Cisplatin-induced renal cell apoptosis: Caspase 3-dependent and -independent pathways

Journal of Pharmacology and Experimental Therapeutics

Volumn 302, Issue 1, 2002, Pages 8-17

  Cummings, Brian S ^a   Schnellmann, Rick G ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b Department of Pharmaceutical Sciences ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BENZOTHIAZOLE DERIVATIVE; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 8; CASPASE 9; CISPLATIN; LIPOCORTIN 5; PHOSPHATIDYLSERINE; PROTEIN P53;

ANIMAL CELL; APOPTOSIS; ARTICLE; CHROMATIN CONDENSATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; FEMALE; KIDNEY CELL; KIDNEY FAILURE; KIDNEY PROXIMAL TUBULE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NONHUMAN; PLOIDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; SIGNAL TRANSDUCTION; TIME;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANNEXIN A5; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASES; CELL CYCLE; CELLS, CULTURED; CHROMATIN; CISPLATIN; COLORING AGENTS; DNA; FEMALE; GUANOSINE TRIPHOSPHATE; HAPLOIDY; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY TUBULES, PROXIMAL; MITOCHONDRIA; PROPIDIUM; RABBITS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0036085726     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.302.1.8     Document Type: Article

References (40)

1. Mechanisms of p53-induced apoptosis
2. Renal and electrolyte disturbances associated with cisplatin
3. Mitochondrial injury: An early event in cisplatin toxicity to renal proximal tubules
4. Role of mitochondrial dysfunction in S-(1,2-dichlorovinyl)-L-cysteine-induced apoptosis
5. Probing mitochondrial membrane potential in living cells by a J-aggregate-forming dye
6. cis-Diaminedichloroplatinum-induced acute renal failure in the rat
7. Expression of glutathione dependent enzymes and cytochrome P450s in freshly isolated and primary cultures of proximal tubular cells from human kidney
8. 2 in cell injury and death
9. GTP depletion but not ATP depletion causes apoptosis in LLC-PK1 cells
10. DNA damage induces p53-dependent down-regulation of hCHK1
11. A novel method for measuring CTL and NK cell-mediated cytotoxicity using annexin V and two-color flow cytometry
12. 2]
13. Methods in Renal Toxicology
14. Oxidative signaling pathway for externalization of plasma membrane phosphatidylserine during apoptosis
15. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy
16. Cisplatin-induced nephrotoxicity in porcine proximal tubule cells: Mitochondrial dysfunction by inhibition of complex I to IV of the respiratory chain
17. Apoptosis induced by cisplatin nephrotoxic injury
18. ATP converts necrosis to apoptosis in oxidant-injured endothelial cells
19. The nomenclature of cell death: Recommendations of an ad hoc Committee of the Society of Toxicologic Pathologists
20. Increased sensitivity to cis-diamminedichloroplatinum induced apoptosis with mitochondrial DNA depletion
21. Mechanisms of death induced by cisplatin in proximal tubular epithelial cells: Apoptosis vs. necrosis
22. Induction of apoptosis and changes in nuclear G-actin are mediated by different pathways: The effect of inhibitors of protein and RNA synthesis in isolated rat hepatocytes
23. Taxanes propagate apoptosis via two cell populations with distinctive cytological and molecular traits
24. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
25. Integrative effects of EGF on metabolism and proliferation in renal proximal tubular cells
26. L-Ascorbic acid regulates growth and metabolism of renal cells: Improvements in cell culture
27. Uptake and metabolism of cisplatin by rat kidney
28. Caspases: Intracellular signaling by proteolysis
29. Ordering ofceramide formation, caspase activation and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells
30. p53 induces apoptosis by caspase activation through mitochandrial cytochrome c release
31. Morphologic, biochemical and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia
32. Annexin V binding assay as a tool to measure apoptosis in differentiated neuronal cells
33. Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis
34. Dephosphorylation of focal adhesion kinase (FAK) and loss of focal contacts precede caspase-mediated cleavage of FAK during apoptosis in renal epithelial cells
35. Cleavage of the actin-capping protein alpha-adducin at Asp-Asp-Ser-Asp633-A1a by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells
36. Protease involvement in fodrin cleavage and phosphatidylserine exposure in apoptosis
37. IMP dehydrogenase inhibitor, tiazofurin, induces apoptosis in K562 human erythroleukemia cells
38. p53 binds to cisplatin-damaged DNA
39. Role of reactive oxygen species and p53 in chromium(VI)-induced apoptosis
40. The roles of caspase-3 and bcl-2 in chemically-induced apoptosis but not necrosis of renal epithelial cells