Direct cleavage of AMPA receptor subunit GluR1 and suppression of AMPA currents by caspase-3: Implications for synaptic plasticity and excitotoxic neuronal death

NeuroMolecular Medicine

Volumn 1, Issue 1, 2002, Pages 69-79

  Lu, Chengbiao ^a   Fu, Weiming ^a   Salvesen, Guy S ^b,c   Mattson, Mark P ^a,b  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BURNHAM INSTITUTE   (United States)

Author keywords

Apoptosis; Calcium; Learning and memory; Neurotrophic factor; NMDA; Patch clamp; Staurosporine

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE INHIBITOR; CYSTEINE PROTEINASE; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID; RECEPTOR PROTEIN; RECEPTOR SUBUNIT; RECOMBINANT CASPASE 3; RECOMBINANT ENZYME; STAUROSPORINE; UNCLASSIFIED DRUG; CALCIUM; CASP3 PROTEIN, RAT; CASPASE; GLUTAMATE RECEPTOR IONOTROPIC, AMPA 1; N METHYLASPARTIC ACID; PROTEIN SUBUNIT; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; DEGENERATIVE DISEASE; DENDRITE; ENZYME ACTIVATION; ENZYME BINDING; ENZYME MECHANISM; ENZYME REGULATION; ENZYME SUBSTRATE; ISOTOPE LABELING; MEMBRANE CURRENT; NERVE CELL NECROSIS; NERVE CELL PLASTICITY; NERVE EXCITABILITY; NERVE EXCITOTOXICITY; NERVOUS SYSTEM DEVELOPMENT; NEUROMODULATION; NEUROPATHOLOGY; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; RECEPTOR UPREGULATION; SYNAPSE; ANIMAL; BIOLOGICAL MODEL; CELL CULTURE; CELL MEMBRANE POTENTIAL; DRUG ANTAGONISM; DRUG EFFECT; HIPPOCAMPUS; KINETICS; METABOLISM; NERVE CELL; PHYSIOLOGY;

ANIMALIA;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; CALCIUM; CASPASE 3; CASPASES; CELLS, CULTURED; ENZYME ACTIVATION; HIPPOCAMPUS; KINETICS; MEMBRANE POTENTIALS; MODELS, NEUROLOGICAL; N-METHYLASPARTATE; NEURONS; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; RATS; RECEPTORS, AMPA; RECOMBINANT PROTEINS;

EID: 0036372055     PISSN: 15351084     EISSN: None     Source Type: Journal    
DOI: 10.1385/NMM:1:1:69     Document Type: Article

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