Telomere shortening in peripheral blood cells was related with aging but not with white blood cell count

Japanese Journal of Human Genetics

Volumn 41, Issue 4, 1996, Pages 413-417

  Satoh, Hiroe ^a   Hiyama, Keiko ^a   Takeda, Masahiro ^a   Awaya, Yukikazu ^a   Watanabe, Kenichiro ^a   Ihara, Yoshinao ^a   Maeda, Hiroyuki ^a   Ishioka, Shinichi ^a   Yamakido, Michio ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

aging; blood cell; cell division; telomere; white blood cell count

Indexed keywords

ADULT; AGED; AGING; ARTICLE; BLOOD CELL; CELL DIVISION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; TELOMERE;

EID: 0030472837     PISSN: 09168478     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01876332     Document Type: Article

References (9)

1. Bridges RB, Rehm SR (1987): Chronic cigarette smoking and obstructive pulmonary disease: peripheral blood leukocytes, neutrophil elastase, myeloperoxidase activities, and serum antiprotease. In: Taylor JC, Mittman C (eds). Pulmonary emphysema and proteolysis: 1986. Academic Press, Orlando, pp 393-398
2. Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK, Allshire RC (1990): Telomere reduction in human colorectal carcinoma and with ageing. Nature 346: 866-868
3. Hiyama K, Hirai Y, Kyoizumi S, Akiyama M, Hiyama E, Piatyszek MA, Shay JW, Ishioka S, Yamakido M (I995a): Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J Immunol 155: 3711-3715
4. Hiyama K, Ishioka S, Shirotani Y, Inai K, Hiyama E, Murakami I, Isobe T, Inamizu T, Yamakido M (1995b): Alterations in telomeric repeat length in lung cancer are associated with loss of heterozygosity in p53 and Rb. Oncogene 10: 937-944
5. Hiyama E, Hiyama K, Tatsumoto N. Kodama T, Shay JW, Yokoyama T (1996): Telomerase activity in human intestine. Int J One 9: 453-458
6. Kirn NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PLC, Coviello GM, Wright WE. Weinrich SL, Shay JW (1994): Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011-2015
7. Ohyashiki JH, Ohyashiki K. Fujimura T, Kawakubo K, Shimamoto T, Iwabuchi A, Totama K (1994): Telomere shortening associated with disease evolution patterns in myelodysplastic syndromes. Cancer Res 54: 3557-3560
8. Shay JW ( 1995): Aging and cancer: are telomeres and telomerase the connection? Mol Med Today 1: 378 384
9. Taylor RS, Ramirez RD, Ogoshi M, Chaffins M, Piatyszek MA. Shay JW (1996): Detection of telomerase activity in malignant and nonmalignant skin conditions. J Invest Dermatol 106: 759-765