p53 is present in synapses where it mediates mitochondrial dysfunction and synaptic degeneration in response to DNA damage, and oxidative and excitotoxic insults

NeuroMolecular Medicine

Volumn 3, Issue 3, 2003, Pages 159-172

  Gilman, Charles P ^a   Chan, Sic L ^a   Guo, Zhihong ^a   Zhu, Xiaoxiang ^a   Greig, Nigel ^a   Mattson, Mark P ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Apoptosis; Cerebral cortex; Synaptosomes; Transcription

Indexed keywords

ETOPOSIDE; GLUTAMIC ACID; MITOCHONDRIAL DNA; PROTEIN P53; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN SYNAPTOSOME; CONTROLLED STUDY; DNA DAMAGE; GENETIC TRANSCRIPTION; HIPPOCAMPUS; MALE; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NERVE CELL PLASTICITY; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; SYNAPSE; SYNAPTOSOME; TUMOR SUPPRESSOR GENE;

ANIMALS; BENZOTHIAZOLES; BRAIN; CELLS, CULTURED; DNA DAMAGE; ETOPOSIDE; MEMBRANE POTENTIALS; MICE; MITOCHONDRIA; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; NEUROTOXINS; NUCLEIC ACID SYNTHESIS INHIBITORS; OXIDATIVE STRESS; PHOSPHORYLATION; PRESYNAPTIC TERMINALS; REACTIVE OXYGEN SPECIES; SYNAPSINS; SYNAPTOSOMES; THIAZOLES; TOLUENE; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 0041825339     PISSN: 15351084     EISSN: None     Source Type: Journal    
DOI: 10.1385/NMM:3:3:159     Document Type: Article

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