A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO

Journal of Biological Chemistry

Volumn 278, Issue 9, 2003, Pages 7494-7499

  Hunter, Allison M ^a,b   Kottachchi, Dan ^a   Lewis, Jennifer ^c   Duckett, Colin S ^c   Korneluk, Robert G ^a,b   Liston, Peter ^a  

^a CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENES; PROTEINS;

APOPTOSIS;

BIOCHEMISTRY;

ALANYLVALYLPROLYLISOLEUCINAMIDE; APOPTOSIS INHIBITOR; CASPASE 3; CASPASE 7; CASPASE 9; CASPASE INHIBITOR; ETOPOSIDE; HYBRID PROTEIN; MITOCHONDRIAL PROTEIN; PEPTIDE FRAGMENT; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; UBIQUITIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; CASP3 PROTEIN, HUMAN; CASP3 PROTEIN, MOUSE; CASP7 PROTEIN, HUMAN; CASP7 PROTEIN, MOUSE; CASP9 PROTEIN, HUMAN; CASP9 PROTEIN, MOUSE; CASPASE; CYTOCHROME C; DIABLO PROTEIN, HUMAN; DIABLO PROTEIN, MOUSE; DNA; GLUTATHIONE TRANSFERASE; PEPTIDE; SIGNAL PEPTIDE;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CHEMOTHERAPY; CHEMOSENSITIVITY; CONTROLLED STUDY; CYTOSOL; ENZYME INHIBITION; GENE DISRUPTION; GENE OVEREXPRESSION; GENE THERAPY; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN INTERACTION; PROTEIN PROCESSING; PROTEIN SECRETION; ANIMAL; CELL DEATH; CELL FRACTIONATION; CELL LINE; CHEMISTRY; CYTOPLASM; DRUG ANTAGONISM; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; HELA CELL; METABOLISM; MITOCHONDRION; MOUSE; PLASMID; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN TERTIARY STRUCTURE; SERODIAGNOSIS; WESTERN BLOTTING;

INTRACISTERNAL A-PARTICLES;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CARRIER PROTEINS; CASPASE 3; CASPASE 7; CASPASE 9; CASPASES; CELL DEATH; CELL LINE; CYTOCHROME C GROUP; CYTOPLASM; DNA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ETOPOSIDE; GLUTATHIONE TRANSFERASE; HELA CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; PEPTIDES; PLASMIDS; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SUBCELLULAR FRACTIONS; TRANSFECTION; UBIQUITIN;

EID: 0037470027     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C200695200     Document Type: Article

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