The role of Toll-like receptors in host defense against microbial infection

Current Opinion in Immunology

Volumn 13, Issue 1, 2001, Pages 104-108

  Krutzik, S R ^a   Sieling, P A ^a   Modlin, R L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BACTERIUM LIPOPOLYSACCHARIDE; CYTOKINE; LIGAND; TOLL LIKE RECEPTOR;

ANTIBACTERIAL ACTIVITY; BACTERIAL INFECTION; CELL ACTIVATION; CYTOKINE RELEASE; DROSOPHILA; EVOLUTION; HOST RESISTANCE; IMMUNE RESPONSE; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN EXPRESSION; REVIEW;

EID: 0035142623     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(00)00189-8     Document Type: Review

References (53)

1. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
2. Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
3. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor
4. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in TIr4 gene
5. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components
6. Repurification of lipopolysaccharide eliminates signaling through both human and murine Toll-like receptor 2
7. Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors
8. Inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by Toll-like receptor 2
9. Cell activation and apoptosis by bacterial lipoproteins through Toll-like receptor-2
10. The lipoprotein of the outer membrane of Escherichia coli: A B-lymphocyte mitogen
11. Lipid modification of the 17-kilodalton membrane immunogen of Treponema pallidum determines macrophage activation as well as amphiphilicity
12. Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a Toll-like receptor 2- and MyD88-dependent signaling pathway
13. Drosophila host defense: Differential induction of antimicrobial peptide genes after infection by various classes of microorganisms
14. The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense
15. Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation
16. Constitutive activation of Toll-mediated antifungal defense in serpin-deficient Drosophila
17. Heat shock protein 60 is a putative endogenous ligand of the Toll-like receptor-4 complex
18. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
19. Inhibition of experimental tumor metastasis by dendritic cells pulsed with alpha-galactosylceramide
20. Toll-like receptor 4-deficient mice have reduced bone destruction following mixed anaerobic infection
21. Activation of Toll-like receptor 2 on human denritic cells triggers induction of IL-12 but not IL-10
22. Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways
23. The human Toll signalling pathway: Divergence of nuclear factor and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)
24. Signaling events induced by lipopolysaccharide-activated Toll-like receptor 2
25. Unresponsiveness of MyD88-deficient mice to endotoxin
26. TAK1 mediates an activation signal from Toll-like receptor(s) to nuclear factor-kappa B in lipopoly-saccharide-stimulated macrophages
27. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
28. A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NF kappa B in human endothelial cells
29. The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila
30. Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses
31. Cell surface expression and lipopolysaccharide signaling via the Toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages
32. Differential expression and regulation of Toll-like receptors (TLR) in human leukocytes: Selective expression of TLR3 in dendritic cells
33. Anti-human RP105 sera induces lymphocyte proliferation
34. The lipopolysaccharide-activated Toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes
35. Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors
36. Bacterial lipopolysaccharide activates NF-kappa B through Toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells. Differential expression of TLR-4 and TLR-2 in endothelial cells
37. The Toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells
38. Human Toll-like receptors 2 and 4 are targets for deactivation of mononuclear phagocytes by interleukin-4
39. PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene
40. Endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface Toll-like receptor 4 expression
41. Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: Dysregulation of cytokine, chemokine, and Toll-like receptor 2 and 4 gene expression
42. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
43. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the Potent antifungal response in Drosophila adults
44. CD14-dependent LPS-induced β-Defensin-2 expression in human tracheobronchial epithelium
45. The apoptotic signaling pathway activated by Toll-like receptor-2
46. Genetic control of susceptibility to Salmonella typhimurium in mice: Role of the LPS gene
47. Host defenses in experimental rickettsialpox: Genetics of natural resistance to infection
48. The importance of a lipopolysaccharide-initiated, cytokine-mediated host defense mechanism in mice against extraintestinally invasive Escherichia coli
49. Macrophage defect and inflammatory cell recruitment dysfunction in Salmonella susceptible C3H/HeJ mice
50. Resistance ranking of some common inbred mouse strains to Mycobacterium tuberculosis and relationship to major histocompatibility complex haplotype and Nramp1 genotype
51. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
52. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors
53. A Toll-like receptor recognizes bacterial DNA