghens, L.2
  • 95
    • 0029786545 scopus 로고    scopus 로고
    • Sepsis and the systemic inflammatory response syndrome: Neuromuscular manifestations
    • Bolton CF. Sepsis and the systemic inflammatory response syndrome: neuromuscular manifestations. Crit Care Med 1996, 24: 1408-16.
    • (1996) Crit. Care Med. , vol.24 , pp. 1408-1416
    • Bolton, C.F.1
  • 98
    • 0033868518 scopus 로고    scopus 로고
    • Increased gut permeability and bacterial translocation in Pseudomonas pneumonia-induced sepsis
    • Yu P, Martin CM. Increased gut permeability and bacterial translocation in Pseudomonas pneumonia-induced sepsis. Crit Care Med 2000, 28: 2573-77.
    • (2000) Crit. Care Med. , vol.28 , pp. 2573-2577
    • Yu, P.1    Martin, C.M.2
  • 99
    • 0028931071 scopus 로고
    • Bacterial translocation from the gastrointestinal tract
    • Berg RD. Bacterial translocation from the gastrointestinal tract. Trends Microbiol 1995, 3: 149-54.
    • (1995) Trends Microbiol. , vol.3 , pp. 149-154
    • Berg, R.D.1
  • 101
    • 0035070998 scopus 로고    scopus 로고
    • Quorum sensing as an integral component of gene regulatory networks in Gram-negative bacteria
    • Withers H, Swift S, Williams P. Quorum sensing as an integral component of gene regulatory networks in Gram-negative bacteria. Curr Opin Microbiol 2001, 4: 186-93.
    • (2001) Curr. Opin. Microbiol. , vol.4 , pp. 186-193
    • Withers, H.1    Swift, S.2    Williams, P.3
  • 102
    • 0036220450 scopus 로고    scopus 로고
    • Bacterial cell-to-cell communication: Sorry, can't talk now - Gone to lunch!
    • Winzer K, Hardie KR, Williams P. Bacterial cell-to-cell communication: sorry, can't talk now - gone to lunch! Curr Opin Microbiol 2002, 5: 216-22.
    • (2002) Curr. Opin. Microbiol. , vol.5 , pp. 216-222
    • Winzer, K.1    Hardie, K.R.2    Williams, P.3
  • 104
    • 0036148647 scopus 로고    scopus 로고
    • Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound
    • Hentzer M, Riedel K, Rasmussen TB, Heydorn A, Andersen JB, Parsek MR et al. Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound. Microbiology 2002, 148: 87-102.
    • (2002) Microbiology , vol.148 , pp. 87-102
    • Hentzer, M.1    Riedel, K.2    Rasmussen, T.B.3    Heydorn, A.4    Andersen, J.B.5    Parsek, M.R.6
  • 105
    • 0034015354 scopus 로고    scopus 로고
    • Biofilm, city of microbes
    • Watnick P, Kolter R. Biofilm, city of microbes. J Bacteriol 2000, 182: 2675-79.
    • (2000) J. Bacteriol. , vol.182 , pp. 2675-2679
    • Watnick, P.1    Kolter, R.2
  • 106
    • 0035014383 scopus 로고    scopus 로고
    • Mechanisms of biofilm resistance to antimicrobial agents
    • Mah TF, O'Toole GA. Mechanisms of biofilm resistance to antimicrobial agents. Trends Microbiol 2001, 9: 34-39.
    • (2001) Trends Microbiol. , vol.9 , pp. 34-39
    • Mah, T.F.1    O'Toole, G.A.2
  • 108
    • 0032973625 scopus 로고    scopus 로고
    • Mucosal immunity and inflammation. I. Mucosal dendritic cells: Their specialized role in initiating T cell responses
    • Iwasaki A, Kelsall BL. Mucosal immunity and inflammation. I. Mucosal dendritic cells: their specialized role in initiating T cell responses. Am J Physiol 1999, 276: G1074-78.
    • (1999) Am. J. Physiol. , vol.276
    • Iwasaki, A.1    Kelsall, B.L.2
  • 109
    • 0036284365 scopus 로고    scopus 로고
    • Getting to the guts of immune regulation
    • Bilsborough J, Viney JL. Getting to the guts of immune regulation. Immunology 2002, 106: 139-43.
    • (2002) Immunology , vol.106 , pp. 139-143
    • Bilsborough, J.1    Viney, J.L.2
  • 110
    • 0031975582 scopus 로고    scopus 로고
    • The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone has immunomodulatory activity
    • Telford G, Wheeler D, Williams P, Tomkins PT, Appleby P, Sewell H et al. The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone has immunomodulatory activity. Infect Immun 1998, 66: 36-42.
    • (1998) Infect. Immun. , vol.66 , pp. 36-42
    • Telford, G.1    Wheeler, D.2    Williams, P.3    Tomkins, P.T.4    Appleby, P.5    Sewell, H.6
  • 111
    • 0036158178 scopus 로고    scopus 로고
    • The Pseudomonas aeruginosa quorum-sensing molecule N-(3oxododecanoyl)homoserine lactone contributes to virulence and induces inflammation in vivo
    • Smith RS, Harris SG, Phipps R, Iglewski B. The Pseudomonas aeruginosa quorum-sensing molecule N-(3oxododecanoyl)homoserine lactone contributes to virulence and induces inflammation in vivo. J Bacteriol 2002, 184: 1132-39.
    • (2002) J. Bacteriol. , vol.184 , pp. 1132-1139
    • Smith, R.S.1    Harris, S.G.2    Phipps, R.3    Iglewski, B.4
  • 112
    • 0037413582 scopus 로고    scopus 로고
    • Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators
    • Chhabra SR, Harty C, Hooi DS, Daykin M, Williams P, Telford G et al. Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators. J Med Chem 2003, 46: 97-104.
    • (2003) J. Med. Chem. , vol.46 , pp. 97-104
    • Chhabra, S.R.1    Harty, C.2    Hooi, D.S.3    Daykin, M.4    Williams, P.5    Telford, G.6
  • 113
    • 0025281827 scopus 로고
    • Dobutamine administration in septic shock: Addition to a standard protocol
    • Vincent JL, Roman A, Kahn RJ. Dobutamine administration in septic shock: addition to a standard protocol. Crit Care Med 1990, 18: 689-93.
    • (1990) Crit. Care Med. , vol.18 , pp. 689-693
    • Vincent, J.L.1    Roman, A.2    Kahn, R.J.3
  • 116
    • 0036333006 scopus 로고    scopus 로고
    • Measurement of endotoxin activity in critically ill patients using whole blood neutrophil dependent chemiluminescence
    • Marshall JC, Walker PM, Foster DM, Harris D, Ribeiro M, Paice J et al. Measurement of endotoxin activity in critically ill patients using whole blood neutrophil dependent chemiluminescence. Crit Care 2002, 6: 342-48.
    • (2002) Crit. Care , vol.6 , pp. 342-348
    • Marshall, J.C.1    Walker, P.M.2    Foster, D.M.3    Harris, D.4    Ribeiro, M.5    Paice, J.6
  • 117
    • 0034924586 scopus 로고    scopus 로고
    • Rationale for restoration of physiological anticoagulant pathways in patients with sepsis and disseminated intravascular coagulation
    • Levi M, de Jonge E, van der Poll T. Rationale for restoration of physiological anticoagulant pathways in patients with sepsis and disseminated intravascular coagulation. Crit Care Med 2001, 29: S90-94.
    • (2001) Crit. Care Med. , vol.29
    • Levi, M.1    de Jonge, E.2    van der Poll, T.3
  • 118
    • 0032874830 scopus 로고    scopus 로고
    • A DA Antithrombin replacement in patients with sepsis and septic shock
    • Giudici D, Baudo F, Palareti G, Ravizza A, Ridolfi L, A DA. Antithrombin replacement in patients with sepsis and septic shock. Haematologica 1999, 84: 452-60.
    • (1999) Haematologica , vol.84 , pp. 452-460
    • Giudici, D.1    Baudo, F.2    Palareti, G.3    Ravizza, A.4    Ridolfi, L.5
  • 119
    • 0026016470 scopus 로고
    • Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial
    • The HA-1A Sepsis Study Group
    • Ziegler EJ, Fisher CJ, Jr., Sprung CL, Straube RC, Sadoff JC, Foulke GE et al. Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A Sepsis Study Group. N Engl J Med 1991, 324: 429-36.
    • (1991) N. Engl. J. Med. , vol.324 , pp. 429-436
    • Ziegler, E.J.1    Fisher C.J., Jr.2    Sprung, C.L.3    Straube, R.C.4    Sadoff, J.C.5    Foulke, G.E.6
  • 120
    • 0025917510 scopus 로고
    • A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis
    • The XOMA Sepsis Study Group
    • Greenman RL, Schein RM, Martin MA, Wenzel RP, MacIntyre NR, Emmanuel G et al. A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group. Jama 1991, 266: 1097-102.
    • (1991) Jama , vol.266 , pp. 1097-1102
    • Greenman, R.L.1    Schein, R.M.2    Martin, M.A.3    Wenzel, R.P.4    MacIntyre, N.R.5    Emmanuel, G.6
  • 121
    • 0027166126 scopus 로고
    • A broadly cross-protective monoclonal antibody binding to Escherichia coli and Salmonella lipopolysaccharides
    • Di Padova FE, Brade H, Barclay GR, Poxton IR, Liehl E, Schuetze E et al. A broadly cross-protective monoclonal antibody binding to Escherichia coli and Salmonella lipopolysaccharides. Infect Immun 1993, 61: 3863-72.
    • (1993) Infect. Immun. , vol.61 , pp. 3863-3872
    • Di Padova, F.E.1    Brade, H.2    Barclay, G.R.3    Poxton, I.R.4    Liehl, E.5    Schuetze, E.6
  • 122
    • 0029835023 scopus 로고    scopus 로고
    • INTERSEPT: An international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis
    • International Sepsis Trial Study Group
    • Cohen J, Carlet J. INTERSEPT: an international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group. Crit Care Med 1996, 24: 1431-40.
    • (1996) Crit. Care Med. , vol.24 , pp. 1431-1440
    • Cohen, J.1    Carlet, J.2
  • 123
    • 0032495658 scopus 로고    scopus 로고
    • Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock
    • NORASEPT II Study Group
    • Abraham E, Anzueto A, Gutierrez G, Tessler S, San Pedro G, Wunderink R et al. Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock. NORASEPT II Study Group. Lancet 1998, 351: 929-33.
    • (1998) Lancet , vol.351 , pp. 929-933
    • Abraham, E.1    Anzueto, A.2    Gutierrez, G.3    Tessler, S.4    San Pedro, G.5    Wunderink, R.6
  • 124
    • 0034895949 scopus 로고    scopus 로고
    • A multicenter, open-label, prospective, randomized, dose-ranging pharmacokinetic study of the anti-TNF-alpha antibody afelimomab in patients with sepsis syndrome
    • Gallagher J, Fisher C, Sherman B, Munger M, Meyers B, Ellison T et al. A multicenter, open-label, prospective, randomized, dose-ranging pharmacokinetic study of the anti-TNF-alpha antibody afelimomab in patients with sepsis syndrome. Intensive Care Med 2001, 27: 1169-78.
    • (2001) Intensive Care Med. , vol.27 , pp. 1169-1178
    • Gallagher, J.1    Fisher, C.2    Sherman, B.3    Munger, M.4    Meyers, B.5    Ellison, T.6
  • 125
    • 0035682336 scopus 로고    scopus 로고
    • Severe sepsis induces deficient interferon-gamma and interleukin-12 production, but interleukin-12 therapy improves survival in peritonitis
    • Ono S, Ueno C, Aosasa S, Tsujimoto H, Seki S, Mochizuki H. Severe sepsis induces deficient interferon-gamma and interleukin-12 production, but interleukin-12 therapy improves survival in peritonitis. Am J Surg 2001, 182: 491-97.
    • (2001) Am. J. Surg. , vol.182 , pp. 491-497
    • Ono, S.1    Ueno, C.2    Aosasa, S.3    Tsujimoto, H.4    Seki, S.5    Mochizuki, H.6
  • 126
    • 0034913364 scopus 로고    scopus 로고
    • Anti-tumor necrosis factor therapy in sepsis: Update on clinical trials and lessons learned
    • Reinhart K, Karzai W. Anti-tumor necrosis factor therapy in sepsis: update on clinical trials and lessons learned. Crit Care Med 2001, 29: S121-25.
    • (2001) Crit. Care Med. , vol.29
    • Reinhart, K.1    Karzai, W.2
  • 127
    • 0036205471 scopus 로고    scopus 로고
    • New and emerging therapies for sepsis
    • Healy DP. New and emerging therapies for sepsis. Ann Pharmacother 2002, 36:648-654.
    • (2002) Ann. Pharmacother. , vol.36 , pp. 648-654
    • Healy, D.P.1
  • 128
    • 0033816376 scopus 로고    scopus 로고
    • Tissue factor inhibition and clinical trial results of tissue factor pathway inhibitor in sepsis
    • Abraham E. Tissue factor inhibition and clinical trial results of tissue factor pathway inhibitor in sepsis. Crit Care Med 2000, 28: S31-33.
    • (2000) Crit. Care Med. , vol.28
    • Abraham, E.1
  • 129
    • 0035904368 scopus 로고    scopus 로고
    • Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: A randomized controlled trial
    • Warren BL, Eid A, Singer P, Pillay SS, Carl P, Novak I et al. Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial. Jama 2001, 286: 1869-78.
    • (2001) Jama , vol.286 , pp. 1869-1878
    • Warren, B.L.1    Eid, A.2    Singer, P.3    Pillay, S.S.4    Carl, P.5    Novak, I.6
  • 130
    • 0028239555 scopus 로고
    • Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial
    • Phase III rhIL-1ra Sepsis Syndrome Study Group
    • Fisher CJ, Jr., Dhainaut JF, Opal SM, Pribble JP, Balk RA, Slotman GJ et al. Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group. Jama 1994, 271: 1836-43.
    • (1994) Jama , vol.271 , pp. 1836-1843
    • Fisher C.J., Jr.1    Dhainaut, J.F.2    Opal, S.M.3    Pribble, J.P.4    Balk, R.A.5    Slotman, G.J.6
  • 132
    • 0027180430 scopus 로고
    • The clinical evaluation of new drugs for sepsis. A prospective study design based on survival analysis
    • Knaus WA, Harrell FE, Fisher CJ, Jr., Wagner DP, Opal SM, Sadoff JC et al. The clinical evaluation of new drugs for sepsis. A prospective study design based on survival analysis. Jama 1993, 270: 1233-41.
    • (1993) Jama , vol.270 , pp. 1233-1241
    • Knaus, W.A.1    Harrell, F.E.2    Fisher C.J., Jr.3    Wagner, D.P.4    Opal, S.M.5    Sadoff, J.C.6
  • 133
    • 0030877935 scopus 로고    scopus 로고
    • Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: A phase III, randomized, double-blind, placebo-controlled, multicenter trial
    • The Interleukin-1 Receptor Antagonist Sepsis Investigator Group
    • Opal SM, Fisher CJ, Jr., Dhainaut JF, Vincent JL, Brase R, Lowry SF et al. Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group. Crit Care Med 1997, 25: 1115-24.
    • (1997) Crit. Care Med. , vol.25 , pp. 1115-1124
    • Opal, S.M.1    Fisher C.J., Jr.2    Dhainaut, J.F.3    Vincent, J.L.4    Brase, R.5    Lowry, S.F.6
  • 134
    • 0026741275 scopus 로고
    • Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo
    • Van Zee KJ, Kohno T, Fischer E, Rock CS, Moldawer LL, Lowry SF. Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo. Proc Natl Acad Sci USA 1992, 89: 4845-49.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 4845-4849
    • Van Zee, K.J.1    Kohno, T.2    Fischer, E.3    Rock, C.S.4    Moldawer, L.L.5    Lowry, S.F.6
  • 135
    • 0025943512 scopus 로고
    • Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide-induced lethality
    • Lesslauer W, Tabuchi H, Gentz R, Brockhaus M, Schlaeger EJ, Grau G et al. Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide-induced lethality. Eur J Immunol 1991, 21: 2883-86.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 2883-2886
    • Lesslauer, W.1    Tabuchi, H.2    Gentz, R.3    Brockhaus, M.4    Schlaeger, E.J.5    Grau, G.6
  • 136
    • 0029900294 scopus 로고    scopus 로고
    • Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein
    • The Soluble TNF Receptor Sepsis Study Group
    • Fisher CJ, Jr., Agosti JM, Opal SM, Lowry SF, Balk RA, Sadoff JC et al. Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group. N Engl J Med 1996, 334: 1697-702.
    • (1996) N. Engl. J. Med. , vol.334 , pp. 1697-1702
    • Fisher C.J., Jr.1    Agosti, J.M.2    Opal, S.M.3    Lowry, S.F.4    Balk, R.A.5    Sadoff, J.C.6
  • 137
    • 8244235133 scopus 로고    scopus 로고
    • p55 Tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock. A randomized controlled multicenter trial
    • Ro 45-2081 Study Group
    • Abraham E, Glauser MP, Butler T, Garbino J, Gelmont D, Laterre PF et al. p55 Tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock. A randomized controlled multicenter trial. Ro 45-2081 Study Group. Jama 1997, 277: 1531-38.
    • (1997) Jama , vol.277 , pp. 1531-1538
    • Abraham, E.1    Glauser, M.P.2    Butler, T.3    Garbino, J.4    Gelmont, D.5    Laterre, P.F.6
  • 139
    • 0037151571 scopus 로고    scopus 로고
    • Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock
    • Annane D, Sebille V, Charpentier C, Bollaert PE, Francois B, Korach JM et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. Jama 2002, 288: 862-71.
    • (2002) Jama , vol.288 , pp. 862-871
    • Annane, D.1    Sebille, V.2    Charpentier, C.3    Bollaert, P.E.4    Francois, B.5    Korach, J.M.6
  • 140
    • 0035144237 scopus 로고    scopus 로고
    • Immunomodulation in septic shock: Hydrocortisone differentially regulates cytokine responses
    • Briegel J, Jochum M, Gippner-Steppert C, Thiel M. Immunomodulation in septic shock: hydrocortisone differentially regulates cytokine responses. J Am Soc Nephrol 2001, 12: S70-74.
    • (2001) J. Am. Soc. Nephrol. , vol.12
    • Briegel, J.1    Jochum, M.2    Gippner-Steppert, C.3    Thiel, M.4
  • 141
    • 0032946372 scopus 로고    scopus 로고
    • Stress doses of hydrocortisone reverse hyperdynamic septic shock: A prospective, randomized, double-blind, single-center study
    • Briegel J, Forst H, Haller M, Schelling G, Kilger E, Kuprat G et al. Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study. Crit Care Med 1999, 27: 723-32.
    • (1999) Crit. Care Med. , vol.27 , pp. 723-732
    • Briegel, J.1    Forst, H.2    Haller, M.3    Schelling, G.4    Kilger, E.5    Kuprat, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.