Insulin induces heterologous desensitization of G protein-coupled receptor and insulin-like growth factor I signaling by downregulating β-arrestin-1

Molecular and Cellular Biology

Volumn 22, Issue 17, 2002, Pages 6272-6285

  Dalle, Stéphane ^a   Imamura, Takeshi ^a   Rose, David W ^a   Worrall, Dorothy Sears ^a   Ugi, Satoshi ^a   Hupfeld, Christopher J ^a   Olefsky, Jerrold M ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; BETA ARRESTIN; G PROTEIN COUPLED RECEPTOR; INSULIN; ISOPRENALINE; LYSOPHOSPHATIDIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; WORTMANNIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENDOCYTOSIS; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; IMMUNOPRECIPITATION; INHIBITION KINETICS; INTERNALIZATION; MITOGENESIS; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ADIPOCYTES; ADRENERGIC BETA-AGONISTS; ANIMALS; ARRESTINS; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; GTP-BINDING PROTEINS; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; ISOPROTERENOL; LYSOPHOSPHOLIPIDS; MAP KINASE KINASE 1; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PEPTIDE HYDROLASES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS PP60(C-SRC); RATS; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; RECEPTORS, ADRENERGIC, BETA-2; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; UBIQUITIN;

ANIMALIA;

EID: 0036333651     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.17.6272-6285.2002     Document Type: Article

References (53)

1. How receptors talk to trimeric G proteins
2. Insulin-like growth factor-I receptor internalization regulates signaling via the Shc/mitogen-activated protein kinase pathway, but not the insulin receptor substrate-1 pathway
3. The ubiquitin-mediated proteolytic pathway: Mode of action and clinical implications
4. Essential role of G protein-coupled receptor endocytosis in the activation of the mitogen-activated protein kinase
5. Insulin and insulin-like growth factor I receptors utilize different G proteins signaling components
6. Signal characteristics of G protein-transactivated EGF receptor
7. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin
8. Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization
9. Identification of the G protein-coupled receptor kinase phosphorylation sites in human beta2-adrenergic receptor
10. Insulin-like growth factors
11. Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor
12. Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis
13. The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades
14. Insulin and interleukin-4 induce desensitization to the mitogenic effects of insulin-like growth factor-I. Pivotal role for insulin receptor substrate-2
15. A rapamycin-sensitive pathway downregulates insulin signaling via phosphorylation and proteosomal degradation of insulin receptor substrate-1
16. Insulin-stimulated GLUT4 translocation is mediated by a divergent intracellular signaling pathway
17. Metabolism of photoaffinity-labeled insulin receptors by adipocytes. Role of internalization, degradation, and recycling
18. The ubiquitin system
19. Biochemistry. All in the ubiquitin family
20. G alpha-q/11 protein plays a key role in insulin-induced glucose transport in 3T3-L1 adipocytes
21. Chronic endothelin-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytes
22. Mechanisms of insulin action
23. Inhibition of Raf-1 signaling by a monoclonal antibody which interferes with Raf-1 activation and with Mek substrate binding
24. Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes
25. Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3′-kinase inhibition
26. G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization
27. Beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor
28. Beta-arrestin: A protein that regulates beta-adrenergic receptor function
29. Beta-arrestin-dependent formation of the beta2 adrenergic receptor-Src protein kinase complexes
30. Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of the mitogen-activated protein kinases
31. The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor
32. A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis
33. Insulin action impaired by deficiency of the G-protein subunit G ialpha2
34. Activation of MAPK cascades by G-protein-coupled receptors: The case of gonadotropin-releasing hormone receptor
35. Gi2-mediated activation of the MAP kinase cascade
36. Cell cycle regulation by the ubiquitin pathway
37. Molecular analysis of human beta-arrestin-1: Cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing
38. Targeting of substrates to the 26S proteasome
39. Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors
40. Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors
41. Insulin and IGF-I receptors signaling in protection from apoptosis
42. Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha-induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways
43. Insulin stimulates the degradation of IRS-1 in 3T3-L1 adipocytes
44. Functional characterization of coactivators using mammalian cell microinjection
45. Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2
46. Comparison of the insulin and insulin-like growth factor I mitogenic intracellular signaling pathways
47. Regulation of receptor fat by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin
48. Molecular mechanisms of receptor desensitization using the beta-adrenergic receptor coupled-adenylate cyclase system as a model
49. Type I insulin-like growth factor receptor activation regulates apoptotic proteins
50. Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway
51. Function of the IGF-I receptor in breast cancer
52. Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
53. Mitogenic signaling via G protein-coupled receptors