메뉴 건너뛰기




Volumn 112, Issue 1, 1997, Pages 235-243

Sepsis: A new hypothesis for pathogenesis of the disease process

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; HUMAN; IMMUNE RESPONSE; MACROPHAGE; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SEPSIS;

EID: 0030843156     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.112.1.235     Document Type: Article
Times cited : (797)

References (57)
  • 1
    • 0025364529 scopus 로고
    • Age, chronic disease, sepsis, organ system failure, and mortality in a medical intensive care unit
    • Tran DD, Groenveld AB, van der Meulen J, et al. Age, chronic disease, sepsis, organ system failure, and mortality in a medical intensive care unit. Crit Care Med 1990; 18:474-79
    • (1990) Crit Care Med , vol.18 , pp. 474-479
    • Tran, D.D.1    Groenveld, A.B.2    Van Der Meulen, J.3
  • 2
    • 0028784689 scopus 로고
    • Multiple organ dysfunction score: A reliable descriptor of a complex clinical outcome
    • Marshall JC, Cook DJ, Christou NC, et al. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 1995; 23:1638-52
    • (1995) Crit Care Med , vol.23 , pp. 1638-1652
    • Marshall, J.C.1    Cook, D.J.2    Christou, N.C.3
  • 3
    • 0026874127 scopus 로고
    • Definitions for sepsis and multiple organ failure, and guidelines for the use of innovative therapies in sepsis
    • American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference. Definitions for sepsis and multiple organ failure, and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20:864-74
    • (1992) Crit Care Med , vol.20 , pp. 864-874
  • 4
    • 0029784526 scopus 로고    scopus 로고
    • Why sepsis trials fail
    • Bone RC. Why sepsis trials fail. JAMA 1996; 276:565-66
    • (1996) JAMA , vol.276 , pp. 565-566
    • Bone, R.C.1
  • 5
    • 0023769976 scopus 로고
    • Depressed interferon-gamma production and monocyte HLA-DR expression after severe injury
    • Livingston DH, Appel SH, Wellhausen SH, et al. Depressed interferon-gamma production and monocyte HLA-DR expression after severe injury. Arch Surg 1988; 123:1309-13
    • (1988) Arch Surg , vol.123 , pp. 1309-1313
    • Livingston, D.H.1    Appel, S.H.2    Wellhausen, S.H.3
  • 6
    • 2342501665 scopus 로고
    • Role of monocytic HLA-DR expression following trauma in predicting clinical outcome
    • Faist E, Ninnemann J, Green D, eds. New York: Springer Verlag
    • Cheadle WG, Hershman MJ, Wellhausen SR, et al. Role of monocytic HLA-DR expression following trauma in predicting clinical outcome. In: Faist E, Ninnemann J, Green D, eds. Immune consequences of trauma, shock and sepsis. New York: Springer Verlag, 1989; 119-22
    • (1989) Immune Consequences of Trauma, Shock and Sepsis , pp. 119-122
    • Cheadle, W.G.1    Hershman, M.J.2    Wellhausen, S.R.3
  • 7
    • 0010430755 scopus 로고
    • Reduction in HLA-DR, HLA-DQ, and HLA-DP expression by Leu-M3+ cells from the peripheral blood of patients with thermal injury
    • Gibbons RA, Martinez OM, Lim OC, et al. Reduction in HLA-DR, HLA-DQ, and HLA-DP expression by Leu-M3+ cells from the peripheral blood of patients with thermal injury. Injury 1989; 19:263-66
    • (1989) Injury , vol.19 , pp. 263-266
    • Gibbons, R.A.1    Martinez, O.M.2    Lim, O.C.3
  • 8
    • 0027477817 scopus 로고
    • Changes in major histocompatibility complex class II expression in monocytes and T cells of patients developing infection after surgery
    • Wakefield CH, Carey PD, Foulds S, et al. Changes in major histocompatibility complex class II expression in monocytes and T cells of patients developing infection after surgery. Br J Surg 1993; 80:205-09
    • (1993) Br J Surg , vol.80 , pp. 205-209
    • Wakefield, C.H.1    Carey, P.D.2    Foulds, S.3
  • 9
    • 0025208420 scopus 로고
    • Beneficial effect of enhanced macrophage function in the trauma patient
    • Broader W, Williams D, Pretus H, et al. Beneficial effect of enhanced macrophage function in the trauma patient. Ann Surg 1990; 211:605-12
    • (1990) Ann Surg , vol.211 , pp. 605-612
    • Broader, W.1    Williams, D.2    Pretus, H.3
  • 10
    • 0022364739 scopus 로고
    • Multiple-organ failure: Generalized antodestructive inflammation?
    • Goris JA, te Boekhorst TPA, Nuytinck JKS, et al. Multiple-organ failure: generalized antodestructive inflammation? Arch Surg 1985; 120:1109-15
    • (1985) Arch Surg , vol.120 , pp. 1109-1115
    • Goris, J.A.1    Te Boekhorst, T.P.A.2    Nuytinck, J.K.S.3
  • 11
    • 0027457502 scopus 로고
    • Serum cytokine levels in human septic shock: Relation to multiple-system organ failure and mortality
    • Pinsky MR, Vincent J-L, Deviere J, et al. Serum cytokine levels in human septic shock: relation to multiple-system organ failure and mortality. Chest 1993; 103:565-75
    • (1993) Chest , vol.103 , pp. 565-575
    • Pinsky, M.R.1    Vincent, J.-L.2    Deviere, J.3
  • 12
    • 0027528798 scopus 로고
    • Anticytokine strategies in the treatment of the systemic inflammatory response syndrome
    • Dinarello CA, Gelland JA, Wolff SM. Anticytokine strategies in the treatment of the systemic inflammatory response syndrome. JAMA 1993; 269:1829-35
    • (1993) JAMA , vol.269 , pp. 1829-1835
    • Dinarello, C.A.1    Gelland, J.A.2    Wolff, S.M.3
  • 13
    • 0028997703 scopus 로고
    • Natural cytokine antagonists and endogenous antiendotoxin core antibodies in sepsis syndrome
    • Goldie AS, Fearon KCH, Ross JA, et al. Natural cytokine antagonists and endogenous antiendotoxin core antibodies in sepsis syndrome. JAMA 1995; 274:172-77
    • (1995) JAMA , vol.274 , pp. 172-177
    • Goldie, A.S.1    Fearon, K.C.H.2    Ross, J.A.3
  • 14
    • 0027697064 scopus 로고
    • Postinjury multiple organ failure: Role of extra-thoracic injury and sepsis in adult respiratory-distress syndrome
    • Moore FA, Moore EE, Read RA. Postinjury multiple organ failure: role of extra-thoracic injury and sepsis in adult respiratory-distress syndrome. New Horizons 1993; 1:538-49
    • (1993) New Horizons , vol.1 , pp. 538-549
    • Moore, F.A.1    Moore, E.E.2    Read, R.A.3
  • 15
    • 0029043636 scopus 로고
    • A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: Results of a prospective, multicenter, randomized clinical trial
    • Bone RC, Balk RA, Fein AM, et al. A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized clinical trial. Crit Care Med 1995; 23:994-1006
    • (1995) Crit Care Med , vol.23 , pp. 994-1006
    • Bone, R.C.1    Balk, R.A.2    Fein, A.M.3
  • 16
    • 0025917510 scopus 로고
    • A controlled trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of Gram-negative sepsis
    • Greenman RI, Schein RM, Martin MA, et al. A controlled trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of Gram-negative sepsis. JAMA 1991; 266: 1097-1102
    • (1991) JAMA , vol.266 , pp. 1097-1102
    • Greenman, R.I.1    Schein, R.M.2    Martin, M.A.3
  • 17
    • 0028557981 scopus 로고
    • Treatment of septic shock with human monoclonal antibody HA-1A: A randomized double-blind, placebo-controlled trial
    • McCloskey RV, Straube RC, Sanders C, et al. Treatment of septic shock with human monoclonal antibody HA-1A: a randomized double-blind, placebo-controlled trial. Ann Intern Med 1994; 121:1-5
    • (1994) Ann Intern Med , vol.121 , pp. 1-5
    • McCloskey, R.V.1    Straube, R.C.2    Sanders, C.3
  • 18
    • 0026016470 scopus 로고
    • Treatment of Gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin
    • Ziegler EJ, Fisher CJ, Sprung CL, et al. Treatment of Gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. N Engl J Med 1991; 324:429-36
    • (1991) N Engl J Med , vol.324 , pp. 429-436
    • Ziegler, E.J.1    Fisher, C.J.2    Sprung, C.L.3
  • 19
    • 0030011909 scopus 로고    scopus 로고
    • Toward a theory regarding the pathogenesis of the systemic inflammatory response syndrome: What we do and do not know about cytokine regulation
    • Bone RC. Toward a theory regarding the pathogenesis of the systemic inflammatory response syndrome: what we do and do not know about cytokine regulation. Crit Care Med 1996; 24:163-72
    • (1996) Crit Care Med , vol.24 , pp. 163-172
    • Bone, R.C.1
  • 20
    • 0024419657 scopus 로고
    • Regulation of serum tumor necrosis factor in glucocorticoid-sensitive and -resistant rodent endotoxin shock models
    • Zuckerman SH, Bendele AM. Regulation of serum tumor necrosis factor in glucocorticoid-sensitive and -resistant rodent endotoxin shock models. Infect Immun 1989; 57:3009-13
    • (1989) Infect Immun , vol.57 , pp. 3009-3013
    • Zuckerman, S.H.1    Bendele, A.M.2
  • 22
    • 0023701260 scopus 로고
    • Effect of ibuprofen on neutrophil function and acute lung injury in canine endotoxin shock
    • Balk RA, Jacobs RF, Tryka AF, et al. Effect of ibuprofen on neutrophil function and acute lung injury in canine endotoxin shock. Crit Care Med 1988; 15:1121-24
    • (1988) Crit Care Med , vol.15 , pp. 1121-1124
    • Balk, R.A.1    Jacobs, R.F.2    Tryka, A.F.3
  • 23
    • 0024342856 scopus 로고
    • The cardiovascular response of normal humans in the administration of endotoxin
    • Suffredini AF, Fromm RE, Parker MM, et al. The cardiovascular response of normal humans in the administration of endotoxin. N Engl J Med 1989; 321:280-87
    • (1989) N Engl J Med , vol.321 , pp. 280-287
    • Suffredini, A.F.1    Fromm, R.E.2    Parker, M.M.3
  • 24
    • 0026048714 scopus 로고
    • The pathogenesis of sepsis
    • Bone RC. The pathogenesis of sepsis. Ann Intern Med 1991; 115:457-69
    • (1991) Ann Intern Med , vol.115 , pp. 457-469
    • Bone, R.C.1
  • 25
    • 0025748883 scopus 로고
    • Dysregulation of in vitro cytokine production by monocytes during sepsis
    • Munoz C, Carlet J, Fitting C, et al. Dysregulation of in vitro cytokine production by monocytes during sepsis. J Clin Invest 1991; 88:1747-54
    • (1991) J Clin Invest , vol.88 , pp. 1747-1754
    • Munoz, C.1    Carlet, J.2    Fitting, C.3
  • 26
    • 0025189944 scopus 로고
    • Identification of a novel tumor necrosis factor a/cachectin from the livers of burned and infected rats
    • Keogh C, Fong Y, Marano MA, et al. Identification of a novel tumor necrosis factor a/cachectin from the livers of burned and infected rats. Arch Surg 1990; 125:79-85
    • (1990) Arch Surg , vol.125 , pp. 79-85
    • Keogh, C.1    Fong, Y.2    Marano, M.A.3
  • 27
    • 0029557622 scopus 로고
    • Applied molecular biology of sepsis
    • Remick DG. Applied molecular biology of sepsis. J Crit Care 1995; 10:198-212
    • (1995) J Crit Care , vol.10 , pp. 198-212
    • Remick, D.G.1
  • 28
    • 0028893025 scopus 로고
    • The natural history of the systemic inflammatory response syndrome (SIRS): A prospective study
    • Rangel-Frausto MS, Pittet D, Costigan M, et al. The natural history of the systemic inflammatory response syndrome (SIRS): a prospective study. JAMA 1995; 272:117-23
    • (1995) JAMA , vol.272 , pp. 117-123
    • Rangel-Frausto, M.S.1    Pittet, D.2    Costigan, M.3
  • 29
    • 0030587937 scopus 로고    scopus 로고
    • Immunologic dissonance: A continuing evolution in our understanding of the systemic inflammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS)
    • Bone RC. Immunologic dissonance: a continuing evolution in our understanding of the systemic inflammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS). Ann Intern Med 1996; 125:680-87
    • (1996) Ann Intern Med , vol.125 , pp. 680-687
    • Bone, R.C.1
  • 30
    • 0028239555 scopus 로고
    • Recombinant human interleukin-1 receptor antagonist in the treatment of patients with sepsis syndrome: Results from a randomized, double-blind, placebo-controlled trial
    • Fisher CJ, Dhainaut JF, Opal SM, et al. Recombinant human interleukin-1 receptor antagonist in the treatment of patients with sepsis syndrome: results from a randomized, double-blind, placebo-controlled trial. JAMA 1994; 271:1836-44
    • (1994) JAMA , vol.271 , pp. 1836-1844
    • Fisher, C.J.1    Dhainaut, J.F.2    Opal, S.M.3
  • 31
    • 0028957549 scopus 로고
    • Efficacy and safety of monoclonal antibody to human tumor necrosis factors in patients with sepsis syndrome
    • Abraham K, Wunderink R, Silverman H, et al. Efficacy and safety of monoclonal antibody to human tumor necrosis factors in patients with sepsis syndrome. JAMA 1995; 273: 934-37
    • (1995) JAMA , vol.273 , pp. 934-937
    • Abraham, K.1    Wunderink, R.2    Silverman, H.3
  • 32
    • 8544264710 scopus 로고
    • Up-regulation of monocytic IL-10 by tumor necrosis factors and cAMP elevating drugs
    • Platzer C, Meisel C, Vogt K, et al. Up-regulation of monocytic IL-10 by tumor necrosis factors and cAMP elevating drugs. Intern Immunol 1995; 7:17-23
    • (1995) Intern Immunol , vol.7 , pp. 17-23
    • Platzer, C.1    Meisel, C.2    Vogt, K.3
  • 33
    • 0028026344 scopus 로고
    • Isolated pulmonary infection acts as a source of systemic tumor necrosis factor
    • Fukushima R, Alexander JW, Gianotti L, et al. Isolated pulmonary infection acts as a source of systemic tumor necrosis factor. Crit Care Med 1994; 22:114-20
    • (1994) Crit Care Med , vol.22 , pp. 114-120
    • Fukushima, R.1    Alexander, J.W.2    Gianotti, L.3
  • 34
    • 0024791603 scopus 로고
    • Characterization of wound cytokines in the sponge matrix model
    • Ford HR, Hoffman HA, Wing EJ, et al. Characterization of wound cytokines in the sponge matrix model. Arch Surg 1989; 124:1422-28
    • (1989) Arch Surg , vol.124 , pp. 1422-1428
    • Ford, H.R.1    Hoffman, H.A.2    Wing, E.J.3
  • 35
    • 0028860550 scopus 로고
    • Inflammatory cytokines in the BAL of patients with ARDS: Persistent elevation over time predicts a poor outcome
    • Meduri GU, Kohler G, Headley S, et al. Inflammatory cytokines in the BAL of patients with ARDS: persistent elevation over time predicts a poor outcome. Chest 1995; 108:1303-14
    • (1995) Chest , vol.108 , pp. 1303-1314
    • Meduri, G.U.1    Kohler, G.2    Headley, S.3
  • 36
    • 0023019024 scopus 로고
    • Stimulation of muscle protein degradation by murine and human epidermal cytokines: Relationship to thermal injury
    • Sauder DN, Semple J, Truscott D, et al. Stimulation of muscle protein degradation by murine and human epidermal cytokines: relationship to thermal injury. J Invest Dermatol 1986; 87:711-14
    • (1986) J Invest Dermatol , vol.87 , pp. 711-714
    • Sauder, D.N.1    Semple, J.2    Truscott, D.3
  • 37
    • 0022549722 scopus 로고
    • The human burn wound as a primary source of interleukin-1 activity
    • Kupper TS, Deitch EA, Baker CC, et al. The human burn wound as a primary source of interleukin-1 activity. Surgery 1986; 100:409-14
    • (1986) Surgery , vol.100 , pp. 409-414
    • Kupper, T.S.1    Deitch, E.A.2    Baker, C.C.3
  • 38
    • 0029017307 scopus 로고
    • Patterns of cytokine expression in community-acquired pneumonia
    • Puren AJ, Feldman C, Savage N, et al. Patterns of cytokine expression in community-acquired pneumonia. Chest 1995; 107:1342-49
    • (1995) Chest , vol.107 , pp. 1342-1349
    • Puren, A.J.1    Feldman, C.2    Savage, N.3
  • 39
    • 0024272982 scopus 로고
    • Cachectin/TNF-alpha in septic shock and adult respiratory distress syndrome
    • Traces KJ, Lowry SF, Ceremi A. Cachectin/TNF-alpha in septic shock and adult respiratory distress syndrome [editorial]. Am Rev Respir Dis 1988; 138:1377-79
    • (1988) Am Rev Respir Dis , vol.138 , pp. 1377-1379
    • Traces, K.J.1    Lowry, S.F.2    Ceremi, A.3
  • 40
    • 0023885007 scopus 로고
    • Tumor necrosis factor causes increased pulmonary permeability and edema: Comparison to septic acute lung injury
    • Stephens KE, Ishikaza A, Larrick JW, et al. Tumor necrosis factor causes increased pulmonary permeability and edema: comparison to septic acute lung injury. Am Rev Respir Dis 1988; 137:1364-70
    • (1988) Am Rev Respir Dis , vol.137 , pp. 1364-1370
    • Stephens, K.E.1    Ishikaza, A.2    Larrick, J.W.3
  • 41
    • 0024599055 scopus 로고
    • 2 in endotoxin shock are unrelated to effects of PAF-acether synthesis
    • 2 in endotoxin shock are unrelated to effects of PAF-acether synthesis. Prostaglandins 1989; 37:237-50
    • (1989) Prostaglandins , vol.37 , pp. 237-250
    • Ibbotson, C.C.1    Wallace, J.L.2
  • 42
    • 0025164256 scopus 로고
    • Leukotrienes and other products of the 5-lipoxygenase pathway: Biochemistry and relation to pathobiology in human diseases
    • Lewis RA, Austen KF, Soberman RJ. Leukotrienes and other products of the 5-lipoxygenase pathway: biochemistry and relation to pathobiology in human diseases. N Engl J Med 1990; 323:645-55
    • (1990) N Engl J Med , vol.323 , pp. 645-655
    • Lewis, R.A.1    Austen, K.F.2    Soberman, R.J.3
  • 43
    • 0024594855 scopus 로고
    • Prostaglandins, cyclo-oxygenase inhibitors, and thromboxane synthesis inhibitors in the pathogenesis of multiple organ failure
    • Petrak RA, Balk RA, Bone RC. Prostaglandins, cyclo-oxygenase inhibitors, and thromboxane synthesis inhibitors in the pathogenesis of multiple organ failure. Crit Care Clin 1989; 35:303-14
    • (1989) Crit Care Clin , vol.35 , pp. 303-314
    • Petrak, R.A.1    Balk, R.A.2    Bone, R.C.3
  • 44
    • 0026777095 scopus 로고
    • Intestinal platelet trapping after traumatic and septic shock: An early sign of sepsis and multiorgan failure in critically ill patients?
    • Sigurdsson GH, Christenson JT, Bader el-Rakshy M, et al. Intestinal platelet trapping after traumatic and septic shock: an early sign of sepsis and multiorgan failure in critically ill patients? JAMA 1992; 20:458-67
    • (1992) JAMA , vol.20 , pp. 458-467
    • Sigurdsson, G.H.1    Christenson, J.T.2    Bader El-Rakshy, M.3
  • 45
    • 0027166655 scopus 로고
    • Secondary organ dysfunction: From clinical perspectives to molecular mediators
    • Cipolle MD, Pasquale NM, Cerra FB. Secondary organ dysfunction: from clinical perspectives to molecular mediators. Crit Care Clin 1993; 9:261-98
    • (1993) Crit Care Clin , vol.9 , pp. 261-298
    • Cipolle, M.D.1    Pasquale, N.M.2    Cerra, F.B.3
  • 46
    • 0025485378 scopus 로고
    • Effect of endotoxin-induced cell injury on 70-kD heat shock proteins in bovine lung endothelial cells
    • Rinaldo JE, Gorry M, Streiter R, et al. Effect of endotoxin-induced cell injury on 70-kD heat shock proteins in bovine lung endothelial cells. Am J Respir Cell Mol Biol 1990; 3:207-16
    • (1990) Am J Respir Cell Mol Biol , vol.3 , pp. 207-216
    • Rinaldo, J.E.1    Gorry, M.2    Streiter, R.3
  • 47
    • 0027312882 scopus 로고
    • Pathogenesis of disseminated intravascular coagulation in sepsis
    • Levi M, ten Cate H, van der Poll T, et al. Pathogenesis of disseminated intravascular coagulation in sepsis. JAMA 1993; 270:975-79
    • (1993) JAMA , vol.270 , pp. 975-979
    • Levi, M.1    Ten Cate, H.2    Van Der Poll, T.3
  • 48
    • 0028870359 scopus 로고
    • L-arginine: Nitric oxide pathway in endotoxemia and human septic shock
    • Gomez-Jimenez J, Salgado A, Mourelle M, et al. L-arginine: nitric oxide pathway in endotoxemia and human septic shock. Crit Care Med 1995; 23:253-58
    • (1995) Crit Care Med , vol.23 , pp. 253-258
    • Gomez-Jimenez, J.1    Salgado, A.2    Mourelle, M.3
  • 49
    • 0025358314 scopus 로고
    • Involvement of endothelin in the regulation of human vascular tonus
    • Miyauchi T, Tomobe Y, Shiba R, et al. Involvement of endothelin in the regulation of human vascular tonus. Circulation 1990; 81:1874-80
    • (1990) Circulation , vol.81 , pp. 1874-1880
    • Miyauchi, T.1    Tomobe, Y.2    Shiba, R.3
  • 50
    • 0028906220 scopus 로고
    • Mechanism of endotoxin desensitization: Involvement of interleukin-10 and transforming growth factor beta
    • Randow F, Syrbe U, Meisel C, et al. Mechanism of endotoxin desensitization: involvement of interleukin-10 and transforming growth factor beta. J Exp Med 1995; 181:1887-92
    • (1995) J Exp Med , vol.181 , pp. 1887-1892
    • Randow, F.1    Syrbe, U.2    Meisel, C.3
  • 52
    • 0024563347 scopus 로고
    • Evidence of a plasma-mediated "window" of immunodeficiency in rats following trauma
    • Mills CD, Caldwell NM, Gann DJ. Evidence of a plasma-mediated "window" of immunodeficiency in rats following trauma. J Clin Immunol 1989; 9:139-50
    • (1989) J Clin Immunol , vol.9 , pp. 139-150
    • Mills, C.D.1    Caldwell, N.M.2    Gann, D.J.3
  • 53
    • 0026728625 scopus 로고
    • TNF-alpha, interleukin-6 and parameters of the cellular immune system in patients with intra-abdominal sepsis
    • Hamilton G, Hofbauer S, Hamilton B. TNF-alpha, interleukin-6 and parameters of the cellular immune system in patients with intra-abdominal sepsis. Scand J Infect Dis 1992; 24:361-68
    • (1992) Scand J Infect Dis , vol.24 , pp. 361-368
    • Hamilton, G.1    Hofbauer, S.2    Hamilton, B.3
  • 54
    • 0031054684 scopus 로고    scopus 로고
    • Interferon-γ in the treatment of the compensatory anti-inflammatory response syndrome (CARS) - A new approach: Proof of principle
    • Kox WJ, Bone RC, Krausch D, et al. Interferon-γ in the treatment of the compensatory anti-inflammatory response syndrome (CARS) - a new approach: proof of principle. Arch Intern Med 1997; 157:389-93
    • (1997) Arch Intern Med , vol.157 , pp. 389-393
    • Kox, W.J.1    Bone, R.C.2    Krausch, D.3
  • 55
    • 0027406403 scopus 로고
    • Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis
    • Fisher CJ Jr, Opal SM, Dhainaut JF, et al. Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis. Crit Care Med 1993; 21:318-27
    • (1993) Crit Care Med , vol.21 , pp. 318-327
    • Fisher Jr., C.J.1    Opal, S.M.2    Dhainaut, J.F.3
  • 56
    • 0026558535 scopus 로고
    • Patterns of cytokines, plasma endotoxin, plasminogen activator inhibitor, and acute-phase proteins during the treatment of severe sepsis in humans
    • Dofferhoff AS, Vom VJ, de Vries-Hospers HG, et al. Patterns of cytokines, plasma endotoxin, plasminogen activator inhibitor, and acute-phase proteins during the treatment of severe sepsis in humans. Crit Care Med 1992; 20:185-92
    • (1992) Crit Care Med , vol.20 , pp. 185-192
    • Dofferhoff, A.S.1    Vom, V.J.2    De Vries-Hospers, H.G.3
  • 57
    • 0025912547 scopus 로고
    • Elevation of serum interleukin-6 concentration precedes acute-phase response and reflects severity in acute pancreatitis
    • Lesser HG, Gross V, Scheibenbogen C, et al. Elevation of serum interleukin-6 concentration precedes acute-phase response and reflects severity in acute pancreatitis. Gastroenterology 1991; 101:782-85
    • (1991) Gastroenterology , vol.101 , pp. 782-785
    • Lesser, H.G.1    Gross, V.2    Scheibenbogen, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.