Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase α (PI3Kα). Functions of lipid kinase-deficient PI3Kα in signaling

Journal of Biological Chemistry

Volumn 276, Issue 24, 2001, Pages 21544-21554

  Pirola, Luciano ^a,c   Zvelebil, Marketa J ^b   Bulgarelli Leva, Genevieve ^a   Van Obberghen, Emmanuel ^c   Waterfield, Michael D ^b,d   Wymann, Matthias P ^a,e  

^a UNIVERSITY OF FRIBOURG   (Switzerland)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^c INSERM   (France)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e Division of Biochemistry   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEINS;

AMINO ACIDS; BIODIVERSITY; INSULIN; LIPIDS; PROTEINS; SUBSTRATES;

BIOCHEMISTRY;

ARGININE; GUANINE NUCLEOTIDE BINDING PROTEIN; HYBRID PROTEIN; INSULIN RECEPTOR SUBSTRATE 1; LYSINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHOINOSITIDE 3 KINASE ALPHA; PROTEIN KINASE; RAPAMYCIN; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; ANDROSTANE DERIVATIVE; ENZYME INHIBITOR; RECOMBINANT PROTEIN; WORTMANNIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVATION; ENZYME DEFICIENCY; ENZYME SPECIFICITY; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LIPID INTERACTION; RESIDUE ANALYSIS; SECOND MESSENGER; SEQUENCE ANALYSIS; TARGET CELL; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CELL STRAIN COS1; CERCOPITHECUS; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER PROGRAM; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; POINT MUTATION; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

ANIMALIA; MAMMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANDROSTADIENES; ANIMALS; BINDING SITES; CELL LINE; CERCOPITHECUS AETHIOPS; CONSERVED SEQUENCE; COS CELLS; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN KINASES; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SIROLIMUS; SOFTWARE; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 0035877577     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M011330200     Document Type: Article

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