Increased gut permeability and bacterial translocation in Pseudomonas pneumonia-induced sepsis

Critical Care Medicine

Volumn 28, Issue 7, 2000, Pages 2573-2577

  Yu, Pei ^a   Martin, Claudio M ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

Author keywords

Bacteria translocation; Gut mucosal permeability; Hemodynamics; Microvascular permeability; Morphology; Pneumonia; Rats; Sepsis

Indexed keywords

ALBUMIN; CHROMIUM 51; EDETIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL PNEUMONIA; BACTERIAL TRANSLOCATION; CONTROLLED STUDY; EXTRAVASATION; HEART INDEX; HEMODYNAMICS; HISTOPATHOLOGY; INTESTINE INJURY; INTESTINE MUCOSA PERMEABILITY; MALE; MEAN ARTERIAL PRESSURE; MESENTERY LYMPH NODE; MULTIPLE ORGAN FAILURE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RAT; SEPSIS;

EID: 0033868518     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200007000-00065     Document Type: Article

References (22)

1. 1. Bone RC: The pathogenesis of sepsis. Ann Intern Med 1991; 115:457-469
2. 2. Dorinsky PM, Gadek JE: Mechanisms of multiple nonpulmonary organ failure in ARDS. Chest 1989; 96:885-892
3. 3. Flamand F, Sibbald WJ, Girotti MJ, et al: Pentoxifylline does not prevent microvascular injury in normotensive, septic rats. Crit Care Med 1995; 23:119-124
4. 4. St. John RC, Mizer LA, Kindt GC, et al: Acid aspiration-induced acute lung injury causes leukocyte-dependent systemic organ injury. J Appl Physiol 1993; 74:1994-2003
5. 5. Goldman G, Welbourn R, Kobzik L, et al: Tumor necrosis factor-a mediates acid aspiration-induced systemic organ injury. Ann Surg 1990; 212:513-520
6. 6. Brackett DJ, Schaefer CF, Tompkins P: Evaluation of cardiac output, total peripheral vascular resistance, and plasma concentrations of vasopressin in the conscious, unrestrained rat during endotoxemia. Circ Shock 1985; 17:273-284
7. 7. Martin CM, Yaghi A, Sibbald WJ, et al: Differential impairment of vascular reactivity of small pulmonary and systemic arteries in hyperdynamic sepsis. Am Rev Respir Dis 1993; 148:164-172
8. 8. Yu P, Boughner DR, Sibbald WJ, et al: Myocardial collagen changes and edema in rats with hyperdynamic sepsis. Crit Care Med 1997; 25:657-662
9. 9. Moolenbeek C, Ruitenberg EJ: The 'Swiss roll': A simple technique for histological studies of the rodent intestine. Lab Animals 1981; 15:57-59
10. 10. Chiu CJ, McArdle AH, Brown R, et al: Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal. Arch Surg 1970; 101: 478-483
11. 11. Deitch EA: The role of intestinal barrier failure and bacterial translocation in the development of systemic infection and multiple organ failure. Arch Surg 1990; 125:403-404
12. 12. Doig CJ, Sutherland LR, Sandham D, et al: Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients. Am J Respir Crit Care Med 1998; 158:444-451
13. 13. Rombeau JL, Takala J: Summary of round table conference: gut dysfunction in critical illness. Intensive Care Med 1998; 23: 476-479
14. 14. O'Boyle CJ, MacFie J, Mitchell CJ, et al: Microbiology of bacterial translocation in humans. Cut 1998; 42:29-35
15. 51Cr-EDTA in patients with gastrointestinal inflammatory disease. Am J Gastroenterol 1987; 82:1159-1164
16. 16. Nylander O, Kvietys PR, Granger DN: Effects of hydrochloric acid on duodenal and jejunal mucosal permeability in the rat. Am J Physiol 1989; 257:G653-G660
17. 17. Behens RH, Szaz KF, Northrop C, et al: Radionuclide studies for the assessment of intestinal permeability. Eur J Clin Invest 1986; 17:100-105
18. 18. Renkin EM, Joyner WL, Gustafson-Sgro M, et al: Albumin extravasation rates in tissues of anesthetized and unanesthetized rats. J Appl Physiol 1989; 66:2056-2060
19. 19. Parillo JE, Parker MM, Ognibene EP: Septic shock in humans. Advances in the understanding of pathogenesis, cardiovascular dysfunction and therapy. Ann Intern Med 1990; 113:227-242
20. 20. Piper RD, Cook DJ, Bone RC, et al: Introducing critical appraisal to studies of animal models investigating novel therapies in sepsis. Crit Care Med 1996; 24:2059-2070
21. 21. van Lanschot JJB, Mealy K, Wilmore DW: The effects of tumor necrosis factor on intestinal structure and metabolism. Ann Surg 1990; 212:663-670
22. 22. Farquhar I, Martin CM, Lam C, et al: Decreased capillary density in vivo in bowel mucosa of rats with normotensive sepsis. J Surg Res 1996; 61:190-196