Disruption of 3-Phosphoinositide-dependent Kinase 1 (PDK1) Signaling by the Anti-tumorigenic and Anti-proliferative Agent N-α -tosyl-L-phenylalanyl Chloromethyl Ketone

Journal of Biological Chemistry

Volumn 276, Issue 15, 2001, Pages 12466-12475

  Ballif, Bryan A ^a   Shimamura, Akiko ^a   Pae, Eunice ^a   Blenis, John ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; IMMUNOLOGY; ONCOLOGY; PROTEINS; TUMORS;

EMBRYONIC STEM CELLS; PHOSPHORYLATION;

BIOCHEMISTRY;

3 PHOSPHOINOSITIDE DEPENDENT KINASE 1; ANTINEOPLASTIC AGENT; INTERLEUKIN 3; MITOGEN ACTIVATED PROTEIN KINASE; N ALPHA TOSYLPHENYLALANYL CHLOROMETHYL KETONE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; PROTEIN BAD; PROTEIN KINASE B; RAPAMYCIN; S6 KINASE; UNCLASSIFIED DRUG; 3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE; 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; TOSYLPHENYLALANYL CHLOROMETHYL KETONE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG TARGETING; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTO ONCOGENE; ANIMAL; CELL DIVISION; CELL LINE; CELL STRAIN 3T3; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALIA;

3T3 CELLS; ANIMALS; ANTICARCINOGENIC AGENTS; CELL DIVISION; CELL LINE, TRANSFORMED; ENZYME ACTIVATION; HUMANS; MICE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION; TOSYLPHENYLALANYL CHLOROMETHYL KETONE;

EID: 0035853797     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009939200     Document Type: Article

References (73)

1. Belham, C., Wu, S., and Avruch, J. (1999) Curr. Biol. 9, R93-6
2. Chan, T. O., Rittenhouse, S. E., and Tsichlis, P. N. (1999) Annu. Rev. Biochem. 68, 965-1014
3. Vanhaesebroeck, B., and Alessi, D. R. (2000) Biochem. J. 346, 561-576
4. Toker, A., and Newton, A. (2000) Cell 103, 185-188
5. Hanks, S. K., Quinn, A. M., and Hunter, T. (1988) Science 241, 42-52
6. Taylor, S. S., and Radzio-Andzelm, E. (1994) Structure 2, 345-355
7. Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B., and Cohen, P. (1997) Curr. Biol. 7, 261-269
8. Alessi, D. R., Kozlowski, M. T., Weng, Q. P., Morrice, N., and Avruch, J. (1998) Curr. Biol. 8, 69-81
9. Pullen, N., Dennis, P. B., Andjelkovic, M., Dufner, A., Kozma, S. C., Hemmings, B. A., and Thomas, G. (1998) Science 279, 707-710
10. Le Good, J. A., Ziegler, W. H., Parekh, D. B., Alessi, D. R., Cohen, P., and Parker, P. J. (1998) Science 281, 2042-2045
11. Chou, M. M., Hou, W., Johnson, J., Graham, L. K., Lee, M. H., Chen, C.-S., Newton, A. C., Schaffhausen, B. S., and Toker, A. (1998) Curr. Biol. 8, 1069-1077
12. Dutil, E. M., Toker, A., and Newton, A. C. (1998) Curr. Biol. 8, 1366-1375
13. Dong, L. Q., Zhang, R. B., Langlais, P., He, H., Clark, M., Zhu, L., and Liu, F. (1999) J. Biol. Chem. 274, 8117-8122
14. Kobayashi, T., Deak, M., Morrice, N., and Cohen, P. (1999) Biochem. J. 344, 189-197
15. Kobayashi, T., and Cohen, P. (1999) Biochem. J. 339, 319-328
16. Park, J., Leong, M. L., Buse, P., Maiyar, A. C., Firestone, G. L., and Hemmings, B. A. (1999) EMBO J. 18, 3024-3033
17. Cheng, X., Ma, Y., Moore, M., Hemmings, B. A., and Taylor, S. S. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 9849-9854
18. Richards, S. A., Fu, J., Romanelli, A., Simamura, A., and Blenis, J. (1999) Curr. Biol. 9, 810-820
19. Jensen, C. J., Buch, M. B., Krag, T. O., Hemmings, B. A., Gammeltoft, S., and Frodin, M. (1999) J. Biol. Chem. 274, 27168-27176
20. Flynn, P., Mellor, H., Casamassima, A., and Parker, P. J. (2000) J. Biol. Chem. 275, 11064-11070
21. King, C. C., Zenke, F. T., Dawson, P. E., Dutil, E. M., Newton, A. C., Hemmings, B. A., and Bokoch, G. M. (2000) J. Biol. Chem. 275, 18108-18113
22. Casamayor, A., Morrice, N. A., and Alessi, D. R. (1999) Biochem. J. 342, 287-292
23. Williams, M. R., Arthur, J. S., Balendran, A., van der Kaay, J., Poli, V., Cohen, P., and Alessi, D. R. (2000) Curr. Biol. 10, 439-448
24. Stokoe, D., Stephens, L. R., Copeland, T., Gaffney, P. R., Reese, C. B., Painter, G. F., Holmes, A. B., McCormick, F., and Hawkins, P. T. (1997) Science 277, 567-570
25. Alessi, D. R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, P., Cohen, P., and Hemmings, B. A. (1996) EMBO J. 15, 6541-6551
26. Filippa, N., Sable, C. L., Hemmings, B. A., and Van Obberghen, E. (2000) Mol. Cell. Biol. 20, 5712-5721
27. Romanelli, A., Martin, K. A., Toker, A., and Blenis, J. (1999) Mol. Cell. Biol. 19, 2921-2928
28. Biondi, R. M., Cheung, P. C., Casamayor, A., Deak, M., Currie, R. A., and Alessi, D. R. (2000) EMBO J. 19, 979-988
29. Frodin, M., Jensen, C. J., Merienne, K., and Gammeltoft, S. (2000) EMBO J. 19, 2924-2934
30. Dutil, E. M., and Newton, A. C. (2000) J. Biol. Chem. 275, 10697-10701
31. Kahan, B. D., Julian, B. A., Pescovitz, M. D., Vanrenterghem, Y., and Neylan, J. (1999) Transplantation 68, 1526-1532
32. Dufner, A., and Thomas, G. (1999) Exp. Cell Res. 253, 100-109
33. Chou, M. M., and Blenis, J. (1995) Curr. Opin. Cell Biol. 7, 806-814
34. Grammer, T. C., Cheatham, L., Chou, M. M., and Blenis, J. (1996) Cancer Surv.
35. Troll, W., Klassen, A., and Janoff, A. (1970) Science 169, 1211-1213
36. Hirschhorn, R., Grossman, J., Troll, W., and Weissmann, G. (1971) J. Clin. Invest. 50, 1206-1217
37. Chou, I. N., Black, P. H., and Roblin, R. O. (1974) Proc. Natl. Acad. Sci. U. S. A. 71, 1748-1752
38. Slaga, T. J., Klein-Szanto, A. J., Fischer, S. M., Weeks, C. E., Nelson, K., and Major, S. (1980) Proc. Natl. Acad. Sci. U. S. A. 77, 2251-2254
39. Su, L. N., Toscano, W. A., Jr., and Kennedy, A. R. (1991) Biochem. Biophys. Res. Commun. 176, 18-24
40. Heussler, V. T., Fernandez, P. C., Machado, J. Jr., Botteron, C., and Dobbelaere, D., A. (1999) Cell Death Differ. 6, 342-350
41. Grammer, T. C., and Blenis, J. (1996) J. Biol. Chem. 271, 23650-23652
42. Shimamura, A., Ballif, B. A., Richards, S. A., and Blenis, J. (2000) Curr. Biol. 10, 127-135
43. Carpenter, C. L., Duckworth, B. C., Auger, K. R., Cohen, B., Schaffhausen, B. S., and Cantley, L. C. (1990) J. Biol. Chem. 265, 19704-19711
44. Chung, J., Kuo, C. J., Crabtree, G. R., and Blenis, J. (1992) Cell 69, 1227-1236
45. Fisher, T. L., and Blenis, J. (1996) Mol. Cell. Bio. 16, 1212-1219
46. Cheatham, L., Monfar, M., Chou, M. M., and Blenis, J. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 11696-11700
47. Peterson, R. T., Desai, B. N., Hardwick, J. S., and Schreiber, S. L. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 4438-4442
48. Kohn, A. D., Barthel, A., Kovacina, K. S., Boge, A., Wallach, B., Summers, S. A., Birnbaum, M. J., Scott, P. H., Lawrence, J. C., Jr., and Roth, R. A. (1998) J. Biol. Chem. 273, 11937-11943
49. Bellacosa, A., Testa, J. R., Staal, S. P., and Tsichlis, P. N. (1991) Science 254, 274-277
50. Verdu, J., Buratovich, M. A., Wilder, E. L., and Birnbaum, M. J. (1999) Nat. Cell Biol. 1, 500-506
51. Montagne, J., Stewart, M. J., Stocker, H., Hafen, E., Kozma, S. C., and Thomas, G. (1999) Science 285, 2126-2129
52. Powers, J. C. (1977) Methods Enzymol. 46, 197-208
53. Kupfer, A., Gani, V., Jimenez, J. S., and Shaltiel, S. (1979) Proc. Natl. Acad. Sci. U. S. A. 76, 3073-3077
54. Vlahos, C. J., Matter, W. F., Brown, R. F., Traynor-Kaplan, A. E., Heyworth, P. G., Prossnitz, E. R., Ye, R. D., Marder, P., Schelm, J. A., Rothfuss, K. J., et al. (1995) J. Immunol. 154, 2413-2422
55. Peterson, R. T., and Schreiber, S. L. (1999) Curr. Biol. 9, R521-R524
56. Toker, A., and Newton, A. C. (2000) J. Biol. Chem. 275, 8271-8274
57. Balendran, A., Casamayor, A., Deak, M., Paterson, A., Gaffney, P., Currie, R., Downes, C. P., and Alessi, D. R. (1999) Curr. Biol. 9, 393-404
58. Persad, S., Attwell, S., Gray, V., Delcommenne, M., Troussard, A., Sanghera, J., and Dedhar, S. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 3207-3212
59. Currie, R. A., Walker, K. S., Gray, A., Deak, M., Casamayor, A., Downes, C. P., Cohen, P., Alessi, D. R., and Lucocq, J. (1999) Biochem. J. 337, 575-583
60. Datta, S. R., Katsov, A., Hu, L., Petros, A., Fesik, S. W., Yaffe, M. B., and Greenberg, M. E. (2000) Mol. Cell 6, 41-51
61. Virdee, K., Parone, P. A., and Tolkovsky, A. M. (2000) Curr. Biol. 10, 1151-1154
62. Schoellmann, G., and Shaw, E. (1962) Biochemistry 2, 252-255
63. Kennedy, A. R. (1998) Pharmacol. Ther. 78, 167-209
64. Ye, R. D., Ahern, S. M., Le Beau, M. M., Lebo, R. V., and Sadler, J. E. (1989) J. Biol. Chem. 264, 5495-5502
65. Miura, M., Zhu, H., Rotello, R., Hartwieg, E. A., and Yuan, J. (1993) Cell 75, 653-660
66. Gagliardini, V., Fernandez, P. A., Lee, R. K., Drexler, H. C., Rotello, R. J., Fishman, M. C., and Yuan, J. (1994) Science 263, 826-828
67. Solomon, D. H., O'Brian, C. A., and Weinstein, I. B. (1985) FEBS Lett. 190, 342-344
68. Stoppler, H., Stoppler, M. C., Adduci, A., Koval, D., and Schlegel, R. (1996) Virology 217, 542-553
69. Wu, M., Lee, H., Bellas, R. E., Schauer, S. L., Arsura, M., Katz, D., FitzGerald, M. J., Rothstein, T. L., Sherr, D. H., and Sonenshein, G. E. (1996) EMBO J. 15, 4682-4690
70. Wu, M., Arsura, M., Bellas, R. E., FitzGerald, M. J., Lee, H., Schauer, S. L., Sherr, D. H., and Sonenshein, G. E. (1996) Mol. Cell. Biol. 16, 5015-5025
71. Mercurio, F., Zhu, H., Murray, B. W., Shevchenko, A., Bennett, B. L., Li J., Young, D. B., Barbosa, M., Mann, M., Manning, A., and Rao, A. (1997) Science 278, 860-866
72. Schouten, G. J., Vertegaal, A. C. O., Whiteside, S. T., Israel, A., Toebes, M., Dorsman, J. C., van der Eb, A. J., and Zantema, A. (1997) EMBO J. 16, 3133-3144
73. Ozes, O. N., Mayo, L. D., Gustin, J. A., Pfeffer, S. R., Pfeffer, L. M., and Donner, D. B. (1999) Nature 401, 82-85