Inhibition of insulin signaling and glycogen synthesis by phorbol dibutyrate in rat skeletal muscle

American Journal of Physiology - Endocrinology and Metabolism

Volumn 281, Issue 1 44-1, 2001, Pages

  Lin, Yenshou ^a   Itani, Samar I ^a   Kurowski, Theodore G ^a   Dean, David J ^a   Lou, Zhijun ^a   Yaney, Gordon C ^a   Ruderman, Neil B ^a,b  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^b BOSTON MEDICAL CENTER   (United States)

Author keywords

Akt protein kinase B; Glycogen synthase kinase 3; Phorbol dibutyrate; Protein kinase C; Soleus muscle

Indexed keywords

CARBON DIOXIDE; DEOXYGLUCOSE; GLYCOGEN; INSULIN; INSULIN RECEPTOR; ISOPROTEIN; LIPID; PHORBOL DIBUTYRATE; PROTEIN KINASE C;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION; SOLEUS MUSCLE;

EID: 0034803855     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.2001.281.1.e8     Document Type: Article

References (35)

1. Phosphorylation of glycogen synthase by the Ca2 +- and phospholipid-activated protein kinase (protein kinase C)
2. Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis
3. Mechanism of hepatic glycogen synthase inactivation induced by Ca2+-mobilizing hormones. Studies using phospholipase C and phorbol myristate acetate
4. Protein kinase C isoforms beta 1 and beta 2 inhibit the tyrosine kinase activity of the insulin receptor
5. Inhibition of protein kinase C by calphostin C is light-dependent
6. Effects of phorbol esters on insulin receptor function and insulin action in hepatocytes: Evidence for heterogeneity
7. Diacylglycerol-protein kinase C signalling-in skeletal muscle: A possible link to insulin resistance
8. Protein kinase C: Mediator or inhibitor of insulin action?
9. Protein kinase C modulates insulin action in human skeletal muscle
10. Expression of the major isoenzyme of protein kinase-C in skeletal muscle, nPKC theta, varies with muscle type and in response to fructoseinduced insulin resistance
11. Protein kinase C isoforms epsilon, eta, delta and zeta in murine adipocytes: Expression, subcellular localization and tissue-specific regulation in insulin-resistant states
12. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
13. Stimulation of IRS-1-associated phosphatidylinositol 3-kinase and Akt/protein kinase B but not glucose transport by beta1-integrin signaling in rat adipocytes
14. Protein kinase C activators selectively inhibit insulin-stimulated system A transport activity in skeletal muscle at a post-receptor level
15. Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells
16. Phorbol esters stimulate muscle glucose transport by a mechanism distinct from the insulin and hypoxia pathways
17. Activation of glucose transport in skeletal muscle by phospholipase C and phorbol ester. Evaluation of the regulatory roles of protein kinase C and calcium
18. Enhanced stimulation of diacylglycerol and lipid synthesis by insulin in denervated muscle. Altered protein kinase C activity and possible link to insulin resistance
19. Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity
20. Phosphatidylinositol-3-kinase in isolated rat adipocytes. Activation by insulin and subcellular distribution
21. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C
22. Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
23. Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-idnase kinase in rat skeletal muscle
24. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
25. Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat
26. Altered protein kinase C distribution, but normal Akt activation in insulin resistant, denervated muscle
27. Protein kinase C and myocardial biology and function
28. Malonyl-CoA, fuel sensing, and insulin resistance
29. Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat
30. Glucose transporters and insulin action - Implications for insulin resistance and diabetes mellitus
31. Diacylglycerol/protein kinase C signalling: A mechanism for insulin resistance?
32. Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats
33. Minimal effects of phorbol esters on glucose transport and insulin sensitivity of rat skeletal muscle
34. Potential role of protein kinase B in glucose transporter 4 translocation in adipocytes
35. Insulin action in skeletal muscle from patients with NIDDM