Structure-activity relationships of novel 2-substituted quinazoline antibacterial agents

Journal of Medicinal Chemistry

Volumn 42, Issue 22, 1999, Pages 4705-4713

  Kung, Pei Pei ^a   Casper, Martin D ^a   Cook, Kimberley L ^a   Wilson Lingardo, Laura ^a   Risen, Lisa M ^a   Vickers, Timothy A ^a   Ranken, Ray ^a   Blyn, Lawrence B ^a   Wyatt, Jacqueline R ^a   Cook, P Dan ^a   Ecker, David J ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [1 (4 AMINO 6,7 DIMETHOXYQUINAZOLIN 2 YL)PIPERIDIN 4 YLAMINO]BENZOIC ACID; ANTIINFECTIVE AGENT; CYCLOHEXIMIDE; QUINAZOLINE DERIVATIVE; RIFAMPICIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STREPTOCOCCUS PYOGENES; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-BACTERIAL AGENTS; BENZOIC ACIDS; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MALE; MICE; MICE, INBRED ICR; PROTEIN BIOSYNTHESIS; QUINAZOLINES; RNA, BACTERIAL; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC;

EID: 0033523896     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9903500     Document Type: Article

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