Telomere shortening in gastric carcinoma with aging despite telomerase activation

Journal of Cancer Research and Clinical Oncology

Volumn 126, Issue 8, 2000, Pages 481-485

  Furugori, Eiki ^a,b   Hirayama, Renzo ^b   Nakamura, Ken Ichi ^a   Kammori, Makoto ^c   Esaki, Yukiyoshi ^a,d   Takubo, Kaiyo ^a,d  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b SAITAMA MEDICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d Tokyo Metropolitan Institute of Gerontology   (Japan)

Author keywords

Aging; Gastric carcinoma; Telomerase; Telomere

Indexed keywords

TELOMERASE;

ADENOCARCINOMA; ADULT; AGED; AGING; ARTICLE; BASE PAIRING; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN TISSUE; INTESTINE METAPLASIA; MALE; PRIORITY JOURNAL; SOUTHERN BLOTTING; STOMACH CARCINOMA; STOMACH MUCOSA; TANDEM REPEAT; TELOMERE;

EID: 0343492552     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004320000137     Document Type: Article

References (14)

1. Ahn MJ, Noh YH, Lee YS, Lee JH, Chung TJ, Kim IS, Choi IY, Kim SH, Lee JS, Lee KH (1997) Telomerase activity and its clinicopathological significance in gastric cancer. Eur J Cancer 33: 1309-1313
2. Blackburn EH (1991) Structure and function of telomeres. Nature 350: 569-573
3. Counter CM, Botelho PM, Wang P, Harley CB, Bacchetti S (1994) Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. J Virol 68: 3410-3414
4. Eastwood GL (1977) Gastrointestinal epithelial renewal. Gastroenterology 72: 962-975
5. Harley CB, Futcher AB, Greider CW (1990) Telomeres shorten during aging of human fibroblasts. Nature 345: 458-460
6. Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK, Allshire RC (1990) Telomere reduction in human colorectal carcinoma and with aging. Nature 346: 866-868
7. Hermanek P, Sobin LH (1987) TNM classification of malignant tumours. Springer, Berlin Heidelberg New York
8. Hiyama E, Yokoyama T, Tatsumoto N, Hiyama K, Imamura Y, Murakami Y, Kodama T, Piatyszek MA, Shay JW, Matsuura Y (1995) Telomerase activity in gastric cancer. Cancer Res 55: 3258-3262
9. Hiyama E, Hiyama K, Tatsumoto N, Kodama T, Shay JW, Yokoyama T (1996) Telomerase activity in human intestine. Int J Oncol 9: 453-458
10. Lindsey J, McGill NI, Lindsey LA, Green DK, Cooke HJ (1991) In vivo loss of telomeric repeats with age in humans. Mutat Res 256: 45-48
11. Maruyama Y, Hanai H, Fujita M, Kaneko E (1997) Telomere length and telomerase activity in carcinogenesis of the stomach. Jpn J Clin Oncol 27: 216-220
12. Takubo K, Nakamura K, Izumiyama N, Sawabe M, Arai T, Esaki Y, Tanaka Y, Mafune K, Fujiwara M, Kammori M, Sasajima K (1999) Telomere shortening with aging in human esophageal mucosa. Age 22: 95-99
13. Takubo K, Nakamura K, Izumiyama N, Furugori E, Sawabe M, Arai T, Esaki Y, Mafune K, Kammori M, Fujiwara M, Kato M, Oshimura M, Sasajima K (2000) Telomere shortening with aging in the liver. J Gerontol Biol Sci (in press)
14. Vaziri H, Schächter F, Uchida I, Wei L, Zhu X, Effros R, Cohen D, Herley CB (1993) Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet 52: 661-667