Human natural killer cells: Their origin, receptors and function

European Journal of Immunology

Volumn 32, Issue 5, 2002, Pages 1205-1211

  Moretta, Lorenzo ^a,c   Bottino, Cristina ^b   Pende, Daniela ^b   Mingari, Maria Cristina ^a,b   Biassoni, Roberto ^b   Moretta, Alessandro ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c G GASLINI INSTITUTE   (Italy)

Author keywords

KIR; MHC class I specific inhibitory receptor; Natural cytotoxicity; NK cell; NK coreceptor

Indexed keywords

CD34 ANTIGEN; CELL RECEPTOR; INTERLEUKIN 15; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ARTICLE; BONE MARROW; CELL ACTIVATION; CELL CULTURE; CELL FUNCTION; CELL ISOLATION; CELL STIMULATION; CELL SURFACE; CONTROLLED STUDY; CYTOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOID CELL; NATURAL KILLER CELL; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STEM CELL; T LYMPHOCYTE; TARGET CELL; THYMUS; TUMOR CELL; UMBILICAL CORD BLOOD; VIRUS INFECTION;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BONE MARROW TRANSPLANTATION; CELL DIFFERENTIATION; CYTOTOXICITY, IMMUNOLOGIC; EVOLUTION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; KILLER CELLS, NATURAL; LIGANDS; MICE; NEOPLASMS; RECEPTORS, IMMUNOLOGIC;

EID: 0036099738     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200205)32:5<1205::AID-IMMU1205>3.0.CO;2-Y     Document Type: Article

References (48)

1. Biology of natural killer cells
2. In vitro proliferation and cloning of CD3-CD16+ cells from human thymocyte precursors
3. A population of early fetal thymocytes expressing FcγRII/III contains precursors of T lymphocytes and natural killer cells
4. The developmental relationship between NK cells and T cells
5. Human NK cells: Origin, clonality, specificity and receptors
6. Interleukin-15-induced maturation of human Natural Killer cells from early thymic precursors. Selective expression of CD94/ NKG2A as the only HLA-class I specific inhibitory receptor
7. In search of the "missing self". MHC molecules and NK cell recognition
8. The Ly49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: The NK gene complex
9. Receptors for HLA-class I-molecules in human natural killer cells
10. NK cell receptors
11. Regulation of immune response through inhibitory receptors
12. Structure and function of the CD94 C-type lectin receptor complex involved in the recognition of HLA class I molecules
13. Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human Natural Killer cells
14. The human leukocyte antigen (HLA)-C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions
15. A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation
16. Activating receptors and coreceptors involved in the natural cytotoxicity
17. Natural cytotoxicity receptors that trigger the human NK-mediated cytolysis. Immunol
18. p46, a novel natural killer cell-specific surface molecule which mediates cell activation
19. Molecular cloning of NKp46: A novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity
20. Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells
21. NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells is involved in non-MHC restricted tumor cell lysis
22. Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human natural killer cells
23. NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh of cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against autologous, cells
24. The murine homologoue of the human NKp46, a triggering receptor involved in the induction of natural cytotoxicity
25. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
26. Role of NKG2D in tumor cell lysis mediated by human NK cells: Cooperation with natural cytotoxicity receptors and capability of recognizing tumors of non epithelial origin
27. 2B4 functions as a co-receptor in human natural killer cell activation
28. Identification of NKp80, a novel triggering molecule expressed by human natural killer cells
29. X-linked lymphoproliferative disease: 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of NK cell to kill EBV-infected cells
30. Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome
31. NTB-A, a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease
32. Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome
33. Host response to EBV infction in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene
34. X-linked lymphoproliferative disease: Twenty-five years after the discovery
35. Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans
36. Identification, molecular cloning and functional characterization of NKp46 and NKp30 natural cytotoxicity receptors in Macaca fascicularis (Macaca Rhesus) NK cells
37. Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family which functions as an inhibitory receptor in human natural killer cells
38. Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells
39. Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation
40. Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells
41. Recognition of viral hemagglutinins by NKp44 but not by NKp30
42. Human CD8+ T lymphocyte subsets that express HLA class I-specific inhibitory receptors represent oligoclonally or monoclonally expanded cell populations
43. The analysis of the natural killer-like activity of human cytolytic T lymphocytes revealed HLA-E as a novel target for TCRα/β-mediated recognition
44. Cellular therapy: Exploiting NK cell alloreactivity in transplantation
45. Natural killer cells in antiviral defense: Function and regulation by innate cytokines
46. Natural killer cells wear different hats: Effector cells of innate resistance and regulatory cells of adoptive immunity and hematopoiesis
47. In vivo natural killer cell activities revealed by natural killer cell-deficient mice
48. Analysis of the molecular mechanism involved in 2B4-mediated NK cell activation: Evidence that human 2B4 is physically and functionally associated with the linker for activation of T cells (LAT)